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38,031 results

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Page 1
Nrf2-Keap1 signaling in oxidative and reductive stress.
Bellezza I, Giambanco I, Minelli A, Donato R. Bellezza I, et al. Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):721-733. doi: 10.1016/j.bbamcr.2018.02.010. Epub 2018 Feb 27. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 29499228 Free article. Review.
Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved intracellular defense mechanism to counteract oxidative stress. ...The heterodimers recognize the AREs, that are enhancer sequences present in the regulatory regions of Nrf2 …
Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved intracellular defense mechanism to count …
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway.
Baird L, Yamamoto M. Baird L, et al. Mol Cell Biol. 2020 Jun 15;40(13):e00099-20. doi: 10.1128/MCB.00099-20. Print 2020 Jun 15. Mol Cell Biol. 2020. PMID: 32284348 Free PMC article. Review.
The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. ...Recent advances have revealed that KEAP1 contains multiple stress sensors and inactivation modalities, which together allow diverse cellular inputs, from oxidative stres …
The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. ...Recent advances have revealed …
NRF2 and the Hallmarks of Cancer.
Rojo de la Vega M, Chapman E, Zhang DD. Rojo de la Vega M, et al. Cancer Cell. 2018 Jul 9;34(1):21-43. doi: 10.1016/j.ccell.2018.03.022. Epub 2018 May 3. Cancer Cell. 2018. PMID: 29731393 Free PMC article. Review.
Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cance …
Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establi …
The Nrf2-HO-1 system and inflammaging.
O'Rourke SA, Shanley LC, Dunne A. O'Rourke SA, et al. Front Immunol. 2024 Sep 24;15:1457010. doi: 10.3389/fimmu.2024.1457010. eCollection 2024. Front Immunol. 2024. PMID: 39380993 Free PMC article. Review.
Nrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. ...In this review, we describe the role of oxidative stress in 'inflammaging' and highlight the potential anti-aging properties of the Nrf2-HO-1 sy …
Nrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. ...In this rev …
Thirty years of NRF2: advances and therapeutic challenges.
Zhang DD. Zhang DD. Nat Rev Drug Discov. 2025 Jun;24(6):421-444. doi: 10.1038/s41573-025-01145-0. Epub 2025 Mar 4. Nat Rev Drug Discov. 2025. PMID: 40038406 Review.
Advances in understanding the mechanistic regulation of NRF2 and its roles in human pathology have propelled the investigation of NRF2-targeted therapeutic strategies. This Review dissects the mechanistic intricacies of NRF2 signalling, its cross-talk with bi …
Advances in understanding the mechanistic regulation of NRF2 and its roles in human pathology have propelled the investigation of …
Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology.
Kasai S, Shimizu S, Tatara Y, Mimura J, Itoh K. Kasai S, et al. Biomolecules. 2020 Feb 17;10(2):320. doi: 10.3390/biom10020320. Biomolecules. 2020. PMID: 32079324 Free PMC article. Review.
Nrf2 is inactivated in certain pathological conditions, such as diabetes, but Keap1 down-regulation or mtROS elimination rescues Nrf2 expression and improves the pathology. These reports aid us in understanding the roles of Nrf2 in pathophysiological alterati …
Nrf2 is inactivated in certain pathological conditions, such as diabetes, but Keap1 down-regulation or mtROS elimination rescues N …
Repression of the Antioxidant NRF2 Pathway in Premature Aging.
Kubben N, Zhang W, Wang L, Voss TC, Yang J, Qu J, Liu GH, Misteli T. Kubben N, et al. Cell. 2016 Jun 2;165(6):1361-1374. doi: 10.1016/j.cell.2016.05.017. Cell. 2016. PMID: 27259148 Free PMC article.
Using a high-throughput siRNA screen, we identify the NRF2 antioxidant pathway as a driver mechanism in HGPS. Progerin sequesters NRF2 and thereby causes its subnuclear mislocalization, resulting in impaired NRF2 transcriptional activity and consequently incr …
Using a high-throughput siRNA screen, we identify the NRF2 antioxidant pathway as a driver mechanism in HGPS. Progerin sequesters …
Nrf2 as a regulator of energy metabolism and mitochondrial function.
Luchkova A, Mata A, Cadenas S. Luchkova A, et al. FEBS Lett. 2024 Sep;598(17):2092-2105. doi: 10.1002/1873-3468.14993. Epub 2024 Aug 8. FEBS Lett. 2024. PMID: 39118293 Free article. Review.
Nuclear factor erythroid-2-related factor 2 (Nrf2) is essential for the control of cellular redox homeostasis. When activated, Nrf2 elicits cytoprotective effects through the expression of several genes encoding antioxidant and detoxifying enzymes. ...Nrf2 al …
Nuclear factor erythroid-2-related factor 2 (Nrf2) is essential for the control of cellular redox homeostasis. When activated, Nrf …
Nrf2 activators for the treatment of rare iron overload diseases: From bench to bedside.
Dong Y, Zheng M, Ding W, Guan H, Xiao J, Li F. Dong Y, et al. Redox Biol. 2025 Apr;81:103551. doi: 10.1016/j.redox.2025.103551. Epub 2025 Feb 14. Redox Biol. 2025. PMID: 39965404 Free PMC article. Review.
As a core regulator on cellular antioxidant reaction, Nrf2 can also decrease systemic and cellular iron levels by regulating iron-related genes and pathways, making Nrf2 activators very good candidates for the treatment of iron overload disorders. ...In addition, a …
As a core regulator on cellular antioxidant reaction, Nrf2 can also decrease systemic and cellular iron levels by regulating iron-rel …
Nrf2-Related Therapeutic Effects of Curcumin in Different Disorders.
Ghafouri-Fard S, Shoorei H, Bahroudi Z, Hussen BM, Talebi SF, Taheri M, Ayatollahi SA. Ghafouri-Fard S, et al. Biomolecules. 2022 Jan 5;12(1):82. doi: 10.3390/biom12010082. Biomolecules. 2022. PMID: 35053230 Free PMC article. Review.
This substance has been shown to affect the activity of Nrf2 signaling, a pathway that is activated in response to stress and decreases levels of reactive oxygen species and electrophilic substances. ...In the current review, we discuss the Nrf2-mediated therapeutic …
This substance has been shown to affect the activity of Nrf2 signaling, a pathway that is activated in response to stress and decreas …
38,031 results
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