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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 1
1953 1
1963 1
1964 5
1965 6
1966 1
1967 2
1968 4
1969 4
1970 10
1971 6
1972 7
1973 2
1974 5
1975 1
1976 6
1977 3
1978 3
1980 3
1981 3
1982 2
1983 1
1984 7
1985 2
1986 2
1987 7
1988 1
1989 4
1990 6
1991 2
1992 3
1993 2
1994 8
1995 3
1996 7
1997 6
1998 3
1999 1
2000 6
2001 6
2002 8
2003 5
2004 4
2005 6
2006 2
2007 4
2008 3
2009 5
2010 9
2011 12
2012 7
2013 11
2014 16
2015 13
2016 9
2017 5
2018 10
2019 15
2020 20
2021 14
2022 17
2023 18
2024 6

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344 results

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Page 1
Depigmentation and Anti-aging Treatment by Natural Molecules.
Zaid AN, Al Ramahi R. Zaid AN, et al. Curr Pharm Des. 2019;25(20):2292-2312. doi: 10.2174/1381612825666190703153730. Curr Pharm Des. 2019. PMID: 31269882 Review.
Many plant-derived and natural molecules have shown to affect melanin synthesis by different mechanisms, examples include Arbutin, Ramulus mori extract, Licorice extract, Glabridin, Liquiritin, Kojic acid, Methyl gentisate, Aloesin, Azelaic acid, Vitamin C, Thioctic …
Many plant-derived and natural molecules have shown to affect melanin synthesis by different mechanisms, examples include Arbutin, Ramulus m …
Ginsenoside Rg1 Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Microbial Tryptophan Metabolism.
Cheng H, Liu J, Zhang D, Wang J, Tan Y, Feng W, Peng C. Cheng H, et al. Front Immunol. 2022 May 17;13:817600. doi: 10.3389/fimmu.2022.817600. eCollection 2022. Front Immunol. 2022. PMID: 35655785 Free PMC article.
DSS decreased the levels of tryptophan metabolites in the serum, including indole-3-carboxaldehyde, indole-3-lactic acid, 3-indolepropionic acid, and niacinamide and Rg1 can increase the levels of these metabolites. ...
DSS decreased the levels of tryptophan metabolites in the serum, including indole-3-carboxaldehyde, indole-3-lactic acid, 3-in …
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
DeWaal D, Nogueira V, Terry AR, Patra KC, Jeon SM, Guzman G, Au J, Long CP, Antoniewicz MR, Hay N. DeWaal D, et al. Nat Commun. 2018 Jan 31;9(1):446. doi: 10.1038/s41467-017-02733-4. Nat Commun. 2018. PMID: 29386513 Free PMC article.
Silencing HK2 in human HCC cells inhibits tumorigenesis and increases cell death, which cannot be restored by GCK or mitochondrial binding deficient HK2. Upon HK2 silencing, glucose flux to pyruvate and lactate is inhibited, but TCA fluxes are maintained. Serine uptake and …
Silencing HK2 in human HCC cells inhibits tumorigenesis and increases cell death, which cannot be restored by GCK or mitochondrial binding d …
beta-HB treatment reverses sorafenib resistance by shifting glycolysis-lactate metabolism in HCC.
Suk FM, Wu CY, Fang CC, Chen TL, Liao YJ. Suk FM, et al. Biomed Pharmacother. 2023 Oct;166:115293. doi: 10.1016/j.biopha.2023.115293. Epub 2023 Aug 9. Biomed Pharmacother. 2023. PMID: 37567069 Free article.
In sorafenib-resistant HCC cells, lower HMGCS2 and beta-HB levels were correlated with more glycolytic alterations and higher lactate production. beta-HB treatment enhanced pyruvate dehydrogenase (PDH) expression and decreased lactate dehydrogenase (LDHA) expression …
In sorafenib-resistant HCC cells, lower HMGCS2 and beta-HB levels were correlated with more glycolytic alterations and higher lactate
Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation.
Miranda-Gonçalves V, Lameirinhas A, Macedo-Silva C, Lobo J, C Dias P, Ferreira V, Henrique R, Jerónimo C. Miranda-Gonçalves V, et al. Cells. 2020 Apr 23;9(4):1053. doi: 10.3390/cells9041053. Cells. 2020. PMID: 32340156 Free PMC article.
