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Oclacitinib 10 years later: lessons learned and directions for the future.
Marsella R, Doerr K, Gonzales A, Rosenkrantz W, Schissler J, White A. Marsella R, et al. J Am Vet Med Assoc. 2023 Mar 25;261(S1):S36-S47. doi: 10.2460/javma.22.12.0570. Print 2023 Jun 1. J Am Vet Med Assoc. 2023. PMID: 36944222 Review.
Oclacitinib was approved in the United States 10 years ago for the management of atopic dermatitis (AD) and allergic skin disease in dogs. ...The purpose of this review is to present the current knowledge on the efficacy, speed of action, effects on the immune system, and …
Oclacitinib was approved in the United States 10 years ago for the management of atopic dermatitis (AD) and allergic skin disease in …
A Comprehensive Overview of Globally Approved JAK Inhibitors.
Shawky AM, Almalki FA, Abdalla AN, Abdelazeem AH, Gouda AM. Shawky AM, et al. Pharmaceutics. 2022 May 6;14(5):1001. doi: 10.3390/pharmaceutics14051001. Pharmaceutics. 2022. PMID: 35631587 Free PMC article. Review.
These drugs are abrocitinib, baricitinib, delgocitinib, fedratinib, filgotinib, oclacitinib, pacritinib, peficitinib, ruxolitinib, tofacitinib, and upadacitinib. ...
These drugs are abrocitinib, baricitinib, delgocitinib, fedratinib, filgotinib, oclacitinib, pacritinib, peficitinib, ruxolitinib, to …
Immunomodulatory effect of long-term oclacitinib maleate therapy in dogs with atopic dermatitis.
De Caro Martins G, da Costa-Val AP, Coura FM, Diamantino GML, Nogueira MM, de Oliveira Melo-Junior OA, Giunchetti RC, da Silveira-Lemos D, Melo MM. De Caro Martins G, et al. Vet Dermatol. 2022 Apr;33(2):142-e40. doi: 10.1111/vde.13037. Epub 2021 Nov 7. Vet Dermatol. 2022. PMID: 34747068
However, the impact of chronic oclacitinib use on immunocompetence requires further investigation. OBJECTIVES: Herein, we examined the potential immunomodulatory effects of prolonged oclacitinib treatment in dogs. ANIMALS: Thirteen privately owned dogs with cAD, tre …
However, the impact of chronic oclacitinib use on immunocompetence requires further investigation. OBJECTIVES: Herein, we examined th …
Use of oclacitinib as antipruritic drug during sarcoptic mange infestation treatment.
Cornegliani L, Guidi E, Vercelli A. Cornegliani L, et al. Vet Dermatol. 2020 Dec;31(6):505. doi: 10.1111/vde.12920. Vet Dermatol. 2020. PMID: 33226173
The aim of this retrospective study was to evaluate efficacy of oclacitinib in alleviating pruritus and inflammation in dogs affected by scabies. ...All dogs were treated at day (D)0 with systemic antiparasitic drugs (e.g. moxidectin, sarolaner, afoxolaner) in association …
The aim of this retrospective study was to evaluate efficacy of oclacitinib in alleviating pruritus and inflammation in dogs affected …
A pharmacokinetic study of oclacitinib maleate in six cats.
Ferrer L, Carrasco I, Cristòfol C, Puigdemont A. Ferrer L, et al. Vet Dermatol. 2020 Apr;31(2):134-137. doi: 10.1111/vde.12819. Epub 2019 Nov 26. Vet Dermatol. 2020. PMID: 31769185
BACKGROUND: Oclacitinib is a Janus kinase (JK)1 inhibitor that has been shown to be effective and safe for the treatment of allergic dermatitis in dogs. ...OBJECTIVE: To determine the pharmacokinetic parameters of oclacitinib in cats after oral and intravenous admin …
BACKGROUND: Oclacitinib is a Janus kinase (JK)1 inhibitor that has been shown to be effective and safe for the treatment of allergic …
Oclacitinib and Myxoma Virus Therapy in Dogs with High-Grade Soft Tissue Sarcoma.
Ashton LV, Weishaar KM, Séguin B, MacNeill AL. Ashton LV, et al. Biomedicines. 2023 Aug 23;11(9):2346. doi: 10.3390/biomedicines11092346. Biomedicines. 2023. PMID: 37760788 Free PMC article.
These studies indicated that, as in murine and human cells, type I interferons (IFN) play an important role in limiting MYXV replication in canine cancer cells. To reduce type I IFN production during OV, oclacitinib (a JAK1 inhibitor) was administered twice daily to dogs f …
These studies indicated that, as in murine and human cells, type I interferons (IFN) play an important role in limiting MYXV replication in …
Efficacy of oclacitinib for the control of feline atopic skin syndrome: correlating plasma concentrations with clinical response.
Carrasco I, Ferrer L, Puigdemont A. Carrasco I, et al. J Feline Med Surg. 2022 Aug;24(8):787-793. doi: 10.1177/1098612X211048458. Epub 2021 Oct 6. J Feline Med Surg. 2022. PMID: 34612749 Free PMC article.
Oclacitinib concentrations showed no correlation with clinical effects (SCORFAD and PVAS). CONCLUSIONS AND RELEVANCE: Oclacitinib emerged as being safe and effective to control clinical signs of FASS. ...
Oclacitinib concentrations showed no correlation with clinical effects (SCORFAD and PVAS). CONCLUSIONS AND RELEVANCE: Oclacitinib …
The use of oclacitinib compared to azathioprine in the management of canine pemphigus foliaceus: A retrospective analysis.
Hernandez-Bures A, Bidot WA, Griffin CE, Rosenkrantz WS. Hernandez-Bures A, et al. Vet Dermatol. 2023 Dec;34(6):554-566. doi: 10.1111/vde.13203. Epub 2023 Sep 12. Vet Dermatol. 2023. PMID: 37700599
BACKGROUND: Oclacitinib (Apoquel; Zoetis) has been reported to be beneficial for treating immune-mediated disorders. HYPOTHESIS/OBJECTIVES: This retrospective study evaluates in which group of dogs [oclacitinib (OC) or azathioprine (AZ)] remission of pemphigus folia …
BACKGROUND: Oclacitinib (Apoquel; Zoetis) has been reported to be beneficial for treating immune-mediated disorders. HYPOTHESIS/OBJEC …
Evaluation of topical oclacitinib and nail trimming as a treatment for murine ulcerative dermatitis in laboratory mice.
Davison SE, Emmer KM, Ugiliweneza B, Sherwood LC. Davison SE, et al. PLoS One. 2022 Oct 18;17(10):e0276333. doi: 10.1371/journal.pone.0276333. eCollection 2022. PLoS One. 2022. PMID: 36256616 Free PMC article.
Additionally, topical oclacitinib was shown to improve an induced model of dermatitis in mice. ...However, further studies may be warranted to investigate other potential applications of oclacitinib to treat UD....
Additionally, topical oclacitinib was shown to improve an induced model of dermatitis in mice. ...However, further studies may be war …
114 results

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