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Year Number of Results
1998 1
1999 3
2000 7
2001 8
2002 17
2003 26
2004 51
2005 67
2006 86
2007 119
2008 167
2009 202
2010 329
2011 347
2012 446
2013 613
2014 725
2015 881
2016 1055
2017 1263
2018 1492
2019 1778
2020 2073
2021 2282
2022 2665
2023 2699
2024 976

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17,744 results

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Page 1
Role of nrf2 in oxidative stress and toxicity.
Ma Q. Ma Q. Annu Rev Pharmacol Toxicol. 2013;53:401-26. doi: 10.1146/annurev-pharmtox-011112-140320. Annu Rev Pharmacol Toxicol. 2013. PMID: 23294312 Free PMC article. Review.
Organismal life encounters reactive oxidants from internal metabolism and environmental toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are traditionally viewed as being harmful. On the other hand, controlled production of oxidants …
Organismal life encounters reactive oxidants from internal metabolism and environmental toxicant exposure. Reactive oxygen and nitrogen spec …
The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging.
Yu C, Xiao JH. Yu C, et al. Oxid Med Cell Longev. 2021 Apr 19;2021:6635460. doi: 10.1155/2021/6635460. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34012501 Free PMC article. Review.
Increased oxidative stress from diverse sources has been implicated in most senescence-related diseases and in aging itself. The Kelch-like ECH-associated protein 1- (Keap1-) nuclear factor-erythroid 2-related factor 2 (Nrf2) system can be used to monitor …
Increased oxidative stress from diverse sources has been implicated in most senescence-related diseases and in aging itself. T …
Oxidative Stress and Cancer: The Role of Nrf2.
Sajadimajd S, Khazaei M. Sajadimajd S, et al. Curr Cancer Drug Targets. 2018;18(6):538-557. doi: 10.2174/1568009617666171002144228. Curr Cancer Drug Targets. 2018. PMID: 28969555 Review.
Oxidative stress due to imbalance between ROS production and detoxification plays a pivotal role in determining cell fate. ...However, through deregulation of biomolecules, high amount of ROS promotes carcinogenesis in cells with defective signaling factors. In this …
Oxidative stress due to imbalance between ROS production and detoxification plays a pivotal role in determining cell fate. ... …
Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation.
Hybertson BM, Gao B, Bose SK, McCord JM. Hybertson BM, et al. Mol Aspects Med. 2011 Aug;32(4-6):234-46. doi: 10.1016/j.mam.2011.10.006. Epub 2011 Oct 15. Mol Aspects Med. 2011. PMID: 22020111 Free article. Review.
For the past 40 years or so, oxidative stress has been increasingly recognized as a contributing factor in aging and in various forms of pathophysiology generally associated with aging. ...Thus, the dysregulation of Nrf2-regulated genes provides a logical exp …
For the past 40 years or so, oxidative stress has been increasingly recognized as a contributing factor in aging and in variou …
Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway.
Chen GH, Song CC, Pantopoulos K, Wei XL, Zheng H, Luo Z. Chen GH, et al. Free Radic Biol Med. 2022 Feb 20;180:95-107. doi: 10.1016/j.freeradbiomed.2022.01.012. Epub 2022 Jan 16. Free Radic Biol Med. 2022. PMID: 35045311
At present, the underlying molecular mechanisms remain elusive. Herein, we hypothesized that mitochondria and the NRF2 (transcription factor nuclear factor E2-related factor 2) are potential mediators of ferroptosis, considering their well-established involvement in the …
At present, the underlying molecular mechanisms remain elusive. Herein, we hypothesized that mitochondria and the NRF2 (transcription …
Nrf2 at the heart of oxidative stress and cardiac protection.
Chen QM, Maltagliati AJ. Chen QM, et al. Physiol Genomics. 2018 Feb 1;50(2):77-97. doi: 10.1152/physiolgenomics.00041.2017. Epub 2017 Nov 29. Physiol Genomics. 2018. PMID: 29187515 Free PMC article. Review.
A long list of small molecules, most derived from natural products, have been characterized as Nrf2 inducers. These compounds disrupt Keap1-mediated Nrf2 ubquitination, thereby prohibiting proteasomal degradation and allowing Nrf2 protein to accumulate and tr …
A long list of small molecules, most derived from natural products, have been characterized as Nrf2 inducers. These compounds disrupt …
Radical-free biology of oxidative stress.
Jones DP. Jones DP. Am J Physiol Cell Physiol. 2008 Oct;295(4):C849-68. doi: 10.1152/ajpcell.00283.2008. Epub 2008 Aug 6. Am J Physiol Cell Physiol. 2008. PMID: 18684987 Free PMC article. Review.
Free radical-induced macromolecular damage has been studied extensively as a mechanism of oxidative stress, but large-scale intervention trials with free radical scavenging antioxidant supplements show little benefit in humans. The present review summarizes data sup …
Free radical-induced macromolecular damage has been studied extensively as a mechanism of oxidative stress, but large-scale in …
Oxidative stress and autophagy: the clash between damage and metabolic needs.
Filomeni G, De Zio D, Cecconi F. Filomeni G, et al. Cell Death Differ. 2015 Mar;22(3):377-88. doi: 10.1038/cdd.2014.150. Epub 2014 Sep 26. Cell Death Differ. 2015. PMID: 25257172 Free PMC article. Review.
A growing amount of evidence in recent years argues for oxidative stress acting as the converging point of these stimuli, with reactive oxygen species (ROS) and reactive nitrogen species (RNS) being among the main intracellular signal transducers sustaining autophag …
A growing amount of evidence in recent years argues for oxidative stress acting as the converging point of these stimuli, with …
Nrf2 Signaling in the Oxidative Stress Response After Spinal Cord Injury.
Guo X, Kang J, Wang Z, Wang Y, Liu M, Zhu D, Yang F, Kang X. Guo X, et al. Neuroscience. 2022 Aug 21;498:311-324. doi: 10.1016/j.neuroscience.2022.06.007. Epub 2022 Jun 14. Neuroscience. 2022. PMID: 35710066 Review.
A series of pathological and physiological changes after SCI (e.g., inflammation, oxidative stress, apoptosis, and mitochondrial dysfunction) promotes further deterioration of the microenvironment at the site of injury, leading to aggravation of neurological functio …
A series of pathological and physiological changes after SCI (e.g., inflammation, oxidative stress, apoptosis, and mitochondri …
Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223/keap1-Nrf2 pathway.
Ding X, Jian T, Wu Y, Zuo Y, Li J, Lv H, Ma L, Ren B, Zhao L, Li W, Chen J. Ding X, et al. Biomed Pharmacother. 2019 Feb;110:85-94. doi: 10.1016/j.biopha.2018.11.018. Epub 2018 Nov 19. Biomed Pharmacother. 2019. PMID: 30466006 Free article.
As a promising new target, miR-233 may regulate oxidative stress by targeting keap1-Nrf2 system to affect the pathological process of liver injury in T2DM. Ellagic acid (EA) is versatile for protecting oxidative stress damage and metabolic disor …
As a promising new target, miR-233 may regulate oxidative stress by targeting keap1-Nrf2 system to affect the pathologi …
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