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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1939 1
1955 1
1958 1
1959 1
1960 4
1961 4
1962 1
1963 9
1964 4
1965 6
1966 5
1967 6
1968 5
1969 9
1970 4
1971 9
1972 12
1973 8
1974 7
1975 49
1976 55
1977 30
1978 40
1979 32
1980 34
1981 21
1982 42
1983 43
1984 37
1985 43
1986 33
1987 39
1988 41
1989 43
1990 47
1991 57
1992 76
1993 64
1994 61
1995 86
1996 96
1997 124
1998 104
1999 95
2000 119
2001 123
2002 115
2003 108
2004 145
2005 129
2006 152
2007 167
2008 175
2009 140
2010 161
2011 169
2012 165
2013 149
2014 197
2015 162
2016 165
2017 141
2018 153
2019 135
2020 164
2021 170
2022 178
2023 190
2024 153
2025 162
2026 94

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5,175 results

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Page 1
Dynamics of nucleoplasm in human leukemia cells: A thrust towards designing anti-leukemic agents.
Bairagya HR. Bairagya HR. J Mol Graph Model. 2024 Sep;131:108807. doi: 10.1016/j.jmgm.2024.108807. Epub 2024 Jun 13. J Mol Graph Model. 2024. PMID: 38908255 Review.
Finally, a computational model and its dynamics of the nucleoplasm for CML cells have been proposed in this short review. This research on nucleoplasm aims to aid the scientific community's understanding of how metabolic enzymes like hIMPDH function in cancer and no …
Finally, a computational model and its dynamics of the nucleoplasm for CML cells have been proposed in this short review. This resear …
Mechanomemory in protein diffusivity of chromatin and nucleoplasm after force cessation.
Rashid F, Liu W, Wang Q, Ji B, Irudayaraj J, Wang N. Rashid F, et al. Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2221432120. doi: 10.1073/pnas.2221432120. Epub 2023 Mar 21. Proc Natl Acad Sci U S A. 2023. PMID: 36943889 Free PMC article.
However, after cessation of the force, how structures are altered in response to the dynamics of the chromatin and molecules in the nucleoplasm remains elusive. Here, using single-molecule imaging approaches, we show that exogenous local forces via integrins applied for 2 …
However, after cessation of the force, how structures are altered in response to the dynamics of the chromatin and molecules in the nucle …
Nucleolar dynamics and interactions with nucleoplasm in living cells.
Caragine CM, Haley SC, Zidovska A. Caragine CM, et al. Elife. 2019 Nov 26;8:e47533. doi: 10.7554/eLife.47533. Elife. 2019. PMID: 31769409 Free PMC article.
Here, we study the motion of human nucleoli in vivo, while monitoring the shape of the nucleolus-nucleoplasm interface. We reveal two types of nucleolar pair dynamics: an unexpected correlated motion prior to coalescence and an independent motion otherwise. ...Our results …
Here, we study the motion of human nucleoli in vivo, while monitoring the shape of the nucleolus-nucleoplasm interface. We reveal two …
Active processes shape and move the genome and nucleoplasm.
Zidovska A. Zidovska A. Curr Opin Genet Dev. 2026 Jun 18;99:102489. doi: 10.1016/j.gde.2026.102489. Online ahead of print. Curr Opin Genet Dev. 2026. PMID: 42314509 Free article. Review.
From genome-based activities such as transcription and replication, to metabolic activity in the nucleoplasm and its liquid condensates, the nucleus is far from thermodynamic equilibrium. The nucleus' active nature leads to many emergent properties of its principal compone …
From genome-based activities such as transcription and replication, to metabolic activity in the nucleoplasm and its liquid condensat …
Off-pore Nucleoporin sPOM121 Transcriptionally Propels β-Catenin-driven Tumor Progression and Immune Escape in Prostate Cancer.
Kirthika P, Jawalagatti V, Li P, Xu M, Carceles-Cordon M, Ertel A, Quinn SA, Petrylak DP, Orme JJ, Dehm SM, Antonarakis ES, Heath EI, Pandey MK, Cordon-Cardo C, Huang H, Dong H, Zhu S, Domingo-Domenech J, Rodriguez-Bravo V. Kirthika P, et al. Cancer Discov. 2025 Nov 3;15(11):2374-2396. doi: 10.1158/2159-8290.CD-25-0629. Cancer Discov. 2025. PMID: 40709833 Free PMC article.
