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Page 1
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment.
Ashok AH, Marques TR, Jauhar S, Nour MM, Goodwin GM, Young AH, Howes OD. Ashok AH, et al. Among authors: nour mm. Mol Psychiatry. 2017 May;22(5):666-679. doi: 10.1038/mp.2017.16. Epub 2017 Mar 14. Mol Psychiatry. 2017. PMID: 28289283 Free PMC article. Review.
In bipolar depression imaging studies show increased dopamine transporter levels, but changes in other aspects of dopaminergic function are inconsistent. ...Thus, it can be speculated that a failure of dopamine receptor and transporter homoeostasis might underlie th …
In bipolar depression imaging studies show increased dopamine transporter levels, but changes in other aspects of dopaminergic functi …
Cognitive maps and schizophrenia.
Nour MM, Liu Y, El-Gaby M, McCutcheon RA, Dolan RJ. Nour MM, et al. Trends Cogn Sci. 2025 Feb;29(2):184-200. doi: 10.1016/j.tics.2024.09.011. Epub 2024 Nov 19. Trends Cogn Sci. 2025. PMID: 39567329 Free article. Review.
The cognitive mapping hypothesis of schizophrenia extends this enquiry to psychiatry, proposing that diverse symptoms - from delusions to conceptual disorganization - stem from abnormalities in how the brain forms structured representations. ...
The cognitive mapping hypothesis of schizophrenia extends this enquiry to psychiatry, proposing that diverse symptoms - from delusion …
Schizophrenia on YouTube.
Nour MM, Nour MH, Tsatalou OM, Barrera A. Nour MM, et al. Among authors: nour mh. Psychiatr Serv. 2017 Jan 1;68(1):70-74. doi: 10.1176/appi.ps.201500541. Epub 2016 Aug 15. Psychiatr Serv. 2017. PMID: 27524369
OBJECTIVE: YouTube ( www.youtube.com ) is the most popular video-sharing Web site on the Internet and is used by medical students as a source of information regarding mental health conditions, including schizophrenia. The accuracy and educational utility of schizophreni …
OBJECTIVE: YouTube ( www.youtube.com ) is the most popular video-sharing Web site on the Internet and is used by medical students as a sourc …
Schizophrenia, Subjectivity, and Mindreading.
Nour MM, Barrera A. Nour MM, et al. Schizophr Bull. 2015 Nov;41(6):1214-9. doi: 10.1093/schbul/sbv035. Epub 2015 Apr 5. Schizophr Bull. 2015. PMID: 25848120 Free PMC article. Review.
A number of recent articles, many appearing in Schizophrenia Bulletin, signal a renewed interest in phenomenological approaches to our understanding of schizophrenia. ...Our hypothesis, while speculative, is an attempt to marry the phenomenological and neuronal real …
A number of recent articles, many appearing in Schizophrenia Bulletin, signal a renewed interest in phenomenological approaches to ou …
Dopamine and Mood in Psychotic Disorders: An 18F-DOPA PET Study.
Jauhar S, McCutcheon RA, Nour MM, Veronese M, Rogdaki M, Bonoldi I, Azis M, Whitehurst T, Arumuham A, Onwordi E, Turkheimer F, McGuire P, Young AH, Howes OD. Jauhar S, et al. Among authors: nour mm. JAMA Psychiatry. 2025 Aug 13;82(10):1009. doi: 10.1001/jamapsychiatry.2025.1811. Online ahead of print. JAMA Psychiatry. 2025. PMID: 40802251 Free PMC article.
IMPORTANCE: There is limited neurobiological or trial evidence guiding treatment of comorbid affective syndromes in psychotic disorders. Given the use of dopamine-blocking antipsychotics, understanding dopamine function across these mood states is warranted. ...CONC …
IMPORTANCE: There is limited neurobiological or trial evidence guiding treatment of comorbid affective syndromes in psychotic disorders. Giv …
Psychosis as a disorder of muscarinic signalling: psychopathology and pharmacology.
McCutcheon RA, Weber LAE, Nour MM, Cragg SJ, McGuire PM. McCutcheon RA, et al. Among authors: nour mm. Lancet Psychiatry. 2024 Jul;11(7):554-565. doi: 10.1016/S2215-0366(24)00100-7. Epub 2024 May 22. Lancet Psychiatry. 2024. PMID: 38795721 Review.
Dopaminergic receptor antagonism is a crucial component of all licensed treatments for psychosis, and dopamine dysfunction has been central to pathophysiological models of psychotic symptoms. ...
Dopaminergic receptor antagonism is a crucial component of all licensed treatments for psychosis, and dopamine dysfunction has been c …
Glutamatergic Modulation of Brain Function in Psychosis: A Systematic Review of Neuroimaging Studies.
Varvari I, Bolte L, Colli C, Mancini V, Nour MM, McGuire P, McCutcheon RA. Varvari I, et al. Among authors: nour mm. Biol Psychiatry Cogn Neurosci Neuroimaging. 2025 Dec;10(12):1221-1238. doi: 10.1016/j.bpsc.2025.07.004. Epub 2025 Jul 21. Biol Psychiatry Cogn Neurosci Neuroimaging. 2025. PMID: 40701342 Free PMC article.
Aberrant dopamine and glutamate signaling are implicated in the pathophysiology of schizophrenia. Existing treatments primarily target dopamine pathways underlying positive symptoms but have relatively little effect on cognitive and negative symptoms. ...
Aberrant dopamine and glutamate signaling are implicated in the pathophysiology of schizophrenia. Existing treatments primaril …
Diagnostic algorithm for clozapine-induced myocarditis: A systematic review.
Mahgoub Y, Alhau R, Magzoub Y, Ali A, Nour E, Saeed MEE, Mohamed SGM, Hassan AOS, Ali O. Mahgoub Y, et al. Among authors: nour e. World J Psychiatry. 2025 Sep 19;15(9):108525. doi: 10.5498/wjp.v15.i9.108525. eCollection 2025 Sep 19. World J Psychiatry. 2025. PMID: 40933150 Free PMC article.
BACKGROUND: Clozapine, the gold standard for resistant schizophrenia, is underused due to risks like clozapine-induced myocarditis (CIM). Non-specific biomarkers and inconsistent imaging, and the significant overlap with clozapine-induced pneumonia (CIP) lead to misdiagnos …
BACKGROUND: Clozapine, the gold standard for resistant schizophrenia, is underused due to risks like clozapine-induced myocarditis (C …
A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia.
Jauhar S, Nour MM, Veronese M, Rogdaki M, Bonoldi I, Azis M, Turkheimer F, McGuire P, Young AH, Howes OD. Jauhar S, et al. Among authors: nour mm. JAMA Psychiatry. 2017 Dec 1;74(12):1206-1213. doi: 10.1001/jamapsychiatry.2017.2943. JAMA Psychiatry. 2017. PMID: 29049482 Free PMC article.
IMPORTANCE: The dopamine hypothesis suggests that dopamine abnormalities underlie psychosis, irrespective of diagnosis, implicating dopamine dysregulation in bipolar affective disorder and schizophrenia, in line with the research domain criteria approa …
IMPORTANCE: The dopamine hypothesis suggests that dopamine abnormalities underlie psychosis, irrespective of diagnosis, implic …
46 results