Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1978 2
1979 5
1981 1
1982 2
1983 1
1985 1
1986 2
1988 4
1989 6
1990 6
1991 2
1992 1
1993 6
1994 5
1995 5
1996 5
1997 5
1998 11
1999 14
2000 12
2001 10
2002 10
2003 19
2004 27
2005 28
2006 31
2007 31
2008 37
2009 46
2010 49
2011 44
2012 42
2013 50
2014 44
2015 54
2016 59
2017 47
2018 39
2019 53
2020 57
2021 50
2022 31
2023 40
2024 54
2025 43
2026 33

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

1,049 results

Results by year

Filters applied: . Clear all
Page 1
Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity.
Palumbieri MD, Merigliano C, González-Acosta D, Kuster D, Krietsch J, Stoy H, von Känel T, Ulferts S, Welter B, Frey J, Doerdelmann C, Sanchi A, Grosse R, Chiolo I, Lopes M. Palumbieri MD, et al. Nat Commun. 2023 Nov 28;14(1):7819. doi: 10.1038/s41467-023-43183-5. Nat Commun. 2023. PMID: 38016948 Free PMC article.
Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. ...Hence, by limiting PrimP …
Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replic …
DNA replication fork speed underlies cell fate changes and promotes reprogramming.
Nakatani T, Lin J, Ji F, Ettinger A, Pontabry J, Tokoro M, Altamirano-Pacheco L, Fiorentino J, Mahammadov E, Hatano Y, Van Rechem C, Chakraborty D, Ruiz-Morales ER, Arguello Pascualli PY, Scialdone A, Yamagata K, Whetstine JR, Sadreyev RI, Torres-Padilla ME. Nakatani T, et al. Nat Genet. 2022 Mar;54(3):318-327. doi: 10.1038/s41588-022-01023-0. Epub 2022 Mar 7. Nat Genet. 2022. PMID: 35256805 Free PMC article.
We show that totipotent cells of the early mouse embryo have slow DNA replication fork speed and that 2CLCs recapitulate this feature, suggesting that fork speed underlies the transition to a totipotent-like state. 2CLCs emerge concomitant with DNA …
We show that totipotent cells of the early mouse embryo have slow DNA replication fork speed and that 2CLCs recapitulat …
A replication fork determinant for the establishment of sister chromatid cohesion.
Minamino M, Bouchoux C, Canal B, Diffley JFX, Uhlmann F. Minamino M, et al. Cell. 2023 Feb 16;186(4):837-849.e11. doi: 10.1016/j.cell.2022.12.044. Epub 2023 Jan 23. Cell. 2023. PMID: 36693376 Free article.
Concomitant with DNA replication, the chromosomal cohesin complex establishes cohesion between newly replicated sister chromatids. ...Here, we explore how cohesin acetylation is linked to DNA replication. Biochemical reconstitution of replica …
Concomitant with DNA replication, the chromosomal cohesin complex establishes cohesion between newly replicated sister …
Improved detection of DNA replication fork-associated proteins.
Rivard RS, Chang YC, Ragland RL, Thu YM, Kassab M, Mandal RS, Van Riper SK, Kulej K, Higgins L, Markowski TM, Shang D, Hedberg J, Erber L, Garcia B, Chen Y, Bielinsky AK, Brown EJ. Rivard RS, et al. Cell Rep. 2024 May 28;43(5):114178. doi: 10.1016/j.celrep.2024.114178. Epub 2024 May 2. Cell Rep. 2024. PMID: 38703364 Free PMC article.
Innovative methods to retrieve proteins associated with actively replicating DNA have provided a glimpse into the molecular dynamics of replication fork stalling. ...Replication protein abundance in retrieved nascent DNA is elevated up to …
Innovative methods to retrieve proteins associated with actively replicating DNA have provided a glimpse into the molecular dy …
ATR prohibits replication catastrophe by preventing global exhaustion of RPA.
Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J. Toledo LI, et al. Cell. 2013 Nov 21;155(5):1088-103. doi: 10.1016/j.cell.2013.10.043. Cell. 2013. PMID: 24267891 Free article.
Although initially stable, stalled forks in ATR-deficient cells undergo nucleus-wide breakage after unscheduled origin firing generates an excess of single-stranded DNA that exhausts the nuclear pool of RPA. Partial reduction of RPA accelerated fork breakage, …
