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1989 1
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43,595 results

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Page 1
Nrf2-Keap1 signaling in oxidative and reductive stress.
Bellezza I, Giambanco I, Minelli A, Donato R. Bellezza I, et al. Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):721-733. doi: 10.1016/j.bbamcr.2018.02.010. Epub 2018 Feb 27. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 29499228 Free article. Review.
Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved intracellular defense mechanism to counteract oxidative stress. ...The heterodimers recognize the AREs, that are enhancer sequences present in the regulatory regions of Nrf2 …
Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved intracellular defense mechanism to count …
NRF2 and the Hallmarks of Cancer.
Rojo de la Vega M, Chapman E, Zhang DD. Rojo de la Vega M, et al. Cancer Cell. 2018 Jul 9;34(1):21-43. doi: 10.1016/j.ccell.2018.03.022. Epub 2018 May 3. Cancer Cell. 2018. PMID: 29731393 Free PMC article. Review.
Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cance …
Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establi …
The Nrf2-HO-1 system and inflammaging.
O'Rourke SA, Shanley LC, Dunne A. O'Rourke SA, et al. Front Immunol. 2024 Sep 24;15:1457010. doi: 10.3389/fimmu.2024.1457010. eCollection 2024. Front Immunol. 2024. PMID: 39380993 Free PMC article. Review.
Nrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. ...In this review, we describe the role of oxidative stress in 'inflammaging' and highlight the potential anti-aging properties of the Nrf2-HO-1 sy …
Nrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. ...In this rev …
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway.
Baird L, Yamamoto M. Baird L, et al. Mol Cell Biol. 2020 Jun 15;40(13):e00099-20. doi: 10.1128/MCB.00099-20. Print 2020 Jun 15. Mol Cell Biol. 2020. PMID: 32284348 Free PMC article. Review.
The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. ...Recent advances have revealed that KEAP1 contains multiple stress sensors and inactivation modalities, which together allow diverse cellular inputs, from oxidative stres …
The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. ...Recent advances have revealed …
Thirty years of NRF2: advances and therapeutic challenges.
Zhang DD. Zhang DD. Nat Rev Drug Discov. 2025 Jun;24(6):421-444. doi: 10.1038/s41573-025-01145-0. Epub 2025 Mar 4. Nat Rev Drug Discov. 2025. PMID: 40038406 Review.
Advances in understanding the mechanistic regulation of NRF2 and its roles in human pathology have propelled the investigation of NRF2-targeted therapeutic strategies. This Review dissects the mechanistic intricacies of NRF2 signalling, its cross-talk with bi …
Advances in understanding the mechanistic regulation of NRF2 and its roles in human pathology have propelled the investigation of …
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.
Yamamoto M, Kensler TW, Motohashi H. Yamamoto M, et al. Physiol Rev. 2018 Jul 1;98(3):1169-1203. doi: 10.1152/physrev.00023.2017. Physiol Rev. 2018. PMID: 29717933 Free PMC article. Review.
KEAP1 represses NRF2 activity under quiescent conditions, whereas NRF2 is liberated from KEAP1-mediated repression on exposure to stresses. ...We believe that controlled harnessing of the KEAP1-NRF2 system is a key to healthy aging and well-being in humans... …
KEAP1 represses NRF2 activity under quiescent conditions, whereas NRF2 is liberated from KEAP1-mediated repression on exposure …
The Dual Roles of NRF2 in Cancer.
Menegon S, Columbano A, Giordano S. Menegon S, et al. Trends Mol Med. 2016 Jul;22(7):578-593. doi: 10.1016/j.molmed.2016.05.002. Epub 2016 Jun 2. Trends Mol Med. 2016. PMID: 27263465 Free article. Review.
NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective functions are deemed to be the main cellular defense mechanism against exogenous and endogenous insults, including xenobiotics and oxidative stress. ...In a rapidly advancing field, thi …
NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective functions are deemed to be the main cellular …
Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology.
Kasai S, Shimizu S, Tatara Y, Mimura J, Itoh K. Kasai S, et al. Biomolecules. 2020 Feb 17;10(2):320. doi: 10.3390/biom10020320. Biomolecules. 2020. PMID: 32079324 Free PMC article. Review.
Nrf2 is inactivated in certain pathological conditions, such as diabetes, but Keap1 down-regulation or mtROS elimination rescues Nrf2 expression and improves the pathology. These reports aid us in understanding the roles of Nrf2 in pathophysiological alterati …
Nrf2 is inactivated in certain pathological conditions, such as diabetes, but Keap1 down-regulation or mtROS elimination rescues N …
NRF2-mediated regulation of lipid pathways in viral infection.
Muzammil K, Sabah Ghnim Z, Saeed Gataa I, Fawzi Al-Hussainy A, Ali Soud N, Adil M, Ali Shallan M, Yasamineh S. Muzammil K, et al. Mol Aspects Med. 2024 Jun;97:101279. doi: 10.1016/j.mam.2024.101279. Epub 2024 May 20. Mol Aspects Med. 2024. PMID: 38772081 Review.
NRF2 may also alter the host's metabolism and innate immunity during viral infection. ...Finally, we investigated the role of NRF2 in lipid modulation during viral infections....
NRF2 may also alter the host's metabolism and innate immunity during viral infection. ...Finally, we investigated the role of NRF2 …
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer.
Bae T, Hallis SP, Kwak MK. Bae T, et al. Exp Mol Med. 2024 Mar;56(3):501-514. doi: 10.1038/s12276-024-01180-8. Epub 2024 Mar 1. Exp Mol Med. 2024. PMID: 38424190 Free PMC article. Review.
Under conditions of excess oxygen and resulting oxidative stress, nuclear factor erythroid 2-related factor 2 (NRF2) activates hundreds of genes for oxidant removal and adaptive cell survival. Hypoxia and oxidative stress are core hallmarks of solid tumors and activated HI …
Under conditions of excess oxygen and resulting oxidative stress, nuclear factor erythroid 2-related factor 2 (NRF2) activates hundre …
43,595 results
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