Thus, in-depth knowledge of lactate's impact on epigenome regulation of highly glycolytic tumors might allow for new therapeutic strategies. ...Treatment with a SIRT1 inhibitor, nicotinamide (NAM), paralleled lactate effects, promoting cell aggressiveness. In …
Thus, in-depth knowledge of lactate's impact on epigenome regulation of highly glycolytic tumors might allow for new therapeut …
NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis.
Pacl HT, Chinta KC, Reddy VP, Nadeem S, Sevalkar RR, Nargan K, Lumamba K, Naidoo T, Glasgow JN, Agarwal A, Steyn AJC. Pacl HT, et al. Nat Commun. 2023 Sep 6;14(1):5472. doi: 10.1038/s41467-023-40545-x. Nat Commun. 2023. PMID: 37673914 Free PMC article.
Flux through the glycolytic pathway in myeloid cells is inextricably linked to the availability of NAD(+), which is maintained by NAD(+) salvage and lactate metabolism. Using lung tissue from tuberculosis (TB) patients and myeloid deficient LDHA (Ldha(LysM-/-)) mice, we de …
Flux through the glycolytic pathway in myeloid cells is inextricably linked to the availability of NAD(+), which is maintained by NAD(+) sal …
Nicotinamide Antagonizes Lipopolysaccharide-Induced Hypoxic Cell Signals in Human Macrophages.
Curran CS, Dougherty EJ, Cui X, Li Y, Jeakle M, Gamble T, Demirkale CY, Torabi-Parizi P. Curran CS, et al. J Immunol. 2023 Jul 15;211(2):261-273. doi: 10.4049/jimmunol.2200552. J Immunol. 2023. PMID: 37314413 Free PMC article.
NAM also increased prolyl hydroxylase domain 2 (PHD2) production, inhibited HIF-1alpha transcription, and promoted the formation of the proteasome, resulting in reduced HIF-1alpha stabilization, decreased glycolysis and phagocytosis, and reductions in NOX2 activity and the produc …
NAM also increased prolyl hydroxylase domain 2 (PHD2) production, inhibited HIF-1alpha transcription, and promoted the formation of the prot …
Norcantharidin potentiates sorafenib antitumor activity in hepatocellular carcinoma rat model through inhibiting IL-6/STAT3 pathway.
Yousef EH, El-Magd NFA, El Gayar AM. Yousef EH, et al. Transl Res. 2023 Oct;260:69-82. doi: 10.1016/j.trsl.2023.05.005. Epub 2023 May 30. Transl Res. 2023. PMID: 37257560
Also, NCTD augmented Sora attenuation activity against TAA-induced angiogenesis and metastasis by decreasing VEGFA, HIF-1alpha, serum lactate dehydrogenase enzyme, and vimentin levels. The combined use of NCTD/Sora suppressed drug resistance and stemness by downregulating …
Also, NCTD augmented Sora attenuation activity against TAA-induced angiogenesis and metastasis by decreasing VEGFA, HIF-1alpha, serum lac
Tumor microenvironment-initiated lipid redox cycling for efficient triple-negative breast cancer therapy.
Zhou TJ, Wan X, Zhang MM, Liu DM, Huang LL, Xing L, Wang Y, Jiang HL. Zhou TJ, et al. Biomaterials. 2023 Sep;300:122205. doi: 10.1016/j.biomaterials.2023.122205. Epub 2023 Jun 17. Biomaterials. 2023. PMID: 37348324
SPC is not only the delivery carrier but an unsaturated lipid supplement for ROS explosion. And LOX catalyzes excessive intratumoral lactate to promote the accumulation of large amounts of H(2)O(2). ...Compared to normal tissue, tumor tissue has higher levels of lactate
SPC is not only the delivery carrier but an unsaturated lipid supplement for ROS explosion. And LOX catalyzes excessive intratumoral lact
Repolarization of macrophages to improve sorafenib sensitivity for combination cancer therapy.
Huang L, Xu R, Li W, Lv L, Lin C, Yang X, Yao Y, Saw PE, Xu X. Huang L, et al. Acta Biomater. 2023 May;162:98-109. doi: 10.1016/j.actbio.2023.03.014. Epub 2023 Mar 16. Acta Biomater. 2023. PMID: 36931417
This nanoparticle (NP) platform is made with a TME pH-responsive methoxyl-poly(ethylene glycol)-b-poly(lactic-co-glycolic acid) copolymer. After intravenous administration, the co-delivery NPs could highly accumulate in the tumor tissues and then respond to the TME …
This nanoparticle (NP) platform is made with a TME pH-responsive methoxyl-poly(ethylene glycol)-b-poly(lactic-co-glycolic acid
344 results