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34 results

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Page 1
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment.
Ashok AH, Marques TR, Jauhar S, Nour MM, Goodwin GM, Young AH, Howes OD. Ashok AH, et al. Among authors: nour mm. Mol Psychiatry. 2017 May;22(5):666-679. doi: 10.1038/mp.2017.16. Epub 2017 Mar 14. Mol Psychiatry. 2017. PMID: 28289283 Free PMC article. Review.
In bipolar depression imaging studies show increased dopamine transporter levels, but changes in other aspects of dopaminergic function are inconsistent. ...Thus, it can be speculated that a failure of dopamine receptor and transporter homoeostasis might underlie th …
In bipolar depression imaging studies show increased dopamine transporter levels, but changes in other aspects of dopaminergic functi …
Schizophrenia on YouTube.
Nour MM, Nour MH, Tsatalou OM, Barrera A. Nour MM, et al. Among authors: nour mh. Psychiatr Serv. 2017 Jan 1;68(1):70-74. doi: 10.1176/appi.ps.201500541. Epub 2016 Aug 15. Psychiatr Serv. 2017. PMID: 27524369
OBJECTIVE: YouTube ( www.youtube.com ) is the most popular video-sharing Web site on the Internet and is used by medical students as a source of information regarding mental health conditions, including schizophrenia. The accuracy and educational utility of schizophreni
OBJECTIVE: YouTube ( www.youtube.com ) is the most popular video-sharing Web site on the Internet and is used by medical students as a sourc …
Schizophrenia, Subjectivity, and Mindreading.
Nour MM, Barrera A. Nour MM, et al. Schizophr Bull. 2015 Nov;41(6):1214-9. doi: 10.1093/schbul/sbv035. Epub 2015 Apr 5. Schizophr Bull. 2015. PMID: 25848120 Free PMC article. Review.
A number of recent articles, many appearing in Schizophrenia Bulletin, signal a renewed interest in phenomenological approaches to our understanding of schizophrenia. ...Our hypothesis, while speculative, is an attempt to marry the phenomenological and neuronal real …
A number of recent articles, many appearing in Schizophrenia Bulletin, signal a renewed interest in phenomenological approaches to ou …
A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia.
Jauhar S, Nour MM, Veronese M, Rogdaki M, Bonoldi I, Azis M, Turkheimer F, McGuire P, Young AH, Howes OD. Jauhar S, et al. Among authors: nour mm. JAMA Psychiatry. 2017 Dec 1;74(12):1206-1213. doi: 10.1001/jamapsychiatry.2017.2943. JAMA Psychiatry. 2017. PMID: 29049482 Free PMC article.
IMPORTANCE: The dopamine hypothesis suggests that dopamine abnormalities underlie psychosis, irrespective of diagnosis, implicating dopamine dysregulation in bipolar affective disorder and schizophrenia, in line with the research domain criteria approa …
IMPORTANCE: The dopamine hypothesis suggests that dopamine abnormalities underlie psychosis, irrespective of diagnosis, implic …
Clozapine Response in Schizophrenia and Hematological Changes.
Blackman G, Lisshammar JEL, Zafar R, Pollak TA, Pritchard M, Cullen AE, Rogers J, Carter B, Griffiths K, Nour M, David AS, McGuire P, Stewart R, MacCabe J. Blackman G, et al. Among authors: nour m. J Clin Psychopharmacol. 2021 Jan/Feb 01;41(1):19-24. doi: 10.1097/JCP.0000000000001329. J Clin Psychopharmacol. 2021. PMID: 33347018 Free PMC article.
BACKGROUND: Clozapine is the only effective medication for treatment-resistant schizophrenia; however, its mechanism of action remains unclear. The present study explored whether its effectiveness is related to changes in hematological measures after clozapine initiation. …
BACKGROUND: Clozapine is the only effective medication for treatment-resistant schizophrenia; however, its mechanism of action remain …
The relationship between childhood trauma, dopamine release and dexamphetamine-induced positive psychotic symptoms: a [11C]-(+)-PHNO PET study.
Dahoun T, Nour MM, McCutcheon RA, Adams RA, Bloomfield MAP, Howes OD. Dahoun T, et al. Among authors: nour mm. Transl Psychiatry. 2019 Nov 11;9(1):287. doi: 10.1038/s41398-019-0627-y. Transl Psychiatry. 2019. PMID: 31712556 Free PMC article.
Childhood trauma is a risk factor for psychosis. Amphetamine increases synaptic striatal dopamine levels and can induce positive psychotic symptoms in healthy individuals and patients with schizophrenia. ...We used [(11)C]-(+)-PHNO positron emission tomography to me …
Childhood trauma is a risk factor for psychosis. Amphetamine increases synaptic striatal dopamine levels and can induce positive psyc …
The relationship between glutamate, dopamine, and cortical gray matter: A simultaneous PET-MR study.
Rogeau A, Nordio G, Veronese M, Brown K, Nour MM, Osugo M, Jauhar S, Howes OD, McCutcheon RA. Rogeau A, et al. Among authors: nour mm. Mol Psychiatry. 2022 Aug;27(8):3493-3500. doi: 10.1038/s41380-022-01596-6. Epub 2022 May 11. Mol Psychiatry. 2022. PMID: 35546633 Free PMC article. Clinical Trial.
Concurrent disruption of these systems is also often seen in neuropsychiatric disease. The simultaneous measurement of striatal dopamine signaling, cortical gray matter, and glutamate levels is therefore of major interest, but has not been previously reported. In the curre …
Concurrent disruption of these systems is also often seen in neuropsychiatric disease. The simultaneous measurement of striatal dopamine
Impaired neural replay of inferred relationships in schizophrenia.
Nour MM, Liu Y, Arumuham A, Kurth-Nelson Z, Dolan RJ. Nour MM, et al. Cell. 2021 Aug 5;184(16):4315-4328.e17. doi: 10.1016/j.cell.2021.06.012. Epub 2021 Jun 30. Cell. 2021. PMID: 34197734 Free PMC article.
In rodents, such representations are supported by sequential place cell reactivations during rest, known as replay. Schizophrenia is proposed to reflect a compromise in structured mental representations, with animal models reporting abnormalities in hippocampal replay and …
In rodents, such representations are supported by sequential place cell reactivations during rest, known as replay. Schizophrenia is …
Disrupted-in-schizophrenia 1 functional polymorphisms and D2 /D3 receptor availability: A [11 C]-(+)-PHNO imaging study.
Dahoun T, Nour MM, Adams RA, Trossbach S, Lee SH, Patel H, Curtis C, Korth C, Howes OD. Dahoun T, et al. Among authors: nour mm. Genes Brain Behav. 2019 Nov;18(8):e12596. doi: 10.1111/gbb.12596. Epub 2019 Jul 5. Genes Brain Behav. 2019. PMID: 31264367 Free PMC article.
The disrupted-in-schizophrenia 1 (DISC1) protein has been implicated in a range of biological mechanisms underlying chronic mental disorders such as schizophrenia. Schizophrenia is associated with abnormal striatal dopamine signalling, and all antipsyc …
The disrupted-in-schizophrenia 1 (DISC1) protein has been implicated in a range of biological mechanisms underlying chronic mental di …
34 results