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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 1
1958 1
1959 2
1960 1
1961 3
1962 4
1963 6
1964 24
1965 33
1966 35
1967 50
1968 74
1969 81
1970 142
1971 226
1972 295
1973 312
1974 356
1975 503
1976 508
1977 446
1978 417
1979 445
1980 468
1981 453
1982 463
1983 494
1984 553
1985 576
1986 505
1987 548
1988 576
1989 711
1990 720
1991 806
1992 856
1993 910
1994 1013
1995 1126
1996 1223
1997 1239
1998 1506
1999 1352
2000 1501
2001 1571
2002 1618
2003 1747
2004 1868
2005 1773
2006 1942
2007 1920
2008 1902
2009 1994
2010 2066
2011 2112
2012 2092
2013 2138
2014 2062
2015 2026
2016 1888
2017 1930
2018 1689
2019 1786
2020 1899
2021 1906
2022 1771
2023 1664
2024 1973
2025 2275
2026 1255

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65,712 results

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Page 1
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Sun L, Wu J, Du F, Chen X, Chen ZJ. Sun L, et al. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012 Dec 20. Science. 2013. PMID: 23258413 Free PMC article.
Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING. Through biochemical fractionation and quantitative mass spectrometry, we i …
Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP …
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling.
Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. Xian H, et al. Immunity. 2022 Aug 9;55(8):1370-1385.e8. doi: 10.1016/j.immuni.2022.06.007. Epub 2022 Jul 13. Immunity. 2022. PMID: 35835107 Free PMC article.
Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via cGAS-STING pathway activation and, when oxidized (Ox-mtDNA), it binds cytosolic NLRP3, thereby triggering inflammasome activation. ...Within mitochondria, Ox-mtDNA was either repaired …
Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via cGAS-STING pathway activation and, when oxidized ( …
p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression.
Ghosh M, Saha S, Li J, Montrose DC, Martinez LA. Ghosh M, et al. Mol Cell. 2023 Jan 19;83(2):266-280.e6. doi: 10.1016/j.molcel.2022.12.023. Epub 2023 Jan 12. Mol Cell. 2023. PMID: 36638783 Free PMC article.
TREX1 overexpression sufficed to block p53 activation of the cGAS/STING pathway. p53-mediated induction of type I interferon (IFNB1) is suppressed by cGAS/STING knockout, and p53's tumor suppressor activities are compromised by the loss of signaling through the cGAS …
TREX1 overexpression sufficed to block p53 activation of the cGAS/STING pathway. p53-mediated induction of type I interferon (IFNB1) …
The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance.
Xu Y, Wang Q, Wang J, Qian C, Wang Y, Lu S, Song L, He Z, Liu W, Wan W. Xu Y, et al. Immunity. 2025 Feb 11;58(2):309-325.e6. doi: 10.1016/j.immuni.2024.11.017. Epub 2024 Dec 16. Immunity. 2025. PMID: 39689715 Free article.
Here, we discovered that the cGAS-STING pathway upregulated lysosomal activity by stimulating lysosome biogenesis independently of the downstream protein kinase TANK-binding kinase 1 (TBK1). ...STING-induced lipidation of GABA type A receptor-associated protein (GABARAP), …
Here, we discovered that the cGAS-STING pathway upregulated lysosomal activity by stimulating lysosome biogenesis independently of th …
DNA-induced liquid phase condensation of cGAS activates innate immune signaling.
Du M, Chen ZJ. Du M, et al. Science. 2018 Aug 17;361(6403):704-709. doi: 10.1126/science.aat1022. Epub 2018 Jul 5. Science. 2018. PMID: 29976794 Free PMC article.
The binding of DNA to cyclic GMP-AMP synthase (cGAS) leads to the production of the secondary messenger cyclic GMP-AMP (cGAMP), which activates innate immune responses. We have shown that DNA binding to cGAS robustly induced the formation of liquidlike droplets in which cG …
The binding of DNA to cyclic GMP-AMP synthase (cGAS) leads to the production of the secondary messenger cyclic GMP-AMP (cGAMP), which act …
XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury.
