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Page 1
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics.
Lundberg JO, Weitzberg E, Gladwin MT. Lundberg JO, et al. Nat Rev Drug Discov. 2008 Feb;7(2):156-67. doi: 10.1038/nrd2466. Nat Rev Drug Discov. 2008. PMID: 18167491 Review.
The inorganic anions nitrate (NO3-) and nitrite (NO2-) were previously thought to be inert end products of endogenous nitric oxide (NO) metabolism. ...This Review discusses the emerging important biological functions of the nitrate-nitrite …
The inorganic anions nitrate (NO3-) and nitrite (NO2-) were previously thought to be inert end products of endogenous nitri …
Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the L-arginine/nitric oxide area of research.
Tsikas D. Tsikas D. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 15;851(1-2):51-70. doi: 10.1016/j.jchromb.2006.07.054. Epub 2006 Sep 6. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 16950667 Review.
Since the discovery of the l-arginine/nitric oxide (l-Arg/NO) pathway in 1987, however, the Griess reaction is the most frequently used analytical approach to quantitate the major metabolites of NO, i.e. nitrite and nitrate, in a variety of biological …
Since the discovery of the l-arginine/nitric oxide (l-Arg/NO) pathway in 1987, however, the Griess reaction is the most freque …
The Nitrate-Nitrite-Nitric Oxide Pathway: Potential Role in Mitigating Oxidative Stress in Hypertensive Disorders of Pregnancy.
Barbosa PO, Tanus-Santos JE, Cavalli RC, Bengtsson T, Montenegro MF, Sandrim VC. Barbosa PO, et al. Nutrients. 2024 May 14;16(10):1475. doi: 10.3390/nu16101475. Nutrients. 2024. PMID: 38794713 Free PMC article. Review.
At the heart of these complications is endothelial dysfunction, with oxidative stress emerging as a pivotal causative factor. The reduction in nitric oxide (NO) bioavailability is a vital indicator of this dysfunction, culminating in blood pressure dysregulation. .. …
At the heart of these complications is endothelial dysfunction, with oxidative stress emerging as a pivotal causative factor. The reduction …
Antiseptic mouthwash, the nitrate-nitrite-nitric oxide pathway, and hospital mortality: a hypothesis generating review.
Blot S. Blot S. Intensive Care Med. 2021 Jan;47(1):28-38. doi: 10.1007/s00134-020-06276-z. Epub 2020 Oct 16. Intensive Care Med. 2021. PMID: 33067640 Free PMC article. Review.
Nitric oxide is essential in multiple physiological processes, and a reduction in nitric oxide bioavailability is associated with the occurrence or worsening of pathologies, such as atherosclerosis, diabetes, and sepsis. Oral facultative anaerobic bact …
Nitric oxide is essential in multiple physiological processes, and a reduction in nitric oxide bioavailability i …
Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care.
Weitzberg E, Hezel M, Lundberg JO. Weitzberg E, et al. Anesthesiology. 2010 Dec;113(6):1460-75. doi: 10.1097/ALN.0b013e3181fcf3cc. Anesthesiology. 2010. PMID: 21045638 Review.
Recently, an alternative pathway for nitric oxide generation was discovered, wherein the inorganic anions nitrate (NO3) and nitrite (NO2), most often considered inert end products from nitric oxide generation, can be reduced back to ni …
Recently, an alternative pathway for nitric oxide generation was discovered, wherein the inorganic anions nitrate (NO3) …
The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway.
Kapil V, Khambata RS, Jones DA, Rathod K, Primus C, Massimo G, Fukuto JM, Ahluwalia A. Kapil V, et al. Pharmacol Rev. 2020 Jul;72(3):692-766. doi: 10.1124/pr.120.019240. Pharmacol Rev. 2020. PMID: 32576603 Free article. Review.
Much evidence has now accumulated demonstrating that nitrite serves as a storage form of nitric oxide, releasing nitric oxide preferentially under acidic and/or hypoxic conditions but also occurring under physiologic conditions: a phenomenon tha …
Much evidence has now accumulated demonstrating that nitrite serves as a storage form of nitric oxide, releasing nit …
The nitrate-nitrite-nitric oxide pathway of neuroinflammation and cognitive impairment in ischemic stroke.
Liu J, Deng Q, Wei S, Cheng L, Shen C, Liu Z, Qiu Y, Teng J, Wang L, Zhang X. Liu J, et al. Front Immunol. 2026 Mar 23;17:1790943. doi: 10.3389/fimmu.2026.1790943. eCollection 2026. Front Immunol. 2026. PMID: 41948314 Free PMC article. Review.
Neuroinflammation following an ischemic stroke is a key factor in cognitive impairment and disease progression, yet effective interventions are lacking. The classical L-arginine-nitric oxide synthase (L-arginine-NO) pathway for nitric oxide (NO) synthe …
Neuroinflammation following an ischemic stroke is a key factor in cognitive impairment and disease progression, yet effective interventions …
Inorganic nitrite and nitrate in cardiovascular therapy: A better alternative to organic nitrates as nitric oxide donors?
Münzel T, Daiber A. Münzel T, et al. Vascul Pharmacol. 2018 Mar;102:1-10. doi: 10.1016/j.vph.2017.11.003. Epub 2017 Nov 22. Vascul Pharmacol. 2018. PMID: 29174923 Free article. Review.
In 1867 the organic nitrite, amyl nitrite, was introduced as a therapeutic agent in the treatment of angina pectoris and was later substituted by the organic nitrate nitroglycerin (NTG). ...Despite these positive aspects there is still a great need to study i …
In 1867 the organic nitrite, amyl nitrite, was introduced as a therapeutic agent in the treatment of angina pectoris and was l …
Therapeutic value of stimulating the nitrate-nitrite-nitric oxide pathway to attenuate oxidative stress and restore nitric oxide bioavailability in cardiorenal disease.
Carlstrom M, Montenegro MF. Carlstrom M, et al. J Intern Med. 2019 Jan;285(1):2-18. doi: 10.1111/joim.12818. Epub 2018 Aug 28. J Intern Med. 2019. PMID: 30039620 Free article. Review.
Mechanistically, oxidative stress and compromised function of the nitric oxide synthase (NOS) system leading to endothelial dysfunction and reduction in nitric oxide (NO) bioavailability have been widely implicated and associated with development and p …
Mechanistically, oxidative stress and compromised function of the nitric oxide synthase (NOS) system leading to endothelial dy …
Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19.
Yamasaki H. Yamasaki H. Nitric Oxide. 2020 Oct 1;103:29-30. doi: 10.1016/j.niox.2020.07.005. Epub 2020 Jul 23. Nitric Oxide. 2020. PMID: 32712272 Free PMC article.
Most outcomes of COVID-19 are associated with dysfunction of the vascular system, particularly in the lung. Inhalation of nitric oxide (NO) gas is currently being investigated as a treatment for patients with moderate to severe COVID-19. ...Since NO is an unstable r …
Most outcomes of COVID-19 are associated with dysfunction of the vascular system, particularly in the lung. Inhalation of nitric o …
8,006 results