Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 1
1992 4
1993 4
1994 3
1995 1
1996 2
1997 7
1998 3
1999 2
2000 2
2001 3
2002 3
2003 10
2004 2
2005 10
2006 7
2007 8
2008 10
2009 11
2010 10
2011 17
2012 17
2013 26
2014 19
2015 12
2016 12
2017 10
2018 5
2019 3
2020 7
2021 5
2022 4
2023 1
2024 3
2025 3
2026 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

216 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS).
Flather MD, Shibata MC, Coats AJ, Van Veldhuisen DJ, Parkhomenko A, Borbola J, Cohen-Solal A, Dumitrascu D, Ferrari R, Lechat P, Soler-Soler J, Tavazzi L, Spinarova L, Toman J, Böhm M, Anker SD, Thompson SG, Poole-Wilson PA; SENIORS Investigators. Flather MD, et al. Eur Heart J. 2005 Feb;26(3):215-25. doi: 10.1093/eurheartj/ehi115. Epub 2005 Jan 9. Eur Heart J. 2005. PMID: 15642700 Clinical Trial.
There was no significant influence of age, gender, or ejection fraction on the effect of nebivolol on the primary outcome. Death (all causes) occurred in 169 (15.8%) on nebivolol and 192 (18.1%) on placebo (HR 0.88, 95% CI 0.71-1.08; P=0.21). CONCLUSION: Nebivolo …
There was no significant influence of age, gender, or ejection fraction on the effect of nebivolol on the primary outcome. Death (all …
Effect of nebivolol on erectile function: a systematic review and meta-analysis of randomized controlled trials.
Lu Y, Li L, Li Q, Sun G. Lu Y, et al. J Sex Med. 2025 Jan 9;22(2):307-316. doi: 10.1093/jsxmed/qdae189. J Sex Med. 2025. PMID: 39713902
BACKGROUND: Historically, beta-blockers have been associated with erectile dysfunction (ED). Nebivolol, a third-generation beta-blocker, may have had no negative effect on erectile function because of its vasodilating properties. ...All included studies compared the effect …
BACKGROUND: Historically, beta-blockers have been associated with erectile dysfunction (ED). Nebivolol, a third-generation beta-block …
Nebivolol for the Treatment of Essential Systemic Arterial Hypertension: A Systematic Review and Meta-Analysis.
Seleme VB, Marques GL, Mendes AEM, Rotta I, Pereira M, Júnior EL, da Cunha CLP. Seleme VB, et al. Am J Cardiovasc Drugs. 2021 Mar;21(2):165-180. doi: 10.1007/s40256-020-00422-0. Am J Cardiovasc Drugs. 2021. PMID: 32710438
After careful analysis, 34 randomized and double-blind clinical trials were included to investigate the efficacy of nebivolol on systolic (SBP) and diastolic blood pressure (DBP) control and adverse effects. ...CONCLUSIONS: Nebivolol demonstrated at least similar co …
After careful analysis, 34 randomized and double-blind clinical trials were included to investigate the efficacy of nebivolol on syst …
Effects of nebivolol versus other antihypertensive drugs on the endothelial dysfunction in patients with essential hypertension.
Li B, Zhang Q, Zhang H, Wang C, Xiu R. Li B, et al. Biosci Rep. 2020 May 29;40(5):BSR20200436. doi: 10.1042/BSR20200436. Biosci Rep. 2020. PMID: 32342981 Free PMC article. Review.
We aim to determine whether nebivolol has a better effect on endothelial dysfunction compared with other beta-blockers or other classes of antihypertensive drugs. ...Nebivolol is not a unique endothelial function-protective agent distinguished from other beta-blocke …
We aim to determine whether nebivolol has a better effect on endothelial dysfunction compared with other beta-blockers or other class …
Effect of nebivolol monotherapy or combination therapy on blood pressure levels in patients with hypertension: an updated systematic review and multilevel meta-analysis of 91 randomized controlled trials.
