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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1940 1
1946 1
1947 2
1948 2
1949 3
1950 1
1951 9
1952 4
1953 6
1954 8
1955 2
1956 4
1957 5
1958 9
1959 6
1960 13
1961 7
1962 8
1963 14
1964 25
1965 28
1966 51
1967 54
1968 76
1969 84
1970 103
1971 144
1972 166
1973 196
1974 204
1975 322
1976 314
1977 305
1978 352
1979 352
1980 360
1981 480
1982 601
1983 660
1984 629
1985 742
1986 755
1987 764
1988 915
1989 1017
1990 1195
1991 1263
1992 1351
1993 1576
1994 1695
1995 1820
1996 1870
1997 2030
1998 2034
1999 2164
2000 2448
2001 2596
2002 2828
2003 2796
2004 3118
2005 3283
2006 3691
2007 3789
2008 4035
2009 4366
2010 4416
2011 4627
2012 4791
2013 4900
2014 4817
2015 4863
2016 4916
2017 4946
2018 4767
2019 4775
2020 4938
2021 4859
2022 4142
2023 4040
2024 4194
2025 4768
2026 2777

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125,439 results

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Page 1
Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: a model for neuronal and synaptic differentiation in neurodegeneration.
Targett IL, Crompton LA, Conway ME, Craig TJ. Targett IL, et al. In Vitro Cell Dev Biol Anim. 2024 Oct;60(9):1058-1067. doi: 10.1007/s11626-024-00948-6. Epub 2024 Jul 17. In Vitro Cell Dev Biol Anim. 2024. PMID: 39017752 Free PMC article.
There has been much interest in the use of cell culture models of neurones, to avoid the animal welfare and cost issues of using primary and human-induced pluripotent stem cell (hiPSC)-derived neurones respectively. The human neuroblastoma cell …
There has been much interest in the use of cell culture models of neurones, to avoid the animal welfare and cost issues of usi …
Differentiation of Human Neurons and Neuron-Like Cells to Study VZV Neuronal Infection.
Wang J, Viejo-Borbolla A. Wang J, et al. Methods Mol Biol. 2025;2950:87-105. doi: 10.1007/978-1-0716-4674-8_7. Methods Mol Biol. 2025. PMID: 40622530
VZV is human specific, and the investigation of VZV-neuron interactions requires human neuronal models, presenting challenges due to limited accessibility and ethical constraints. Here, we describe approaches to generate mechanoreceptive sensory neurons from …
VZV is human specific, and the investigation of VZV-neuron interactions requires human neuronal models, presenting challenges …
Differentiation of human glioblastoma U87 cells into cholinergic neuron.
Liu H, Xia J, Wang T, Li W, Song Y, Tan G. Liu H, et al. Neurosci Lett. 2019 Jun 21;704:1-7. doi: 10.1016/j.neulet.2019.03.049. Epub 2019 Mar 28. Neurosci Lett. 2019. PMID: 30928478
As a result, we found that sodium butyrate induced U87 cell differentiation into cells with neuronal characteristics and increased not only the expression levels of the cholinergic neuron-related proteins M1, M4, ChAT and SYP in D-U87 cells but also th …
As a result, we found that sodium butyrate induced U87 cell differentiation into cells with neuronal characteristics an …
Neuroblastoma SH-SY5Y Cell Differentiation to Mature Neuron by AM580 Treatment.
Cai A, Lin Z, Liu N, Li X, Wang J, Wu Y, Gao K, Jiang Y. Cai A, et al. Neurochem Res. 2022 Dec;47(12):3723-3732. doi: 10.1007/s11064-022-03730-w. Epub 2022 Sep 6. Neurochem Res. 2022. PMID: 36066699 Free PMC article.
In this study, the neuronal differentiation impact of AM580 was investigated using the human neuroblastoma cell line SH-SY5Y as a model. ...AM580 also induced the neuronal marker beta-tubulin III and mature neurons marker Neurofilament H. Our st …
In this study, the neuronal differentiation impact of AM580 was investigated using the human neuroblastoma cell line SH …
Molecular regulation of GABAergic neuron differentiation and diversity in the developing midbrain.
