Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1950 1
1952 3
1953 9
1954 5
1955 8
1956 1
1957 6
1958 5
1959 2
1960 8
1961 12
1962 11
1963 18
1964 16
1965 6
1969 1
1974 2
1977 4
1978 1
1979 1
1981 1
1982 4
1983 5
1984 1
1985 1
1986 5
1987 3
1988 3
1989 4
1990 3
1991 3
1992 4
1993 10
1994 7
1995 8
1996 4
1997 11
1998 6
1999 10
2000 17
2001 6
2002 9
2003 8
2004 9
2005 8
2006 13
2007 21
2008 17
2009 20
2010 17
2011 13
2012 13
2013 12
2014 12
2015 14
2016 21
2017 26
2018 27
2019 22
2020 34
2021 31
2022 24
2023 31
2024 25
2025 34
2026 26

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

672 results

Results by year

Filters applied: . Clear all
Page 1
NAD(+) repletion with niacin counteracts cancer cachexia.
Beltrà M, Pöllänen N, Fornelli C, Tonttila K, Hsu MY, Zampieri S, Moletta L, Corrà S, Porporato PE, Kivelä R, Viscomi C, Sandri M, Hulmi JJ, Sartori R, Pirinen E, Penna F. Beltrà M, et al. Nat Commun. 2023 Apr 3;14(1):1849. doi: 10.1038/s41467-023-37595-6. Nat Commun. 2023. PMID: 37012289 Free PMC article.
Testing NAD(+) repletion therapy in cachectic mice reveals that NAD(+) precursor, vitamin B3 niacin, efficiently corrects tissue NAD(+) levels, improves mitochondrial metabolism and ameliorates cancer- and chemotherapy-induced cachexia. ...Overall, our results propo …
Testing NAD(+) repletion therapy in cachectic mice reveals that NAD(+) precursor, vitamin B3 niacin, efficiently corrects tissue NAD( …
The Promise of Niacin in Neurology.
Wuerch E, Urgoiti GR, Yong VW. Wuerch E, et al. Neurotherapeutics. 2023 Jul;20(4):1037-1054. doi: 10.1007/s13311-023-01376-2. Epub 2023 Apr 21. Neurotherapeutics. 2023. PMID: 37084148 Free PMC article. Review.
Niacin (vitamin B3) is an essential nutrient that treats pellagra, and prior to the advent of statins, niacin was commonly used to counter dyslipidemia. ...Niacin also has roles outside of metabolism, largely through engaging hydroxycarboxylic acid rec …
Niacin (vitamin B3) is an essential nutrient that treats pellagra, and prior to the advent of statins, niacin was commonly use …
Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial.
Raison CL, Sanacora G, Woolley J, Heinzerling K, Dunlop BW, Brown RT, Kakar R, Hassman M, Trivedi RP, Robison R, Gukasyan N, Nayak SM, Hu X, O'Donnell KC, Kelmendi B, Sloshower J, Penn AD, Bradley E, Kelly DF, Mletzko T, Nicholas CR, Hutson PR, Tarpley G, Utzinger M, Lenoch K, Warchol K, Gapasin T, Davis MC, Nelson-Douthit C, Wilson S, Brown C, Linton W, Ross S, Griffiths RR. Raison CL, et al. JAMA. 2023 Sep 5;330(9):843-853. doi: 10.1001/jama.2023.14530. JAMA. 2023. PMID: 37651119 Free PMC article.
RESULTS: A total of 104 participants (mean [SD] age, 41.1 [11.3] years; 52 [50%] women) were randomized (51 to the psilocybin group and 53 to the niacin group). Psilocybin treatment was associated with significantly reduced MADRS scores compared with niacin from bas …
RESULTS: A total of 104 participants (mean [SD] age, 41.1 [11.3] years; 52 [50%] women) were randomized (51 to the psilocybin group and 53 t …
NAD precursors cycle between host tissues and the gut microbiome.
Chellappa K, McReynolds MR, Lu W, Zeng X, Makarov M, Hayat F, Mukherjee S, Bhat YR, Lingala SR, Shima RT, Descamps HC, Cox T, Ji L, Jankowski C, Chu Q, Davidson SM, Thaiss CA, Migaud ME, Rabinowitz JD, Baur JA. Chellappa K, et al. Cell Metab. 2022 Dec 6;34(12):1947-1959.e5. doi: 10.1016/j.cmet.2022.11.004. Cell Metab. 2022. PMID: 36476934 Free PMC article.
The microbiome converts host-derived nicotinamide into nicotinic acid, which is used for NAD synthesis in host tissues and maintains circulating nicotinic acid levels even in the absence of dietary consumption. Moreover, the main route from oral nicoti …
The microbiome converts host-derived nicotinamide into nicotinic acid, which is used for NAD synthesis in host tissues and mai …
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.
Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, Lee JR, Offermanns S, Ganapathy V. Singh N, et al. Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9. Immunity. 2014. PMID: 24412617 Free PMC article.
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation. ...Consequently, Niacr1(-/-) mice were susceptible to development of colonic inflamm …
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by …
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.
Liu L, Su X, Quinn WJ 3rd, Hui S, Krukenberg K, Frederick DW, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison TJ, Baur JA, Rabinowitz JD. Liu L, et al. Cell Metab. 2018 May 1;27(5):1067-1080.e5. doi: 10.1016/j.cmet.2018.03.018. Cell Metab. 2018. PMID: 29685734 Free PMC article.
Niacin.
Kirkland JB, Meyer-Ficca ML. Kirkland JB, et al. Adv Food Nutr Res. 2018;83:83-149. doi: 10.1016/bs.afnr.2017.11.003. Epub 2018 Feb 1. Adv Food Nutr Res. 2018. PMID: 29477227
Nicotinic acid and nicotinamide, collectively referred to as niacin, are nutritional precursors of the bioactive molecules nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). ...Insight into the role of niacin …
Nicotinic acid and nicotinamide, collectively referred to as niacin, are nutritional precursors of the bioactive molecu …
A review of nicotinamide: treatment of skin diseases and potential side effects.
Rolfe HM. Rolfe HM. J Cosmet Dermatol. 2014 Dec;13(4):324-8. doi: 10.1111/jocd.12119. J Cosmet Dermatol. 2014. PMID: 25399625 Review.
It is a precursor of essential coenzymes for numerous reactions in the body including adenosine triphosphate (ATP) production. Nicotinic acid, also known as niacin, is converted into nicotinamide in the body. The use of topical nicotinamide in the treatment o …
It is a precursor of essential coenzymes for numerous reactions in the body including adenosine triphosphate (ATP) production. Nicotinic …
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z. Zhao C, et al. Mol Cell. 2023 Sep 7;83(17):3171-3187.e7. doi: 10.1016/j.molcel.2023.07.030. Epub 2023 Aug 18. Mol Cell. 2023. PMID: 37597514 Free article.
Hydroxycarboxylic acid receptor 2 (HCAR2), modulated by endogenous ketone body beta-hydroxybutyrate and exogenous niacin, is a promising therapeutic target for inflammation-related diseases. ...Furthermore, four structures of HCAR2-G(i) complex bound to orthosteric …
Hydroxycarboxylic acid receptor 2 (HCAR2), modulated by endogenous ketone body beta-hydroxybutyrate and exogenous niacin, is a …
672 results