Although initially stable, stalled forks in ATR-deficient cells undergo nucleus-wide breakage after unscheduled origin firing generates an e …
IFI16 senses and protects stalled replication forks.
Gamble A, Ward TA, Wheeler OPG, Morris JP, Jones CM, Bennett LG, Vernon EG, Thanendran V, Ceppi I, Halder S, Borrello D, Walker TDJ, Rajan J, Suleiman H, Harrison D, Alshetiwi M, Dunphy G, Jackson-Jones LH, Cejka P, Unterholzner L, Staples CJ. Gamble A, et al. Mol Cell. 2026 Jan 22;86(2):258-272.e6. doi: 10.1016/j.molcel.2025.12.024. Epub 2026 Jan 8. Mol Cell. 2026. PMID: 41512859 Free article.
Replication stress is a key driver of DNA damage and genome instability. Here, we report that replication stress induces an inflammatory response in the absence of DNA damage. ...Replication stress-induced fork remodeling generates a new …
Replication stress is a key driver of DNA damage and genome instability. Here, we report that replication stress induce …
DNA replication and replication stress response in the context of nuclear architecture.
González-Acosta D, Lopes M. González-Acosta D, et al. Chromosoma. 2024 Jan;133(1):57-75. doi: 10.1007/s00412-023-00813-7. Epub 2023 Dec 6. Chromosoma. 2024. PMID: 38055079 Free PMC article. Review.
The DNA replication process needs to be coordinated with other DNA metabolism transactions and must eventually extend to the full genome, regardless of chromatin status, gene expression, secondary structures and DNA lesions. ...While much has recently …
The DNA replication process needs to be coordinated with other DNA metabolism transactions and must eventually extend t …
ATRX cooperates with TOP2B for replication fork stability and DNA damage response through G-quadruplex regulation.
Pang Y, Cheng M, Wang J, Wang R, Chen X, Zhang C, Yang Y, Ji T, Liu M, Zhang J, Zhong C. Pang Y, et al. Nucleic Acids Res. 2025 Sep 23;53(18):gkaf939. doi: 10.1093/nar/gkaf939. Nucleic Acids Res. 2025. PMID: 40990248 Free PMC article.
Here, we identify TOP2B as a previously unrecognized regulator of G4 homeostasis and show that it functionally cooperates with ATRX to facilitate G4 resolution during DNA replication. Disruption of this pathway by CX-5461, a small molecule originally developed as an …
Here, we identify TOP2B as a previously unrecognized regulator of G4 homeostasis and show that it functionally cooperates with ATRX to facil …
RIF1 controls replication timing in early mouse embryos independently of lamina-associated nuclear organization.
Nakatani T, Schauer T, Pal M, Ettinger A, Altamirano-Pacheco L, Zorn J, Gilbert DM, Torres-Padilla ME. Nakatani T, et al. Dev Cell. 2025 Aug 18;60(16):2149-2162.e7. doi: 10.1016/j.devcel.2025.03.016. Epub 2025 Apr 21. Dev Cell. 2025. PMID: 40262611 Free PMC article.
Here, by combining loss-of-function analysis with genome-wide investigation of RT in mouse embryos, we identify Rap1 interacting factor 1 (RIF1) as a regulator of the progressive consolidation of RT. Embryos without RIF1 show DNA replication features of an early, mo …
Here, by combining loss-of-function analysis with genome-wide investigation of RT in mouse embryos, we identify Rap1 interacting factor 1 (R …
53BP1-the 'Pandora's box' of genome integrity.
Kilgas S, Swift ML, Chowdhury D. Kilgas S, et al. DNA Repair (Amst). 2024 Dec;144:103779. doi: 10.1016/j.dnarep.2024.103779. Epub 2024 Oct 28. DNA Repair (Amst). 2024. PMID: 39476547 Free PMC article. Review.
While its DSB repair functions are relatively well-characterized, its role in DNA replication and replication fork protection is less understood. In response to replication stress, 53BP1 contributes to fork protection by regulating for …
While its DSB repair functions are relatively well-characterized, its role in DNA replication and replication fork …
1,049 results