Lahti L, Achim K, Partanen J. Lahti L, et al. Acta Physiol (Oxf). 2013 Apr;207(4):616-27. doi: 10.1111/apha.12062. Epub 2013 Feb 8. Acta Physiol (Oxf). 2013. PMID: 23297792 Review.
In this review, we briefly introduce distinct subpopulations of the midbrain GABAergic neurones and discuss knowledge on their development, including the developmental origins of midbrain GABAergic neurones as well as transcriptional regulatory mechanisms guiding th …
In this review, we briefly introduce distinct subpopulations of the midbrain GABAergic neurones and discuss knowledge on their develo …
Differentiation of neural stem cells from human olfactory mucosa into dopaminergic neuron-like cells.
Ertem T, Uysal O. Ertem T, et al. IUBMB Life. 2024 Sep;76(9):697-711. doi: 10.1002/iub.2822. Epub 2024 Apr 25. IUBMB Life. 2024. PMID: 38662920 Free article.
The neurospheres were subjected to immunophenotypic analysis and neuronal differentiation assays. Furthermore, hOM-NSCs were differentiated into dopaminergic neuron-like cells in vitro. ...It was concluded that hOM-NSCs may be a source of neural stem c …
The neurospheres were subjected to immunophenotypic analysis and neuronal differentiation assays. Furthermore, hOM-NSCs were …
An in vitro model for neuroscience: differentiation of SH-SY5Y cells into cells with morphological and biochemical characteristics of mature neurons.
Agholme L, Lindström T, Kågedal K, Marcusson J, Hallbeck M. Agholme L, et al. J Alzheimers Dis. 2010;20(4):1069-82. doi: 10.3233/JAD-2010-091363. J Alzheimers Dis. 2010. PMID: 20413890
To counteract this, many attempts to differentiate cell lines into more neuron-like cells have been performed, resulting in partial expression of neuronal features. ...To obtain cells with neuronal differentiation and function, we investi …
To counteract this, many attempts to differentiate cell lines into more neuron-like cells have been performed, resultin …
SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease.
Xie HR, Hu LS, Li GY. Xie HR, et al. Chin Med J (Engl). 2010 Apr 20;123(8):1086-92. Chin Med J (Engl). 2010. PMID: 20497720 Review.
OBJECTIVE: To evaluate the human neuroblastoma SH-SY5Y cell line as an in vitro model of dopaminergic (DAergic) neurons for Parkinson's disease (PD) research and to determine the effect of differentiation on this cell model. ...CONCLUSIONS: Differen …
OBJECTIVE: To evaluate the human neuroblastoma SH-SY5Y cell line as an in vitro model of dopaminergic (DAergic) neurons for Pa …
Basal Protrusions Mediate Spatiotemporal Patterns of Spinal Neuron Differentiation.
Hadjivasiliou Z, Moore RE, McIntosh R, Galea GL, Clarke JDW, Alexandre P. Hadjivasiliou Z, et al. Dev Cell. 2019 Jun 17;49(6):907-919.e10. doi: 10.1016/j.devcel.2019.05.035. Dev Cell. 2019. PMID: 31211994 Free PMC article.
During early spinal cord development, neurons of particular subtypes differentiate with a sparse periodic pattern while later neurons differentiate in the intervening space to eventually produce continuous columns of similar neurons. ...These pr …
During early spinal cord development, neurons of particular subtypes differentiate with a sparse periodic pattern while later …
Differentiation of Wharton's Jelly-Derived Mesenchymal Stem Cells into Motor Neuron-Like Cells on Three-Dimensional Collagen-Grafted Nanofibers.
Bagher Z, Azami M, Ebrahimi-Barough S, Mirzadeh H, Solouk A, Soleimani M, Ai J, Nourani MR, Joghataei MT. Bagher Z, et al. Mol Neurobiol. 2016 May;53(4):2397-408. doi: 10.1007/s12035-015-9199-x. Epub 2015 May 24. Mol Neurobiol. 2016. PMID: 26001761
WJMSCs were seeded on nanofibrous and tissue culture plate (TCP) and viability of WJMSCs were measured by MTT assay and then induced to differentiate into motor neuron-like cells for 15 days. Differentiated cells were evaluated morphologically, and real-time …
WJMSCs were seeded on nanofibrous and tissue culture plate (TCP) and viability of WJMSCs were measured by MTT assay and then induced to d …
125,439 results
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