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438 results

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Page 1
NS1619 Alleviate Brain-Derived Extracellular Vesicle-Induced Brain Injury by Regulating BKca Channel and Nrf2/HO-1/NF-qB Pathway.
Gao Y, Zhang H, Li X, Li L, Li F, Li T, Peng R, Wang C, Wang J, Liu X, Zhang S, Zhang J. Gao Y, et al. Oxid Med Cell Longev. 2022 Nov 23;2022:2257427. doi: 10.1155/2022/2257427. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 36466093 Free PMC article.
The role of BDEV and NS1619 on the Nrf2/HO-1/p65 pathway was also evaluated in HT-22. Finally, we administrated TBI mice with NS1619 to clarify the role of NS1619 against BDEV in vivo. ...NS1619 pretreatment alleviated above process and enhanced antiox …
The role of BDEV and NS1619 on the Nrf2/HO-1/p65 pathway was also evaluated in HT-22. Finally, we administrated TBI mice with NS16 …
NS1619-induced vasodilation is enhanced and differentially mediated in chronically hypoxic lungs.
McCullough DJ, Vang A, Choudhary G. McCullough DJ, et al. Lung. 2014 Oct;192(5):811-7. doi: 10.1007/s00408-014-9633-2. Epub 2014 Aug 8. Lung. 2014. PMID: 25104232 Free PMC article.
PURPOSE: To identify the effect of the benzimidazalone derivative, NS1619, on modulating pulmonary vascular tone in lungs from rats exposed to normoxia (21% FiO2) or chronic hypoxia (10% FiO2) for three weeks. ...RESULTS: Compared to normoxia, NS1619-induced vasodil …
PURPOSE: To identify the effect of the benzimidazalone derivative, NS1619, on modulating pulmonary vascular tone in lungs from rats e …
Immediate neuronal preconditioning by NS1619.
Gáspár T, Domoki F, Lenti L, Katakam PV, Snipes JA, Bari F, Busija DW. Gáspár T, et al. Brain Res. 2009 Aug 18;1285:196-207. doi: 10.1016/j.brainres.2009.06.008. Epub 2009 Jun 11. Brain Res. 2009. PMID: 19523929 Free PMC article.
NS1619 depolarized mitochondria and increased reactive oxygen species (ROS) generation, but neither of these effects was inhibited by BK(Ca) channel antagonists. NS1619 also activated the extracellular signal-regulated kinase signaling pathways. One-hour treatment w …
NS1619 depolarized mitochondria and increased reactive oxygen species (ROS) generation, but neither of these effects was inhibited by …
BK(Ca) Activator NS1619 Improves the Structure and Function of Skeletal Muscle Mitochondria in Duchenne Dystrophy.
Dubinin MV, Starinets VS, Belosludtseva NV, Mikheeva IB, Chelyadnikova YA, Igoshkina AD, Vafina AB, Vedernikov AA, Belosludtsev KN. Dubinin MV, et al. Pharmaceutics. 2022 Oct 29;14(11):2336. doi: 10.3390/pharmaceutics14112336. Pharmaceutics. 2022. PMID: 36365155 Free PMC article.
This effect of NS1619 contributed to the reduction of degeneration/regeneration cycles and fibrosis in the skeletal muscles of mdx mice as well as a normalization of sarcomere size, but had no effect on the leakage of muscle enzymes and muscle strength loss. In the case of …
This effect of NS1619 contributed to the reduction of degeneration/regeneration cycles and fibrosis in the skeletal muscles of mdx mi …
BK channel openers NS1619 and NS11021 reverse hydrogen peroxide-induced membrane potential changes in skeletal muscle.
Coskun C, Buyuknacar HS, Cicek F, Gunay I. Coskun C, et al. J Recept Signal Transduct Res. 2020 Oct;40(5):449-455. doi: 10.1080/10799893.2020.1756324. Epub 2020 Apr 23. J Recept Signal Transduct Res. 2020. PMID: 32326798
For this purpose, resting membrane potentials and action potentials (AP) of frog gastrocnemius muscles were recorded in the presence of commonly used BK channel openers NS1619 and NS11021, H(2)O(2) (a type of ROS), and both using intracellular microelectrode technique. The …
For this purpose, resting membrane potentials and action potentials (AP) of frog gastrocnemius muscles were recorded in the presence of comm …
The potassium channel opener NS1619 modulates calcium homeostasis in muscle cells by inhibiting SERCA.
