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2002 1
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2009 2
2020 0
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A step toward liver gene therapy: efficient correction of the genetic defect of hepatocytes isolated from a patient with Crigler-Najjar syndrome type 1 with lentiviral vectors.
Birraux J, Menzel O, Wildhaber B, Jond C, Nguyen TH, Chardot C. Birraux J, et al. Among authors: nguyen th. Transplantation. 2009 Apr 15;87(7):1006-12. doi: 10.1097/TP.0b013e31819ca245. Transplantation. 2009. PMID: 19352119
BACKGROUND: Ex vivo liver gene therapy may be a future alternative to orthotopic liver transplantation for the treatment of some liver diseases. ...After having been subjected to the SLIT, lentivirally transduced CN-1 hepatocytes engrafted long term (up to 26 …
BACKGROUND: Ex vivo liver gene therapy may be a future alternative to orthotopic liver transplantation for the treatment of so …
Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes.
Nguyen TH, Mai G, Villiger P, Oberholzer J, Salmon P, Morel P, Bühler L, Trono D. Nguyen TH, et al. J Hepatol. 2005 Dec;43(6):1031-7. doi: 10.1016/j.jhep.2005.05.036. Epub 2005 Jul 5. J Hepatol. 2005. PMID: 16169114
BACKGROUND/AIMS: Liver failure is a life threatening condition currently treated by palliative measures and, when applicable, organ transplantation. The use of a bioartificial organ capable of fulfilling the main functions of the liver would represent an attractive …
BACKGROUND/AIMS: Liver failure is a life threatening condition currently treated by palliative measures and, when applicable, organ t …
Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates.
Menzel O, Birraux J, Wildhaber BE, Jond C, Lasne F, Habre W, Trono D, Nguyen TH, Chardot C. Menzel O, et al. Among authors: nguyen th. Mol Ther. 2009 Oct;17(10):1754-60. doi: 10.1038/mt.2009.143. Epub 2009 Jun 30. Mol Ther. 2009. PMID: 19568222 Free PMC article.
Ex vivo gene therapy is an interesting alternative to orthotopic liver transplantation (OLT) for treating metabolic liver diseases. ...Hepatocytes isolated from liver lobectomy were transduced in suspension with a bicistronic liver-specific lentiviral …
Ex vivo gene therapy is an interesting alternative to orthotopic liver transplantation (OLT) for treating metabolic liver dise …
Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes.
Mai G, Nguyen TH, Morel P, Mei J, Andres A, Bosco D, Baertschiger R, Toso C, Berney T, Majno P, Mentha G, Trono D, Buhler LH. Mai G, et al. Among authors: nguyen th. Xenotransplantation. 2005 Nov;12(6):457-64. doi: 10.1111/j.1399-3089.2005.00248.x. Xenotransplantation. 2005. PMID: 16202069
BACKGROUND: The aim of this study was to evaluate in vitro and in vivo functions of isolated hepatocytes after immortalization, cryopreservation, encapsulation and xenotransplantation into mice with fulminant liver failure (FLF). ...These results indicate that naïve and ge …
BACKGROUND: The aim of this study was to evaluate in vitro and in vivo functions of isolated hepatocytes after immortalization, cryopreserva …
Ex vivo lentivirus transduction and immediate transplantation of uncultured hepatocytes for treating hyperbilirubinemic Gunn rat.
Nguyen TH, Birraux J, Wildhaber B, Myara A, Trivin F, Le Coultre C, Trono D, Chardot C. Nguyen TH, et al. Transplantation. 2006 Sep 27;82(6):794-803. doi: 10.1097/01.tp.0000234675.56598.35. Transplantation. 2006. PMID: 17006327
BACKGROUND: Ex vivo liver gene therapy provides an attractive alternative to orthotopic liver transplantation for the treatment of liver diseases. ...Therefore, this study demonstrates the therapeutic proof-of-principle and potential of the SLIT approach for …
BACKGROUND: Ex vivo liver gene therapy provides an attractive alternative to orthotopic liver transplantation for the treatmen …
A simple and highly effective method for the stable transduction of uncultured porcine hepatocytes using lentiviral vector.
Nguyen TH, Khakhoulina T, Simmons A, Morel P, Trono D. Nguyen TH, et al. Cell Transplant. 2005;14(7):489-96. doi: 10.3727/000000005783982828. Cell Transplant. 2005. PMID: 16285257
In addition, effective lentivector-mediated gene transfer onto porcine hepatocytes could advance in cell-based therapies for acute liver failure. ...Up to 80% of hepatocytes stably expressed a GFP transgene after a single exposure to lentiviral vector coding for GFP under …
In addition, effective lentivector-mediated gene transfer onto porcine hepatocytes could advance in cell-based therapies for acute liver
Therapeutic lentivirus-mediated neonatal in vivo gene therapy in hyperbilirubinemic Gunn rats.
Nguyen TH, Bellodi-Privato M, Aubert D, Pichard V, Myara A, Trono D, Ferry N. Nguyen TH, et al. Mol Ther. 2005 Nov;12(5):852-9. doi: 10.1016/j.ymthe.2005.06.482. Epub 2005 Sep 2. Mol Ther. 2005. PMID: 16140582 Free article.
Lentiviral vectors harboring the human UGT1 cDNA (approved symbol UGT1A1) under the control of a liver-specific transthyretin promoter were produced. ...PCR and Western blots confirmed the presence and expression of UGT1 in liver. The estimated proportion of transdu …
Lentiviral vectors harboring the human UGT1 cDNA (approved symbol UGT1A1) under the control of a liver-specific transthyretin promote …
Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins.
Arnaud C, Burger F, Steffens S, Veillard NR, Nguyen TH, Trono D, Mach F. Arnaud C, et al. Among authors: nguyen th. Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1231-6. doi: 10.1161/01.ATV.0000163840.63685.0c. Epub 2005 Mar 24. Arterioscler Thromb Vasc Biol. 2005. PMID: 15790934
Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes.
Nguyen TH, Oberholzer J, Birraux J, Majno P, Morel P, Trono D. Nguyen TH, et al. Mol Ther. 2002 Aug;6(2):199-209. doi: 10.1006/mthe.2002.0653. Mol Ther. 2002. PMID: 12161186 Free article.
Gene therapy is an attractive approach for the treatment of liver disease. We demonstrate that a so-called third-generation human immunodeficiency virus (HIV)-derived vector system can govern the efficient delivery, integration, and stable expression of a transgene into pr …
Gene therapy is an attractive approach for the treatment of liver disease. We demonstrate that a so-called third-generation human imm …
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