The roles of nucleoplasm-residing nucleoporins (NUP) in solid tumors, including prostate cancer, remain unknown. ...Using orthogonal methodologies in human samples, sPOM121 was identified as the predominantly expressed nucleoplasmic NUP in prostate cancer. Unbiased …
The roles of nucleoplasm-residing nucleoporins (NUP) in solid tumors, including prostate cancer, remain unknown. ...Using orthogonal …
Mad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila.
Raich N, Mahmoudi S, Emre D, Karess RE. Raich N, et al. Open Biol. 2018 Oct 17;8(10):180166. doi: 10.1098/rsob.180166. Open Biol. 2018. PMID: 30333236 Free PMC article.
The Drosophila Mad1 spindle checkpoint protein helps organize several nucleoplasmic components, and flies lacking Mad1 present changes in gene expression reflecting altered chromatin conformation. ...Together these results suggest that Drosophila Mad1, by helping organize …
The Drosophila Mad1 spindle checkpoint protein helps organize several nucleoplasmic components, and flies lacking Mad1 present change …
Studying lamins in invertebrate models.
Lyakhovetsky R, Gruenbaum Y. Lyakhovetsky R, et al. Adv Exp Med Biol. 2014;773:245-62. doi: 10.1007/978-1-4899-8032-8_11. Adv Exp Med Biol. 2014. PMID: 24563351 Review.
Lamins form a proteinaceous meshwork that outlines the nucleoplasmic side of the inner nuclear membrane, while a small fraction of lamin molecules is also present in the nucleoplasm. ...
Lamins form a proteinaceous meshwork that outlines the nucleoplasmic side of the inner nuclear membrane, while a small fraction of la …
LINCing Senescence and Nuclear Envelope Changes.
Meqbel BRM, Gomes M, Omer A, Gallouzi IE, Horn HF. Meqbel BRM, et al. Cells. 2022 May 30;11(11):1787. doi: 10.3390/cells11111787. Cells. 2022. PMID: 35681483 Free PMC article. Review.
Beyond its role as a barrier to separate the nucleoplasm from the cytoplasm, the NE's role in supporting and maintaining a myriad of other functions has made it a target of study in many cellular processes, including senescence. ...LINC complexes span the NE, forming physi …
Beyond its role as a barrier to separate the nucleoplasm from the cytoplasm, the NE's role in supporting and maintaining a myriad of …
Single ovalbumin molecules exploring nucleoplasm and nucleoli of living cell nuclei.
Speil J, Kubitscheck U. Speil J, et al. Biochim Biophys Acta. 2010 Mar;1803(3):396-404. doi: 10.1016/j.bbamcr.2009.10.010. Epub 2009 Nov 4. Biochim Biophys Acta. 2010. PMID: 19895852 Free article.
Like many macromolecular probes ovalbumin was significantly less abundant in nucleoli compared to the nucleoplasm. High-speed fluorescence microscopy allowed visualizing and analyzing single tracer molecule trajectories within nucleoli and nucleoplasm. In accordance …
Like many macromolecular probes ovalbumin was significantly less abundant in nucleoli compared to the nucleoplasm. High-speed fluores …
Three-dimensional imaging reveals endo(sarco)plasmic reticulum-containing invaginations within the nucleoplasm of muscle.
Lee SH, Hadipour-Lakmehsari S, Miyake T, Gramolini AO. Lee SH, et al. Am J Physiol Cell Physiol. 2018 Mar 1;314(3):C257-C267. doi: 10.1152/ajpcell.00141.2017. Epub 2017 Nov 22. Am J Physiol Cell Physiol. 2018. PMID: 29167149 Free PMC article.
In fact, nucleoplasmic Ca(2+) homeostasis has been implicated in the regulation of gene expression, DNA repair, and cell death. ...We have shown for the first time the presence of STIM1 and ORAI1 in the nucleoplasm, suggesting the presence of store-operated calcium …
In fact, nucleoplasmic Ca(2+) homeostasis has been implicated in the regulation of gene expression, DNA repair, and cell death. ...We …
5,175 results