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Did you mean negative regulation of tlr signaling (1,452 results)?
Foot-and-mouth disease virus VP1 degrades YTHDF2 through autophagy to regulate IRF3 activity for viral replication.
Liu H, Xue Q, Yang F, Cao W, Liu P, Liu X, Zhu Z, Zheng H. Liu H, et al. Autophagy. 2024 Jul;20(7):1597-1615. doi: 10.1080/15548627.2024.2330105. Epub 2024 Mar 22. Autophagy. 2024. PMID: 38516932 Free PMC article.
Here, we found that the host GTPBP4/NOG1 (GTP binding protein 4) is a negative regulator of innate immune responses. GTPBP4 deficiency promotes the antiviral innate immune response, resulting in the ability of GTPBP4 to promote FMDV replication. ...In conclusion, ou …
Here, we found that the host GTPBP4/NOG1 (GTP binding protein 4) is a negative regulator of innate immune responses. GTPBP4 de …
A negative feedback loop of TOR signaling balances growth and stress-response trade-offs in plants.
Jamsheer K M, Jindal S, Sharma M, Awasthi P, S S, Sharma M, Mannully CT, Laxmi A. Jamsheer K M, et al. Cell Rep. 2022 Apr 5;39(1):110631. doi: 10.1016/j.celrep.2022.110631. Cell Rep. 2022. PMID: 35385724 Free article.
In this study, we describe a negative feedback loop of TOR signaling helping in the adaptability of plants in changing environmental conditions. ...FLZ8 negatively regulates TOR signaling by promoting antagonistic SnRK1alpha1 si …
In this study, we describe a negative feedback loop of TOR signaling helping in the adaptability of plants in changing …
Negative Regulation of Mitochondrial Antiviral Signaling Protein-Mediated Antiviral Signaling by the Mitochondrial Protein LRPPRC During Hepatitis C Virus Infection.
Refolo G, Ciccosanti F, Di Rienzo M, Basulto Perdomo A, Romani M, Alonzi T, Tripodi M, Ippolito G, Piacentini M, Fimia GM. Refolo G, et al. Hepatology. 2019 Jan;69(1):34-50. doi: 10.1002/hep.30149. Epub 2018 Dec 18. Hepatology. 2019. PMID: 30070380
Moreover, we showed that LRPPRC acts as a negative regulator of the mitochondrial-mediated antiviral immunity, by interacting with mitochondrial antiviral signaling protein (MAVS) and inhibiting its association with TRAF3 and TRAF6. ...Conclusion: Overall, ou …
Moreover, we showed that LRPPRC acts as a negative regulator of the mitochondrial-mediated antiviral immunity, by interacting …
Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis.
Mukherjee R, Vanaja KG, Boyer JA, Gadal S, Solomon H, Chandarlapaty S, Levchenko A, Rosen N. Mukherjee R, et al. Mol Cell. 2021 Feb 18;81(4):708-723.e5. doi: 10.1016/j.molcel.2021.01.033. Mol Cell. 2021. PMID: 33606974 Free PMC article.
We now show that both physiologic and oncogenic activation of PI3K signaling increase the expression of its negative regulator PTEN. This limits the duration of the signal and output of the pathway. ...Translational regulation of PTEN is therefo …
We now show that both physiologic and oncogenic activation of PI3K signaling increase the expression of its negative regula …
Hypoxia-induced regulation of mTOR signaling by miR-7 targeting REDD1.
Seong M, Lee J, Kang H. Seong M, et al. J Cell Biochem. 2019 Mar;120(3):4523-4532. doi: 10.1002/jcb.27740. Epub 2018 Oct 9. J Cell Biochem. 2019. PMID: 30302791
A subset of microRNAs (miRNAs) termed the hypoxamir has been suggested to be a critical mediator of the cellular response to hypoxia. Regulated in development and DNA damage response 1 (REDD1) is a negative regulator of mammalian target of rapamycin (mTOR) …
A subset of microRNAs (miRNAs) termed the hypoxamir has been suggested to be a critical mediator of the cellular response to hypoxia. Reg …
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Cell. 2002 Jul 26;110(2):163-75. doi: 10.1016/s0092-8674(02)00808-5. Cell. 2002. PMID: 12150925 Free article.
mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone-sensitive signaling pathway that regulates cell growth. We report that mTOR forms a stoichiometric complex with raptor, an evolutionarily conse …
mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone-sensitive sign …
Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis.
Dungan CM, Williamson DL. Dungan CM, et al. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1067-1072. doi: 10.1016/j.bbrc.2016.11.159. Epub 2016 Nov 29. Biochem Biophys Res Commun. 2017. PMID: 27913296
Recent findings in adipocytes suggest that mitogen-activated protein kinase (MAPK)/extracellular-regulated signaling kinase (ERK) kinase 1/2 (MEK1/2) signaling regulates regulated in development and DNA damage 1 (REDD1) protein expression. ...Th …
Recent findings in adipocytes suggest that mitogen-activated protein kinase (MAPK)/extracellular-regulated signaling kinase (E …
Yeast TOR signaling: a mechanism for metabolic regulation.
Powers T, Dilova I, Chen CY, Wedaman K. Powers T, et al. Curr Top Microbiol Immunol. 2004;279:39-51. doi: 10.1007/978-3-642-18930-2_3. Curr Top Microbiol Immunol. 2004. PMID: 14560950 Review.
Understanding how cell growth is regulated in response to environmental signals remains a challenging biological problem. ...This network affects all aspects of gene expression, including transcription, translation, and protein stability, making TOR an excell …
Understanding how cell growth is regulated in response to environmental signals remains a challenging biological problem. ...T …
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Kapahi P, et al. Curr Biol. 2004 May 25;14(10):885-90. doi: 10.1016/j.cub.2004.03.059. Curr Biol. 2004. PMID: 15186745 Free PMC article.
In Drosophila, the target of rapamycin (TOR) and the insulin pathways have emerged as major regulators of growth and size. Hence we examined the role of TOR pathway genes in regulating lifespan by using Drosophila. ...In Drosophila, TSC1 and TSC2 (tube …
In Drosophila, the target of rapamycin (TOR) and the insulin pathways have emerged as major regulators of growth and size. Hen …
Smad7 in TGF-beta-mediated negative regulation of gut inflammation.
Monteleone G, Pallone F, MacDonald TT. Monteleone G, et al. Trends Immunol. 2004 Oct;25(10):513-7. doi: 10.1016/j.it.2004.07.008. Trends Immunol. 2004. PMID: 15364052 Review.
Mice with targeted disruptions of the transforming growth factor-beta1 (TGF-beta1) gene or TGF-beta1 intracellular signalling pathways develop intestinal inflammation. Conversely, TGF-beta1-producing regulatory T cells protect against experimental colitis. ...Here we discu …
Mice with targeted disruptions of the transforming growth factor-beta1 (TGF-beta1) gene or TGF-beta1 intracellular signalling pathway …
1,956 results