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534 results

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WNT signaling in bone homeostasis and disease: from human mutations to treatments.
Baron R, Kneissel M. Baron R, et al. Nat Med. 2013 Feb;19(2):179-92. doi: 10.1038/nm.3074. Epub 2013 Feb 6. Nat Med. 2013. PMID: 23389618 Review.
A decade ago, rare human mutations affecting bone negatively (osteoporosis-pseudoglioma syndrome) or positively (high-bone mass phenotype, sclerosteosis and Van Buchem disease) have been identified and found to all reside in components of the canonical WNT …
A decade ago, rare human mutations affecting bone negatively (osteoporosis-pseudoglioma syndrome) or positively (high-bone mass pheno …
Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancer.
Rajamäki K, Taira A, Katainen R, Välimäki N, Kuosmanen A, Plaketti RM, Seppälä TT, Ahtiainen M, Wirta EV, Vartiainen E, Sulo P, Ravantti J, Lehtipuro S, Granberg KJ, Nykter M, Tanskanen T, Ristimäki A, Koskensalo S, Renkonen-Sinisalo L, Lepistö A, Böhm J, Taipale J, Mecklin JP, Aavikko M, Palin K, Aaltonen LA. Rajamäki K, et al. Gastroenterology. 2021 Aug;161(2):592-607. doi: 10.1053/j.gastro.2021.04.042. Epub 2021 Apr 27. Gastroenterology. 2021. PMID: 33930428 Free article.
RESULTS: Transcriptome-based tumor subtyping revealed the complete absence of canonical epithelial tumor subtype associated with WNT signaling in IBD-CRCs, dominated instead by mesenchymal stroma-rich subtype. Negative WNT regulators AXIN …
RESULTS: Transcriptome-based tumor subtyping revealed the complete absence of canonical epithelial tumor subtype associated with W …
Chemotherapy-Treated Breast Cancer Cells Activate the WNT Signaling Pathway to Enter a Diapause-Like Early Persister State.
El Laithy Y, Abreu De Oliveira WA, Pabba A, Qualizza A, Cosemans G, Garcia-Diaz P, Richard F, Athanasouli P, Rios Luci C, De Wispelaere W, Mourao L, Hamer S, Moens S, De Jaime-Soguero A, Baietti MF, Hutten SJ, Jonkers J, Sammut SJ, Soenen S, Scheele CLGJ, Bruna A, Desmedt C, Annibali D, Lluis F. El Laithy Y, et al. Cancer Res. 2026 Jan 16;86(2):310-330. doi: 10.1158/0008-5472.CAN-24-4165. Cancer Res. 2026. PMID: 41117706 Free PMC article.
In this study, we showed that following chemotherapy, diverse therapeutic agents converge on WNT pathway activation to induce a de novo diapause-like cell state across various triple-negative breast cancer cell line, xenograft, and patient-derived organoid mo …
In this study, we showed that following chemotherapy, diverse therapeutic agents converge on WNT pathway activation to induce …
Negative regulators of Wnt signaling in non-small cell lung cancer: Theoretical basis and therapeutic potency.
Song Z, Wang H, Zhang S. Song Z, et al. Biomed Pharmacother. 2019 Oct;118:109336. doi: 10.1016/j.biopha.2019.109336. Epub 2019 Aug 10. Biomed Pharmacother. 2019. PMID: 31545260 Free article. Review.
Moreover, the aberrant Wnt pathway plays a significant role in NSCLC and is associated with cancer cell proliferation, metastasis, invasion and drug resistance, and the suppression of canonical or noncanonical Wnt signaling through various biolo …
Moreover, the aberrant Wnt pathway plays a significant role in NSCLC and is associated with cancer cell proliferation, metasta …
The role of the non-canonical Wnt-planar cell polarity pathway in neural crest migration.
Mayor R, Theveneau E. Mayor R, et al. Biochem J. 2014 Jan 1;457(1):19-26. doi: 10.1042/BJ20131182. Biochem J. 2014. PMID: 24325550 Review.
