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Neem leaf glycoprotein directs T-bet-associated type 1 immune commitment.
Bose A, Chakraborty K, Sarkar K, Goswami S, Haque E, Chakraborty T, Ghosh D, Roy S, Laskar S, Baral R. Bose A, et al. Hum Immunol. 2009 Jan;70(1):6-15. doi: 10.1016/j.humimm.2008.09.004. Epub 2008 Nov 5. Hum Immunol. 2009. PMID: 18983881
Neem leaf glycoprotein (NLGP)-mediated immune activation and associated immune polarization was studied. NLGP-induced activation is reflected in upregulation of early activation marker CD69 on lymphocytes, monocytes, and dendritic cells. ...A type 1-specific
Neem leaf glycoprotein (NLGP)-mediated immune activation and associated immune polarization was studied. NLGP-induced a
Enhanced anti-tumor efficacy of checkpoint inhibitors in combination with the histone deacetylase inhibitor Belinostat in a murine hepatocellular carcinoma model.
Llopiz D, Ruiz M, Villanueva L, Iglesias T, Silva L, Egea J, Lasarte JJ, Pivette P, Trochon-Joseph V, Vasseur B, Dixon G, Sangro B, Sarobe P. Llopiz D, et al. Cancer Immunol Immunother. 2019 Mar;68(3):379-393. doi: 10.1007/s00262-018-2283-0. Epub 2018 Dec 13. Cancer Immunol Immunother. 2019. PMID: 30547218
Immune checkpoint inhibitors are currently tested in different combinations in patients with advanced hepatocellular carcinoma (HCC). ...Epigenetic drugs have immune-mediated antitumor effects that may improve the activity of immunotherapy agents. Our aim was to stu
Immune checkpoint inhibitors are currently tested in different combinations in patients with advanced hepatocellular carcinoma (HCC).
Enhancement of immune responses to neem leaf extract (Azadirachta indica) correlates with antineoplastic activity in BALB/c-mice.
Beuth J, Schneider H, Ko HL. Beuth J, et al. In Vivo. 2006 Mar-Apr;20(2):247-51. In Vivo. 2006. PMID: 16634526 Free article.
An aqueous plant extract from Azadirachta indica and its chromatographic fraction F1 (neem extract) exerted immunomodulating and antimetastatic activities in BALB/ c-mice. ...To evaluate the antimetastatic activity of neem extract, sarcoma L-1 cells and lymphosarcom …
An aqueous plant extract from Azadirachta indica and its chromatographic fraction F1 (neem extract) exerted immunomodulating and anti …
Plant extract-based diets differently modulate immune responses and resistance to bacterial infection in striped catfish (Pangasianodon hypophthalmus).
Nhu TQ, Bich Hang BT, Bach LT, Buu Hue BT, Quetin-Leclercq J, Scippo ML, Phuong NT, Kestemont P. Nhu TQ, et al. Fish Shellfish Immunol. 2019 Sep;92:913-924. doi: 10.1016/j.fsi.2019.07.025. Epub 2019 Jul 12. Fish Shellfish Immunol. 2019. PMID: 31306761
[Mp]; neem, Azadirachta indica A. Juss [Ai] and asthma plant, Euphorbia hirta L. [Eh]) on the immune response and disease resistance against Edwardsiella ictaluri infection of striped catfish (Pangasianodon hypophthalmus). ...Specifically, diets enriched with extrac …
[Mp]; neem, Azadirachta indica A. Juss [Ai] and asthma plant, Euphorbia hirta L. [Eh]) on the immune response and disease resi …
Screening of immuno-modulatory potential of different herbal plant extracts using striped catfish (Pangasianodon hypophthalmus) leukocyte-based in vitro tests.
Nhu TQ, Bich Hang BT, Vinikas A, Bach LT, Buu Hue BT, Thanh Huong DT, Quetin-Leclercq J, Scippo ML, Phuong NT, Kestemont P. Nhu TQ, et al. Fish Shellfish Immunol. 2019 Oct;93:296-307. doi: 10.1016/j.fsi.2019.07.064. Epub 2019 Jul 25. Fish Shellfish Immunol. 2019. PMID: 31352112
Several humoral immune parameters (lysozyme, complement and total immunoglobulin) were examined at 24-h post stimulation (hps). ...(As), neem Azadirachta indica A. Juss (Ai), asthma-plant Euphorbia hirta L. (Eh), bhumi amla Phyllanthus amarus Schum. et Thonn (Pa), a …
Several humoral immune parameters (lysozyme, complement and total immunoglobulin) were examined at 24-h post stimulation (hps). ...(A …
Neem leaf glycoprotein prophylaxis transduces immune dependent stop signal for tumor angiogenic switch within tumor microenvironment.
