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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1991 1
1992 1
1993 1
1994 2
1995 6
1996 6
1997 8
1998 13
1999 14
2000 25
2001 30
2002 53
2003 60
2004 95
2005 138
2006 202
2007 238
2008 314
2009 361
2010 565
2011 665
2012 821
2013 1090
2014 1244
2015 1515
2016 1757
2017 2094
2018 2404
2019 2814
2020 2457
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16,569 results
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Page 1
The KEAP1-NRF2 System in Cancer.
Taguchi K, Yamamoto M. Taguchi K, et al. Front Oncol. 2017 May 4;7:85. doi: 10.3389/fonc.2017.00085. eCollection 2017. Front Oncol. 2017. PMID: 28523248 Free PMC article. Review.
Therefore, NRF2 has been studied as a therapeutic target molecule in cancer. Two strategies have been used to target NRF2 via therapeutic drugs: inhibition of NRF2 and induction of NRF2. ...Diagnosis of NRF2 activation could facilitate the use o …
Therefore, NRF2 has been studied as a therapeutic target molecule in cancer. Two strategies have been used to target NRF2 via …
Nrf2-Keap1 signaling in oxidative and reductive stress.
Bellezza I, Giambanco I, Minelli A, Donato R. Bellezza I, et al. Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):721-733. doi: 10.1016/j.bbamcr.2018.02.010. Epub 2018 Feb 27. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 29499228 Free article. Review.
Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved intracellular defense mechanism to counteract oxidative stress. ...In the present review we briefly introduce the Nrf2-Keap1 system and describe Nrf2 functions, illus
Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved intracellular defense mechanism to count
Transcriptional Regulation by Nrf2.
Tonelli C, Chio IIC, Tuveson DA. Tonelli C, et al. Antioxid Redox Signal. 2018 Dec 10;29(17):1727-1745. doi: 10.1089/ars.2017.7342. Epub 2017 Oct 20. Antioxid Redox Signal. 2018. PMID: 28899199 Free PMC article. Review.
Given the wide range of processes that Nrf2 controls, its activity is tightly regulated at multiple levels. Here, we review the different modes of regulation of Nrf2 activity and the current knowledge of Nrf2-mediated transcriptional control. CRITICAL ISSUES: …
Given the wide range of processes that Nrf2 controls, its activity is tightly regulated at multiple levels. Here, we review the diffe …
NRF2 addiction in cancer cells.
Kitamura H, Motohashi H. Kitamura H, et al. Cancer Sci. 2018 Apr;109(4):900-911. doi: 10.1111/cas.13537. Epub 2018 Mar 10. Cancer Sci. 2018. PMID: 29450944 Free PMC article. Review.
Inhibition of NRF2 is a promising therapeutic approach for NRF2-addicted cancers and NRF2 inhibitors are being actively developed. However, giving systemic NRF2 inhibitors might have undesirable effects on cancer-bearing hosts, considering the central …
Inhibition of NRF2 is a promising therapeutic approach for NRF2-addicted cancers and NRF2 inhibitors are being actively …
Roles of Nrf2 in cell proliferation and differentiation.
Murakami S, Motohashi H. Murakami S, et al. Free Radic Biol Med. 2015 Nov;88(Pt B):168-178. doi: 10.1016/j.freeradbiomed.2015.06.030. Epub 2015 Jun 25. Free Radic Biol Med. 2015. PMID: 26119783 Review.
The activity of Nrf2 is regulated by Keap1, which promotes the ubiquitination and subsequent degradation of Nrf2 under normal conditions and releases the inhibited Nrf2 activity upon exposure to the stresses. ...In addition, analyses of the genome-wide distri …
The activity of Nrf2 is regulated by Keap1, which promotes the ubiquitination and subsequent degradation of Nrf2 under normal …
Molecular basis of the Keap1-Nrf2 system.
Suzuki T, Yamamoto M. Suzuki T, et al. Free Radic Biol Med. 2015 Nov;88(Pt B):93-100. doi: 10.1016/j.freeradbiomed.2015.06.006. Epub 2015 Jun 25. Free Radic Biol Med. 2015. PMID: 26117331 Review.
On the other hand, Nrf2 is found to promote both oncogenesis and cancer cell resistance against chemotherapeutic drugs. Thus, although Nrf2 acts to protect our body from deleterious stresses, cancer cells hijack the Nrf2 activity to support their malignant gr …
On the other hand, Nrf2 is found to promote both oncogenesis and cancer cell resistance against chemotherapeutic drugs. Thus, althoug …
Nrf2 at the heart of oxidative stress and cardiac protection.
Chen QM, Maltagliati AJ. Chen QM, et al. Physiol Genomics. 2018 Feb 1;50(2):77-97. doi: 10.1152/physiolgenomics.00041.2017. Epub 2017 Nov 29. Physiol Genomics. 2018. PMID: 29187515 Free PMC article. Review.
While Nrf2 has been the topic of intensive research in cancer biology since its discovery in 1994, understanding the role of Nrf2 in cardiovascular disease has just begun. ...A long list of small molecules, most derived from natural products, have been characterized …
While Nrf2 has been the topic of intensive research in cancer biology since its discovery in 1994, understanding the role of Nrf2
Oxidative Stress and Cancer: The Role of Nrf2.
Sajadimajd S, Khazaei M. Sajadimajd S, et al. Curr Cancer Drug Targets. 2018;18(6):538-557. doi: 10.2174/1568009617666171002144228. Curr Cancer Drug Targets. 2018. PMID: 28969555 Review.
However, high amount of ROS activates tyrosine kinases to dissociate Nrf2: Keap1 complex, nuclear import of Nrf2 and coordinated activation of cytoprotective gene expression. ...Owning to the interplay of ROS and Nrf2 signaling pathways with carcinogenesis, …
However, high amount of ROS activates tyrosine kinases to dissociate Nrf2: Keap1 complex, nuclear import of Nrf2 and coordinat …
The Roles of NRF2 in Modulating Cellular Iron Homeostasis.
Kerins MJ, Ooi A. Kerins MJ, et al. Antioxid Redox Signal. 2018 Dec 10;29(17):1756-1773. doi: 10.1089/ars.2017.7176. Epub 2017 Sep 21. Antioxid Redox Signal. 2018. PMID: 28793787 Free PMC article. Review.
Constitutive NRF2 activation and subsequent deregulation of iron metabolism have been implicated in cancer development: NRF2-mediated upregulation of the iron storage protein ferritin or heme oxygenase 1 can lead to enhanced proliferation and therapy resistance. ... …
Constitutive NRF2 activation and subsequent deregulation of iron metabolism have been implicated in cancer development: NRF2-m …
The multifaceted role of Nrf2 in mitochondrial function.
Holmström KM, Kostov RV, Dinkova-Kostova AT. Holmström KM, et al. Curr Opin Toxicol. 2016 Dec;1:80-91. doi: 10.1016/j.cotox.2016.10.002. Curr Opin Toxicol. 2016. PMID: 28066829 Free PMC article. Review.
The transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) is the master regulator of the cellular redox homeostasis. ...Increased Nrf2 activity defends against mitochondrial toxins. Reduced glutathione, the principal small molecule antioxidant …
The transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) is the master regulator of the cellular redox homeost …
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