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32,474 results

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Page 1
NRF2, a Transcription Factor for Stress Response and Beyond.
He F, Ru X, Wen T. He F, et al. Int J Mol Sci. 2020 Jul 6;21(13):4777. doi: 10.3390/ijms21134777. Int J Mol Sci. 2020. PMID: 32640524 Free PMC article. Review.
Elevated or decreased NRF2 activity by pharmacological and genetic manipulations of NRF2 activation is associated with many metabolism- or inflammation-related diseases. Emerging evidence shows that NRF2 lies at the center of a complex regulatory network and …
Elevated or decreased NRF2 activity by pharmacological and genetic manipulations of NRF2 activation is associated with many me …
Transcriptional Regulation by Nrf2.
Tonelli C, Chio IIC, Tuveson DA. Tonelli C, et al. Antioxid Redox Signal. 2018 Dec 10;29(17):1727-1745. doi: 10.1089/ars.2017.7342. Epub 2017 Oct 20. Antioxid Redox Signal. 2018. PMID: 28899199 Free PMC article. Review.
Given the wide range of processes that Nrf2 controls, its activity is tightly regulated at multiple levels. Here, we review the different modes of regulation of Nrf2 activity and the current knowledge of Nrf2-mediated transcriptional control. CRITICAL ISSUES: …
Given the wide range of processes that Nrf2 controls, its activity is tightly regulated at multiple levels. Here, we review the diffe …
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription.
Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M. Kobayashi EH, et al. Nat Commun. 2016 May 23;7:11624. doi: 10.1038/ncomms11624. Nat Commun. 2016. PMID: 27211851 Free PMC article.
Further, we found that Nrf2-mediated inhibition is independent of the Nrf2-binding motif and reactive oxygen species level. ...This study identifies Nrf2 as the upstream regulator of cytokine production and establishes a molecular basis for an Nrf2-med …
Further, we found that Nrf2-mediated inhibition is independent of the Nrf2-binding motif and reactive oxygen species level. .. …
Nrf2 at the heart of oxidative stress and cardiac protection.
Chen QM, Maltagliati AJ. Chen QM, et al. Physiol Genomics. 2018 Feb 1;50(2):77-97. doi: 10.1152/physiolgenomics.00041.2017. Epub 2017 Nov 29. Physiol Genomics. 2018. PMID: 29187515 Free PMC article. Review.
A long list of small molecules, most derived from natural products, have been characterized as Nrf2 inducers. These compounds disrupt Keap1-mediated Nrf2 ubquitination, thereby prohibiting proteasomal degradation and allowing Nrf2 protein to accumulate and tr …
A long list of small molecules, most derived from natural products, have been characterized as Nrf2 inducers. These compounds disrupt …
A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.
Dong Y, Kang H, Peng R, Liu Z, Liao F, Hu SA, Ding W, Wang P, Yang P, Zhu M, Wang S, Wu M, Ye D, Gan X, Li F, Song K. Dong Y, et al. Cell Metab. 2024 Aug 6;36(8):1679-1695.e6. doi: 10.1016/j.cmet.2024.03.005. Epub 2024 Apr 2. Cell Metab. 2024. PMID: 38569557
However, there is currently no Nrf2 activator approved for treating chronic diseases, and the downstream mechanism underlying the regulation of Nrf2 on osteoclast differentiation remains unclear. ...Collectively, our findings identify a novel clinical-stage Nrf2 …
However, there is currently no Nrf2 activator approved for treating chronic diseases, and the downstream mechanism underlying the reg …
The Roles of NRF2 in Modulating Cellular Iron Homeostasis.
Kerins MJ, Ooi A. Kerins MJ, et al. Antioxid Redox Signal. 2018 Dec 10;29(17):1756-1773. doi: 10.1089/ars.2017.7176. Epub 2017 Sep 21. Antioxid Redox Signal. 2018. PMID: 28793787 Free PMC article. Review.
Recent works have identified that several genes involved in heme synthesis, hemoglobin catabolism, iron storage, and iron export are under the control of NRF2. Constitutive NRF2 activation and subsequent deregulation of iron metabolism have been implicated in cancer …
Recent works have identified that several genes involved in heme synthesis, hemoglobin catabolism, iron storage, and iron export are under t …
NRF2 in Viral Infection.
Herengt A, Thyrsted J, Holm CK. Herengt A, et al. Antioxidants (Basel). 2021 Sep 18;10(9):1491. doi: 10.3390/antiox10091491. Antioxidants (Basel). 2021. PMID: 34573123 Free PMC article. Review.
The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflamm …
The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many t …
Oxidative Stress and Cancer: The Role of Nrf2.
Sajadimajd S, Khazaei M. Sajadimajd S, et al. Curr Cancer Drug Targets. 2018;18(6):538-557. doi: 10.2174/1568009617666171002144228. Curr Cancer Drug Targets. 2018. PMID: 28969555 Review.
However, high amount of ROS activates tyrosine kinases to dissociate Nrf2: Keap1 complex, nuclear import of Nrf2 and coordinated activation of cytoprotective gene expression. ...Owning to the interplay of ROS and Nrf2 signaling pathways with carcinogenesis, …
However, high amount of ROS activates tyrosine kinases to dissociate Nrf2: Keap1 complex, nuclear import of Nrf2 and coordinat …
The emerging role of the Nrf2-Keap1 signaling pathway in cancer.
Jaramillo MC, Zhang DD. Jaramillo MC, et al. Genes Dev. 2013 Oct 15;27(20):2179-91. doi: 10.1101/gad.225680.113. Genes Dev. 2013. PMID: 24142871 Free PMC article. Review.
Just as Nrf2 protects normal cells, studies have shown that Nrf2 may also protect cancer cells from chemotherapeutic agents and facilitate cancer progression. ...This discovery has opened up a broad spectrum of research geared toward a better understanding of the ro …
Just as Nrf2 protects normal cells, studies have shown that Nrf2 may also protect cancer cells from chemotherapeutic agents an …
Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice.
Liu Y, Uruno A, Saito R, Matsukawa N, Hishinuma E, Saigusa D, Liu H, Yamamoto M. Liu Y, et al. Redox Biol. 2022 Dec;58:102525. doi: 10.1016/j.redox.2022.102525. Epub 2022 Oct 28. Redox Biol. 2022. PMID: 36335764 Free PMC article.
Specifically, we prepared compound Ins2(Akita/+) (Akita) and Nrf2 knockout (Akita::Nrf2(-/-)) or Akita and Nrf2 induction (Akita::Keap1(FA/FA)) mutant mice. ...To further examine the progression of DKD, we compared forty-week-old Akita mouse kidney compounds …
Specifically, we prepared compound Ins2(Akita/+) (Akita) and Nrf2 knockout (Akita::Nrf2(-/-)) or Akita and Nrf2 inducti …
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