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Year Number of Results
1985 1
1993 1
1995 1
1996 2
1997 3
1998 3
2000 3
2001 2
2002 7
2003 3
2004 4
2005 3
2006 7
2007 5
2008 6
2009 12
2010 5
2011 6
2012 2
2013 8
2014 6
2015 10
2016 14
2017 7
2018 9
2019 4
2020 11
2021 4
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140 results
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[Mesenchymal stem cells and regenerative medicine: future perspectives in osteoarthritis].
Maumus M, Pers YM, Ruiz M, Jorgensen C, Noël D. Maumus M, et al. Among authors: noel d. Med Sci (Paris). 2018 Dec;34(12):1092-1099. doi: 10.1051/medsci/2018294. Epub 2019 Jan 9. Med Sci (Paris). 2018. PMID: 30623767 Free article. Review. French.
A therapy based on MSCs can be justified in osteoarthritis (OA) thanks to their differentiation abilities but mostly, to their paracrine and immunosuppressive properties. ...Depending on the mode of administration and behavior after implantation, they can decrease local in …
A therapy based on MSCs can be justified in osteoarthritis (OA) thanks to their differentiation abilities but mostly, to their paracr …
Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development.
Malaise O, Tachikart Y, Constantinides M, Mumme M, Ferreira-Lopez R, Noack S, Krettek C, Noël D, Wang J, Jorgensen C, Brondello JM. Malaise O, et al. Among authors: noel d. Aging (Albany NY). 2019 Oct 22;11(20):9128-9146. doi: 10.18632/aging.102379. Epub 2019 Oct 22. Aging (Albany NY). 2019. PMID: 31644429 Free PMC article.
Tissue accumulation of p16(INK4a)-positive senescent cells is associated with age-related disorders, such as osteoarthritis (OA). These cell-cycle arrested cells affect tissue function through a specific secretory phenotype. ...Upon senescence induction, their intrinsic st …
Tissue accumulation of p16(INK4a)-positive senescent cells is associated with age-related disorders, such as osteoarthritis (OA). The …
Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis.
Cosenza S, Ruiz M, Toupet K, Jorgensen C, Noël D. Cosenza S, et al. Among authors: noel d. Sci Rep. 2017 Nov 24;7(1):16214. doi: 10.1038/s41598-017-15376-8. Sci Rep. 2017. PMID: 29176667 Free PMC article.
Mesenchymal stem or stromal cells (MSCs) exert chondroprotective effects in preclinical models of osteoarthritis (OA). ...MPs and Exos were isolated from bone marrow murine BM-MSCs through differential centrifugation. Effect of MPs or Exos was evaluated on OA-like m
Mesenchymal stem or stromal cells (MSCs) exert chondroprotective effects in preclinical models of osteoarthritis (OA). ...MPs
Mesenchymal Stem Cells in Systemic Sclerosis: Allogenic or Autologous Approaches for Therapeutic Use?
Rozier P, Maria A, Goulabchand R, Jorgensen C, Guilpain P, Noël D. Rozier P, et al. Among authors: noel d. Front Immunol. 2018 Dec 14;9:2938. doi: 10.3389/fimmu.2018.02938. eCollection 2018. Front Immunol. 2018. PMID: 30619298 Free PMC article. Review.
This is an intractable disease with an urgent need to provide better therapeutic options to patients. Mesenchymal stem cells (MSCs) represent a promising therapeutic approach thanks to the number of trophic and pleiotropic properties they exert. ...
This is an intractable disease with an urgent need to provide better therapeutic options to patients. Mesenchymal stem cells (MSCs) r …
Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles.
Cosenza S, Ruiz M, Maumus M, Jorgensen C, Noël D. Cosenza S, et al. Among authors: noel d. Int J Mol Sci. 2017 Apr 22;18(4):889. doi: 10.3390/ijms18040889. Int J Mol Sci. 2017. PMID: 28441721 Free PMC article. Review.
They are involved in many biological processes that regulate tissue homeostasis and physiopathology of diseases. In rheumatic diseases, namely osteoarthritis (OA) and rheumatoid arthritis (RA), EVs have been isolated from synovial fluid and shown to play pathogenic …
They are involved in many biological processes that regulate tissue homeostasis and physiopathology of diseases. In rheumatic diseases, name …
Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial.
