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Cognitive Enhancer Noopept Activates Transcription Factor HIF-1.
Zainullina LF, Ivanova TV, Sadovnikov SV, Vakhitova YV, Seredenin SB. Zainullina LF, et al. Dokl Biochem Biophys. 2020 Sep;494(1):256-260. doi: 10.1134/S1607672920050129. Epub 2020 Oct 20. Dokl Biochem Biophys. 2020. PMID: 33119829
The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cells and the mechanisms of stabilization of this transcription factor were studied in vitro. Noopept was shown to increase both the bas …
The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cel …
Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.
Ostrovskaya RU, Vakhitova YV, Kuzmina USh, Salimgareeva MKh, Zainullina LF, Gudasheva TA, Vakhitov VA, Seredenin SB. Ostrovskaya RU, et al. J Biomed Sci. 2014 Aug 6;21(1):74. doi: 10.1186/s12929-014-0074-2. J Biomed Sci. 2014. PMID: 25096780 Free PMC article.
BACKGROUND: Noopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cognition enhancer, piracetam. Our previous experiments have demonstrated the cognition restoring effect of noopept in …
BACKGROUND: Noopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cog
The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model.
Ostrovskaya RU, Gruden MA, Bobkova NA, Sewell RD, Gudasheva TA, Samokhin AN, Seredinin SB, Noppe W, Sherstnev VV, Morozova-Roche LA. Ostrovskaya RU, et al. J Psychopharmacol. 2007 Aug;21(6):611-9. doi: 10.1177/0269881106071335. Epub 2006 Nov 8. J Psychopharmacol. 2007. PMID: 17092975
The effects of the novel proline-containing nootropic and neuroprotective dipeptide, noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) were investigated in NMRI mice following olfactory bulbectomy. ...These actions of noopept, combined with …
The effects of the novel proline-containing nootropic and neuroprotective dipeptide, noopept (GVS-111, N-phenylacetyl-L-prolyl …
[Comparative study of the long-term behavioral effects of noopept and piracetam in adult male rats and female rats in postnatal period].
Voronina TA, Guzevatykh LS, Trofimov SS. Voronina TA, et al. Eksp Klin Farmakol. 2005 Mar-Apr;68(2):3-7. Eksp Klin Farmakol. 2005. PMID: 15934357 Russian.
Adult male and female rats were treated with the peptide nootrope drug noopept (daily dose, 0.1 mg/kg) and piracetam (200 mg/kg). In the period from 8th to 20th day, both drugs (cognitive enhancers) suppressed the horizontal and vertical activity and the anxi …
Adult male and female rats were treated with the peptide nootrope drug noopept (daily dose, 0.1 mg/kg) and piracetam (200 mg/kg). In …
The scoop on brain health dietary supplement products containing huperzine A.
Crawford C, Wang YH, Avula B, Bae JY, Khan IA, Deuster PA. Crawford C, et al. Clin Toxicol (Phila). 2020 Oct;58(10):991-996. doi: 10.1080/15563650.2020.1713337. Epub 2020 Jan 28. Clin Toxicol (Phila). 2020. PMID: 31990212
We found these products were listed in Natural Medicines and Dietary Supplement Databases and being queried by Military Service Members for enhanced mental focus, alertness and energy. Analyses were conducted by using Liquid Chromatography-Quadrupole Time of Flight Mass Sp …
We found these products were listed in Natural Medicines and Dietary Supplement Databases and being queried by Military Service Members for …
[The original nootropic and neuroprotective drug noopept potentiates the anticonvulsant activity of valproate in mice].
Kravchenko EV, Ponteleeva IV, Trofimov SS, Lapa VI, Ostrovskaia RU, Voronina TA. Kravchenko EV, et al. Eksp Klin Farmakol. 2009 Nov-Dec;72(6):15-7. Eksp Klin Farmakol. 2009. PMID: 20095393 Russian.
Neither a single administration of noopept (0.5 mg/kg, i.p.) nor its repeated introduction in 10 or 35 days enhanced the convulsant effect of corazole, which is evidence that noopept alone does not possess anticonvulsant properties. ...In addition, the admini …
Neither a single administration of noopept (0.5 mg/kg, i.p.) nor its repeated introduction in 10 or 35 days enhanced the convu …
[Effect of the novel nootropic and neuroprotective dipeptide noopept on the streptozotocin-induced model of sporadic Alzheimer disease in rats].
Ostrovskaia RU, Tsaplina AP, Vakhitova IuV, Salimgareeva MKh, Iamidanov RS. Ostrovskaia RU, et al. Eksp Klin Farmakol. 2010 Jan;73(1):2-6. Eksp Klin Farmakol. 2010. PMID: 20184279 Russian.
Diabetogenic toxin streptozotocin (STZ) administered in both cerebral ventricles in a dose of 3 mg/kg decreases the expression of NGF and BDNF mainly in the hippocampus and increases the content of malonic dialdehyde (MDA)--a product of lipid peroxidation--in the brain tissues. T …
Diabetogenic toxin streptozotocin (STZ) administered in both cerebral ventricles in a dose of 3 mg/kg decreases the expression of NGF and BD …
[Effects of nootropic drugs on behavior of BALB/c and C57BL/6 mice in the exploratory cross-maze test].
Vasil'eva EV, Salimov RM, Kovalev GI. Vasil'eva EV, et al. Eksp Klin Farmakol. 2012;75(7):3-7. Eksp Klin Farmakol. 2012. PMID: 23025044 Russian.
Exploratory behavior, locomotor activity, and anxiety in inbred mice of C57BL/6 and BALB/c strains subchronically treated with placebo or various types of nootropic (cognition enhancing) drugs (piracetam, phenotropil, noopept, semax, pantogam, nooglutil) have …
Exploratory behavior, locomotor activity, and anxiety in inbred mice of C57BL/6 and BALB/c strains subchronically treated with placebo or va …
GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons.
Pelsman A, Hoyo-Vadillo C, Gudasheva TA, Seredenin SB, Ostrovskaya RU, Busciglio J. Pelsman A, et al. Int J Dev Neurosci. 2003 May;21(3):117-24. doi: 10.1016/s0736-5748(03)00031-5. Int J Dev Neurosci. 2003. PMID: 12711349
The neuroprotective activity of a novel N-acylprolyl-containing dipeptide analog of the nootropic 2-oxo-1-pyrrolidine acetamide (Piracetam) designated as GVS-111 (DVD-111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: norm …
The neuroprotective activity of a novel N-acylprolyl-containing dipeptide analog of the nootropic 2-oxo-1-pyrrolidine acetamide (Piracetam) …
The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine.
Gudasheva TA, Boyko SS, Ostrovskaya RU, Voronina TA, Akparov VK, Trofimov SS, Rozantsev GG, Skoldinov AP, Zherdev VP, Seredenin SB. Gudasheva TA, et al. Eur J Drug Metab Pharmacokinet. 1997 Jul-Sep;22(3):245-52. doi: 10.1007/BF03189814. Eur J Drug Metab Pharmacokinet. 1997. PMID: 9358206
The metabolism of a new piracetam analogue, the dipeptide cognitive enhancer N-phenylacetyl-L-prolylglycine ethyl ester (GVS-111) was studied in vivo. ...
The metabolism of a new piracetam analogue, the dipeptide cognitive enhancer N-phenylacetyl-L-prolylglycine ethyl
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