Recent work performed in chicks, zebrafish and frogs has shown that the non-canonical Wnt-PCP (planar cell polarity) pathway plays a major role in neural crest migration. ...The present review summarizes the mechanisms that control neural crest migrati …
Recent work performed in chicks, zebrafish and frogs has shown that the non-canonical Wnt-PCP (planar cell polarity) pathwa …
Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins.
Tejeda-Muñoz N, Albrecht LV, Bui MH, De Robertis EM. Tejeda-Muñoz N, et al. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10402-10411. doi: 10.1073/pnas.1903506116. Epub 2019 May 6. Proc Natl Acad Sci U S A. 2019. PMID: 31061124 Free PMC article.
Canonical Wnt signaling is emerging as a major regulator of endocytosis. Wnt treatment markedly increased the endocytosis and degradation in lysosomes of BSA. ...Macropinocytosis was blocked by dominant-negative vacuolar protein sorting 4 …
Canonical Wnt signaling is emerging as a major regulator of endocytosis. Wnt treatment markedly increased …
In Vitro Anti-cancer Effect of Crataegus oxyacantha Berry Extract on Hormone Receptor Positive and Triple Negative Breast Cancers via Regulation of Canonical Wnt Signaling Pathway.
Kombiyil S, Sivasithamparam ND. Kombiyil S, et al. Appl Biochem Biotechnol. 2023 Apr;195(4):2687-2708. doi: 10.1007/s12010-021-03724-4. Epub 2022 Mar 9. Appl Biochem Biotechnol. 2023. PMID: 35262883
Molecular targets were selected from different levels of canonical Wnt signaling pathway (such as autocrine and antagonistic ligands, receptor, effector, cytoplasmic components, downstream targets, and pathway antagonist), since they are frequen …
Molecular targets were selected from different levels of canonical Wnt signaling pathway (such as autocrine and …
Canonical Wnt/beta-catenin signaling has positive effects on osteogenesis, but can have negative effects on cementogenesis.
Li T, Wang H, Jiang Y, Guan Y, Chen S, Wu Z, Zou S, Bonewald LF, Duan P. Li T, et al. J Periodontol. 2022 Nov;93(11):1725-1737. doi: 10.1002/JPER.21-0599. Epub 2022 Aug 10. J Periodontol. 2022. PMID: 35642884
This study aims to elucidate the regulatory mechanism of Wnt pathway in cementogenesis. METHODS: The effects of canonical Wnt signaling were compared in vitro using immortalized murine cementocyte cell line IDG-CM6 and osteocyte cell line IDG-SW …
This study aims to elucidate the regulatory mechanism of Wnt pathway in cementogenesis. METHODS: The effects of canonical …
Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway.
Skalka N, Caspi M, Caspi E, Loh YP, Rosin-Arbesfeld R. Skalka N, et al. Oncogene. 2013 Jun 6;32(23):2836-47. doi: 10.1038/onc.2012.308. Epub 2012 Jul 23. Oncogene. 2013. PMID: 22824791 Free PMC article.
In this study, we used a new functional screen based on cell survival in the presence of cDNAs encoding proteins that activate the Wnt pathway thus identifying novel Wnt signaling components. Here we identify carboxypeptidase E (|CPE) and its splice va …
In this study, we used a new functional screen based on cell survival in the presence of cDNAs encoding proteins that activate the Wnt …
Therapeutic targeting of Wnt antagonists by small molecules for treatment of osteoporosis.
Abhishek Shah A, Chand D, Ahamad S, Porwal K, Chourasia MK, Mohanan K, Srivastava KR, Chattopadhyay N. Abhishek Shah A, et al. Biochem Pharmacol. 2024 Dec;230(Pt 2):116587. doi: 10.1016/j.bcp.2024.116587. Epub 2024 Oct 22. Biochem Pharmacol. 2024. PMID: 39447984 Review.
Wnt signaling is one of the key regulators of bone development and homeostasis. Wnt signaling regulates key biological events, including stem cell fate and osteoblast and osteoclast activity, leading to the maintenance of bone mass and st …
Wnt signaling is one of the key regulators of bone development and homeostasis. Wnt signaling regulate …
534 results