Manolis A, Karakasis P, Patoulias D, Doumas M, Kallistratos M, Thomopoulos C, Koutsaki M, Grassi G, Mancia G. Manolis A, et al. High Blood Press Cardiovasc Prev. 2025 Jan;32(1):7-31. doi: 10.1007/s40292-024-00687-5. Epub 2024 Oct 29. High Blood Press Cardiovasc Prev. 2025. PMID: 39467996
In contrast, compared to the active comparators, there was no significant difference in systolic BP reduction, but a significant reduction in diastolic BP favoring nebivolol. Based on moderator analyses, the impact of nebivolol on the pooled estimates remained indep …
In contrast, compared to the active comparators, there was no significant difference in systolic BP reduction, but a significant reduction i …
Efficacy and safety of nebivolol in hypertensive patients: a meta-analysis of randomized controlled trials.
Liu JY, Guo LN, Peng WZ, Jiang Y, Wang AL, Guo XM, Xu ZS. Liu JY, et al. J Int Med Res. 2020 Oct;48(10):300060520931625. doi: 10.1177/0300060520931625. J Int Med Res. 2020. PMID: 33081551 Free PMC article.
The incidence of AEs was lower in patients taking nebivolol compared with patients taking other second-generation beta blockers. CONCLUSIONS: No significant difference was demonstrated between nebivolol and other second-generation beta blockers in the reduction of b …
The incidence of AEs was lower in patients taking nebivolol compared with patients taking other second-generation beta blockers. CONC …
Beta-blockers for hypertension.
Wiysonge CS, Bradley HA, Volmink J, Mayosi BM, Opie LH. Wiysonge CS, et al. Cochrane Database Syst Rev. 2017 Jan 20;1(1):CD002003. doi: 10.1002/14651858.CD002003.pub5. Cochrane Database Syst Rev. 2017. PMID: 28107561 Free PMC article.
We found no outcome trials involving the newer vasodilating beta-blockers (e.g. nebivolol).There was no difference in all-cause mortality between beta-blockers and placebo (RR 0.99, 95% CI 0.88 to 1.11), diuretics or RAS inhibitors, but it was higher for beta-blockers comp …
We found no outcome trials involving the newer vasodilating beta-blockers (e.g. nebivolol).There was no difference in all-cause morta …
Efficacy and tolerability of nebivolol compared with other antihypertensive drugs: a meta-analysis.
Van Bortel LM, Fici F, Mascagni F. Van Bortel LM, et al. Am J Cardiovasc Drugs. 2008;8(1):35-44. doi: 10.2165/00129784-200808010-00005. Am J Cardiovasc Drugs. 2008. PMID: 18303936
This meta-analysis investigates the efficacy and tolerability of nebivolol compared with other antihypertensive drugs and placebo in patients with hypertension. ...The percentage of patients experiencing adverse events did not differ between nebivolol and placebo; a …
This meta-analysis investigates the efficacy and tolerability of nebivolol compared with other antihypertensive drugs and placebo in …
Nebivolol reduces short-term blood pressure variability more potently than irbesartan in patients with intradialytic hypertension.
Loutradis C, Bikos A, Raptis V, Afkou Z, Tzanis G, Pyrgidis N, Panagoutsos S, Pasadakis P, Balaskas E, Zebekakis P, Liakopoulos V, Papagianni A, Parati G, Sarafidis P. Loutradis C, et al. Hypertens Res. 2019 Jul;42(7):1001-1010. doi: 10.1038/s41440-018-0194-2. Epub 2019 Jan 8. Hypertens Res. 2019. PMID: 30622317 Clinical Trial.
The diastolic-BPV indices decreased with nebivolol and increased with irbesartan, resulting in significant differences between the two drugs (SD: baseline 10.56 2.50; nebivolol 9.75 2.12; irbesartan 10.84 1.98, between-drug p = 0.014; wSD: baseline 9.86 2.12 …
The diastolic-BPV indices decreased with nebivolol and increased with irbesartan, resulting in significant differences between the tw …
216 results