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72 results

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Page 1
Ofloxacin otic solution: a review of its use in the management of ear infections.
Simpson KL, Markham A. Simpson KL, et al. Drugs. 1999 Sep;58(3):509-31. doi: 10.2165/00003495-199958030-00019. Drugs. 1999. PMID: 10493278 Review.
Ofloxacin has been formulated as a 0.3% otic solution for the treatment of ear infections. Topical administration of ofloxacin otic solution 0.3% produces very high concentrations of drug in the ear, thus broadening the spectrum of activity of oflox …
Ofloxacin has been formulated as a 0.3% otic solution for the treatment of ear infections. Topical administration of ofloxa …
A benefit-risk assessment of ofloxacin otic solution in ear infection.
Wai TK, Tong MC. Wai TK, et al. Drug Saf. 2003;26(6):405-20. doi: 10.2165/00002018-200326060-00003. Drug Saf. 2003. PMID: 12688832 Review.
Adverse reactions to ofloxacin otic solution were generally mild. The lack of ototoxic effect from ofloxacin eardrops, even in the concentration higher than 0.3%, has been demonstrated in animal studies. In the clinical setting, no increase in bone-conduction …
Adverse reactions to ofloxacin otic solution were generally mild. The lack of ototoxic effect from ofloxacin eardrops, …
Ofloxacin.
[No authors listed] [No authors listed] 2025 Jan 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2025 Jan 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000114 Free Books & Documents. Review.
Developmental problems have been reported in two infants exposed to ofloxacin in breastmilk, but their mothers were also exposed to several drugs during pregnancy and during breastfeeding, so the problems cannot necessarily be attributed to ofloxacin. ...Avoiding br …
Developmental problems have been reported in two infants exposed to ofloxacin in breastmilk, but their mothers were also exposed to s …
Efficacy of ofloxacin and other otic preparations for otitis externa.
Ruben RJ. Ruben RJ. Pediatr Infect Dis J. 2001 Jan;20(1):108-10; discussion 120-2. doi: 10.1097/00006454-200101000-00039. Pediatr Infect Dis J. 2001. PMID: 11176588 Review.
Ofloxacin otic is as effective in curing otitis externa in children (<12 years of age) as is the preparation combining polymyxin/neomycin plus hydrocortisone and as ciprofloxacin otic. Furthermore ofloxacin otic, as it requires less frequent …
Ofloxacin otic is as effective in curing otitis externa in children (<12 years of age) as is the preparation combining poly …
Safety of ofloxacin otic and other ototopical treatments in animal models and in humans.
Gates GA. Gates GA. Pediatr Infect Dis J. 2001 Jan;20(1):104-7; discussion 120-2. doi: 10.1097/00006454-200101000-00038. Pediatr Infect Dis J. 2001. PMID: 11176587 Review.
Moreover auditory brainstem testing revealed no change in auditory thresholds in the ofloxacin-treated animals, whereas neomycin-treated animals showed substantial threshold shifts. In human studies, use of topical ofloxacin 0.3% was not associated with any change i …
Moreover auditory brainstem testing revealed no change in auditory thresholds in the ofloxacin-treated animals, whereas neomycin-trea …
Ofloxacin otic solution in patients with otitis media: an analysis of drug concentrations.
Ohyama M, Furuta S, Ueno K, Katsuda K, Nobori T, Kiyota R, Miyazaki Y. Ohyama M, et al. Arch Otolaryngol Head Neck Surg. 1999 Mar;125(3):337-40. doi: 10.1001/archotol.125.3.337. Arch Otolaryngol Head Neck Surg. 1999. PMID: 10190808
OBJECTIVE: To measure the concentration of ofloxacin in otorrhea, serum, and middle ear mucosa after topical administration of 0.3% ofloxacin otic solution. DESIGN: Study of 0.3% ofloxacin otic solution administered in a single dose of 0.5 mL in …
OBJECTIVE: To measure the concentration of ofloxacin in otorrhea, serum, and middle ear mucosa after topical administration of 0.3% …
Repair of large traumatic tympanic membrane perforation using ofloxacin otic solution and gelatin sponge.
Li X, Zhang H, Zhang Y. Li X, et al. Braz J Otorhinolaryngol. 2022 Jan-Feb;88(1):9-14. doi: 10.1016/j.bjorl.2020.03.007. Epub 2020 May 5. Braz J Otorhinolaryngol. 2022. PMID: 32456874 Free PMC article. Clinical Trial.
Few studies have compared the healing and hearing outcomes between gelatin sponge patching and ofloxacin otic solution. OBJECTIVES: To compare the healing outcomes of large traumatic tympanic membrane perforations treated with gelatin sponge, ofloxacin oti …
Few studies have compared the healing and hearing outcomes between gelatin sponge patching and ofloxacin otic solution. OBJECT …
Comparison of systemic and otic administration of ofloxacin.
Koulich E, Roland PS, Pawlowski KS. Koulich E, et al. Laryngoscope. 2010 Oct;120(10):2083-8. doi: 10.1002/lary.21088. Laryngoscope. 2010. PMID: 20830758
OBJECTIVES: To assess the feasibility of delivering ofloxacin across the intact tympanic membrane; to compare middle ear bioavailability of ofloxacin after otic and systemic administrations; to determine distribution of otically delivered ofloxacin to …
OBJECTIVES: To assess the feasibility of delivering ofloxacin across the intact tympanic membrane; to compare middle ear bioavailabil …
Ofloxacin otic solution for treatment of otitis externa in children and adults.
Jones RN, Milazzo J, Seidlin M. Jones RN, et al. Arch Otolaryngol Head Neck Surg. 1997 Nov;123(11):1193-200. doi: 10.1001/archotol.1997.01900110047007. Arch Otolaryngol Head Neck Surg. 1997. PMID: 9366699 Clinical Trial.
OBJECTIVE: To compare the safety and efficacy of ofloxacin otic solution with those of Cortisporin otic solutions (neomycin sulfate, polymyxin B sulfate, and hydrocortisone) in otitis externa in adults and children. ...RESULTS: Cure was observed in 82% and 97 …
OBJECTIVE: To compare the safety and efficacy of ofloxacin otic solution with those of Cortisporin otic solutions (neom …
72 results