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18,738 results

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Page 1
Molecular mechanisms regulating NLRP3 inflammasome activation.
Jo EK, Kim JK, Shin DM, Sasakawa C. Jo EK, et al. Cell Mol Immunol. 2016 Mar;13(2):148-59. doi: 10.1038/cmi.2015.95. Epub 2015 Nov 9. Cell Mol Immunol. 2016. PMID: 26549800 Free PMC article. Review.
Thus, the NLRP3 inflammasome may be a promising target for anti-inflammatory therapies. In this review, we summarize the current understanding of the mechanisms by which the NLRP3 inflammasome is activated in the cytosol. We also describe the binding p …
Thus, the NLRP3 inflammasome may be a promising target for anti-inflammatory therapies. In this review, we summarize the curre …
The NLRP3 inflammasome: contributions to inflammation-related diseases.
Chen Y, Ye X, Escames G, Lei W, Zhang X, Li M, Jing T, Yao Y, Qiu Z, Wang Z, Acuña-Castroviejo D, Yang Y. Chen Y, et al. Cell Mol Biol Lett. 2023 Jun 27;28(1):51. doi: 10.1186/s11658-023-00462-9. Cell Mol Biol Lett. 2023. PMID: 37370025 Free PMC article. Review.
This review first explains the activation and regulatory mechanism of the NLRP3 inflammasome. Secondly, we focus on the role of the NLRP3 inflammasome in various inflammation-related diseases. Finally, we look forward to new methods for targeting the …
This review first explains the activation and regulatory mechanism of the NLRP3 inflammasome. Secondly, we focus on the role o …
Mechanism and Regulation of NLRP3 Inflammasome Activation.
He Y, Hara H, Núñez G. He Y, et al. Trends Biochem Sci. 2016 Dec;41(12):1012-1021. doi: 10.1016/j.tibs.2016.09.002. Epub 2016 Sep 23. Trends Biochem Sci. 2016. PMID: 27669650 Free PMC article. Review.
Unlike other inflammasomes, the NLRP3 inflammasome can be activated by diverse stimuli. The importance of the NLRP3 inflammasome in immunity and human diseases has been well documented, but the mechanism and regulation of its activation remain u …
Unlike other inflammasomes, the NLRP3 inflammasome can be activated by diverse stimuli. The importance of the NLRP3 …
NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation.
Yu T, Hou D, Zhao J, Lu X, Greentree WK, Zhao Q, Yang M, Conde DG, Linder ME, Lin H. Yu T, et al. Cell Rep. 2024 Apr 23;43(4):114070. doi: 10.1016/j.celrep.2024.114070. Epub 2024 Apr 6. Cell Rep. 2024. PMID: 38583156 Free PMC article.
Nucleotide oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome hyperactivation contributes to many human chronic inflammatory diseases, and understanding how NLRP3 inflammasome is regulated can provide strategies to treat inflamma …
Nucleotide oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome hyperactivation contributes to many human …
Regulation of the NLRP3 inflammasome by autophagy and mitophagy.
Gupta S, Cassel SL, Sutterwala FS, Dagvadorj J. Gupta S, et al. Immunol Rev. 2025 Jan;329(1):e13410. doi: 10.1111/imr.13410. Epub 2024 Oct 17. Immunol Rev. 2025. PMID: 39417249 Free PMC article. Review.
The NLRP3 inflammasome is a multiprotein complex that upon activation by the innate immune system drives a broad inflammatory response. ...Here, we discuss several of the proposed pathways of activation of the NLRP3 inflammasome. We examine the role of …
The NLRP3 inflammasome is a multiprotein complex that upon activation by the innate immune system drives a broad inflammatory …
The NLRP3-inflammasome as a sensor of organelle dysfunction.
Seoane PI, Lee B, Hoyle C, Yu S, Lopez-Castejon G, Lowe M, Brough D. Seoane PI, et al. J Cell Biol. 2020 Dec 7;219(12):e202006194. doi: 10.1083/jcb.202006194. J Cell Biol. 2020. PMID: 33044555 Free PMC article. Review.
Diverse pathogen- and damage-associated stresses drive inflammation via activation of the multimolecular NLRP3-inflammasome complex. How the effects of diverse stimuli are integrated by the cell to regulate NLRP3 has been the subject of intense research, and …
Diverse pathogen- and damage-associated stresses drive inflammation via activation of the multimolecular NLRP3-inflammasome co …
The NLRP3 inflammasome in allergic diseases: mechanisms and therapeutic implications.
Zhou H, Wang L, Lv W, Yu H. Zhou H, et al. Clin Exp Med. 2024 Sep 26;24(1):231. doi: 10.1007/s10238-024-01492-z. Clin Exp Med. 2024. PMID: 39325206 Free PMC article. Review.
Dysfunction of the NLRP3 inflammasome may serve as a key driver of inflammatory diseases, leading to pyroptosis and amplifying the local inflammatory response. As preliminarily demonstrated, specific NLRP3 inflammatory vesicle inhibitors play refectory roles …
Dysfunction of the NLRP3 inflammasome may serve as a key driver of inflammatory diseases, leading to pyroptosis and amplifying …
NLRP3 inflammasome and its role in autoimmune diseases: A promising therapeutic target.
Ren W, Sun Y, Zhao L, Shi X. Ren W, et al. Biomed Pharmacother. 2024 Jun;175:116679. doi: 10.1016/j.biopha.2024.116679. Epub 2024 May 3. Biomed Pharmacother. 2024. PMID: 38701567 Free article. Review.
This review also identifies studies where the involvement of the NLRP3 inflammasome in the disease mechanism within the same disease appears contradictory, as well as differences in NLRP3-related gene polymorphisms among different ethnic groups. Additionally, …
This review also identifies studies where the involvement of the NLRP3 inflammasome in the disease mechanism within the same d …
The NLRP3 Inflammasome and Its Role in the Pathogenicity of Leukemia.
Urwanisch L, Luciano M, Horejs-Hoeck J. Urwanisch L, et al. Int J Mol Sci. 2021 Jan 28;22(3):1271. doi: 10.3390/ijms22031271. Int J Mol Sci. 2021. PMID: 33525345 Free PMC article. Review.
Overactivation of the NLRP3 inflammasome can be a driver of various diseases. Since leukemia is known to be an inflammation-driven cancer and IL-1beta is produced in elevated levels by leukemic cells, research on NLRP3 in the context of leukemia has increased …
Overactivation of the NLRP3 inflammasome can be a driver of various diseases. Since leukemia is known to be an inflammation-dr …
Targeting the NLRP3 inflammasome for inflammatory disease therapy.
Cabral JE, Wu A, Zhou H, Pham MA, Lin S, McNulty R. Cabral JE, et al. Trends Pharmacol Sci. 2025 Jun;46(6):503-519. doi: 10.1016/j.tips.2025.04.007. Epub 2025 May 15. Trends Pharmacol Sci. 2025. PMID: 40374417 Free PMC article. Review.
The NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome is a megadalton complex implicated in numerous inflammation-driven diseases including COVID-19, Alzheimer's disease, and gout. ...In addition, oxidized DNA (oxDNA) has emerged as a key inflammas …
The NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome is a megadalton complex implicated in numerous inflammati …
18,738 results
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