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2003 1
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2013 2
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61 results

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Page 1
The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities.
Xu DH, Cullen BD, Tang M, Fang Y. Xu DH, et al. Curr Pharm Biotechnol. 2020;21(5):390-402. doi: 10.2174/1389201020666191202111534. Curr Pharm Biotechnol. 2020. PMID: 31793418 Clinical Trial.
BACKGROUND: Peripheral neuropathy can significantly impact the quality of life for those who are affected, as therapies from the current treatment algorithm often fail to deliver adequate symptom relief. ...CONCLUSION: Our findings demonstrate that the transdermal applicat …
BACKGROUND: Peripheral neuropathy can significantly impact the quality of life for those who are affected, as therapies from the curr …
Oral cannabidiol for prevention of acute and transient chemotherapy-induced peripheral neuropathy.
Nielsen SW, Hasselsteen SD, Dominiak HSH, Labudovic D, Reiter L, Dalton SO, Herrstedt J. Nielsen SW, et al. Support Care Cancer. 2022 Nov;30(11):9441-9451. doi: 10.1007/s00520-022-07312-y. Epub 2022 Aug 6. Support Care Cancer. 2022. PMID: 35933415
PURPOSE: To assess the safety, dosing, and preventive effects of cannabidiol (CBD) on chemotherapy-induced peripheral neuropathy (CIPN) in patients receiving oxaliplatin- or paclitaxel-based chemotherapy. ...
PURPOSE: To assess the safety, dosing, and preventive effects of cannabidiol (CBD) on chemotherapy-induced peripheral neuropathy
Diversity of molecular targets and signaling pathways for CBD.
de Almeida DL, Devi LA. de Almeida DL, et al. Pharmacol Res Perspect. 2020 Dec;8(6):e00682. doi: 10.1002/prp2.682. Pharmacol Res Perspect. 2020. PMID: 33169541 Free PMC article. Review.
Cannabidiol (CBD) is the second most abundant component of the Cannabis plant and is known to have effects distinct from delta(9) -tetrahydrocannabinol (THC). ...Evidence derived from randomized clinical trials, in vitro and in vivo models and real-world observations suppo
Cannabidiol (CBD) is the second most abundant component of the Cannabis plant and is known to have effects distinct from delta(9) -te
Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Cisplatin-Induced Neuropathy in Mice.
Harris HM, Sufka KJ, Gul W, ElSohly MA. Harris HM, et al. Planta Med. 2016 Aug;82(13):1169-72. doi: 10.1055/s-0042-106303. Epub 2016 May 23. Planta Med. 2016. PMID: 27214593
This research examined whether tetrahydocannabinol or cannabidiol alone could attenuate or prevent cisplatin-induced tactile allodynia. ...Cisplatin produced a reduction in g of force indicative of neuropathy that was attenuated by gabapentin, tetrahydocannabinol, a …
This research examined whether tetrahydocannabinol or cannabidiol alone could attenuate or prevent cisplatin-induced tactile allodyni …
Medicinal cannabis.
Murnion B. Murnion B. Aust Prescr. 2015 Dec;38(6):212-5. doi: 10.18773/austprescr.2015.072. Epub 2015 Dec 1. Aust Prescr. 2015. PMID: 26843715 Free PMC article. Review.
Possible clinical indications include spasticity and pain in multiple sclerosis, cancer-associated nausea and vomiting, cancer pain and HIV neuropathy. However, evidence is limited, may reflect subjective rather than objective outcomes, and is not conclusive. ...Nabiximols …
Possible clinical indications include spasticity and pain in multiple sclerosis, cancer-associated nausea and vomiting, cancer pain and HIV …
Cannabidiol-rich non-psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2-mediated microglial neuroinflammation.
