Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2012 3
2013 5
2014 8
2015 4
2016 10
2017 7
2018 14
2019 10
2020 1
2021 3
2022 6
2023 4
2024 2
2025 2

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

72 results

Results by year

Filters applied: . Clear all
Page 1
Did you mean necroptotic linkermann (10 results)?
Ferroptosis and Necroptosis in the Kidney.
Belavgeni A, Meyer C, Stumpf J, Hugo C, Linkermann A. Belavgeni A, et al. Cell Chem Biol. 2020 Apr 16;27(4):448-462. doi: 10.1016/j.chembiol.2020.03.016. Cell Chem Biol. 2020. PMID: 32302582 Free article. Review.
In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI) and AKI to chronic kidney disease (CKD) progression has been revisited as our understanding of ferroptosis and necroptosis has emerged. A growing body of evidence, reviewed here, …
In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI) and AKI to chronic kidney disease (CKD) progre …
Necroptosis.
Linkermann A, Green DR. Linkermann A, et al. N Engl J Med. 2014 Jan 30;370(5):455-65. doi: 10.1056/NEJMra1310050. N Engl J Med. 2014. PMID: 24476434 Free PMC article. Review. No abstract available.
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Marti… See abstract for full author list ➔ Galluzzi L, et al. Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Cell Death Differ. 2018. PMID: 29362479 Free PMC article. Review.
As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-depe …
As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability trans …
Mechanisms and Models of Kidney Tubular Necrosis and Nephron Loss.
Maremonti F, Meyer C, Linkermann A. Maremonti F, et al. J Am Soc Nephrol. 2022 Mar;33(3):472-486. doi: 10.1681/ASN.2021101293. Epub 2022 Jan 12. J Am Soc Nephrol. 2022. PMID: 35022311 Free PMC article. Review.
However, during AKI, the transition of AKI to CKD, sepsis-associated AKI, and kidney transplantation ferroptosis and necroptosis, two pathways associated with the loss of plasma membrane integrity, kill renal cells. ...Importantly, the necroinflammatory response to cells t …
However, during AKI, the transition of AKI to CKD, sepsis-associated AKI, and kidney transplantation ferroptosis and necroptosis, two …
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease.
Del Re DP, Amgalan D, Linkermann A, Liu Q, Kitsis RN. Del Re DP, et al. Physiol Rev. 2019 Oct 1;99(4):1765-1817. doi: 10.1152/physrev.00022.2018. Physiol Rev. 2019. PMID: 31364924 Free PMC article. Review.
We review in detail the basic biology of nine including death receptor-mediated apoptosis, death receptor-mediated necrosis (necroptosis), mitochondrial-mediated apoptosis, mitochondrial-mediated necrosis, autophagy-dependent cell death, ferroptosis, pyroptosis, parthanato …
We review in detail the basic biology of nine including death receptor-mediated apoptosis, death receptor-mediated necrosis (necroptosis …
Ferroptosis as a target for protection against cardiomyopathy.
Fang X, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, Cheng Q, Zhang P, Dai W, Chen J, Yang F, Yang HT, Linkermann A, Gu W, Min J, Wang F. Fang X, et al. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2672-2680. doi: 10.1073/pnas.1821022116. Epub 2019 Jan 28. Proc Natl Acad Sci U S A. 2019. PMID: 30692261 Free PMC article.
Here, we discovered and demonstrated that ferroptosis, a programmed iron-dependent cell death, as a mechanism in murine models of doxorubicin (DOX)- and ischemia/reperfusion (I/R)-induced cardiomyopathy. In canonical apoptosis and/or necroptosis-defective Ripk3(-/-), Mlkl( …
Here, we discovered and demonstrated that ferroptosis, a programmed iron-dependent cell death, as a mechanism in murine models of doxorubici …
Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI.
Martin-Sanchez D, Ruiz-Andres O, Poveda J, Carrasco S, Cannata-Ortiz P, Sanchez-Niño MD, Ruiz Ortega M, Egido J, Linkermann A, Ortiz A, Sanz AB. Martin-Sanchez D, et al. J Am Soc Nephrol. 2017 Jan;28(1):218-229. doi: 10.1681/ASN.2015121376. Epub 2016 Jun 27. J Am Soc Nephrol. 2017. PMID: 27352622 Free PMC article.
Additionally, although FA-AKI resulted in increased protein expression of the necroptosis mediators receptor-interacting protein kinase 3 (RIPK3) and mixed lineage domain-like protein (MLKL), targeting necroptosis with the RIPK1 inhibitor necrostatin-1 or genetic de …
Additionally, although FA-AKI resulted in increased protein expression of the necroptosis mediators receptor-interacting protein kina …
Phenytoin inhibits necroptosis.
von Mässenhausen A, Tonnus W, Himmerkus N, Parmentier S, Saleh D, Rodriguez D, Ousingsawat J, Ang RL, Weinberg JM, Sanz AB, Ortiz A, Zierleyn A, Becker JU, Baratte B, Desban N, Bach S, Schiessl IM, Nogusa S, Balachandran S, Anders HJ, Ting AT, Bleich M, Degterev A, Kunzelmann K, Bornstein SR, Green DR, Hugo C, Linkermann A. von Mässenhausen A, et al. Cell Death Dis. 2018 Mar 2;9(3):359. doi: 10.1038/s41419-018-0394-3. Cell Death Dis. 2018. PMID: 29500402 Free PMC article.
RIPK3-deficient mice have recently been demonstrated to be protected in a series of disease models, but direct evidence for activation of necroptosis in vivo is still limited. Here, we sought to further examine the activation of necroptosis in kidney ischemia-reperf …
RIPK3-deficient mice have recently been demonstrated to be protected in a series of disease models, but direct evidence for activation of …
Synchronized renal tubular cell death involves ferroptosis.
Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, Prokai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, Vanden Berghe T, Vandenabeele P, Pasparakis M, Bleich M, Weinberg JM, Reichel CA, Bräsen JH, Kunzendorf U, Anders HJ, Stockwell BR, Green DR, Krautwald S. Linkermann A, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41. doi: 10.1073/pnas.1415518111. Epub 2014 Nov 10. Proc Natl Acad Sci U S A. 2014. PMID: 25385600 Free PMC article.
Receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis is thought to be the pathophysiologically predominant pathway that leads to regulated necrosis of parenchymal cells in ischemia-reperfusion injury (IRI), and loss of either Fas-associated protein with death …
Receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis is thought to be the pathophysiologically predominant pathway that …
We AIM2 Inflame.
Linkermann A, Parmentier SP, Hugo C. Linkermann A, et al. J Am Soc Nephrol. 2018 Apr;29(4):1077-1079. doi: 10.1681/ASN.2018020116. Epub 2018 Mar 6. J Am Soc Nephrol. 2018. PMID: 29511112 Free PMC article. No abstract available.
72 results