Abstract
Clinical efficacy of sodium nucleospermate (SNS) has shown in the treatment of 26 female patients with chronic endometritis, unsuccessful attempts at in vitro fertilization, and persistent viral infection. Cells from endometrium were processed by liquid cytology and studied by immunocytochemistry techniques. It has been clearly established that, after SNS treatment, the frequency of CD20- and CD56-positive cells was significantly decreased (p < 0.05) and the frequency of TLR4 and TLR9 expressing cells in endometrium has been significantly improved (p < 0.05). In addition, the human papilloma virus (HPV) load was reduced as manifested by the real-time PCR test. The obtained results show good prospects for successful use SNS as a means of pathogenetic therapy in patients with this diagnosis.
MeSH terms
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Antigens, CD20 / immunology
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Antiviral Agents / administration & dosage*
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CD56 Antigen / immunology
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Endometritis* / complications
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Endometritis* / drug therapy
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Endometritis* / immunology
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Endometritis* / pathology
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Endometritis* / virology
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Endometrium / immunology*
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Endometrium / pathology
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Female
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Humans
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Immunologic Factors / administration & dosage*
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Infertility, Female* / drug therapy
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Infertility, Female* / etiology
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Infertility, Female* / immunology
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Infertility, Female* / pathology
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Infertility, Female* / virology
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Papillomavirus Infections* / complications
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Papillomavirus Infections* / diet therapy
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Papillomavirus Infections* / immunology
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Papillomavirus Infections* / pathology
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Toll-Like Receptor 4 / immunology
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Toll-Like Receptor 9 / immunology
Substances
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Antigens, CD20
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Antiviral Agents
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CD56 Antigen
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Immunologic Factors
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NCAM1 protein, human
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TLR4 protein, human
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TLR9 protein, human
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Toll-Like Receptor 4
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Toll-Like Receptor 9