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16 results

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Page 1
Chronic Nicotine Exposure Alters Metabotropic Glutamate Receptor 5: Longitudinal PET Study and Behavioural Assessment in Rats.
Müller Herde A, Mihov Y, Krämer SD, Mu L, Adamantidis A, Ametamey SM, Hasler G. Müller Herde A, et al. Neurotox Res. 2019 Nov;36(4):806-816. doi: 10.1007/s12640-019-00055-5. Epub 2019 May 22. Neurotox Res. 2019. PMID: 31119680
As human PET data either reflect the impact of chronic nicotine exposure or a pre-existing vulnerability to nicotine addiction, we designed a preclinical, longitudinal study to investigate the effect of chronic nicotine exposure on mGluR5 with the nove …
As human PET data either reflect the impact of chronic nicotine exposure or a pre-existing vulnerability to nicotine ad …
Averting comfortable lifestyle crises.
Bilton R. Bilton R. Sci Prog. 2013;96(Pt 4):319-68. doi: 10.3184/003685013X13743292107915. Sci Prog. 2013. PMID: 24547668 Free PMC article. Review.
Containment of the obesity epidemic is compounded by the addictive properties of sugar which involve the same dopamine receptors in the pleasure centres of the brain as for cocaine, nicotine and alcohol. Of the many other toxic effects of excessive sugar consumption …
Containment of the obesity epidemic is compounded by the addictive properties of sugar which involve the same dopamine receptors in the plea …
PET imaging in clinical drug abuse research.
Gatley SJ, Volkow ND, Wang GJ, Fowler JS, Logan J, Ding YS, Gerasimov M. Gatley SJ, et al. Curr Pharm Des. 2005;11(25):3203-19. doi: 10.2174/138161205774424717. Curr Pharm Des. 2005. PMID: 16250850 Review.
Over the last two decades, SPECT (single photon emission computed tomography) and especially PET (positron emission tomography) have proven increasingly effective imaging modalities in the study of human psychopharmacology. ...Individual human subjects can be studied using …
Over the last two decades, SPECT (single photon emission computed tomography) and especially PET (positron emission tomography) have …
Comparative studies of epibatidine derivatives [18F]NFEP and [18F]N-methyl-NFEP: kinetics, nicotine effect, and toxicity.
Ding YS, Molina PE, Fowler JS, Logan J, Volkow ND, Kuhar MJ, Carroll FI. Ding YS, et al. Nucl Med Biol. 1999 Jan;26(1):139-48. doi: 10.1016/s0969-8051(98)00070-5. Nucl Med Biol. 1999. PMID: 10096514
We have previously shown that [18F]norchlorofluoroepibatidine ([18F]NFEP) would be an ideal radiotracer for positron emission tomography (PET) imaging of nicotinic acetylcholine receptors (nAChR); however, its high toxicity is a limiting factor for human studies. .. …
We have previously shown that [18F]norchlorofluoroepibatidine ([18F]NFEP) would be an ideal radiotracer for positron emission tomography ( …
Airborne PET nanoplastics alter tobacco's chemical risk.
Tan MM, Sun XD, Wang Y, Duan JL, Ma JY, Liu XY, Liu MY, Sun YC, Xing RX, Wang SG, Chen W, Yuan XZ. Tan MM, et al. Proc Natl Acad Sci U S A. 2025 Dec 23;122(51):e2519054122. doi: 10.1073/pnas.2519054122. Epub 2025 Dec 18. Proc Natl Acad Sci U S A. 2025. PMID: 41410772 Free PMC article.
Atmospheric micro(nano)plastics (MNPs), including polyethylene terephthalate (PET), enter plants via leaves, accumulating in tissues. Foliar PET nanoplastic exposure alters Nicotiana benthamiana nicotine biosynthesis, favoring the more potent (S)-isomer even …
Atmospheric micro(nano)plastics (MNPs), including polyethylene terephthalate (PET), enter plants via leaves, accumulating in tissues. …
Ligands for in vivo imaging of nicotinic receptor subtypes in Alzheimer brain.
Sihver W, Långström B, Nordberg A. Sihver W, et al. Acta Neurol Scand Suppl. 2000;176:27-33. doi: 10.1034/j.1600-0404.2000.00304.x. Acta Neurol Scand Suppl. 2000. PMID: 11261802 Review.
There is a great interest to image nAChRs noninvasive for detection of receptor impairments even at a presymptomatic stage of AD as well for monitoring outcome of drug treatment. (S) [11C]Nicotine, has so far been the only nAChR ligand used in positron emission tomography …
There is a great interest to image nAChRs noninvasive for detection of receptor impairments even at a presymptomatic stage of AD as well for …
Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a review.
Kostrzewa RM, Segura-Aguilar J. Kostrzewa RM, et al. Neurotox Res. 2003;5(6):375-83. doi: 10.1007/BF03033166. Neurotox Res. 2003. PMID: 14715440 Review.
Even brief exposure to some substances, in ontogeny and sometimes in adulthood, can have lasting effects on behaviors because of their prominent toxicity (e.g., NMDA receptor antagonists) or because they sensitize receptors (e.g., dopamine D2 agonists), possibly permanentl …
Even brief exposure to some substances, in ontogeny and sometimes in adulthood, can have lasting effects on behaviors because of their promi …
Evaluation of (S)-T1 and (S)-T2 ligands targeting alpha3beta4 nAChR as potential nicotine addiction pharmacotherapy.
Nianpanich S, Rodsiri R, Islamie R, Limpikirati P, Thanusuwannasak T, Vajragupta O, Kanasuwan A, Sarasamkan J. Nianpanich S, et al. Psychopharmacology (Berl). 2024 Dec;241(12):2485-2495. doi: 10.1007/s00213-024-06675-w. Epub 2024 Aug 23. Psychopharmacology (Berl). 2024. PMID: 39177808
Both compounds significantly attenuated nicotine-induced CPP, with (S)-T1 exhibiting a dose-dependent effect. Furthermore, the co-administration of (S)-T2 (10 mg/kg) with nicotine markedly reduced locomotor activity compared to nicotine treatment alone. ...CO …
Both compounds significantly attenuated nicotine-induced CPP, with (S)-T1 exhibiting a dose-dependent effect. Furthermore, the co-adm …
First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke Exposure.
Groppetti D, Pizzi G, Giussani E, Pecile A, Mazzola SM, Bronzo V, Fusi E. Groppetti D, et al. Vet Sci. 2024 Nov 26;11(12):598. doi: 10.3390/vetsci11120598. Vet Sci. 2024. PMID: 39728938 Free PMC article.
However, no data are currently available on the presence of cotinine, a nicotine metabolite, in the canine ejaculate. This study aimed to evaluate the detectability of cotinine in the semen of dogs living with smoking owners. ...This study is the first to demonstrate the p …
However, no data are currently available on the presence of cotinine, a nicotine metabolite, in the canine ejaculate. This study aime …
The quest for Eldorado: development of radioligands for in vivo imaging of nicotinic acetylcholine receptors in human brain.
Horti AG, Villemagne VL. Horti AG, et al. Curr Pharm Des. 2006;12(30):3877-900. doi: 10.2174/138161206778559605. Curr Pharm Des. 2006. PMID: 17073685 Review.
In the past two decades, researchers have developed an extensive series of radioligands for the assessment of nAChRs in vivo through emission tomography, PET and SPECT. Several radioligands, derivatives of A-85380: 2-[(18)F]FA, 6-[(18)F]FA and 5-[(123)I]IA, are now being e …
In the past two decades, researchers have developed an extensive series of radioligands for the assessment of nAChRs in vivo through emissio …
16 results