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Page 1
Role of nrf2 in oxidative stress and toxicity.
Ma Q. Ma Q. Annu Rev Pharmacol Toxicol. 2013;53:401-26. doi: 10.1146/annurev-pharmtox-011112-140320. Annu Rev Pharmacol Toxicol. 2013. PMID: 23294312 Free PMC article. Review.
Reactive oxidants are counterbalanced by complex antioxidant defense systems regulated by a web of pathways to ensure that the response to oxidants is adequate for the body's needs. ...This review discusses the impact of Nrf2 on oxidative stress …
Reactive oxidants are counterbalanced by complex antioxidant defense systems regulated by a web of pathways to ensure that the respon …
Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway.
Lin X, Bai D, Wei Z, Zhang Y, Huang Y, Deng H, Huang X. Lin X, et al. PLoS One. 2019 May 21;14(5):e0216711. doi: 10.1371/journal.pone.0216711. eCollection 2019. PLoS One. 2019. PMID: 31112588 Free PMC article.
Here, we measured the activity of some antioxidant enzymes and chose the Nrf2-Keap1 signaling pathway to study the protective effects of curcumin on macrophages under oxidative stress in vitro. ...Furthermore, the translocation of Nrf2 protein was also invest …
Here, we measured the activity of some antioxidant enzymes and chose the Nrf2-Keap1 signaling pathway to study the protective effects …
Oxidative Stress.
Sies H, Berndt C, Jones DP. Sies H, et al. Annu Rev Biochem. 2017 Jun 20;86:715-748. doi: 10.1146/annurev-biochem-061516-045037. Epub 2017 Apr 24. Annu Rev Biochem. 2017. PMID: 28441057 Review.
Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to biomolecules, maintenance of a physiological level of oxidant challenge, termed oxidative eustress, is essential for governing life processes through redox signaling. . …
Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to biomolecules, maintenance of a physiologic …
Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury.
Chen QM. Chen QM. Free Radic Biol Med. 2022 Feb 1;179:133-143. doi: 10.1016/j.freeradbiomed.2021.12.001. Epub 2021 Dec 16. Free Radic Biol Med. 2022. PMID: 34921930 Review.
Oxidative stress causes Nrf2 activation via Keap1 dissociation, de novo protein translation, and nuclear translocation related to inactivation of GSK3beta. The mechanism of Keap 1 mediated Nrf2 activation has been hijacked for Nrf2 activation by small …
Oxidative stress causes Nrf2 activation via Keap1 dissociation, de novo protein translation, and nuclear translocation related …
Radical-free biology of oxidative stress.
Jones DP. Jones DP. Am J Physiol Cell Physiol. 2008 Oct;295(4):C849-68. doi: 10.1152/ajpcell.00283.2008. Epub 2008 Aug 6. Am J Physiol Cell Physiol. 2008. PMID: 18684987 Free PMC article. Review.
The redox states of thiol systems are sensitive to two-electron oxidants and controlled by the thioredoxins (Trx), glutathione (GSH), and cysteine (Cys). ...Because of the nonequilibrium conditions in the thiol pathways, aberrant generation of nonradical oxidants at …
The redox states of thiol systems are sensitive to two-electron oxidants and controlled by the thioredoxins (Trx), glutathione (GSH), …
Oxidative stress-based therapeutics in COPD.
Barnes PJ. Barnes PJ. Redox Biol. 2020 Jun;33:101544. doi: 10.1016/j.redox.2020.101544. Epub 2020 Apr 20. Redox Biol. 2020. PMID: 32336666 Free PMC article. Review.
There is increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in cigarette smoke and air pollution and due to endogenous generation of reactive oxygen species by inflammatory and structural cells in the lung. Mitochondrial oxidative …
There is increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in cigarette smoke and air polluti …
MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.
Wang T, Jian Z, Baskys A, Yang J, Li J, Guo H, Hei Y, Xian P, He Z, Li Z, Li N, Long Q. Wang T, et al. Biomaterials. 2020 Oct;257:120264. doi: 10.1016/j.biomaterials.2020.120264. Epub 2020 Jul 28. Biomaterials. 2020. PMID: 32791387
Here, we investigated the therapeutic effects of MSC-Exo on oxidative injury in H(2)O(2)-stimulated epidermal keratinocytes and UV-irradiated wild type and nuclear factor-erythroid 2-related factor-2 (Nrf2) knocked down cell and animal models. ...These results indic …
Here, we investigated the therapeutic effects of MSC-Exo on oxidative injury in H(2)O(2)-stimulated epidermal keratinocytes and UV-ir …
Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress.
Sies H. Sies H. Redox Biol. 2017 Apr;11:613-619. doi: 10.1016/j.redox.2016.12.035. Epub 2017 Jan 5. Redox Biol. 2017. PMID: 28110218 Free PMC article. Review.
The present overview focuses on recent progress on metabolic sources and sinks of H(2)O(2) and on the role of H(2)O(2) in redox signaling under physiological conditions (1-10nM), denoted as oxidative eustress. Higher concentrations lead to adaptive stress responses via mas …
The present overview focuses on recent progress on metabolic sources and sinks of H(2)O(2) and on the role of H(2)O(2) in redox signaling un …
Oxidative stress and decreased Nrf2 level in pediatric patients with COVID-19.
Gümüş H, Erat T, Öztürk İ, Demir A, Koyuncu I. Gümüş H, et al. J Med Virol. 2022 May;94(5):2259-2264. doi: 10.1002/jmv.27640. Epub 2022 Feb 16. J Med Virol. 2022. PMID: 35128704 Free PMC article.
The aim of this study was to investigate the change in nuclear factor erythroid 2-related factor (Nrf2), which plays a critical role in cytoprotection against oxidative stress, in pediatric patients with coronavirus disease 2019 (COVID-19) infection positivity, and …
The aim of this study was to investigate the change in nuclear factor erythroid 2-related factor (Nrf2), which plays a critical role …
Metabolomics of oxidative stress: Nrf2 independent depletion of NAD or increases of sugar alcohols.
Zhu C, Gu H, Jin Y, Wurm D, Freidhof B, Lu Y, Chen QM. Zhu C, et al. Toxicol Appl Pharmacol. 2022 May 1;442:115949. doi: 10.1016/j.taap.2022.115949. Epub 2022 Feb 25. Toxicol Appl Pharmacol. 2022. PMID: 35227738
Using LC-MS/MS-based metabolomics, we addressed whether knocking out the Nrf2 gene in AC16 human cardiomyocytes affects metabolic reprogramming by oxidative stress. ...Knocking out Nrf2 did not affect these changes. Biochemical assays confirmed depletion of N …
Using LC-MS/MS-based metabolomics, we addressed whether knocking out the Nrf2 gene in AC16 human cardiomyocytes affects metabolic rep …
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