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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 1
1992 1
1994 1
1995 2
1997 2
1998 6
1999 7
2000 2
2001 5
2002 7
2003 14
2004 11
2005 9
2006 13
2007 15
2008 22
2009 15
2010 29
2011 47
2012 44
2013 33
2014 50
2015 57
2016 74
2017 65
2018 70
2019 80
2020 85
2021 24
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683 results
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Page 1
Mitochondria and neuroplasticity.
Cheng A, Hou Y, Mattson MP. Cheng A, et al. ASN Neuro. 2010 Oct 4;2(5):e00045. doi: 10.1042/AN20100019. ASN Neuro. 2010. PMID: 20957078 Free PMC article. Review.
Particularly intriguing is emerging data suggesting that mitochondria emit molecular signals (e.g. reactive oxygen species, proteins and lipid mediators) that can act locally or travel to distant targets including the nucleus. Disturbances in mitochondrial functions and si …
Particularly intriguing is emerging data suggesting that mitochondria emit molecular signals (e.g. reactive oxygen species, proteins …
Mitochondrial biogenesis in neurodegeneration.
Li PA, Hou X, Hao S. Li PA, et al. J Neurosci Res. 2017 Oct;95(10):2025-2029. doi: 10.1002/jnr.24042. Epub 2017 Mar 16. J Neurosci Res. 2017. PMID: 28301064 Review.
Mitochondria play a key role in energy production, calcium homeostasis, cell survival, and death. ...Therefore, preserving or promoting mitochondrial function is a potential therapeutic target for the treatment of neurodegenerative disorders. Mitochondrial biogenesis is a
Mitochondria play a key role in energy production, calcium homeostasis, cell survival, and death. ...Therefore, preserving or promoti
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.
Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS. Bartelt A, et al. Nat Med. 2018 Mar;24(3):292-303. doi: 10.1038/nm.4481. Epub 2018 Feb 5. Nat Med. 2018. PMID: 29400713 Free PMC article.
In mice, under thermogenic conditions, brown-adipocyte-specific deletion of Nfe2l1 (Nrf1) resulted in ER stress, tissue inflammation, markedly diminished mitochondrial function and whitening of the BAT. ...In conclusion, Nrf1 emerges as a novel guardian of brown adi …
In mice, under thermogenic conditions, brown-adipocyte-specific deletion of Nfe2l1 (Nrf1) resulted in ER stress, tissue inflammation, …
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
Ma B, Cheng H, Mu C, Geng G, Zhao T, Luo Q, Ma K, Chang R, Liu Q, Gao R, Nie J, Xie J, Han J, Chen L, Ma G, Zhu Y, Chen Q. Ma B, et al. Nat Commun. 2019 Mar 4;10(1):1034. doi: 10.1038/s41467-019-08618-y. Nat Commun. 2019. PMID: 30833558 Free PMC article.
Dampening NRF1 degradation under hypoxia not only impairs the polarization of TAMs, but also promotes tumor cells to become more susceptible to apoptosis in a FADD-dependent fashion, resulting in secondary necrosis due to the impairment of efferocytosis. These data represe …
Dampening NRF1 degradation under hypoxia not only impairs the polarization of TAMs, but also promotes tumor cells to become more susc …
N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1.
Yang K, Huang R, Fujihira H, Suzuki T, Yan N. Yang K, et al. J Exp Med. 2018 Oct 1;215(10):2600-2616. doi: 10.1084/jem.20180783. Epub 2018 Aug 22. J Exp Med. 2018. PMID: 30135079 Free PMC article.
Here, we find that NGLY1-deficient human and mouse cells chronically activate cytosolic nucleic acid-sensing pathways, leading to elevated interferon gene signature. We also find that cellular clearance of damaged mitochondria by mitophagy is impaired in the absence of NGL …
Here, we find that NGLY1-deficient human and mouse cells chronically activate cytosolic nucleic acid-sensing pathways, leading to elevated i …
Estrogenic control of mitochondrial function.
Klinge CM. Klinge CM. Redox Biol. 2020 Apr;31:101435. doi: 10.1016/j.redox.2020.101435. Epub 2020 Jan 23. Redox Biol. 2020. PMID: 32001259 Free PMC article. Review.
IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3beta-Nrf2-BNIP3 Pathway.
Riis S, Murray JB, O'Connor R. Riis S, et al. Cells. 2020 Jan 8;9(1):147. doi: 10.3390/cells9010147. Cells. 2020. PMID: 31936236 Free PMC article.
Suppression of IGF-1 signaling, Nrf2 or BNIP3 caused the accumulation of elongated mitochondria and altered the mitochondrial dynamics. IGF-1R null Mouse Embryonic Fibroblasts (MEFs) were impaired in the BNIP3 expression and in the capacity to mount a cell survival respons …
Suppression of IGF-1 signaling, Nrf2 or BNIP3 caused the accumulation of elongated mitochondria and altered the mitochondrial dynamic …
Mitochondrial biogenesis: pharmacological approaches.
Valero T. Valero T. Curr Pharm Des. 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118. Curr Pharm Des. 2014. PMID: 24606795
This pivotal role makes mitochondria a potential target to treat a great variety of diseases. ...Although it is known that many neurodegenerative and neurodevelopmental diseases are originated in mitochondria, the regulation of mitochondrial biogenesis has never bee …
This pivotal role makes mitochondria a potential target to treat a great variety of diseases. ...Although it is known that many neuro …
ATM is activated by ATP depletion and modulates mitochondrial function through NRF1.
Chow HM, Cheng A, Song X, Swerdel MR, Hart RP, Herrup K. Chow HM, et al. J Cell Biol. 2019 Mar 4;218(3):909-928. doi: 10.1083/jcb.201806197. Epub 2019 Jan 14. J Cell Biol. 2019. PMID: 30642892 Free PMC article.
We find that when ATM is activated by oxidative stress, but not by DNA damage, ATM phosphorylates NRF1. This leads to NRF1 dimerization, nuclear translocation, and the up-regulation of nuclear-encoded mitochondrial genes, thus enhancing the capacity of the electron …
We find that when ATM is activated by oxidative stress, but not by DNA damage, ATM phosphorylates NRF1. This leads to NRF1 dim …
Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.
Yau WW, Singh BK, Lesmana R, Zhou J, Sinha RA, Wong KA, Wu Y, Bay BH, Sugii S, Sun L, Yen PM. Yau WW, et al. Autophagy. 2019 Jan;15(1):131-150. doi: 10.1080/15548627.2018.1511263. Epub 2018 Sep 13. Autophagy. 2019. PMID: 30209975 Free PMC article.
The thyroid hormone triiodothyronine (T(3)) activates thermogenesis by uncoupling electron transport from ATP synthesis in brown adipose tissue (BAT) mitochondria. Although T(3) can induce thermogenesis by sympathetic innervation, little is known about its cell autonomous …
The thyroid hormone triiodothyronine (T(3)) activates thermogenesis by uncoupling electron transport from ATP synthesis in brown adipose tis …
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