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6,857 results

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Page 1
SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine.
Wobst HJ, Viader A, Muncipinto G, Hollibaugh R, van Kalken D, Burkhart CT, Cantin SM, Bates RM, Regimbald-Dumas Y, Gross L, Antalek MT, Zweig JE, Wu F, Rettenmaier TJ, Labenski MT, Pullen N, Blanchette HS, Henderson JL, Weng HH, Vaughn TA, Brown DG, Throup JP, Barrish JC. Wobst HJ, et al. JCI Insight. 2024 Nov 8;9(21):e182876. doi: 10.1172/jci.insight.182876. JCI Insight. 2024. PMID: 39513367 Free PMC article. Clinical Trial.
Solute carrier family 6 member 19 (SLC6A19) is the major transporter responsible for the (re)absorption of Phe in the kidney and intestine. Here, we describe the characterization of the first small molecule SLC6A19 inhibitor to enter clinical development for the treatment …
Solute carrier family 6 member 19 (SLC6A19) is the major transporter responsible for the (re)absorption of Phe in the kidney and inte …
Structural basis of anticancer drug recognition and amino acid transport by LAT1.
Lee Y, Jin C, Ohgaki R, Xu M, Ogasawara S, Warshamanage R, Yamashita K, Murshudov G, Nureki O, Murata T, Kanai Y. Lee Y, et al. Nat Commun. 2025 Feb 14;16(1):1635. doi: 10.1038/s41467-025-56903-w. Nat Commun. 2025. PMID: 39952931 Free PMC article.
LAT1 (SLC7A5) transports large neutral amino acids and plays pivotal roles in cancer proliferation, immune response and drug delivery. ...Physiological substrates like L-Phe lack such effects, whereas melphalan poses steric hindrance, explaining its in …
LAT1 (SLC7A5) transports large neutral amino acids and plays pivotal roles in cancer proliferation, immune respo …
The role of system A for neutral amino acid transport in the regulation of cell volume.
Bussolati O, Dall'Asta V, Franchi-Gazzola R, Sala R, Rotoli BM, Visigalli R, Casado J, Lopez-Fontanals M, Pastor-Anglada M, Gazzola GC. Bussolati O, et al. Mol Membr Biol. 2001 Jan-Mar;18(1):27-38. doi: 10.1080/09687680110033756. Mol Membr Biol. 2001. PMID: 11396608 Free article. Review.
System A is a secondary active, sodium dependent transport system for neutral amino acids. ...Many hormones and drugs affect system A activity in specific cell models or tissues. In all the cell models tested thus far the activity …
System A is a secondary active, sodium dependent transport system for neutral amino acids. ...Many …
The SLC6A15-SLC6A20 Neutral Amino Acid Transporter Subfamily: Functions, Diseases, and Their Therapeutic Relevance.
Kukułowicz J, Pietrzak-Lichwa K, Klimończyk K, Idlin N, Bajda M. Kukułowicz J, et al. Pharmacol Rev. 2023 Dec 15;76(1):142-193. doi: 10.1124/pharmrev.123.000886. Pharmacol Rev. 2023. PMID: 37940347 Review.
The neutral amino acid transporter subfamily that consists of six members, consecutively SLC6A15-SLC620, also called orphan transporters, represents membrane, sodium-dependent symporter proteins that belong to the family of solute …
The neutral amino acid transporter subfamily that consists of six members, consecutively SLC6A15-SLC620, also ca …
Kidney amino acid transport.
Verrey F, Singer D, Ramadan T, Vuille-dit-Bille RN, Mariotta L, Camargo SM. Verrey F, et al. Pflugers Arch. 2009 May;458(1):53-60. doi: 10.1007/s00424-009-0638-2. Epub 2009 Jan 28. Pflugers Arch. 2009. PMID: 19184091 Review.
A new finding is that the luminal Na(+)-dependent neutral amino acid transporters of the SLC6 family require an associated protein for their surface expression as shown for the Hartnup transporter B(0)AT1 (SLC6A19) and suggested for the L: -prol …
A new finding is that the luminal Na(+)-dependent neutral amino acid transporters of the SLC6 family require an …
Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family.
Mackenzie B, Erickson JD. Mackenzie B, et al. Pflugers Arch. 2004 Feb;447(5):784-95. doi: 10.1007/s00424-003-1117-9. Epub 2003 Jul 4. Pflugers Arch. 2004. PMID: 12845534 Review.
The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family resemble the classically-described System A and System N transport activities in terms of their functional properties and patterns of regulation. …
The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family resemble the classically-desc …
System L: heteromeric exchangers of large, neutral amino acids involved in directional transport.
Verrey F. Verrey F. Pflugers Arch. 2003 Feb;445(5):529-33. doi: 10.1007/s00424-002-0973-z. Epub 2002 Nov 21. Pflugers Arch. 2003. PMID: 12634921 Review.
The plasma membrane transport system L is in many cells the only (efficient) pathway for the import of large branched and aromatic neutral amino acids. ...Therefore, net directional transport of large, neutral amino …
The plasma membrane transport system L is in many cells the only (efficient) pathway for the import of large branched a …
Inhibiting neutral amino acid transport for the treatment of phenylketonuria.
Belanger AM, Przybylska M, Gefteas E, Furgerson M, Geller S, Kloss A, Cheng SH, Zhu Y, Yew NS. Belanger AM, et al. JCI Insight. 2018 Jul 26;3(14):e121762. doi: 10.1172/jci.insight.121762. eCollection 2018 Jul 26. JCI Insight. 2018. PMID: 30046012 Free PMC article.
SLC6A19 is a neutral amino acid transporter responsible for absorption of the majority of free Phe in the small intestine and reuptake of Phe by renal proximal tubule cells. Transgenic KO mice lacking SLC6A19 have elevated levels of Phe and other am …
SLC6A19 is a neutral amino acid transporter responsible for absorption of the majority of free Phe in the small …
Thyroid hormone transport across L-type amino acid transporters: What can molecular modelling tell us?
Krause G, Hinz KM. Krause G, et al. Mol Cell Endocrinol. 2017 Dec 15;458:68-75. doi: 10.1016/j.mce.2017.03.018. Epub 2017 Mar 21. Mol Cell Endocrinol. 2017. PMID: 28341457 Review.
Thyroid hormones (THs) and their derivatives require transmembrane transporters (TTs) to mediate their translocation across the cell membrane. Among these TTs, the L-type amino acid transporters (LAT) not only transport amino ac …
Thyroid hormones (THs) and their derivatives require transmembrane transporters (TTs) to mediate their translocation across the cell …
Characterization of neutral amino acid transport in a marine pseudomonad.
Fein JE, MacLeod RA. Fein JE, et al. J Bacteriol. 1975 Dec;124(3):1177-90. doi: 10.1128/jb.124.3.1177-1190.1975. J Bacteriol. 1975. PMID: 1194233 Free PMC article.
The transport of neutral amino acids in marine pseudomonad B-16 (ATCC 19855) has been investigated. ...The other system (LIV) showed high stereospecificity for neutral amino acids with the L configuration and served primaril …
The transport of neutral amino acids in marine pseudomonad B-16 (ATCC 19855) has been investigated. ...The other …
6,857 results