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Page 1
Genetics of obsessive-compulsive disorder.
Mahjani B, Bey K, Boberg J, Burton C. Mahjani B, et al. Psychol Med. 2021 Oct;51(13):2247-2259. doi: 10.1017/S0033291721001744. Epub 2021 May 25. Psychol Med. 2021. PMID: 34030745 Free PMC article. Review.
Multiple studies have provided reliable support for a large additive genetic contribution to liability to OCD, with discrete OCD symptom dimensions having both shared and unique genetic risks. ...Future investigations should increase ancestral genetic diversity, exp …
Multiple studies have provided reliable support for a large additive genetic contribution to liability to OCD, with discrete OCD …
Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective.
Pauls DL, Abramovitch A, Rauch SL, Geller DA. Pauls DL, et al. Nat Rev Neurosci. 2014 Jun;15(6):410-24. doi: 10.1038/nrn3746. Nat Rev Neurosci. 2014. PMID: 24840803 Review.
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviours that are experienced as unwanted. Family and twin studies have demonstrated that OCD is a multifactorial familial condition that involves both polygenic and environmental risk …
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviours that are experienced as unwanted. Family a …
Serotonin system gene variants and regional brain volume differences in pediatric OCD.
Sinopoli VM, Erdman L, Burton CL, Easter P, Rajendram R, Baldwin G, Peterman K, Coste J, Shaheen SM, Hanna GL, Rosenberg DR, Arnold PD. Sinopoli VM, et al. Brain Imaging Behav. 2020 Oct;14(5):1612-1625. doi: 10.1007/s11682-019-00092-w. Brain Imaging Behav. 2020. PMID: 31187473 Free PMC article.
We hypothesized that select serotonin gene variants would differ in their relationship with brain volume in specific regions of the cortico-striato-thalamo-cortical (CSTC) circuits between OCD patients and controls. ...In males and females separately, we first teste …
We hypothesized that select serotonin gene variants would differ in their relationship with brain volume in specific regions of the c …
Association between TNF-alpha-238G/A gene polymorphism and OCD susceptibility: A meta-analysis.
Jiang C, Ma X, Qi S, Han G, Li Y, Liu Y, Liu L. Jiang C, et al. Medicine (Baltimore). 2018 Feb;97(5):e9769. doi: 10.1097/MD.0000000000009769. Medicine (Baltimore). 2018. PMID: 29384866 Free PMC article.
We performed this meta-analysis to assess the relationship between susceptibility to OCD and the TNF-alpha-238G/A gene polymorphism. METHODS: An extensive search of the available literature on the association between the susceptibility to OCD and the TNF g …
We performed this meta-analysis to assess the relationship between susceptibility to OCD and the TNF-alpha-238G/A gene polymor …
OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior.
Zike ID, Chohan MO, Kopelman JM, Krasnow EN, Flicker D, Nautiyal KM, Bubser M, Kellendonk C, Jones CK, Stanwood G, Tanaka KF, Moore H, Ahmari SE, Veenstra-VanderWeele J. Zike ID, et al. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5719-5724. doi: 10.1073/pnas.1701736114. Epub 2017 May 15. Proc Natl Acad Sci U S A. 2017. PMID: 28507136 Free PMC article.
Using amphetamine as a probe, we found that EAAT3 loss prevents expected increases in (i) locomotor activity, (ii) stereotypy, and (iii) immediate early gene induction in the dorsal striatum following amphetamine administration. Further, Slc1a1-STOP mice showed diminished …
Using amphetamine as a probe, we found that EAAT3 loss prevents expected increases in (i) locomotor activity, (ii) stereotypy, and (iii) imm …
Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis.
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS). International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS). Mol Psychiatry. 2018 May;23(5):1181-1188. doi: 10.1038/mp.2017.154. Epub 2017 Aug 1. Mol Psychiatry. 2018. PMID: 28761083 Free PMC article.
Two obsessive-compulsive disorder (OCD) genome-wide association studies (GWASs) have been published by independent OCD consortia, the International Obsessive-Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and the OCD Collaborative Genetics A …
Two obsessive-compulsive disorder (OCD) genome-wide association studies (GWASs) have been published by independent OCD consort …
Prader-Willi Syndrome and Chromosome 15q11.2 BP1-BP2 Region: A Review.
Butler MG. Butler MG. Int J Mol Sci. 2023 Feb 21;24(5):4271. doi: 10.3390/ijms24054271. Int J Mol Sci. 2023. PMID: 36901699 Free PMC article. Review.
Lower magnesium levels are reported in those with Type I deletions. The CYFIP1 gene encodes a protein associated with fragile X syndrome. The TUBGCP5 gene is associated with attention-deficit hyperactivity disorder (ADHD) and compulsions, more commonly seen in PWS w …
Lower magnesium levels are reported in those with Type I deletions. The CYFIP1 gene encodes a protein associated with fragile X syndr …
Relationship between gene-environment interaction and obsessive-compulsive disorder: A systematic review.
Wang L, Chen Y, Wang M, Zhao C, Qiao D. Wang L, et al. J Psychiatr Res. 2023 Aug;164:281-290. doi: 10.1016/j.jpsychires.2023.06.004. Epub 2023 Jun 24. J Psychiatr Res. 2023. PMID: 37390623 Review.
G E has been studied in the occurrence and development of many neuropsychiatric disorders, including obsessive-compulsive disorder (OCD). AIM: A systematic review was conducted to investigate the role of G E plays in OCD. ...RESULTS: Information from this systematic …
G E has been studied in the occurrence and development of many neuropsychiatric disorders, including obsessive-compulsive disorder (OCD …
Genetics of obsessive-compulsive disorder.
Purty A, Nestadt G, Samuels JF, Viswanath B. Purty A, et al. Indian J Psychiatry. 2019 Jan;61(Suppl 1):S37-S42. doi: 10.4103/psychiatry.IndianJPsychiatry_518_18. Indian J Psychiatry. 2019. PMID: 30745675 Free PMC article. Review.
The family studies and twin studies establish the heritability of OCD. Candidate gene approaches have implicated genes in the serotonergic, glutamatergic, and dopaminergic pathways. GWAS has not produced significant results possibly due to the small sample si …
The family studies and twin studies establish the heritability of OCD. Candidate gene approaches have implicated genes …
Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis.
Kumar P, Rai V. Kumar P, et al. Metab Brain Dis. 2020 Feb;35(2):241-251. doi: 10.1007/s11011-019-00495-0. Epub 2019 Dec 26. Metab Brain Dis. 2020. PMID: 31879835 Review.
Catechol-O-methyltransferase (COMT) enzyme has an important role in inactivation of dopamine and higher dopamine levels may be implicated in OCD, hence COMT gene is a suitable candidate for OCD. Several case-control studies have evaluated the role of COMT Val …
Catechol-O-methyltransferase (COMT) enzyme has an important role in inactivation of dopamine and higher dopamine levels may be implicated in …
715 results