Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity.
Xie LQ, Hu B, Lu RB, Cheng YL, Chen X, Wen J, Xiao Y, An YZ, Peng N, Dai Y, Xie G, Guo Q, Peng H, Luo XH.
Xie LQ, et al.
Cell Res. 2025 Mar;35(3):165-185. doi: 10.1038/s41422-025-01078-8. Epub 2025 Jan 29.
Cell Res. 2025.
PMID: 39875551
Free PMC article.
Raptin-GRM3 signaling mediates anorexigenic effects via PI3K-AKT signaling. Of note, we verify the connections between deficiencies in the sleeping state, impaired Raptin release, and obesity in patients with sleep deficiency. Moreover, humans carrying an RCN2 nonse …
Raptin-GRM3 signaling mediates anorexigenic effects via PI3K-AKT signaling. Of note, we verify the connections between deficiencies i …