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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1987 1
1988 8
1989 5
1990 4
1991 10
1992 3
1993 17
1994 19
1995 24
1996 10
1997 15
1998 17
1999 13
2000 12
2001 11
2002 12
2003 18
2004 16
2005 21
2006 16
2007 21
2008 17
2009 13
2010 20
2011 35
2012 81
2013 87
2014 107
2015 110
2016 75
2017 60
2018 52
2019 59
2020 60
2021 71
2022 74
2023 51
2024 54
2025 42
2026 11

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1,205 results

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Page 1
Treatment of Tobacco Smoking: A Review.
Rigotti NA, Kruse GR, Livingstone-Banks J, Hartmann-Boyce J. Rigotti NA, et al. JAMA. 2022 Feb 8;327(6):566-577. doi: 10.1001/jama.2022.0395. JAMA. 2022. PMID: 35133411 Review.
The EAGLES trial, a randomized double-blind clinical trial of 8144 people who smoked, directly compared the efficacy and safety of varenicline, bupropion, nicotine patch, and placebo and found a significantly higher 6-month quit rate for varenicline (21.8%) than for …
The EAGLES trial, a randomized double-blind clinical trial of 8144 people who smoked, directly compared the efficacy and safety of varenicli …
Tobacco and nicotine use.
Le Foll B, Piper ME, Fowler CD, Tonstad S, Bierut L, Lu L, Jha P, Hall WD. Le Foll B, et al. Nat Rev Dis Primers. 2022 Mar 24;8(1):19. doi: 10.1038/s41572-022-00346-w. Nat Rev Dis Primers. 2022. PMID: 35332148 Review.
Neurobiological findings have identified the mechanisms by which nicotine in tobacco affects the brain reward system and causes addiction. These brain changes contribute to the maintenance of nicotine or tobacco use despite knowledge of its negative co …
Neurobiological findings have identified the mechanisms by which nicotine in tobacco affects the brain reward system and cause …
Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial.
Anthenelli RM, Benowitz NL, West R, St Aubin L, McRae T, Lawrence D, Ascher J, Russ C, Krishen A, Evins AE. Anthenelli RM, et al. Lancet. 2016 Jun 18;387(10037):2507-20. doi: 10.1016/S0140-6736(16)30272-0. Epub 2016 Apr 22. Lancet. 2016. PMID: 27116918 Free article. Clinical Trial.
INTERPRETATION: The study did not show a significant increase in neuropsychiatric adverse events attributable to varenicline or bupropion relative to nicotine patch or placebo. Varenicline was more effective than placebo, nicotine patch, and bup …
INTERPRETATION: The study did not show a significant increase in neuropsychiatric adverse events attributable to varenicline or bupro …
Nicotine replacement therapy versus control for smoking cessation.
Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T. Hartmann-Boyce J, et al. Cochrane Database Syst Rev. 2018 May 31;5(5):CD000146. doi: 10.1002/14651858.CD000146.pub5. Cochrane Database Syst Rev. 2018. PMID: 29852054 Free PMC article.
The pooled RRs for each type were 1.49 (95% CI 1.40 to 1.60, 56 trials, 22,581 participants) for nicotine gum; 1.64 (95% CI 1.53 to 1.75, 51 trials, 25,754 participants) for nicotine patch; 1.52 (95% CI 1.32 to 1.74, 8 trials, 4439 participants) for oral tabl …
The pooled RRs for each type were 1.49 (95% CI 1.40 to 1.60, 56 trials, 22,581 participants) for nicotine gum; 1.64 (95% CI 1.53 to 1 …
What are the respiratory effects of e-cigarettes?
Gotts JE, Jordt SE, McConnell R, Tarran R. Gotts JE, et al. BMJ. 2019 Sep 30;366:l5275. doi: 10.1136/bmj.l5275. BMJ. 2019. PMID: 31570493 Free PMC article. Review.
Electronic cigarettes (e-cigarettes) are alternative, non-combustible tobacco products that generate an inhalable aerosol containing nicotine, flavors, propylene glycol, and vegetable glycerin. ...Here, we review the evidence on the effects of e-cigarettes on …
Electronic cigarettes (e-cigarettes) are alternative, non-combustible tobacco products that generate an inhalable aerosol containing …
Electronic Nicotine-Delivery Systems for Smoking Cessation.
