Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1991 1
1992 1
1993 1
1994 2
1995 6
1996 6
1997 8
1998 13
1999 14
2000 25
2001 30
2002 53
2003 60
2004 95
2005 138
2006 202
2007 238
2008 314
2009 361
2010 565
2011 665
2012 821
2013 1086
2014 1240
2015 1511
2016 1751
2017 2091
2018 2397
2019 2812
2020 3342
2021 774
Text availability
Article attribute
Article type
Publication date

Search Results

17,889 results
Results by year
Filters applied: . Clear all
Page 1
Transcriptional Regulation by Nrf2.
Tonelli C, Chio IIC, Tuveson DA. Tonelli C, et al. Antioxid Redox Signal. 2018 Dec 10;29(17):1727-1745. doi: 10.1089/ars.2017.7342. Epub 2017 Oct 20. Antioxid Redox Signal. 2018. PMID: 28899199 Free PMC article. Review.
Here, we review the different modes of regulation of Nrf2 activity and the current knowledge of Nrf2-mediated transcriptional control. CRITICAL ISSUES: It is now clear that Nrf2 lies at the center of a complex regulatory network. A full comprehension of the …
Here, we review the different modes of regulation of Nrf2 activity and the current knowledge of Nrf2-mediated transcriptional …
The KEAP1-NRF2 System in Cancer.
Taguchi K, Yamamoto M. Taguchi K, et al. Front Oncol. 2017 May 4;7:85. doi: 10.3389/fonc.2017.00085. eCollection 2017. Front Oncol. 2017. PMID: 28523248 Free PMC article. Review.
Two strategies have been used to target NRF2 via therapeutic drugs: inhibition of NRF2 and induction of NRF2. NRF2 inhibitors may be effective against NRF2-addicted cancer cells in which NRF2 is aberrantly activated. ...
Two strategies have been used to target NRF2 via therapeutic drugs: inhibition of NRF2 and induction of NRF2. NRF2
Nrf2-Keap1 signaling in oxidative and reductive stress.
Bellezza I, Giambanco I, Minelli A, Donato R. Bellezza I, et al. Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):721-733. doi: 10.1016/j.bbamcr.2018.02.010. Epub 2018 Feb 27. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 29499228 Free article. Review.
Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved intracellular defense mechanism to counteract oxidative stress. ...In the present review we briefly introduce the Nrf2-Keap1 system and describe Nrf2 functions, illus
Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved intracellular defense mechanism to count
NRF2 addiction in cancer cells.
Kitamura H, Motohashi H. Kitamura H, et al. Cancer Sci. 2018 Apr;109(4):900-911. doi: 10.1111/cas.13537. Epub 2018 Mar 10. Cancer Sci. 2018. PMID: 29450944 Free PMC article. Review.
Inhibition of NRF2 is a promising therapeutic approach for NRF2-addicted cancers and NRF2 inhibitors are being actively developed. However, giving systemic NRF2 inhibitors might have undesirable effects on cancer-bearing hosts, considering the central …
Inhibition of NRF2 is a promising therapeutic approach for NRF2-addicted cancers and NRF2 inhibitors are being actively …
Regulation of Nrf2-an update.
Niture SK, Khatri R, Jaiswal AK. Niture SK, et al. Free Radic Biol Med. 2014 Jan;66:36-44. doi: 10.1016/j.freeradbiomed.2013.02.008. Epub 2013 Feb 19. Free Radic Biol Med. 2014. PMID: 23434765 Free PMC article. Review.
This prepares nuclei for unhindered import of Nrf2. Oxidative/electrophilic modification of INrf2 cysteine 151 followed by PKC phosphorylation of Nrf2 serine 40 in the induction response results in the escape or release of Nrf2 from INrf2. ...Fyn phosphorylat …
This prepares nuclei for unhindered import of Nrf2. Oxidative/electrophilic modification of INrf2 cysteine 151 followed by PKC phosph …
Molecular basis of the Keap1-Nrf2 system.
Suzuki T, Yamamoto M. Suzuki T, et al. Free Radic Biol Med. 2015 Nov;88(Pt B):93-100. doi: 10.1016/j.freeradbiomed.2015.06.006. Epub 2015 Jun 25. Free Radic Biol Med. 2015. PMID: 26117331 Review.
Thus, although Nrf2 acts to protect our body from deleterious stresses, cancer cells hijack the Nrf2 activity to support their malignant growth. Nrf2 has emerged as a new therapeutic target, and both inducers and inhibitors of Nrf2 are awaited. ...
Thus, although Nrf2 acts to protect our body from deleterious stresses, cancer cells hijack the Nrf2 activity to support their …
Roles of Nrf2 in cell proliferation and differentiation.
Murakami S, Motohashi H. Murakami S, et al. Free Radic Biol Med. 2015 Nov;88(Pt B):168-178. doi: 10.1016/j.freeradbiomed.2015.06.030. Epub 2015 Jun 25. Free Radic Biol Med. 2015. PMID: 26119783 Review.
The Keap1-Nrf2 system plays pivotal roles in defense mechanisms by regulating cellular redox homeostasis. ...The activity of Nrf2 is regulated by Keap1, which promotes the ubiquitination and subsequent degradation of Nrf2 under normal conditions and releases …
The Keap1-Nrf2 system plays pivotal roles in defense mechanisms by regulating cellular redox homeostasis. ...The activity of Nrf2
Nrf2 at the heart of oxidative stress and cardiac protection.
Chen QM, Maltagliati AJ. Chen QM, et al. Physiol Genomics. 2018 Feb 1;50(2):77-97. doi: 10.1152/physiolgenomics.00041.2017. Epub 2017 Nov 29. Physiol Genomics. 2018. PMID: 29187515 Free PMC article. Review.
A long list of small molecules, most derived from natural products, have been characterized as Nrf2 inducers. These compounds disrupt Keap1-mediated Nrf2 ubquitination, thereby prohibiting proteasomal degradation and allowing Nrf2 protein to accumulate and tr …
A long list of small molecules, most derived from natural products, have been characterized as Nrf2 inducers. These compounds disrupt …
Role of Nrf2 and Its Activators in Respiratory Diseases.
Liu Q, Gao Y, Ci X. Liu Q, et al. Oxid Med Cell Longev. 2019 Jan 8;2019:7090534. doi: 10.1155/2019/7090534. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 30728889 Free PMC article. Review.
Under the unstressed conditions, natural inhibitor of Nrf2, Kelch-like ECH-associated protein 1 (Keap1), traps Nrf2 in the cytoplasm and promotes the degradation of Nrf2 by the 26S proteasome. ...Conversely, Nrf2 activation confers protective effects o …
Under the unstressed conditions, natural inhibitor of Nrf2, Kelch-like ECH-associated protein 1 (Keap1), traps Nrf2 in the cyt …
Oxidative Stress and Cancer: The Role of Nrf2.
Sajadimajd S, Khazaei M. Sajadimajd S, et al. Curr Cancer Drug Targets. 2018;18(6):538-557. doi: 10.2174/1568009617666171002144228. Curr Cancer Drug Targets. 2018. PMID: 28969555 Review.
However, high amount of ROS activates tyrosine kinases to dissociate Nrf2: Keap1 complex, nuclear import of Nrf2 and coordinated activation of cytoprotective gene expression. ...Owning to the interplay of ROS and Nrf2 signaling pathways with carcinogenesis, …
However, high amount of ROS activates tyrosine kinases to dissociate Nrf2: Keap1 complex, nuclear import of Nrf2 and coordinat …
17,889 results
You have reached the last page of results. A maximum of 10,000 results are available.
Jump to page