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1970 1
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2015 2
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2019 6
2020 2
2021 3
2022 2
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The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment.
Ashok AH, Marques TR, Jauhar S, Nour MM, Goodwin GM, Young AH, Howes OD. Ashok AH, et al. Among authors: nour mm. Mol Psychiatry. 2017 May;22(5):666-679. doi: 10.1038/mp.2017.16. Epub 2017 Mar 14. Mol Psychiatry. 2017. PMID: 28289283 Free PMC article. Review.
In bipolar depression imaging studies show increased dopamine transporter levels, but changes in other aspects of dopaminergic function are inconsistent. ...Thus, it can be speculated that a failure of dopamine receptor and transporter homoeostasis might underlie th …
In bipolar depression imaging studies show increased dopamine transporter levels, but changes in other aspects of dopaminergic functi …
Impaired neural replay of inferred relationships in schizophrenia.
Nour MM, Liu Y, Arumuham A, Kurth-Nelson Z, Dolan RJ. Nour MM, et al. Cell. 2021 Aug 5;184(16):4315-4328.e17. doi: 10.1016/j.cell.2021.06.012. Epub 2021 Jun 30. Cell. 2021. PMID: 34197734 Free PMC article.
In rodents, such representations are supported by sequential place cell reactivations during rest, known as replay. Schizophrenia is proposed to reflect a compromise in structured mental representations, with animal models reporting abnormalities in hippocampal replay and …
In rodents, such representations are supported by sequential place cell reactivations during rest, known as replay. Schizophrenia is …
Schizophrenia, Subjectivity, and Mindreading.
Nour MM, Barrera A. Nour MM, et al. Schizophr Bull. 2015 Nov;41(6):1214-9. doi: 10.1093/schbul/sbv035. Epub 2015 Apr 5. Schizophr Bull. 2015. PMID: 25848120 Free PMC article. Review.
A number of recent articles, many appearing in Schizophrenia Bulletin, signal a renewed interest in phenomenological approaches to our understanding of schizophrenia. ...Our hypothesis, while speculative, is an attempt to marry the phenomenological and neuronal real …
A number of recent articles, many appearing in Schizophrenia Bulletin, signal a renewed interest in phenomenological approaches to ou …
Schizophrenia on YouTube.
Nour MM, Nour MH, Tsatalou OM, Barrera A. Nour MM, et al. Among authors: nour mh. Psychiatr Serv. 2017 Jan 1;68(1):70-74. doi: 10.1176/appi.ps.201500541. Epub 2016 Aug 15. Psychiatr Serv. 2017. PMID: 27524369
OBJECTIVE: YouTube ( www.youtube.com ) is the most popular video-sharing Web site on the Internet and is used by medical students as a source of information regarding mental health conditions, including schizophrenia. The accuracy and educational utility of schizophreni …
OBJECTIVE: YouTube ( www.youtube.com ) is the most popular video-sharing Web site on the Internet and is used by medical students as a sourc …
Clozapine Response in Schizophrenia and Hematological Changes.
Blackman G, Lisshammar JEL, Zafar R, Pollak TA, Pritchard M, Cullen AE, Rogers J, Carter B, Griffiths K, Nour M, David AS, McGuire P, Stewart R, MacCabe J. Blackman G, et al. Among authors: nour m. J Clin Psychopharmacol. 2021 Jan/Feb 01;41(1):19-24. doi: 10.1097/JCP.0000000000001329. J Clin Psychopharmacol. 2021. PMID: 33347018 Free PMC article.
BACKGROUND: Clozapine is the only effective medication for treatment-resistant schizophrenia; however, its mechanism of action remains unclear. The present study explored whether its effectiveness is related to changes in hematological measures after clozapine initiation. …
BACKGROUND: Clozapine is the only effective medication for treatment-resistant schizophrenia; however, its mechanism of action remain …
A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia.
Jauhar S, Nour MM, Veronese M, Rogdaki M, Bonoldi I, Azis M, Turkheimer F, McGuire P, Young AH, Howes OD. Jauhar S, et al. Among authors: nour mm. JAMA Psychiatry. 2017 Dec 1;74(12):1206-1213. doi: 10.1001/jamapsychiatry.2017.2943. JAMA Psychiatry. 2017. PMID: 29049482 Free PMC article.
IMPORTANCE: The dopamine hypothesis suggests that dopamine abnormalities underlie psychosis, irrespective of diagnosis, implicating dopamine dysregulation in bipolar affective disorder and schizophrenia, in line with the research domain criteria approa …
IMPORTANCE: The dopamine hypothesis suggests that dopamine abnormalities underlie psychosis, irrespective of diagnosis, implic …
The relationship between childhood trauma, dopamine release and dexamphetamine-induced positive psychotic symptoms: a [11C]-(+)-PHNO PET study.
Dahoun T, Nour MM, McCutcheon RA, Adams RA, Bloomfield MAP, Howes OD. Dahoun T, et al. Among authors: nour mm. Transl Psychiatry. 2019 Nov 11;9(1):287. doi: 10.1038/s41398-019-0627-y. Transl Psychiatry. 2019. PMID: 31712556 Free PMC article.
Childhood trauma is a risk factor for psychosis. Amphetamine increases synaptic striatal dopamine levels and can induce positive psychotic symptoms in healthy individuals and patients with schizophrenia. ...We used [(11)C]-(+)-PHNO positron emission tomography to me …
Childhood trauma is a risk factor for psychosis. Amphetamine increases synaptic striatal dopamine levels and can induce positive psyc …
The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study.
McCutcheon RA, Jauhar S, Pepper F, Nour MM, Rogdaki M, Veronese M, Turkheimer FE, Egerton A, McGuire P, Mehta MM, Howes OD. McCutcheon RA, et al. Among authors: nour mm. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Nov;5(11):1040-1051. doi: 10.1016/j.bpsc.2020.04.004. Epub 2020 Apr 23. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020. PMID: 32653578 Free PMC article.
One hypothesis is that the consequences of aberrant dopamine signaling vary depending on where within the striatum the dysfunction occurs. Positron emission tomography allows for the quantification of dopamine function across the striatum. In the current study, we u …
One hypothesis is that the consequences of aberrant dopamine signaling vary depending on where within the striatum the dysfunction oc …
The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy imaging study.
Jauhar S, McCutcheon R, Borgan F, Veronese M, Nour M, Pepper F, Rogdaki M, Stone J, Egerton A, Turkheimer F, McGuire P, Howes OD. Jauhar S, et al. Among authors: nour m. Lancet Psychiatry. 2018 Oct;5(10):816-823. doi: 10.1016/S2215-0366(18)30268-2. Epub 2018 Sep 17. Lancet Psychiatry. 2018. PMID: 30236864 Free PMC article.
Disruption in cortical glutamatergic signalling causing aberrant striatal dopamine synthesis capacity is a proposed model for psychosis, but has not been tested in vivo. ...INTERPRETATION: These observations are consistent with the hypothesis that cortical glutamate dysfun …
Disruption in cortical glutamatergic signalling causing aberrant striatal dopamine synthesis capacity is a proposed model for psychos …
27 results