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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1954 2
1957 1
1959 2
1960 1
1961 2
1962 4
1963 4
1964 5
1965 5
1966 7
1967 4
1968 7
1969 9
1970 4
1971 4
1972 10
1973 19
1974 20
1975 26
1976 16
1977 16
1978 13
1979 11
1980 12
1981 9
1982 9
1983 5
1984 15
1985 9
1986 16
1987 10
1988 9
1989 9
1990 9
1991 8
1992 6
1993 9
1994 6
1995 13
1996 9
1997 16
1998 6
1999 9
2000 12
2001 22
2002 20
2003 16
2004 17
2005 16
2006 25
2007 20
2008 21
2009 31
2010 26
2011 48
2012 42
2013 57
2014 44
2015 49
2016 52
2017 48
2018 67
2019 96
2020 93
2021 133
2022 155
2023 150
2024 95

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1,601 results

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Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns.
Nadeeshani H, Li J, Ying T, Zhang B, Lu J. Nadeeshani H, et al. J Adv Res. 2021 Aug 11;37:267-278. doi: 10.1016/j.jare.2021.08.003. eCollection 2022 Mar. J Adv Res. 2021. PMID: 35499054 Free PMC article. Review.
BACKGROUND: Elderly population has been progressively rising in the world, thus the demand for anti-aging heath products to assure longevity as well as to ameliorate age-related complications is also on the rise. Among various anti-aging health products, nicotinamide mo
BACKGROUND: Elderly population has been progressively rising in the world, thus the demand for anti-aging heath products to assure longevity …
The efficacy and safety of beta-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.
Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V. Yi L, et al. Geroscience. 2023 Feb;45(1):29-43. doi: 10.1007/s11357-022-00705-1. Epub 2022 Dec 8. Geroscience. 2023. PMID: 36482258 Free PMC article. Clinical Trial.
In animal studies, beta-nicotinamide mononucleotide (NMN) supplementation increases nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and lifespan with great safety. ...
In animal studies, beta-nicotinamide mononucleotide (NMN) supplementation increases nicotinamide adenine dinucleotide ( …
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.
Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J. Song Q, et al. Adv Nutr. 2023 Nov;14(6):1416-1435. doi: 10.1016/j.advnut.2023.08.008. Epub 2023 Aug 22. Adv Nutr. 2023. PMID: 37619764 Free PMC article. Review.
The importance of nicotinamide adenine dinucleotide (NAD(+)) in human physiology is well recognized. As the NAD(+) concentration in human skin, blood, liver, muscle, and brain are thought to decrease with age, finding ways to increase NAD(+) status could possibly influence …
The importance of nicotinamide adenine dinucleotide (NAD(+)) in human physiology is well recognized. As the NAD(+) concentration in h …
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.
Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Yoshino M, et al. Science. 2021 Jun 11;372(6547):1224-1229. doi: 10.1126/science.abe9985. Epub 2021 Apr 22. Science. 2021. PMID: 33888596 Free PMC article. Clinical Trial.
In rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, which contributes to metabolic dysfunction. Nicotinamide mononucleotide (NMN) availability is a rate-limiting factor in mammalian NAD(+) biosynthesis. ...
In rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, which contributes to metabolic dysfunct …
The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions.
Soma M, Lalam SK. Soma M, et al. Mol Biol Rep. 2022 Oct;49(10):9737-9748. doi: 10.1007/s11033-022-07459-1. Epub 2022 Apr 20. Mol Biol Rep. 2022. PMID: 35441939 Review.
Biosynthesis and regulation of nicotinamide adenine dinucleotide (NAD(+)) has recently gained a lot of attention. ...Some of the new studies conducted in mice and humans have targeted the NAD(+) metabolism with NAD(+) intermediates. Of these, nicotinamide mononuc
Biosynthesis and regulation of nicotinamide adenine dinucleotide (NAD(+)) has recently gained a lot of attention. ...Some of the new …
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.
Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Mills KF, et al. Cell Metab. 2016 Dec 13;24(6):795-806. doi: 10.1016/j.cmet.2016.09.013. Epub 2016 Oct 27. Cell Metab. 2016. PMID: 28068222 Free PMC article.
NAD(+) availability decreases with age and in certain disease conditions. Nicotinamide mononucleotide (NMN), a key NAD(+) intermediate, has been shown to enhance NAD(+) biosynthesis and ameliorate various pathologies in mouse disease models. ...
NAD(+) availability decreases with age and in certain disease conditions. Nicotinamide mononucleotide (NMN), a key NAD(+) inte …
NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health.
Alegre GFS, Pastore GM. Alegre GFS, et al. Curr Nutr Rep. 2023 Sep;12(3):445-464. doi: 10.1007/s13668-023-00475-y. Epub 2023 Jun 5. Curr Nutr Rep. 2023. PMID: 37273100 Free PMC article. Review.
In this review, we will show the biochemistry and metabolism of NAD+ precursors NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide), the latest findings on their beneficial physiological effects, their interplay with gut microbiota, and the futur …
In this review, we will show the biochemistry and metabolism of NAD+ precursors NR (nicotinamide riboside) and NMN (nicotinamide
Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study.
Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Liao B, et al. J Int Soc Sports Nutr. 2021 Jul 8;18(1):54. doi: 10.1186/s12970-021-00442-4. J Int Soc Sports Nutr. 2021. PMID: 34238308 Free PMC article. Clinical Trial.
BACKGROUND: Recent studies in rodents indicate that a combination of exercise training and supplementation with nicotinamide adenine dinucleotide (NAD(+)) precursors has synergistic effects. ...OBJECTIVE: This study investigates the effects of a combination of exercise tra …
BACKGROUND: Recent studies in rodents indicate that a combination of exercise training and supplementation with nicotinamide adenine …
beta-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice.
Li HR, Liu Q, Zhu CL, Sun XY, Sun CY, Yu CM, Li P, Deng XM, Wang JF. Li HR, et al. Redox Biol. 2023 Jul;63:102745. doi: 10.1016/j.redox.2023.102745. Epub 2023 May 13. Redox Biol. 2023. PMID: 37201414 Free PMC article.
Sirtuin 1 (SIRT1) has been reported to be downregulated in the hippocampus and SIRT1 agonists can attenuated the cognitive dysfunction in septic mice. Nicotinamide adenine dinucleotide (NAD+) is a key substrate to maintain the deacetylation activity of SIRT1. As an interme …
Sirtuin 1 (SIRT1) has been reported to be downregulated in the hippocampus and SIRT1 agonists can attenuated the cognitive dysfunction in se …
Biological synthesis of nicotinamide mononucleotide.
Shen Q, Zhang SJ, Xue YZ, Peng F, Cheng DY, Xue YP, Zheng YG. Shen Q, et al. Biotechnol Lett. 2021 Dec;43(12):2199-2208. doi: 10.1007/s10529-021-03191-1. Epub 2021 Oct 9. Biotechnol Lett. 2021. PMID: 34626279 Review.
Nicotinamide mononucleotide (NMN) or Nicotinamide-1-ium-1-beta-D-ribofuranoside 5'-phosphate is a nucleotide that can be converted into nicotinamide adenine dinucleotide (NAD) in human cells. ...The majority of biological synthetic routes for NMN is th
Nicotinamide mononucleotide (NMN) or Nicotinamide-1-ium-1-beta-D-ribofuranoside 5'-phosphate is a nucleotide that can b
1,601 results