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Page 1
Hypermobile Ehlers-Danlos Syndrome: Cerebrovascular, Autonomic and Neuropathic Features.
Novak P, Systrom DM, Marciano SP, Witte A, Warren A, Felsenstein D, Giannetti MP, Hamilton MJ, Nicoloro-SantaBarbara J, Castells M, Farhad K, Pilgrim DM, Mullally WJ, Fishman MC, Milunsky JM, Milunsky A, Krier J. Novak P, et al. Am J Med Open. 2025 Jul 18;14:100111. doi: 10.1016/j.ajmo.2025.100111. eCollection 2025 Dec. Am J Med Open. 2025. PMID: 40843452 Free PMC article.
Outcome measures include validated surveys (Survey of Autonomic Functions, Neuropathy Total Symptom Score-6 (SAS)) and autonomic function testing (Valsalva maneuver, deep breathing, head-up tilt and sudomotor), cerebrovascular (cerebral blood flow velocity (CBFv) in the middle ce …
Outcome measures include validated surveys (Survey of Autonomic Functions, Neuropathy Total Symptom Score-6 (SAS)) and autonomic function te …
[Neuropathic pain as a symptom in autonomic neuropathies and other rare diseases : Small fiber neuropathy: its recognition, diagnosis, and treatment].
Fischer F, Dohrn MF, Kapfenberger R, Igharo D, Seeber D, de Moya Rubio E, Pitarokoili K, Börsch N, Mücke M, Rolke R, Schulz JB, Maier A. Fischer F, et al. Schmerz. 2024 Feb;38(1):33-40. doi: 10.1007/s00482-023-00783-w. Epub 2024 Jan 10. Schmerz. 2024. PMID: 38197939 Review. German.
BACKGROUND: Neuropathic pain is difficult to diagnose and treat. Small fiber neuropathy (SFN) flies under the radar of nerve conduction studies. OBJECTIVES: The importance of a structured patient history and physical examination in the context of neuropath …
BACKGROUND: Neuropathic pain is difficult to diagnose and treat. Small fiber neuropathy (SFN) flies under the radar of …
Corneal Confocal Microscopy in Postural Orthostatic Tachycardia Syndrome (POTS) as a Diagnostic Tool for Small Fiber Neuropathy.
Cantrell C, Rilinger R, Stallkamp Tidd SJ, Wilson R. Cantrell C, et al. Cureus. 2025 Apr 22;17(4):e82781. doi: 10.7759/cureus.82781. eCollection 2025 Apr. Cureus. 2025. PMID: 40271232 Free PMC article.
The neuropathic symptoms of POTS may be caused by small fiber neuropathy (SFN), which is currently diagnosed using skin nerve biopsy. ...Our study aimed to determine whether CCM could detect differences in small nerve fiber parameters bet …
The neuropathic symptoms of POTS may be caused by small fiber neuropathy (SFN), which is currently diagnosed usi …
Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome.
Azcue N, Del Pino R, Acera M, Fernández-Valle T, Ayo-Mentxakatorre N, Pérez-Concha T, Murueta-Goyena A, Lafuente JV, Prada A, López de Munain A, Ruiz Irastorza G, Martín-Iglesias D, Ribacoba L, Gabilondo I, Gómez-Esteban JC, Tijero-Merino B. Azcue N, et al. J Transl Med. 2023 Nov 15;21(1):814. doi: 10.1186/s12967-023-04678-3. J Transl Med. 2023. PMID: 37968647 Free PMC article.
The hemodynamic autonomic function was evaluated using the deep breathing technique, Valsalva maneuver, and Tilt test. The presence of autonomic and sensory small fiber neuropathy (SFN) was assessed with the Sudoscan and with heat and cold evoked potentials, respect …
The hemodynamic autonomic function was evaluated using the deep breathing technique, Valsalva maneuver, and Tilt test. The presence of auton …
Small fiber neuropathy in children, adolescents, and young adults with chronic orthostatic intolerance and postural orthostatic tachycardia syndrome: A retrospective study.