Banerjee S, Ghosh T, Barik S, Das A, Ghosh S, Bhuniya A, Bose A, Baral R. Banerjee S, et al. PLoS One. 2014 Nov 12;9(11):e110040. doi: 10.1371/journal.pone.0110040. eCollection 2014. PLoS One. 2014. PMID: 25391149 Free PMC article.
We have reported that prophylactic as well as therapeutic administration of neem leaf glycoprotein (NLGP) induces significant restriction of solid tumor growth in mice. ...Studies in immune compromised mice confirmed that these vascular and intratumoral changes in a …
We have reported that prophylactic as well as therapeutic administration of neem leaf glycoprotein (NLGP) induces significant restric …
Effect of Azadirachta indica (Sapindales: Meliaceae) Oil on the Immune System of Spodoptera frugiperda (Lepidoptera: Noctuidae) Immatures.
Duarte JP, Redaelli LR, Silva CE, Jahnke SM. Duarte JP, et al. J Insect Sci. 2020 May 1;20(3):17. doi: 10.1093/jisesa/ieaa048. J Insect Sci. 2020. PMID: 32556318 Free PMC article.
The insect immune system includes several mechanisms responsible for defending against pathogens, parasites, and parasitoids. Some botanical insecticides, such as Azadirachta indica oil, cause changes in the immune system of various insect species. Spo …
The insect immune system includes several mechanisms responsible for defending against pathogens, parasites, and parasitoids. …
NLGP counterbalances the immunosuppressive effect of tumor-associated mesenchymal stem cells to restore effector T cell functions.
Ghosh T, Nandi P, Ganguly N, Guha I, Bhuniya A, Ghosh S, Sarkar A, Saha A, Dasgupta S, Baral R, Bose A. Ghosh T, et al. Stem Cell Res Ther. 2019 Sep 23;10(1):296. doi: 10.1186/s13287-019-1349-z. Stem Cell Res Ther. 2019. PMID: 31547863 Free PMC article.
., MSCs, interact and eventually modulate the biology and functions of cancer and immune cells. Our recent finding disclosed a novel mechanism stating that tumor-associated MSCs inhibit the T cell proliferation and effector functions by blocking cysteine transport to T cel …
., MSCs, interact and eventually modulate the biology and functions of cancer and immune cells. Our recent finding disclosed a novel …
Neem leaf preparation enhances Th1 type immune response and anti-tumor immunity against breast tumor associated antigen.
Mandal-Ghosh I, Chattopadhyay U, Baral R. Mandal-Ghosh I, et al. Cancer Immun. 2007 Mar 30;7:8. Cancer Immun. 2007. PMID: 17394284 Free PMC article.
The potent immune activation by an aqueous preparation of neem (Azadirachta indica) leaf (NLP) suggests its possible utility for enhancing immune responses to tumor vaccines. ...As NLP is nontoxic, abundantly available in the Indian subcontinent and can be ex …
The potent immune activation by an aqueous preparation of neem (Azadirachta indica) leaf (NLP) suggests its possible utility f …
Azadirachta indica (neem) leaf dietary effects on the immunity response and disease resistance of Asian seabass, Lates calcarifer challenged with Vibrio harveyi.
Talpur AD, Ikhwanuddin M. Talpur AD, et al. Fish Shellfish Immunol. 2013 Jan;34(1):254-64. doi: 10.1016/j.fsi.2012.11.003. Epub 2012 Nov 20. Fish Shellfish Immunol. 2013. PMID: 23178500
Dietary doses of neem leaf diet significantly influenced the immune parameters, haematological parameters and blood biochemical indices of treated fish. The results suggested that fish fed neem leaf-supplemented diet improved the immune system a …
Dietary doses of neem leaf diet significantly influenced the immune parameters, haematological parameters and blood biochemica …
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