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Nuclear orphan receptor NR2F6 confers cisplatin resistance in epithelial ovarian cancer cells by activating the Notch3 signaling pathway.
Li H, Zhang W, Niu C, Lin C, Wu X, Jian Y, Li Y, Ye L, Dai Y, Ouyang Y, Chen J, Qiu J, Song L, Zhang Y. Li H, et al. Int J Cancer. 2019 Oct 1;145(7):1921-1934. doi: 10.1002/ijc.32293. Epub 2019 Apr 4. Int J Cancer. 2019. PMID: 30895619 Free PMC article.
Moreover, overexpression of NR2F6 promotes the EOC cancer stem cell phenotype; conversely, knockdown of NR2F6 represses the EOC cancer stem cell phenotype and sensitizes EOC to cisplatin in vitro and in vivo. Our results fur …
Moreover, overexpression of NR2F6 promotes the EOC cancer stem cell phenotype; conversely, knockdown of NR2F6
The orphan nuclear receptor EAR-2 (NR2F6) inhibits hematopoietic cell differentiation and induces myeloid dysplasia in vivo.
Ichim CV, Dervovic DD, Chan LSA, Robertson CJ, Chesney A, Reis MD, Wells RA. Ichim CV, et al. Biomark Res. 2018 Dec 7;6:36. doi: 10.1186/s40364-018-0149-4. eCollection 2018. Biomark Res. 2018. PMID: 30555701 Free PMC article.
Ex vivo transduced cells were flow sorted. In some experiments cells were cultured in vitro, in other experiments cells were injected into lethally irradiated recipients, along with non-transduced bone marrow cells. ...CONCLUSIONS: This data suggest th …
Ex vivo transduced cells were flow sorted. In some experiments cells were cultured in vitro, in other experiments cells
The orphan nuclear receptor Ear-2 (Nr2f6) is a novel negative regulator of T cell development.
Ichim CV, Dervović DD, Zúñiga-Pflücker JC, Wells RA. Ichim CV, et al. Exp Hematol. 2014 Jan;42(1):46-58. doi: 10.1016/j.exphem.2013.09.010. Epub 2013 Oct 2. Exp Hematol. 2014. PMID: 24096122
Ear-2-transduced murine BM hematopoietic stem cells (HSCs) in OP9-DL1 cultures showed a proliferation deficit during days 1-5 after induction of differentiation, which corresponded to increased expression of the cell cycle regulators p21 (cdkn1a) and p27 (cdk …
Ear-2-transduced murine BM hematopoietic stem cells (HSCs) in OP9-DL1 cultures showed a proliferation deficit during days 1-5 …
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