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Page 1
Inflammation and JNK's Role in Niacin-GPR109A Diminished Flushed Effect in Microglial and Neuronal Cells With Relevance to Schizophrenia.
Ansarey SH. Ansarey SH. Front Psychiatry. 2021 Nov 30;12:771144. doi: 10.3389/fpsyt.2021.771144. eCollection 2021. Front Psychiatry. 2021. PMID: 34916973 Free PMC article. Review.
Antipsychotics fail to alleviate symptoms when patients enter the chronic stage of illness. Topical application of niacin showed diminished skin flush in the majority of patients with schizophrenia compared to the general population who showed flushing. ...Th …
Antipsychotics fail to alleviate symptoms when patients enter the chronic stage of illness. Topical application of niacin showed dimi …
Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor.
Adepu KK, Kachhap S, Anishkin A, Chintapalli SV. Adepu KK, et al. Bioinform Biol Insights. 2021 Nov 27;15:11779322211056122. doi: 10.1177/11779322211056122. eCollection 2021. Bioinform Biol Insights. 2021. PMID: 34866904 Free PMC article.
The transmembrane G-protein coupled receptor GPR109A has been previously shown to function as a receptor for niacin in mediating antilipolytic effects. ...To get into the structural insights on niacin binding to GPR109A, we have performed 100 nanosecon …
The transmembrane G-protein coupled receptor GPR109A has been previously shown to function as a receptor for niacin in mediati …
[Niacin in therapy].
Nagalski A, Bryła J. Nagalski A, et al. Postepy Hig Med Dosw (Online). 2007 May 15;61:288-302. Postepy Hig Med Dosw (Online). 2007. PMID: 17554232 Review. Polish.
However, it is necessary to point out that the currently applied niacin preparations might exhibit such side effects as cutaneous flushing, gastrointestinal disturbances, and hepatotoxicity, particularly during treatment with sustained-release niacin preparat …
However, it is necessary to point out that the currently applied niacin preparations might exhibit such side effects as cutaneous …
Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.
Lauring B, Taggart AK, Tata JR, Dunbar R, Caro L, Cheng K, Chin J, Colletti SL, Cote J, Khalilieh S, Liu J, Luo WL, Maclean AA, Peterson LB, Polis AB, Sirah W, Wu TJ, Liu X, Jin L, Wu K, Boatman PD, Semple G, Behan DP, Connolly DT, Lai E, Wagner JA, Wright SD, Cuffie C, Mitchel YB, Rader DJ, Paolini JF, Waters MG, Plump A. Lauring B, et al. Sci Transl Med. 2012 Aug 22;4(148):148ra115. doi: 10.1126/scitranslmed.3003877. Sci Transl Med. 2012. PMID: 22914621 Clinical Trial.
In mice, the absence of GPR109A had no effect on niacin's lipid efficacy despite complete abrogation of the anti-lipolytic effect. ...Chronic FFA suppression was not sustainable via GPR109A agonism with niacin, MK-1903, or SCH900271. We conclude …
In mice, the absence of GPR109A had no effect on niacin's lipid efficacy despite complete abrogation of the anti-lipoly …
Developing a risk assessment model for treatment-resistant schizophrenia: The role of niacin receptor GPR109A and prostaglandin receptors DP(1), EP(2), and EP(4) in the niacin-induced flushing pathway.
Chiu CW, Chen BY, Lin JJ, Tseng HH, Huang CC, Wang TY, Jang FL, Yao CY, Chang WH, Chen PS, Lin SH. Chiu CW, et al. Schizophr Res. 2025 Jun;280:30-38. doi: 10.1016/j.schres.2025.04.003. Epub 2025 Apr 11. Schizophr Res. 2025. PMID: 40220605
Schizophrenia patients show attenuated niacin flush responses compared to healthy controls (HC) attributed to abnormalities in the niacin-induced flushing pathway. ...These findings suggest that the niacin receptor GPR109A and PG receptor …
Schizophrenia patients show attenuated niacin flush responses compared to healthy controls (HC) attributed to abnormalities in …
Future of GPR109A agonists in the treatment of dyslipidaemia.
Wanders D, Judd RL. Wanders D, et al. Diabetes Obes Metab. 2011 Aug;13(8):685-91. doi: 10.1111/j.1463-1326.2011.01400.x. Diabetes Obes Metab. 2011. PMID: 21418500 Review.
Recently, the receptor for niacin, GPR109A, was discovered. GPR109A in the adipocyte mediates a niacin-induced inhibition of lipolysis, which could play a crucial part in its role as a lipid-modifying drug. GPR109A in epidermal Langerhans cells …
Recently, the receptor for niacin, GPR109A, was discovered. GPR109A in the adipocyte mediates a niacin-induced i …
The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.
Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Lan L, Singh N, Martin PM, Hawthorn L, Prasad PD, Ganapathy V, Thangaraju M. Elangovan S, et al. Cancer Res. 2014 Feb 15;74(4):1166-78. doi: 10.1158/0008-5472.CAN-13-1451. Epub 2013 Dec 26. Cancer Res. 2014. PMID: 24371223 Free PMC article.
GPR109A, a G-protein-coupled receptor, is activated by niacin and butyrate. Upon activation in colonocytes, GPR109A potentiates anti-inflammatory pathways, induces apoptosis, and protects against inflammation-induced colon cancer. In contrast, GPR109A …
GPR109A, a G-protein-coupled receptor, is activated by niacin and butyrate. Upon activation in colonocytes, GPR109A pot …
Nicotinic acid: recent developments.
Kamanna VS, Vo A, Kashyap ML. Kamanna VS, et al. Curr Opin Cardiol. 2008 Jul;23(4):393-8. doi: 10.1097/HCO.0b013e3283021c82. Curr Opin Cardiol. 2008. PMID: 18520725 Review.
PURPOSE OF REVIEW: To review the recent progress in niacin research that is made in two major areas: new preparations to decrease flushing and niacin's mechanism of action. ...SUMMARY: Recent developments suggest that the niacin receptor GPR1 …
PURPOSE OF REVIEW: To review the recent progress in niacin research that is made in two major areas: new preparations to decrease …
Niacin-induced flushing: Mechanism, pathophysiology, and future perspectives.
Javaid A, Mudavath SL. Javaid A, et al. Arch Biochem Biophys. 2024 Nov;761:110163. doi: 10.1016/j.abb.2024.110163. Epub 2024 Sep 23. Arch Biochem Biophys. 2024. PMID: 39322100 Review.
The study focuses on niacin-induced flushing, a well-researched side effect of the niacin, a drug which increases cholesterol levels. Niacin-induced flushing occurs when the hydroxycarboxylic acid receptor 2 (HCA2 or GPR109A) is activated …
The study focuses on niacin-induced flushing, a well-researched side effect of the niacin, a drug which increases chole …
Niacin inhibits skin dendritic cell mobilization in a GPR109A independent manner but has no impact on monocyte trafficking in atherosclerosis.
Ingersoll MA, Potteaux S, Alvarez D, Hutchison SB, van Rooijen N, Randolph GJ. Ingersoll MA, et al. Immunobiology. 2012 May;217(5):548-57. doi: 10.1016/j.imbio.2011.05.014. Epub 2011 May 30. Immunobiology. 2012. PMID: 21798616 Free PMC article.
Skin flushing results from niacin-induced activation of GPR109A and subsequent release of prostaglandins that promote vasodilation. ...Surprisingly, niacin-mediated impaired dendritic cell mobilization could not be reversed by cyclooxygenase inhibitor …
Skin flushing results from niacin-induced activation of GPR109A and subsequent release of prostaglandins that promote v …
50 results