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22,990 results

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Page 1
Role of nrf2 in oxidative stress and toxicity.
Ma Q. Ma Q. Annu Rev Pharmacol Toxicol. 2013;53:401-26. doi: 10.1146/annurev-pharmtox-011112-140320. Annu Rev Pharmacol Toxicol. 2013. PMID: 23294312 Free PMC article. Review.
The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance to oxidants. Nrf2 controls the basal and induced expression of an array of antioxidant response element-dependent genes to regulate the physiological and pa …
The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance to oxidants. Nrf2 …
Oxidative Stress.
Sies H, Berndt C, Jones DP. Sies H, et al. Annu Rev Biochem. 2017 Jun 20;86:715-748. doi: 10.1146/annurev-biochem-061516-045037. Epub 2017 Apr 24. Annu Rev Biochem. 2017. PMID: 28441057 Review.
Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to biomolecules, maintenance of a physiological level of oxidant challenge, termed oxidative eustress, is essential for governing life processes through redox signaling. . …
Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to biomolecules, maintenance of a physiologic …
Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway.
Lin X, Bai D, Wei Z, Zhang Y, Huang Y, Deng H, Huang X. Lin X, et al. PLoS One. 2019 May 21;14(5):e0216711. doi: 10.1371/journal.pone.0216711. eCollection 2019. PLoS One. 2019. PMID: 31112588 Free PMC article.
Here, we measured the activity of some antioxidant enzymes and chose the Nrf2-Keap1 signaling pathway to study the protective effects of curcumin on macrophages under oxidative stress in vitro. ...Furthermore, middle-dose curcumin upregulated Nrf2 expression …
Here, we measured the activity of some antioxidant enzymes and chose the Nrf2-Keap1 signaling pathway to study the protective effects …
Radical-free biology of oxidative stress.
Jones DP. Jones DP. Am J Physiol Cell Physiol. 2008 Oct;295(4):C849-68. doi: 10.1152/ajpcell.00283.2008. Epub 2008 Aug 6. Am J Physiol Cell Physiol. 2008. PMID: 18684987 Free PMC article. Review.
Nonradical oxidants, including peroxides, aldehydes, quinones, and epoxides, are generated enzymatically from both endogenous and exogenous precursors and do not require free radicals as intermediates to oxidize or modify these thiols. Because of the nonequilibrium …
Nonradical oxidants, including peroxides, aldehydes, quinones, and epoxides, are generated enzymatically from both endogenous and exo …
Oxidative stress-based therapeutics in COPD.
Barnes PJ. Barnes PJ. Redox Biol. 2020 Jun;33:101544. doi: 10.1016/j.redox.2020.101544. Epub 2020 Apr 20. Redox Biol. 2020. PMID: 32336666 Free PMC article. Review.
Oxidative stress is a major driving mechanism in the pathogenesis of COPD. There is increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in cigarette smoke and air pollution and due to endogenous generation of reactive oxygen spe …
Oxidative stress is a major driving mechanism in the pathogenesis of COPD. There is increased oxidative stress in the lungs of …
Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury.
Chen QM. Chen QM. Free Radic Biol Med. 2022 Feb 1;179:133-143. doi: 10.1016/j.freeradbiomed.2021.12.001. Epub 2021 Dec 16. Free Radic Biol Med. 2022. PMID: 34921930 Review.
Oxidative stress causes Nrf2 activation via Keap1 dissociation, de novo protein translation, and nuclear translocation related to inactivation of GSK3beta. The mechanism of Keap 1 mediated Nrf2 activation has been hijacked for Nrf2 activation by small …
Oxidative stress causes Nrf2 activation via Keap1 dissociation, de novo protein translation, and nuclear translocation related …
MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.
Wang T, Jian Z, Baskys A, Yang J, Li J, Guo H, Hei Y, Xian P, He Z, Li Z, Li N, Long Q. Wang T, et al. Biomaterials. 2020 Oct;257:120264. doi: 10.1016/j.biomaterials.2020.120264. Epub 2020 Jul 28. Biomaterials. 2020. PMID: 32791387
Here, we investigated the therapeutic effects of MSC-Exo on oxidative injury in H(2)O(2)-stimulated epidermal keratinocytes and UV-irradiated wild type and nuclear factor-erythroid 2-related factor-2 (Nrf2) knocked down cell and animal models. ...These results indic …
Here, we investigated the therapeutic effects of MSC-Exo on oxidative injury in H(2)O(2)-stimulated epidermal keratinocytes and UV-ir …
Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress.
Sies H. Sies H. Redox Biol. 2017 Apr;11:613-619. doi: 10.1016/j.redox.2016.12.035. Epub 2017 Jan 5. Redox Biol. 2017. PMID: 28110218 Free PMC article. Review.
The present overview focuses on recent progress on metabolic sources and sinks of H(2)O(2) and on the role of H(2)O(2) in redox signaling under physiological conditions (1-10nM), denoted as oxidative eustress. Higher concentrations lead to adaptive stress responses via mas …
The present overview focuses on recent progress on metabolic sources and sinks of H(2)O(2) and on the role of H(2)O(2) in redox signaling un …
Oxidative stress and decreased Nrf2 level in pediatric patients with COVID-19.
Gümüş H, Erat T, Öztürk İ, Demir A, Koyuncu I. Gümüş H, et al. J Med Virol. 2022 May;94(5):2259-2264. doi: 10.1002/jmv.27640. Epub 2022 Feb 16. J Med Virol. 2022. PMID: 35128704 Free PMC article.
The aim of this study was to investigate the change in nuclear factor erythroid 2-related factor (Nrf2), which plays a critical role in cytoprotection against oxidative stress, in pediatric patients with coronavirus disease 2019 (COVID-19) infection positivity, and …
The aim of this study was to investigate the change in nuclear factor erythroid 2-related factor (Nrf2), which plays a critical role …
Oxidative stress-induced lncRNA CYLD-AS1 promotes RPE inflammation via Nrf2/miR-134-5p/NF-kappaB signaling pathway.
Du H, Huang Z, Zhou X, Kuang X, Long C, Tang H, Zeng J, Huang H, Liu H, Zhu B, Fu L, Hu K, Lin S, Wang H, Zhang Q, Yan J, Shen H. Du H, et al. FASEB J. 2022 Oct;36(10):e22577. doi: 10.1096/fj.202200887R. FASEB J. 2022. PMID: 36165267
Long noncoding RNAs (lncRNAs) have important roles in various biological processes. In this study, using an oxidative damage model in RPE cells, we identified a novel oxidation-related lncRNA named CYLD-AS1. ...Mechanistically, CYLD-AS1 also regulated the expression …
Long noncoding RNAs (lncRNAs) have important roles in various biological processes. In this study, using an oxidative damage model in …
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