Auer R, Schoeni A, Humair JP, Jacot-Sadowski I, Berlin I, Stuber MJ, Haller ML, Tango RC, Frei A, Strassmann A, Bruggmann P, Baty F, Brutsche M, Tal K, Baggio S, Jakob J, Sambiagio N, Hopf NB, Feller M, Rodondi N, Berthet A. Auer R, et al. N Engl J Med. 2024 Feb 15;390(7):601-610. doi: 10.1056/NEJMoa2308815. N Engl J Med. 2024. PMID: 38354139 Free article. Clinical Trial.
BACKGROUND: Electronic nicotine-delivery systems - also called e-cigarettes - are used by some tobacco smokers to assist with quitting. ...Secondary outcomes included participant-reported abstinence from tobacco and from any nicotine (including smoking …
BACKGROUND: Electronic nicotine-delivery systems - also called e-cigarettes - are used by some tobacco smokers to assist with …
Reinforcement Enhancing Effects of Nicotine Via Patch and Nasal Spray.
Perkins KA, Karelitz JL, Boldry MC. Perkins KA, et al. Nicotine Tob Res. 2019 May 21;21(6):778-783. doi: 10.1093/ntr/nty038. Nicotine Tob Res. 2019. PMID: 29514317 Free PMC article.
In a fully within-subjects design using a double-dummy procedure, these sessions involved: (1) nicotine patch (Nicoderm 14 mg) plus placebo spray, (2) placebo patch plus nicotine spray (Nicotrol, 2 1 mg/trial), or (3) placebo patch plus placeb …
In a fully within-subjects design using a double-dummy procedure, these sessions involved: (1) nicotine patch (Nicoderm 14 mg) …
Effects of Varenicline, Bupropion, Nicotine Patch, and Placebo on Treating Smoking Among Persons With Current or Past Major Depressive Disorder: Secondary Analysis of a Double-Blind, Randomized, Placebo-Controlled Trial.
Kypriotakis G, Cinciripini PM, Green CE, Lawrence D, Anthenelli RM, Minnix JA, Beneventi D, Morris C, Karam-Hage M, Blalock JA. Kypriotakis G, et al. Am J Psychiatry. 2025 Feb 1;182(2):174-186. doi: 10.1176/appi.ajp.20230855. Epub 2024 Dec 11. Am J Psychiatry. 2025. PMID: 39659160 Clinical Trial.
OBJECTIVE: The aim of this study was to compare the safety and efficacy of the leading smoking cessation medications among individuals with current versus past major depressive disorder (MDD). ...Interventions included 12 weeks of pharmacotherapy with placebo, nicotine …
OBJECTIVE: The aim of this study was to compare the safety and efficacy of the leading smoking cessation medications among individual …
Tobacco Use Disorder.
Leone FT, Evers-Casey S. Leone FT, et al. Med Clin North Am. 2022 Jan;106(1):99-112. doi: 10.1016/j.mcna.2021.08.011. Med Clin North Am. 2022. PMID: 34823737 Free PMC article. Review.
Although sometimes trivialized as a minor substance, effects of nicotine on behavior lead to profound morbidity over a lifetime of exposure. Innovations in processing have led to potent forms of tobacco and delivery devices. Proactive treatment strateg …
Although sometimes trivialized as a minor substance, effects of nicotine on behavior lead to profound morbidity over a lifetim …
Cardiac adverse effects of nicotine replacement therapy.
[No authors listed] [No authors listed] Prescrire Int. 2015 Dec;24(166):292-3. Prescrire Int. 2015. PMID: 26788573 Review.
Smoking markedly increases the risk of cardiovascular disease. Nicotine replacement therapy is available to assist in smoking cessation. To assess the cardiac adverse effects of nicotine replacement therapy, we conducted a review of the literatu …
Smoking markedly increases the risk of cardiovascular disease. Nicotine replacement therapy is available to assist in smoking cess …
1,205 results