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Nociplastic pain: towards an understanding of prevalent pain conditions.
Fitzcharles MA, Cohen SP, Clauw DJ, Littlejohn G, Usui C, Häuser W. Fitzcharles MA, et al. Lancet. 2021 May 29;397(10289):2098-2110. doi: 10.1016/S0140-6736(21)00392-5. Lancet. 2021. PMID: 34062144 Review.
Nociplastic pain is the semantic term suggested by the international community of pain researchers to describe a third category of pain that is mechanistically distinct from nociceptive pain, which is caused by ongoing inflammation and damage of
Nociplastic pain is the semantic term suggested by the international community of pain researchers to describe a third
Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms.
Kaplan CM, Kelleher E, Irani A, Schrepf A, Clauw DJ, Harte SE. Kaplan CM, et al. Nat Rev Neurol. 2024 Jun;20(6):347-363. doi: 10.1038/s41582-024-00966-8. Epub 2024 May 16. Nat Rev Neurol. 2024. PMID: 38755449 Review.
Nociplastic pain is a mechanistic term used to describe pain that arises or is sustained by altered nociception, despite the absence of tissue damage. Although nociplastic pain has distinct pathophysiology from nociceptive and neuropathic pai
Nociplastic pain is a mechanistic term used to describe pain that arises or is sustained by altered nociception, despit
The concept of nociplastic pain-where to from here?
Kosek E. Kosek E. Pain. 2024 Nov 1;165(11S):S50-S57. doi: 10.1097/j.pain.0000000000003305. Pain. 2024. PMID: 39560415 Review.
Nociplastic pain, a third mechanistic pain descriptor in addition to nociceptive and neuropathic pain, was adopted in 2017 by the International Association for the Study of Pain (IASP). ...Peripheral and/or central sensitization, manifesting as
Nociplastic pain, a third mechanistic pain descriptor in addition to nociceptive and neuropathic pain, was adopt
Microglia polarization in nociplastic pain: mechanisms and perspectives.
Atta AA, Ibrahim WW, Mohamed AF, Abdelkader NF. Atta AA, et al. Inflammopharmacology. 2023 Jun;31(3):1053-1067. doi: 10.1007/s10787-023-01216-x. Epub 2023 Apr 17. Inflammopharmacology. 2023. PMID: 37069462 Free PMC article. Review.
The main pathophysiological mechanism for developing nociplastic pain is central sensitization (CS) in which pain amplification and hypersensitivity occur. ...Illustrating the mechanisms underlying microglia activation in central sensitization a …
The main pathophysiological mechanism for developing nociplastic pain is central sensitization (CS) in which pain
Nociceptive, neuropathic, or nociplastic low back pain? The low back pain phenotyping (BACPAP) consortium's international and multidisciplinary consensus recommendations.
Nijs J, Kosek E, Chiarotto A, Cook C, Danneels LA, Fernández-de-Las-Peñas C, Hodges PW, Koes B, Louw A, Ostelo R, Scholten-Peeters GGM, Sterling M, Alkassabi O, Alsobayel H, Beales D, Bilika P, Clark JR, De Baets L, Demoulin C, de Zoete RMJ, Elma Ö, Gutke A, Hanafi R, Hotz Boendermaker S, Huysmans E, Kapreli E, Lundberg M, Malfliet A, Meziat Filho N, Reis FJJ, Voogt L, Zimney K, Smeets R, Morlion B, de Vlam K, George SZ. Nijs J, et al. Lancet Rheumatol. 2024 Mar;6(3):e178-e188. doi: 10.1016/S2665-9913(23)00324-7. Epub 2024 Feb 1. Lancet Rheumatol. 2024. PMID: 38310923 Free article. Review.
The potential to classify low back pain as being characterised by dominant nociceptive, neuropathic, or nociplastic mechanisms is a clinically relevant issue. ...The BACPAP consortium's recommendations are also intended to provide direction for future clinica …
The potential to classify low back pain as being characterised by dominant nociceptive, neuropathic, or nociplastic mechani
Current understanding of nociplastic pain.
Yoo YM, Kim KH. Yoo YM, et al. Korean J Pain. 2024 Apr 1;37(2):107-118. doi: 10.3344/kjp.23326. Epub 2024 Mar 20. Korean J Pain. 2024. PMID: 38504389 Free PMC article.
Nociplastic pain by the "International Association for the Study of Pain" is defined as pain that arises from altered nociception despite no clear evidence of nociceptive or neuropathic pain. Augmented central nervous system pain and sens
Nociplastic pain by the "International Association for the Study of Pain" is defined as pain that arises from al
Chronic pain: an update on burden, best practices, and new advances.
Cohen SP, Vase L, Hooten WM. Cohen SP, et al. Lancet. 2021 May 29;397(10289):2082-2097. doi: 10.1016/S0140-6736(21)00393-7. Lancet. 2021. PMID: 34062143 Review.
Unlike acute pain, which carries survival value, chronic pain might be best considered to be a disease, with treatment (eg, to be active despite the pain) and psychological (eg, pain acceptance and optimism as goals) implications. Pain can be ca …
Unlike acute pain, which carries survival value, chronic pain might be best considered to be a disease, with treatment (eg, to …
Nociplastic Pain: Facts, Controversies and Future Tasks.
Häuser W, Kosek E. Häuser W, et al. Eur J Pain. 2026 Jan;30(1):e70175. doi: 10.1002/ejp.70175. Eur J Pain. 2026. PMID: 41294344 Review.
BACKGROUND: Nociplastic pain, a third mechanistic pain descriptor in addition to nociceptive and neuropathic pain is defined as 'pain that arises from altered nociception' not fully explained by nociceptive or neuropathic pain mechanis
BACKGROUND: Nociplastic pain, a third mechanistic pain descriptor in addition to nociceptive and neuropathic pain
The pathophysiology, assessment, and management of acute pain.
Mears L, Mears J. Mears L, et al. Br J Nurs. 2023 Jan 26;32(2):58-65. doi: 10.12968/bjon.2023.32.2.58. Br J Nurs. 2023. PMID: 36715521 Review.
This article reviews the pathophysiology and treatment of acute pain. Two definitions of pain are considered, along with the International Association for the Study of Pain taxonomy for nociceptive, neuropathic and nociplastic pain. The mecha
This article reviews the pathophysiology and treatment of acute pain. Two definitions of pain are considered, along with the I …
Shoulder pain phenotyping: A guide for clinicians to determine predominant nociceptive, neuropathic, or nociplastic shoulder pain.
De Baets L, Kuppens K, Labie C, Haik MN, Kapreli E, Bilika P, Struyf F, Borms D, Fernández-de-Las-Peñas C, Kosek E, Lluch E, Testa M, Lewis J, Goossens Z, Schilz M, Bonneux I, Nijs J. De Baets L, et al. Braz J Phys Ther. 2025 Nov-Dec;29(6):101240. doi: 10.1016/j.bjpt.2025.101240. Epub 2025 Aug 26. Braz J Phys Ther. 2025. PMID: 40865430 Free PMC article.
One possibility is the manner underlying mechanisms related to persistent shoulder pain are managed. Being able to determine the predominant pain phenotype in people with persistent shoulder pain (i.e., nociceptive, neuropathic, or nociplastic
One possibility is the manner underlying mechanisms related to persistent shoulder pain are managed. Being able to determine t …
283 results