Pers YM, Rackwitz L, Ferreira R, Pullig O, Delfour C, Barry F, Sensebe L, Casteilla L, Fleury S, Bourin P, Noël D, Canovas F, Cyteval C, Lisignoli G, Schrauth J, Haddad D, Domergue S, Noeth U, Jorgensen C; ADIPOA Consortium. Pers YM, et al. Among authors: noel d. Stem Cells Transl Med. 2016 Jul;5(7):847-56. doi: 10.5966/sctm.2015-0245. Epub 2016 May 23. Stem Cells Transl Med. 2016. PMID: 27217345 Free PMC article. Clinical Trial.
: Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. ...Larger and controlled long-term studies are now mandatory to confirm whether this new strategy of cell therapy can improve pain and induce structural benefit in osteoarthritis....
: Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. ...Larger and controlled long-term studies are now m …
Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis.
Maumus M, Manferdini C, Toupet K, Peyrafitte JA, Ferreira R, Facchini A, Gabusi E, Bourin P, Jorgensen C, Lisignoli G, Noël D. Maumus M, et al. Among authors: noel d. Stem Cell Res. 2013 Sep;11(2):834-44. doi: 10.1016/j.scr.2013.05.008. Epub 2013 Jun 4. Stem Cell Res. 2013. PMID: 23811540 Free article.
We used primary chondrocytes, ASCs from different sources and bone marrow mesenchymal stromal cells (MSC) from OA donors. ASCs or MSCs were co-cultured with chondrocytes in a minimal medium and using cell culture inserts. Under these conditions, ASCs did not …
We used primary chondrocytes, ASCs from different sources and bone marrow mesenchymal stromal cells (MSC) from OA donors. ASCs …
p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis.
Philipot D, Guérit D, Platano D, Chuchana P, Olivotto E, Espinoza F, Dorandeu A, Pers YM, Piette J, Borzi RM, Jorgensen C, Noel D, Brondello JM. Philipot D, et al. Among authors: noel d. Arthritis Res Ther. 2014 Feb 27;16(1):R58. doi: 10.1186/ar4494. Arthritis Res Ther. 2014. PMID: 24572376 Free PMC article.
Here, we evaluated the role of p16INK4a in the OA-induced SASP and its regulation by microRNAs (miRs). METHODS: We used IL-1-beta-treated primary OA chondrocytes cultured in three-dimensional setting or mesenchymal stem cells differentiated into chondrocyte t …
Here, we evaluated the role of p16INK4a in the OA-induced SASP and its regulation by microRNAs (miRs). METHODS: We used IL-1-beta-treated pr …
Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis.
Cosenza S, Toupet K, Maumus M, Luz-Crawford P, Blanc-Brude O, Jorgensen C, Noël D. Cosenza S, et al. Among authors: noel d. Theranostics. 2018 Feb 3;8(5):1399-1410. doi: 10.7150/thno.21072. eCollection 2018. Theranostics. 2018. PMID: 29507629 Free PMC article.
Although MSCs can prevent arthritis, the role of MSCs-derived EVs has never been reported in rheumatoid arthritis. ...Our work is the first demonstration of the therapeutic potential of MSCs-derived EVs in inflammatory arthritis....
Although MSCs can prevent arthritis, the role of MSCs-derived EVs has never been reported in rheumatoid arthritis. ...Our work …
Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging.
Boulestreau J, Maumus M, Rozier P, Jorgensen C, Noël D. Boulestreau J, et al. Among authors: noel d. Front Cell Dev Biol. 2020 Feb 21;8:107. doi: 10.3389/fcell.2020.00107. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32154253 Free PMC article. Review.
Emerging evidence suggests that the changes in the number and composition of extracellular vesicles (EVs) released by senescent cells contribute to the adverse effects of senescence in aging. In addition, age-related alterations in mesenchymal stem/stromal cells (MSCs) hav …
Emerging evidence suggests that the changes in the number and composition of extracellular vesicles (EVs) released by senescent cells contri …
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