Liu Z, Wang M, Wang X, Bu Q, Wang Q, Su W, Li L, Zhou H, Lu L. Liu Z, et al. Redox Biol. 2022 Jun;52:102305. doi: 10.1016/j.redox.2022.102305. Epub 2022 Mar 28. Redox Biol. 2022. PMID: 35367811 Free PMC article.
Here, we investigated the effects of XBP1 inhibition on promoting hepatocellular pyroptosis to activate macrophage STING signaling during ALI. While both TAA- and LPS-induced ALI triggered XBP1 activation in hepatocytes, hepatocyte-specific XBP1 knockout mice exhibi …
Here, we investigated the effects of XBP1 inhibition on promoting hepatocellular pyroptosis to activate macrophage STING signaling du …
The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications.
Shen M, Jiang X, Peng Q, Oyang L, Ren Z, Wang J, Peng M, Zhou Y, Deng X, Liao Q. Shen M, et al. J Hematol Oncol. 2025 Apr 5;18(1):40. doi: 10.1186/s13045-025-01691-5. J Hematol Oncol. 2025. PMID: 40188340 Free PMC article. Review.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is a key innate immune signal that activates the immune response and exerts antitumor effects; this is primarily attributed to the DNA receptor function of cGAS, which recognizes ex …
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is a key innate immune signal that activates …
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS.
Lahaye X, Tran Van P, Chakraborty C, Shmakova A, Cao NTB, Ferran H, Ait-Mohamed O, Maurin M, Waterfall JJ, Kaufer BB, Fischer P, Hennig T, Dölken L, Lomonte P, Fachinetti D, Manel N. Lahaye X, et al. Cell. 2025 Jul 24;188(15):4043-4057.e21. doi: 10.1016/j.cell.2025.05.008. Epub 2025 Jun 2. Cell. 2025. PMID: 40460826 Free article.
While cytosolic cGAS detects viral DNA, most DNA viruses shield their genome and invade the nucleus, where chromatin restricts cGAS activation. How viruses may activate nuclear cGAS is not well understood. Here, we show that several herpesvirus proteins trigger nucl …
While cytosolic cGAS detects viral DNA, most DNA viruses shield their genome and invade the nucleus, where chromatin restricts cGAS activ …
mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.
Yang NS, Zhong WJ, Sha HX, Zhang CY, Jin L, Duan JX, Xiong JB, You ZJ, Zhou Y, Guan CX. Yang NS, et al. Int J Biol Sci. 2024 Mar 3;20(5):1927-1946. doi: 10.7150/ijbs.91543. eCollection 2024. Int J Biol Sci. 2024. PMID: 38481801 Free PMC article.
We found that prolonged anesthesia with sevoflurane induced cognitive dysfunction and triggered the neuroinflammation characterized by the activation of NLRP3 inflammasome in vivo. Interestingly, the cGAS-STING pathway was activated in the hippocampus of mice receiv …
We found that prolonged anesthesia with sevoflurane induced cognitive dysfunction and triggered the neuroinflammation characterized by the …
The mechanism of STING autoinhibition and activation.
Liu S, Yang B, Hou Y, Cui K, Yang X, Li X, Chen L, Liu S, Zhang Z, Jia Y, Xie Y, Xue Y, Li X, Yan B, Wu C, Deng W, Qi J, Lu D, Gao GF, Wang P, Shang G. Liu S, et al. Mol Cell. 2023 May 4;83(9):1502-1518.e10. doi: 10.1016/j.molcel.2023.03.029. Epub 2023 Apr 21. Mol Cell. 2023. PMID: 37086726 Free article.
2',3'-cGAMP, produced by the DNA sensor cGAS, activates stimulator of interferon genes (STING) and triggers immune response during infection. ...Our data together provide a panoramic vision regarding STING autoinhibition and activation, which adds substantially to c …
2',3'-cGAMP, produced by the DNA sensor cGAS, activates stimulator of interferon genes (STING) and triggers immune response during in …
65,712 results
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