Borgonetti V, Anceschi L, Brighenti V, Corsi L, Governa P, Manetti F, Pellati F, Galeotti N. Borgonetti V, et al. Phytother Res. 2023 May;37(5):1924-1937. doi: 10.1002/ptr.7710. Epub 2022 Dec 30. Phytother Res. 2023. PMID: 36583304
The principal aim of this work is to investigate the potential pain-relieving effect of innovative cannabidiol-rich non-psychotropic C. sativa oils, with a high content of terpenes (K2), compared to the same extract devoid of terpenes (K1). Oral administration of K2 (25 mg …
The principal aim of this work is to investigate the potential pain-relieving effect of innovative cannabidiol-rich non-psychotropic …
Cannabidiol and mitragynine exhibit differential interactive effects in the attenuation of paclitaxel-induced mechanical allodynia, acute antinociception, and schedule-controlled responding in mice.
Ortiz YT, Bilbrey JA, Felix JS, Kienegger EA, Mottinelli M, Mukhopadhyay S, McCurdy CR, McMahon LR, Wilkerson JL. Ortiz YT, et al. Pharmacol Rep. 2023 Aug;75(4):937-950. doi: 10.1007/s43440-023-00498-w. Epub 2023 May 27. Pharmacol Rep. 2023. PMID: 37243887
BACKGROUND: For many chemotherapy patients peripheral neuropathy is a debilitating side effect. Mitragyna speciosa (kratom) contains the alkaloid mitragynine (MG), which produces analgesia in multiple preclinical pain models. In humans, anecdotal reports suggest cannabi
BACKGROUND: For many chemotherapy patients peripheral neuropathy is a debilitating side effect. Mitragyna speciosa (kratom) contains …
Pharmacological Interaction Between Cannabidiol and Tramadol on Experimental Diabetic Neuropathic Pain: An Isobolographic Analysis.
Evans AA, Jesus CHA, Martins LL, Fukuyama AH, Gasparin AT, Crippa JA, Zuardi AW, Hallak JEC, Genaro K, de Castro Junior CJ, Zanoveli JM, Cunha JMD. Evans AA, et al. Cannabis Cannabinoid Res. 2023 May 19. doi: 10.1089/can.2021.0242. Online ahead of print. Cannabis Cannabinoid Res. 2023. PMID: 37205869
Introduction: Diabetic neuropathies are the most prevalent chronic complications of diabetes, characterized by pain and substantial morbidity. ...TMD, recommended as a second-line treatment can lead to unwanted side effects. Cannabidiol (CBD) has been gaining attent …
Introduction: Diabetic neuropathies are the most prevalent chronic complications of diabetes, characterized by pain and substantial m …
Chronic Pain and Cannabidiol in Animal Models: Behavioral Pharmacology and Future Perspectives.
Silva-Cardoso GK, Leite-Panissi CRA. Silva-Cardoso GK, et al. Cannabis Cannabinoid Res. 2023 Apr;8(2):241-253. doi: 10.1089/can.2022.0096. Epub 2022 Nov 10. Cannabis Cannabinoid Res. 2023. PMID: 36355044 Review.
In this perspective, animal models are used to assess the manifestations of neuropathy, such as allodynia and hyperalgesia, through nociceptive tests, such as von Frey, Hargreaves, hot plate, tail-flick, Randall & Selitto, and others. Cannabidiol (CBD) has been …
In this perspective, animal models are used to assess the manifestations of neuropathy, such as allodynia and hyperalgesia, through n …
Synthesis and Antiallodynic Activity of Cannabidiol Analogue on Peripheral Neuropathy in Mice.
Marques GVL, Braga AV, Silva IR, de Souza ARB, Kohlhoff M, César IC, Machado RR, Oliveira RB. Marques GVL, et al. Chem Biodivers. 2024 Feb 16:e202301935. doi: 10.1002/cbdv.202301935. Online ahead of print. Chem Biodivers. 2024. PMID: 38363210
Cannabidiol (CBD) is a substance that exerts several therapeutic actions, including analgesia. ...Additionally, its effect was investigated in a model of neuropathic pain induced by the chemotherapy drug paclitaxel in mice, in comparison with cannabidiol itself.
Cannabidiol (CBD) is a substance that exerts several therapeutic actions, including analgesia. ...Additionally, its effect was invest
61 results