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Year Number of Results
1978 1
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2,317 results

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Page 1
NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.
Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen G, Li Y, Liao X, Shang Y, Hu G, Chen Q, Zhu Y. Zhao T, et al. EMBO J. 2023 Aug 15;42(16):e113258. doi: 10.15252/embj.2022113258. Epub 2023 Jul 6. EMBO J. 2023. PMID: 37409632 Free PMC article.
Notably, virus-activated kinase TBK1 phosphorylated NRF1 at Ser318 and thereby triggered the inactivation of the NRF1-TFAM axis during HSV-1 infection. A knock-in (KI) strategy that mimicked TBK1-NRF1 signaling revealed that interrupting the TBK1-NRF1 …
Notably, virus-activated kinase TBK1 phosphorylated NRF1 at Ser318 and thereby triggered the inactivation of the NRF1-TFAM axi …
NRF1-mediated innate immune response drives inflammaging.
Lei H, Zhao T, Zhang J, Long Y, Chen Y, Zhu Y, Meng Y, Tang Y, Liu X, Sun J, Li Z, Su J, Gong F, Chen G, Sun B, Chen Y, Chen Q, Li Y, Zhu Y. Lei H, et al. Nat Commun. 2025 Dec 11;16(1):11367. doi: 10.1038/s41467-025-66368-6. Nat Commun. 2025. PMID: 41381492 Free PMC article.
NRF1 deficiency delayed cellular senescence and ameliorated age-related deterioration in multiple organs. ...Additionally, DNA damage activated ATM kinase, which phosphorylated NRF1 at Ser393, augmenting the NRF1-TBK1/IRF3-type I interferon axis and exacerbat …
NRF1 deficiency delayed cellular senescence and ameliorated age-related deterioration in multiple organs. ...Additionally, DNA damage …
Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance.
Cui M, Atmanli A, Morales MG, Tan W, Chen K, Xiao X, Xu L, Liu N, Bassel-Duby R, Olson EN. Cui M, et al. Nat Commun. 2021 Sep 6;12(1):5270. doi: 10.1038/s41467-021-25653-w. Nat Commun. 2021. PMID: 34489413 Free PMC article.
Genetic deletion of Nrf1 prevented regenerating cardiomyocytes from activating a transcriptional program required for heart regeneration. Conversely, Nrf1 overexpression protected the adult mouse heart from ischemia/reperfusion (I/R) injury. ...
Genetic deletion of Nrf1 prevented regenerating cardiomyocytes from activating a transcriptional program required for heart regenerat …
NRF1-mediated microglial activation triggers high-altitude cerebral edema.
Wang X, Chen G, Wan B, Dong Z, Xue Y, Luo Q, Wang D, Lu Y, Zhu L. Wang X, et al. J Mol Cell Biol. 2022 Sep 19;14(5):mjac036. doi: 10.1093/jmcb/mjac036. J Mol Cell Biol. 2022. PMID: 35704676 Free PMC article.
Up-regulated nuclear respiratory factor 1 (NRF1) accelerated pro-inflammatory factors through transcriptional regulation on nuclear factor kappa B p65 (NF-kappaB p65) and mitochondrial transcription factor A (TFAM) in activated microglia under hypoxia. NRF1 also up- …
Up-regulated nuclear respiratory factor 1 (NRF1) accelerated pro-inflammatory factors through transcriptional regulation on nuclear f …
Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation.
Yoshida Y, Takahashi T, Ishii N, Matsuo I, Takahashi S, Inoue H, Endo A, Tsuchiya H, Okada M, Ando C, Suzuki T, Dohmae N, Saeki Y, Tanaka K, Suzuki T. Yoshida Y, et al. Mol Cell. 2024 Aug 22;84(16):3115-3127.e11. doi: 10.1016/j.molcel.2024.07.013. Epub 2024 Aug 7. Mol Cell. 2024. PMID: 39116872 Free article.
Proteasome is essential for cell survival, and proteasome inhibition induces proteasomal gene transcription via the activated endoplasmic-reticulum-associated transcription factor nuclear factor erythroid 2-like 1 (Nrf1/NFE2L1). Nrf1 activation requires proteolytic …
Proteasome is essential for cell survival, and proteasome inhibition induces proteasomal gene transcription via the activated endoplasmic-re …
Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation.
