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Year Number of Results
2009 3
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360 results

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Page 1
Niclosamide repositioning for treating cancer: Challenges and nano-based drug delivery opportunities.
Barbosa EJ, Löbenberg R, de Araujo GLB, Bou-Chacra NA. Barbosa EJ, et al. Eur J Pharm Biopharm. 2019 Aug;141:58-69. doi: 10.1016/j.ejpb.2019.05.004. Epub 2019 May 9. Eur J Pharm Biopharm. 2019. PMID: 31078739 Review.
Drug repositioning may be defined as a process when new biological effects for known drugs are identified, leading to recommendations for new therapeutic applications. Niclosamide, present in the Model List of Essential Medicines, from the World Health Organization, has be …
Drug repositioning may be defined as a process when new biological effects for known drugs are identified, leading to recommendations for ne …
Niclosamide as a Promising Therapeutic Player in Human Cancer and Other Diseases.
Wang Z, Ren J, Du J, Wang H, Liu J, Wang G. Wang Z, et al. Int J Mol Sci. 2022 Dec 17;23(24):16116. doi: 10.3390/ijms232416116. Int J Mol Sci. 2022. PMID: 36555754 Free PMC article. Review.
However, over the past few years, increasing evidence has shown that niclosamide could treat diseases beyond parasitic diseases, which include metabolic diseases, immune system diseases, bacterial and viral infections, asthma, arterial constriction, myopia, and cancer …
However, over the past few years, increasing evidence has shown that niclosamide could treat diseases beyond parasitic diseases, whic …
Niclosamide improves cancer immunotherapy by modulating RNA-binding protein HuR-mediated PD-L1 signaling.
Zhang Q, Yang Z, Hao X, Dandreo LJ, He L, Zhang Y, Wang F, Wu X, Xu L. Zhang Q, et al. Cell Biosci. 2023 Oct 17;13(1):192. doi: 10.1186/s13578-023-01137-w. Cell Biosci. 2023. PMID: 37848943 Free PMC article.
Niclosamide enhanced T cell-mediated killing of cancer cells and significantly improved the efficacy of anti-PD-1 immunotherapy in two syngeneic animal tumor models. ...Our study demonstrates a novel strategy for targeting HuR/PD-L1 and provides the first proof-of-p …
Niclosamide enhanced T cell-mediated killing of cancer cells and significantly improved the efficacy of anti-PD-1 immunotherap …
New insights into niclosamide action: autophagy activation in colorectal cancer.
Newton PT. Newton PT. Biochem J. 2019 Mar 6;476(5):779-781. doi: 10.1042/BCJ20190020. Biochem J. 2019. PMID: 30842311 Review.
Amongst the most promising new therapies, niclosamide-an FDA-approved drug for treating tapeworm infections-is being assessed in a stage II clinical trial for the treatment of metastatic colorectal cancer. ...This finding provides a further understanding of the acti …
Amongst the most promising new therapies, niclosamide-an FDA-approved drug for treating tapeworm infections-is being assessed in a st …
Optimizing Niclosamide for Cancer Therapy: Improving Bioavailability via Structural Modification and Nanotechnology.
Wiggins R, Woo J, Mito S. Wiggins R, et al. Cancers (Basel). 2024 Oct 21;16(20):3548. doi: 10.3390/cancers16203548. Cancers (Basel). 2024. PMID: 39456642 Free PMC article. Review.
Inhibition of multiple cancer-related pathways has made niclosamide a promising candidate for the treatment of various cancers. ...For example, niclosamide derivatives, such as o-alkylamino-tethered niclosamide derivates, niclosamide etha …
Inhibition of multiple cancer-related pathways has made niclosamide a promising candidate for the treatment of various canc …
Niclosamide's potential direct targets in ovarian cancer.
Sekulovski N, MacLean JA, Bheemireddy SR, Yu Z, Okuda H, Pru C, Plunkett KN, Matzuk M, Hayashi K. Sekulovski N, et al. Biol Reprod. 2021 Aug 3;105(2):403-412. doi: 10.1093/biolre/ioab071. Biol Reprod. 2021. PMID: 33855343 Free PMC article.
Recent evidence indicates that niclosamide is an anti-cancer compound that is able to inhibit several signaling pathways. ...The present study identifies key signal transduction mechanisms altered by niclosamide in ovarian cancer. Using affinity purifi …
Recent evidence indicates that niclosamide is an anti-cancer compound that is able to inhibit several signaling pathways. ...T …
Combination of niclosamide and current therapies to overcome resistance for cancer: New frontiers for an old drug.
Ren J, Wang B, Wu Q, Wang G. Ren J, et al. Biomed Pharmacother. 2022 Nov;155:113789. doi: 10.1016/j.biopha.2022.113789. Epub 2022 Oct 8. Biomed Pharmacother. 2022. PMID: 36271567 Free article. Review.
Niclosamide is a drug used to treat parasitic infections. Recent studies have shown that niclosamide may have a wide range of clinical applications and can be used to treat cancer and other diseases. ...This review summarizes the drug combination strategies a …
Niclosamide is a drug used to treat parasitic infections. Recent studies have shown that niclosamide may have a wide range of …
Injectable pegylated niclosamide (polyethylene glycol-modified niclosamide) for cancer therapy.
Ma R, Ma ZG, Gao JL, Tai Y, Li LJ, Zhu HB, Li L, Dong DL, Sun ZJ. Ma R, et al. J Biomed Mater Res A. 2020 Jan;108(1):30-38. doi: 10.1002/jbm.a.36788. Epub 2019 Sep 5. J Biomed Mater Res A. 2020. PMID: 31433913
The antitumor activity was evaluated in CT26 and HCT116 colon cancer cells in vitro and nude mouse xenograft model of CT26 cells in vivo. The water solubility of niclosamide in mPEG5000-Nic was significantly increased. ...Our study demonstrates that pegylated nic …
The antitumor activity was evaluated in CT26 and HCT116 colon cancer cells in vitro and nude mouse xenograft model of CT26 cells in v …
Niclosamide in prostate cancer: An inhibitor of AR-V7, a mitochondrial uncoupler, or more?
Sakellakis M. Sakellakis M. Cancer Treat Res Commun. 2023;35:100685. doi: 10.1016/j.ctarc.2023.100685. Epub 2023 Jan 22. Cancer Treat Res Commun. 2023. PMID: 36706514 Free article.
A recent phase Ib study investigating the use of reformulated niclosamide in combination with abiraterone and prednisone in patients with castration-resistant prostate cancer (CRPC) demonstrated encouraging preliminary efficacy with low toxicity. ...However, some mi …
A recent phase Ib study investigating the use of reformulated niclosamide in combination with abiraterone and prednisone in patients …
Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.
Li Y, Li PK, Roberts MJ, Arend RC, Samant RS, Buchsbaum DJ. Li Y, et al. Cancer Lett. 2014 Jul 10;349(1):8-14. doi: 10.1016/j.canlet.2014.04.003. Epub 2014 Apr 13. Cancer Lett. 2014. PMID: 24732808 Free PMC article. Review.
A number of studies have established the anticancer activities of niclosamide in both in vitro and in vivo models. Moreover, the inhibitory effects of niclosamide on cancer stem cells provide further evidence for its consideration as a promising drug for c …
A number of studies have established the anticancer activities of niclosamide in both in vitro and in vivo models. Moreover, the inhi …
360 results