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1,356 results

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Page 1
Niacinamide: A B vitamin that improves aging facial skin appearance.
Bissett DL, Oblong JE, Berge CA. Bissett DL, et al. Dermatol Surg. 2005 Jul;31(7 Pt 2):860-5; discussion 865. doi: 10.1111/j.1524-4725.2005.31732. Dermatol Surg. 2005. PMID: 16029679 Clinical Trial.
OBJECTIVE: To clinically determine the effect of topical niacinamide on additional skin appearance and property end points (wrinkles, yellowing, and elasticity). ...RESULTS: Analyses of the data revealed a variety of significant skin appearance improvement ef …
OBJECTIVE: To clinically determine the effect of topical niacinamide on additional skin appearance and property end points (wr …
Niacinamide: a review on dermal delivery strategies and clinical evidence.
Ong RR, Goh CF. Ong RR, et al. Drug Deliv Transl Res. 2024 Dec;14(12):3512-3548. doi: 10.1007/s13346-024-01593-y. Epub 2024 May 9. Drug Deliv Transl Res. 2024. PMID: 38722460 Review.
Niacinamide, an active form of vitamin B3, is recognised for its significant dermal benefits including skin brightening, anti-ageing properties and the protection of the skin barrier. ...Therefore, a fundamental understanding of the skin permeation beh …
Niacinamide, an active form of vitamin B3, is recognised for its significant dermal benefits including skin brightening, anti- …
Niacinamide - mechanisms of action and its topical use in dermatology.
Wohlrab J, Kreft D. Wohlrab J, et al. Skin Pharmacol Physiol. 2014;27(6):311-5. doi: 10.1159/000359974. Epub 2014 Jun 27. Skin Pharmacol Physiol. 2014. PMID: 24993939 Review.
Niacinamide, an amide of vitamin B3 (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have long been described in the literature. Given a sufficient bioavailability, niacinamide has antipruritic, antimicrobial, vasoactive, p …
Niacinamide, an amide of vitamin B3 (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have …
The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
Hakozaki T, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE. Hakozaki T, et al. Br J Dermatol. 2002 Jul;147(1):20-31. doi: 10.1046/j.1365-2133.2002.04834.x. Br J Dermatol. 2002. PMID: 12100180 Clinical Trial.
In addition, many Asian women desire a lighter skin colour. Thus, there is a need for the development of skin lightening agents. Niacinamide is a possible candidate. OBJECTIVES: To investigate the effects of niacinamide on melanogenesis in vitro and on …
In addition, many Asian women desire a lighter skin colour. Thus, there is a need for the development of skin lightening agent …
A Mixture of Topical Forms of Polydeoxyribonucleotide, Vitamin C, and Niacinamide Attenuated Skin Pigmentation and Increased Skin Elasticity by Modulating Nuclear Factor Erythroid 2-like 2.
Kim HM, Byun KA, Oh S, Yang JY, Park HJ, Chung MS, Son KH, Byun K. Kim HM, et al. Molecules. 2022 Feb 14;27(4):1276. doi: 10.3390/molecules27041276. Molecules. 2022. PMID: 35209068 Free PMC article.
It is well-known that increased oxidative stress caused by ultraviolet B (UV-B) radiation induces melanogenesis and activates metalloproteinases (MMPs), which degrade collagen and elastin fibers, leading to decreased skin elasticity. Various antioxidant agents, such as vit …
It is well-known that increased oxidative stress caused by ultraviolet B (UV-B) radiation induces melanogenesis and activates metalloprotein …
Cosmeceutical Aptitudes of Niacinamide: A Review.
Madaan P, Sikka P, Malik DS. Madaan P, et al. Recent Adv Antiinfect Drug Discov. 2021;16(3):196-208. doi: 10.2174/2772434416666211129105629. Recent Adv Antiinfect Drug Discov. 2021. PMID: 34844552 Review.
Based upon type and severity, the conditions may vary from superficial to deep systemic skin infections. Niacinamide, an amide analog of vitamin B3 which was conventionally utilized as a food supplement, is now explored for the management of skin disorders. . …
Based upon type and severity, the conditions may vary from superficial to deep systemic skin infections. Niacinamide, an amide …
Top weapons in skin aging and actives to target the consequences of skin cell senescence.
Draelos Z, Bogdanowicz P, Saurat JH. Draelos Z, et al. J Eur Acad Dermatol Venereol. 2024 Jul;38 Suppl 4:15-22. doi: 10.1111/jdv.19648. J Eur Acad Dermatol Venereol. 2024. PMID: 38881445 Review.
Skin aging has long been considered a purely cosmetic problem. However, as life expectancy increases, skin aging is taking on a functional dimension that goes beyond cosmetics and appearance. Preventive or therapeutic strategies are needed to target cellular senesce …
Skin aging has long been considered a purely cosmetic problem. However, as life expectancy increases, skin aging is taking on …
The effect of 2% niacinamide on facial sebum production.
Draelos ZD, Matsubara A, Smiles K. Draelos ZD, et al. J Cosmet Laser Ther. 2006 Jun;8(2):96-101. doi: 10.1080/14764170600717704. J Cosmet Laser Ther. 2006. PMID: 16766489 Clinical Trial.
OBJECTIVE: To demonstrate the effect of topical 2% niacinamide on sebum excretion rates and casual sebum production in Oriental and Caucasian populations. ...Fifty subjects applied the 2% niacinamide moisturizer to the face for 4 weeks and 50 subjects used a placebo …
OBJECTIVE: To demonstrate the effect of topical 2% niacinamide on sebum excretion rates and casual sebum production in Oriental and C …
Nicotinamide for Skin Cancer Chemoprevention.
Breglio KF, Knox KM, Hwang J, Weiss R, Maas K, Zhang S, Yao L, Madden C, Xu Y, Hartman RI, Wheless L. Breglio KF, et al. JAMA Dermatol. 2025 Nov 1;161(11):1140-1147. doi: 10.1001/jamadermatol.2025.3238. JAMA Dermatol. 2025. PMID: 40960808
Overall, there was a significant 14% reduction in skin cancer risk. When nicotinamide was initiated after a first skin cancer, the risk reduction rose to 54%, although this benefit declined with initiation following subsequent skin cancers. ...CONCLUSIONS AND …
Overall, there was a significant 14% reduction in skin cancer risk. When nicotinamide was initiated after a first skin cancer, …
Final report of the safety assessment of niacinamide and niacin.
Cosmetic Ingredient Review Expert Panel. Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005;24 Suppl 5:1-31. doi: 10.1080/10915810500434183. Int J Toxicol. 2005. PMID: 16596767 Review.
Skin irritation tests of up to 2.5% Niacinamide in rabbits produced only marginal irritation. Skin sensitization tests of Niacinamide at 5% during induction and 20% during challenge were negative in guinea pigs. ...
Skin irritation tests of up to 2.5% Niacinamide in rabbits produced only marginal irritation. Skin sensitization tests …
1,356 results