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2,088 results

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Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns.
Nadeeshani H, Li J, Ying T, Zhang B, Lu J. Nadeeshani H, et al. J Adv Res. 2021 Aug 11;37:267-278. doi: 10.1016/j.jare.2021.08.003. eCollection 2022 Mar. J Adv Res. 2021. PMID: 35499054 Free PMC article. Review.
Among various anti-aging health products, nicotinamide mononucleotide (NMN) has been gaining attentions of the consumers and the scientific community. AIM OF REVIEW: This article intends to provide an overview on the current knowledge on promises and safety concerns of …
Among various anti-aging health products, nicotinamide mononucleotide (NMN) has been gaining attentions of the consumers and the scie …
The efficacy and safety of beta-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.
Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V. Yi L, et al. Geroscience. 2023 Feb;45(1):29-43. doi: 10.1007/s11357-022-00705-1. Epub 2022 Dec 8. Geroscience. 2023. PMID: 36482258 Free PMC article. Clinical Trial.
Blood NAD concentrations were highest in the groups taking 600 mg and 900 mg NMN. No safety issues, based on monitoring adverse events (AEs), laboratory and clinical measures, were found, and NMN supplementation was well tolerated. ...NMN supplementation incr …
Blood NAD concentrations were highest in the groups taking 600 mg and 900 mg NMN. No safety issues, based on monitoring adverse event …
NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health.
Alegre GFS, Pastore GM. Alegre GFS, et al. Curr Nutr Rep. 2023 Sep;12(3):445-464. doi: 10.1007/s13668-023-00475-y. Epub 2023 Jun 5. Curr Nutr Rep. 2023. PMID: 37273100 Free PMC article. Review.
RECENT FINDINGS: NMN and NR demonstrated protect against diabetes, Alzheimer disease, endothelial dysfunction, and inflammation. ...NMN and NR can be obtained through the diet either in their free form or as metabolites derivate from the digestion of NAD+. ...
RECENT FINDINGS: NMN and NR demonstrated protect against diabetes, Alzheimer disease, endothelial dysfunction, and inflammation. ... …
Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner.
Kane AE, Chellappa K, Schultz MB, Arnold M, Li J, Amorim J, Diener C, Zhu D, Mitchell SJ, Griffin P, Tian X, Petty C, Conway R, Walsh K, Shelerud L, Duesing C, Mueller A, Li K, McNamara M, Shima RT, Mitchell J, Bonkowski MS, de Cabo R, Gibbons SM, Wu LE, Ikeno Y, Baur JA, Rajman L, Sinclair DA. Kane AE, et al. bioRxiv [Preprint]. 2024 Jun 27:2024.06.21.599604. doi: 10.1101/2024.06.21.599604. bioRxiv. 2024. PMID: 38979132 Free PMC article. Preprint.
Whether or not the NAD (+) precursor nicotinamide mononucleotide (NMN) extends lifespan in mammals is not known. Here we investigate the effect of long-term administration of NMN on the health, cancer burden, frailty and lifespan of male and female mice. ...NMN …
Whether or not the NAD (+) precursor nicotinamide mononucleotide (NMN) extends lifespan in mammals is not known. Here we investigate …
Biological properties, synthetic pathways and anti-aging mechanisms of nicotinamide mononucleotide (NMN): Research progress and challenges.
Wang E, Wang Y, Zhang Z, Jiang Y, Zhao C. Wang E, et al. Biogerontology. 2025 Jun 23;26(4):124. doi: 10.1007/s10522-025-10270-7. Biogerontology. 2025. PMID: 40550930 Review.
The molecular mechanism of NMN in slowing down the aging process through multi-target synergistic effects is elucidated. However, critical issues such as age-stratified dosage modeling, long-term safety, and efficacy of NMN still require in-depth research. This revi …
The molecular mechanism of NMN in slowing down the aging process through multi-target synergistic effects is elucidated. However, cri …
NMN: The NAD precursor at the intersection between axon degeneration and anti-ageing therapies.
Loreto A, Antoniou C, Merlini E, Gilley J, Coleman MP. Loreto A, et al. Neurosci Res. 2023 Dec;197:18-24. doi: 10.1016/j.neures.2023.01.004. Epub 2023 Jan 16. Neurosci Res. 2023. PMID: 36657725 Free article. Review.
Extensive data demonstrate that the NAD precursor NMN binds to and activates the pro-degenerative enzyme SARM1, so a failure to convert sufficient NMN into NAD leads to toxic NMN accumulation and axon degeneration. This involvement of NMN brings the ax …
Extensive data demonstrate that the NAD precursor NMN binds to and activates the pro-degenerative enzyme SARM1, so a failure to conve …
The NMN Module Conducts Nodule Number Orchestra.
Wang Z, Wang L, Wang Y, Li X. Wang Z, et al. iScience. 2020 Feb 21;23(2):100825. doi: 10.1016/j.isci.2020.100825. Epub 2020 Jan 9. iScience. 2020. PMID: 31978752 Free PMC article. Review.
Nodule Inception (NIN) is essential for rhizobial infection and nodule organogenesis in legumes. The GmNINa-miR172c-NNC1 (NMN) module, which consists of two positive regulators, GmNINa and miR172c, and a suppressor, NNC1, integrates both pathways. ...Conversely, activation …
Nodule Inception (NIN) is essential for rhizobial infection and nodule organogenesis in legumes. The GmNINa-miR172c-NNC1 (NMN) module …
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.
Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J. Song Q, et al. Adv Nutr. 2023 Nov;14(6):1416-1435. doi: 10.1016/j.advnut.2023.08.008. Epub 2023 Aug 22. Adv Nutr. 2023. PMID: 37619764 Free PMC article. Review.
The promotion of NMN as an antiaging health supplement has gained popularity due to such findings; however, since most studies evaluating the effects of NMN have been conducted in cell or animal models, a concern remains regarding the safety and physiological effect …
The promotion of NMN as an antiaging health supplement has gained popularity due to such findings; however, since most studies evalua …
Advancements in NMN biotherapy and research updates in the field of digestive system diseases.
Liao G, Xie Y, Peng H, Li T, Zou X, Yue F, Guo J, Rong L. Liao G, et al. J Transl Med. 2024 Aug 30;22(1):805. doi: 10.1186/s12967-024-05614-9. J Transl Med. 2024. PMID: 39215316 Free PMC article. Review.
Given the sustained global research interest in NMN and the substantial market expectations for the future, here, we comprehensively review the milestones in research on NMN biotherapy over the past 10 years. Additionally, we highlight the current research on NMN …
Given the sustained global research interest in NMN and the substantial market expectations for the future, here, we comprehensively …
[Research progress on anti-aging effects of beta-nicotinamide mononucleotide (NMN)].
Han M, Hua JL. Han M, et al. Sheng Li Xue Bao. 2024 Dec 25;76(6):1032-1042. Sheng Li Xue Bao. 2024. PMID: 39780578 Free article. Review. Chinese.
beta-Nicotinamide mononucleotide (NMN), as the precursor of nicotinamide adenine dinucleotide (NAD), plays an important role in enhancing NAD levels. ...NMN demonstrates both efficacy and safety in anti-aging. The use of NMN in China has gradually gained acce …
beta-Nicotinamide mononucleotide (NMN), as the precursor of nicotinamide adenine dinucleotide (NAD), plays an important role in enhan …
2,088 results