Yan J, Zhang X, Wang H, Jia X, Wang R, Wu S, Zhu ZJ, Tan M, Horng T. Yan J, et al. Cell Rep. 2024 Oct 22;43(10):114780. doi: 10.1016/j.celrep.2024.114780. Epub 2024 Sep 25. Cell Rep. 2024. PMID: 39325625 Free article.
In macrophages exposed to the bacterial product lipopolysaccharide (LPS), an initial induction of protein biosynthesis is followed by compensatory induction of the transcription factor nuclear factor erythroid 2-like 1 (NRF1), leading to increased flux through the ubiquiti …
In macrophages exposed to the bacterial product lipopolysaccharide (LPS), an initial induction of protein biosynthesis is followed by compen …
Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy.
Ward MA, Vangala JR, Kamber Kaya HE, Byers HA, Hosseini N, Diaz A, Cuervo AM, Kaushik S, Radhakrishnan SK. Ward MA, et al. J Cell Biol. 2024 Jun 3;223(6):e202306150. doi: 10.1083/jcb.202306150. Epub 2024 Apr 24. J Cell Biol. 2024. PMID: 38656405 Free PMC article.
This phenomenon was also recapitulated in NGLY1 knockout cells, where Nrf1 is known to be non-functional. Conversely, overexpression of Nrf1 induced ALP genes and endowed the cells with an increased capacity to clear aggresomes. Overall, our results significantly ex …
This phenomenon was also recapitulated in NGLY1 knockout cells, where Nrf1 is known to be non-functional. Conversely, overexpression …
Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation.
Chen Y, He W, Qiu J, Luo Y, Jiang C, Zhao F, Wei H, Meng J, Long T, Zhang X, Yang L, Xu Q, Wang J, Zhang C. Chen Y, et al. Cell Mol Biol Lett. 2024 Aug 28;29(1):114. doi: 10.1186/s11658-024-00634-1. Cell Mol Biol Lett. 2024. PMID: 39198723 Free PMC article.
The brain infarct size, neuroinflammation and microglial availability were also determined. Dual-luciferase reporter, Nrf1 protein stability and co-immunoprecipitation assays were conducted to analyse histone deacetylase 3 (HDAC3)/Nrf1-regulated Nrf1 in an OG …
The brain infarct size, neuroinflammation and microglial availability were also determined. Dual-luciferase reporter, Nrf1 protein st …
Understanding the Transcription Factor NFE2L1/NRF1 from the Perspective of Hallmarks of Cancer.
Zhang H, Liu Y, Zhang K, Hong Z, Liu Z, Liu Z, Li G, Xu Y, Pi J, Fu J, Xu Y. Zhang H, et al. Antioxidants (Basel). 2024 Jun 22;13(7):758. doi: 10.3390/antiox13070758. Antioxidants (Basel). 2024. PMID: 39061827 Free PMC article. Review.
Nuclear factor erythroid 2-related factor 1 (NFE2L1, also named NRF1) belongs to the cap'n'collar (CNC) basic-region leucine zipper (bZIP) family. It acts as a transcription factor and is indispensable for maintaining both cellular homoeostasis and organ integrity during d …
Nuclear factor erythroid 2-related factor 1 (NFE2L1, also named NRF1) belongs to the cap'n'collar (CNC) basic-region leucine zipper ( …
NFE2L1/Nrf1 serves as a potential therapeutical target for neurodegenerative diseases.
Łuczyńska K, Zhang Z, Pietras T, Zhang Y, Taniguchi H. Łuczyńska K, et al. Redox Biol. 2024 Feb;69:103003. doi: 10.1016/j.redox.2023.103003. Epub 2023 Dec 18. Redox Biol. 2024. PMID: 38150994 Free PMC article. Review.
The proteasome expression is tightly regulated by a CNC (cap'n'collar) family of transcription factors, amongst which the nuclear factor-erythroid 2-like bZIP factor 1 (NFE2L1, also known as Nrf1, with its long isoform TCF11 and short isoform LCR-F1) has been identified as …
The proteasome expression is tightly regulated by a CNC (cap'n'collar) family of transcription factors, amongst which the nuclear factor-ery …
2,317 results