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Page 1
Nicotinamide for Skin Cancer Chemoprevention.
Breglio KF, Knox KM, Hwang J, Weiss R, Maas K, Zhang S, Yao L, Madden C, Xu Y, Hartman RI, Wheless L. Breglio KF, et al. JAMA Dermatol. 2025 Nov 1;161(11):1140-1147. doi: 10.1001/jamadermatol.2025.3238. JAMA Dermatol. 2025. PMID: 40960808
IMPORTANCE: Nicotinamide supplementation has been studied as a chemopreventive medication for reducing skin cancer risk, but large-scale data are limited. ...Overall, there was a significant 14% reduction in skin cancer risk. When nico …
IMPORTANCE: Nicotinamide supplementation has been studied as a chemopreventive medication for reducing skin cancer …
Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.
Allen NC, Martin AJ, Snaidr VA, Eggins R, Chong AH, Fernandéz-Peñas P, Gin D, Sidhu S, Paddon VL, Banney LA, Lim A, Upjohn E, Schaider H, Ganhewa AD, Nguyen J, McKenzie CA, Prakash S, McLean C, Lochhead A, Ibbetson J, Dettrick A, Landgren A, Allnutt KJ, Allison C, Davenport RB, Mumford BP, Wong B, Stagg B, Tedman A, Gribbin H, Edwards HA, De Rosa N, Stewart T, Doolan BJ, Kok Y, Simpson K, Low ZM, Kovitwanichkanont T, Scolyer RA, Dhillon HM, Vardy JL, Chadban SJ, Bowen DG, Chen AC, Damian DL. Allen NC, et al. N Engl J Med. 2023 Mar 2;388(9):804-812. doi: 10.1056/NEJMoa2203086. N Engl J Med. 2023. PMID: 36856616 Clinical Trial.
BACKGROUND: Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B(3)) enhances the repair of ultraviolet (UV) radiation-induced DNA damage, reduces the cutaneous immunosuppressive …
BACKGROUND: Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. N …
Oral nicotinamide: The role in skin cancer chemoprevention.
Giacalone S, Spigariolo CB, Bortoluzzi P, Nazzaro G. Giacalone S, et al. Dermatol Ther. 2021 May;34(3):e14892. doi: 10.1111/dth.14892. Epub 2021 Mar 1. Dermatol Ther. 2021. PMID: 33595161 Review.
The incidence of skin cancer has gradually increased in the last years and exposition to ultraviolet radiation remains the main risk factor. We performed a comprehensive review on the role of nicotinamide (NAM) in the chemoprevention of skin can …
The incidence of skin cancer has gradually increased in the last years and exposition to ultraviolet radiation remains the mai …
Nicotinamide for skin cancer chemoprevention.
Damian DL. Damian DL. Australas J Dermatol. 2017 Aug;58(3):174-180. doi: 10.1111/ajd.12631. Epub 2017 Mar 20. Australas J Dermatol. 2017. PMID: 28321860 Review.
Nicotinamide (vitamin B(3) ) has a range of photoprotective effects in vitro and in vivo; it enhances DNA repair, reduces UV radiation-induced suppression of skin immune responses, modulates inflammatory cytokine production and skin barrier function and resto …
Nicotinamide (vitamin B(3) ) has a range of photoprotective effects in vitro and in vivo; it enhances DNA repair, reduces UV radiatio …
A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
Chen AC, Martin AJ, Choy B, Fernández-Peñas P, Dalziell RA, McKenzie CA, Scolyer RA, Dhillon HM, Vardy JL, Kricker A, St George G, Chinniah N, Halliday GM, Damian DL. Chen AC, et al. N Engl J Med. 2015 Oct 22;373(17):1618-26. doi: 10.1056/NEJMoa1506197. N Engl J Med. 2015. PMID: 26488693 Free article. Clinical Trial.
Secondary end points included the number of new squamous-cell carcinomas and basal-cell carcinomas and the number of actinic keratoses during the 12-month intervention period, the number of nonmelanoma skin cancers in the 6-month postintervention period, and the safety of …
Secondary end points included the number of new squamous-cell carcinomas and basal-cell carcinomas and the number of actinic keratoses durin …
Nicotinamide for Skin Cancer Chemoprevention: The Jury Was Out and Still is.
Tan E, Williams HC. Tan E, et al. Am J Clin Dermatol. 2026 Mar;27(2):209-215. doi: 10.1007/s40257-025-01005-y. Epub 2026 Jan 8. Am J Clin Dermatol. 2026. PMID: 41505062 Free PMC article. Review.
Nicotinamide has been widely promoted as a low-cost safe chemopreventive agent against non-melanoma skin cancer. A recent large retrospective study of more than 33,000 US veterans reported a 14% reduction in overall skin cancer risk and a …
Nicotinamide has been widely promoted as a low-cost safe chemopreventive agent against non-melanoma skin cancer. …
Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention.
Fania L, Mazzanti C, Campione E, Candi E, Abeni D, Dellambra E. Fania L, et al. Int J Mol Sci. 2019 Nov 26;20(23):5946. doi: 10.3390/ijms20235946. Int J Mol Sci. 2019. PMID: 31779194 Free PMC article. Review.
Moreover, NAM reduces skin cancer incidence and prevents the immune-suppressive effects of UV in mice. Thus, NAM is involved in the maintenance of genomic stability and may have beneficial effects against skin aging changes and tumor development. ...Furthermo …
Moreover, NAM reduces skin cancer incidence and prevents the immune-suppressive effects of UV in mice. Thus, NAM is involved i …
Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety.
Snaidr VA, Damian DL, Halliday GM. Snaidr VA, et al. Exp Dermatol. 2019 Feb;28 Suppl 1:15-22. doi: 10.1111/exd.13819. Exp Dermatol. 2019. PMID: 30698874 Review.
Nicotinamide is a water-soluble vitamin B3 derivative that has many roles in medicine. This review examines the role of nicotinamide in dermatology and its actions in preventing photoageing and skin cancers in humans. ...Randomised controlled clinical trials …
Nicotinamide is a water-soluble vitamin B3 derivative that has many roles in medicine. This review examines the role of nicotinami …
80 results