Wrzosek A. Wrzosek A. Cell Calcium. 2014 Jul;56(1):14-24. doi: 10.1016/j.ceca.2014.03.005. Epub 2014 Apr 18. Cell Calcium. 2014. PMID: 24813114
NS1619 also decreased the activity of SERCA derived from rat skeletal muscle. The calcium release from cell internal stores and inhibition of SERCA by NS1619 are pH dependent. ...The primary target of NS1619 is SERCA, which is located in SR vesicles. The effe …
NS1619 also decreased the activity of SERCA derived from rat skeletal muscle. The calcium release from cell internal stores and inhib …
Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle.
Holland M, Langton PD, Standen NB, Boyle JP. Holland M, et al. Br J Pharmacol. 1996 Jan;117(1):119-29. doi: 10.1111/j.1476-5381.1996.tb15163.x. Br J Pharmacol. 1996. PMID: 8825352 Free PMC article.
In whole cell recordings made from cells voltage-clamped at 0 mV using the perforated-patch technique, addition of NS1619 (10-30 microM) activated an outward current, which reversed following washout of NS1619. 4. ...The activation produced by NS1619 was calc …
In whole cell recordings made from cells voltage-clamped at 0 mV using the perforated-patch technique, addition of NS1619 (10-30 micr …
The BK channel-NS1619 agonist complex reveals molecular insights on allosteric activation gating.
Gonzalez-Sanabria N, Contreras GF, Rojas M, Duarte Y, Gonzalez-Nilo FD, Perozo E, Latorre R. Gonzalez-Sanabria N, et al. bioRxiv [Preprint]. 2025 Apr 1:2025.03.27.645783. doi: 10.1101/2025.03.27.645783. bioRxiv. 2025. Update in: Proc Natl Acad Sci U S A. 2026 Feb 03;123(5):e2507707123. doi: 10.1073/pnas.2507707123. PMID: 40235977 Free PMC article. Updated. Preprint.
Using cryo-electron microscopy and molecular dynamic simulations, we identified that NS1619, a synthetic benzimidazolone agonist, first described as a BK opener, binds within a pocket formed by the S6/RCK1 linker and the S4 transmembrane segment. ...TEASER: BK channel acti …
Using cryo-electron microscopy and molecular dynamic simulations, we identified that NS1619, a synthetic benzimidazolone agonist, fir …
NS1619 regulates the expression of caveolin-1 protein in a time-dependent manner via ROS/PI3K/PKB/FoxO1 signaling pathway in brain tumor microvascular endothelial cells.
Cai RP, Xue YX, Huang J, Wang JH, Wang JH, Zhao SY, Guan TT, Zhang Z, Gu YT. Cai RP, et al. J Neurol Sci. 2016 Oct 15;369:109-118. doi: 10.1016/j.jns.2016.08.007. Epub 2016 Aug 4. J Neurol Sci. 2016. PMID: 27653874
The expression of caveolin-1 and FoxO1 protein at tumor microvessels was enhanced and caveolae-mediated CTB endocytosis was increased by NS1619 infusion for 15min. Compared with the 15min group, the expression of caveolin-1 protein was significantly decreased and the level …
The expression of caveolin-1 and FoxO1 protein at tumor microvessels was enhanced and caveolae-mediated CTB endocytosis was increased by …
Effect of Large-Conductance Calcium-Dependent K(+) Channel Activator NS1619 on Function of Mitochondria in the Heart of Dystrophin-Deficient Mice.
Dubinin MV, Starinets VS, Chelyadnikova YA, Belosludtseva NV, Mikheeva IB, Penkina DK, Igoshkina AD, Talanov EY, Kireev II, Zorov DB, Belosludtsev KN. Dubinin MV, et al. Biochemistry (Mosc). 2023 Feb;88(2):189-201. doi: 10.1134/S0006297923020037. Biochemistry (Mosc). 2023. PMID: 37072326
In addition, we found positive changes in the tissue manifested by the decrease in the level of fibrosis in the heart of dystrophin-deficient animals treated with NS1619. It was noted that NS1619 had no significant effect on the structure and function of heart mitoc …
In addition, we found positive changes in the tissue manifested by the decrease in the level of fibrosis in the heart of dystrophin-deficien …
438 results