Moak JP, Ramwell CB, Gordish-Dressman H, Sule SD, Bettini E. Moak JP, et al. Auton Neurosci. 2024 Jun;253:103163. doi: 10.1016/j.autneu.2024.103163. Epub 2024 Mar 8. Auton Neurosci. 2024. PMID: 38537312
Statistical analysis was performed using Wilcoxon rank sum tests. RESULTS: In CAYA patients with OI or POTS and neuropathic symptoms, skin biopsy for small fiber neuropathy was abnormal in 53 %. ...CONCLUSION: Our data suggest a link between OI and …
Statistical analysis was performed using Wilcoxon rank sum tests. RESULTS: In CAYA patients with OI or POTS and neuropathic sy …
Orthostatic intolerance with tachycardia (postural tachycardia syndrome) and without (hypocapnic cerebral hypoperfusion) represent a spectrum of the same disorder.
Novak P, Systrom DM, Witte A, Marciano SP. Novak P, et al. Front Neurol. 2024 Oct 30;15:1476918. doi: 10.3389/fneur.2024.1476918. eCollection 2024. Front Neurol. 2024. PMID: 39544990 Free PMC article.
Autonomic testing showed widespread but similar abnormalities in POTS and HYCH that included: reduced orthostatic CBFv and end-tidal CO(2,) preload failure (assessed in 16/19 POTS/HYCH), mild autonomic failure, and frequent small fiber neuropathy. CONC …
Autonomic testing showed widespread but similar abnormalities in POTS and HYCH that included: reduced orthostatic CBFv and end-tidal …
Small-fiber neuropathy with cardiac denervation in postural tachycardia syndrome.
Haensch CA, Tosch M, Katona I, Weis J, Isenmann S. Haensch CA, et al. Muscle Nerve. 2014 Dec;50(6):956-61. doi: 10.1002/mus.24245. Epub 2014 Aug 29. Muscle Nerve. 2014. PMID: 24647968
Our objective in this study was to evaluate the correlation between C-fiber involvement as shown by skin biopsy and adrenergic cardiac metaiodobenzylguanadine (MIBG) uptake in POTS patients. ...Low IENF density correlated with reduced cardiac MIBG uptake (r = 0.39, …
Our objective in this study was to evaluate the correlation between C-fiber involvement as shown by skin biopsy and adrenergic cardia …
Internal Tremor in Long COVID May Be a Symptom of Dysautonomia and Small Fiber Neuropathy.
Blitshteyn S, Ruhoy IS, Natbony LR, Saperstein DS. Blitshteyn S, et al. Neurol Int. 2024 Dec 25;17(1):2. doi: 10.3390/neurolint17010002. Neurol Int. 2024. PMID: 39852767 Free PMC article.
Methods: We describe a patient with Long COVID who experienced IT as part of post-COVID postural orthostatic tachycardia syndrome (POTS) and small fiber neuropathy (SFN) and review the limited literature available on this topic. Results: Our patient's IT impr …
Methods: We describe a patient with Long COVID who experienced IT as part of post-COVID postural orthostatic tachycardia syndrome (POTS …
Shared autonomic phenotype of long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.
Novak P, Systrom DM, Witte A, Marciano SP, Felsenstein D, Milunsky JM, Milunsky A, Krier J, Fishman MC. Novak P, et al. PLoS One. 2026 Jan 23;21(1):e0341278. doi: 10.1371/journal.pone.0341278. eCollection 2026. PLoS One. 2026. PMID: 41576003 Free PMC article.
The evaluations included autonomic tests (Valsalva maneuver, deep breathing, tilt-table test, and sudomotor function) with capnography and transcranial Doppler monitoring of cerebral blood flow velocity (CBFv) in the middle cerebral artery, neuropathic assessment through s …
The evaluations included autonomic tests (Valsalva maneuver, deep breathing, tilt-table test, and sudomotor function) with capnography and t …
Symptoms and objective signs of peripheral sensory neuropathy in POTS and correlations to gastrointestinal symptoms.
Ekman L, Tufvesson H, Englund E, Dahlin LB, Ohlsson B. Ekman L, et al. PLoS One. 2025 Jul 3;20(7):e0327549. doi: 10.1371/journal.pone.0327549. eCollection 2025. PLoS One. 2025. PMID: 40608783 Free PMC article.
We aimed to investigate subjective and objective signs of small and large fiber neuropathy in a Swedish POTS cohort compared with healthy controls. ...Neuropathic and gastrointestinal symptoms were closely associated within POTS....
We aimed to investigate subjective and objective signs of small and large fiber neuropathy in a Swedish POTS cohort com …
20 results