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Dual-Cross-Linked Methacrylated Alginate Sub-Microspheres for Intracellular Chemotherapeutic Delivery.
Fenn SL, Miao T, Scherrer RM, Oldinski RA. Fenn SL, et al. ACS Appl Mater Interfaces. 2016 Jul 20;8(28):17775-17783. doi: 10.1021/acsami.6b03245. Epub 2016 Jul 11. ACS Appl Mater Interfaces. 2016. PMID: 27378419 Free PMC article.
Intracellular delivery vehicles comprised of methacrylated alginate (Alg-MA) were developed for the internalization and release of doxorubicin hydrochloride (DOX). ...Photo-cross-linked Alg-MA sub-microspheres may be a potential chemotherapeutic delivery system for …
Intracellular delivery vehicles comprised of methacrylated alginate (Alg-MA) were developed for the internalization and release of do …
Osteogenic differentiation of human mesenchymal stem cells through alginate-graft-poly(ethylene glycol) microsphere-mediated intracellular growth factor delivery.
Miao T, Rao KS, Spees JL, Oldinski RA. Miao T, et al. J Control Release. 2014 Oct 28;192:57-66. doi: 10.1016/j.jconrel.2014.06.029. Epub 2014 Jun 28. J Control Release. 2014. PMID: 24979209 Free PMC article.
The intracellular delivery of growth factors increases opportunities for controlling cell behavior and maintaining tissue homeostasis. ...These results demonstrating the internalization of alginate-based microspheres and intracellular delivery of VEGFA support the e …
The intracellular delivery of growth factors increases opportunities for controlling cell behavior and maintaining tissue homeostasis …
Internalized FGF-2-Loaded Nanoparticles Increase Nuclear ERK1/2 Content and Result in Lung Cancer Cell Death.
Miao T, Little AC, Aronshtam A, Marquis T, Fenn SL, Hristova M, Krementsov DN, Vliet AV, Spees JL, Oldinski RA. Miao T, et al. Nanomaterials (Basel). 2020 Mar 27;10(4):612. doi: 10.3390/nano10040612. Nanomaterials (Basel). 2020. PMID: 32230722 Free PMC article.
Nanoparticles provide controlled intracellular biomolecule delivery in the absence of activating external cell surface receptors. ...Compared to A549s exposed to empty (i.e., blank) ABNs, the intracellular delivery of FGF-2 via ABNs significantly increased the level …
Nanoparticles provide controlled intracellular biomolecule delivery in the absence of activating external cell surface receptors. ... …
Dual-crosslinked homogeneous alginate microspheres for mesenchymal stem cell encapsulation.
Etter JN, Karasinski M, Ware J, Oldinski RA. Etter JN, et al. J Mater Sci Mater Med. 2018 Aug 27;29(9):143. doi: 10.1007/s10856-018-6151-4. J Mater Sci Mater Med. 2018. PMID: 30151747
Methods for fabricating homogeneous stimuli-responsive microspheres for MSC encapsulation and cell delivery have gained interest to increase viability and manipulate microencapsulation within microspheres 10-1000 m in diameter. ...
Methods for fabricating homogeneous stimuli-responsive microspheres for MSC encapsulation and cell delivery have gained interest to i …
Self-Healing and Thermoresponsive Dual-Cross-Linked Alginate Hydrogels Based on Supramolecular Inclusion Complexes.
Miao T, Fenn SL, Charron PN, Oldinski RA. Miao T, et al. Biomacromolecules. 2015 Dec 14;16(12):3740-50. doi: 10.1021/acs.biomac.5b00940. Epub 2015 Nov 11. Biomacromolecules. 2015. PMID: 26509214 Free PMC article.
The mechanical properties of the dual-cross-linked, multi-stimuli-responsive hydrogels were tuned as high as 30 kPa at body temperature and are advantageous for biomedical applications such as drug delivery and cell transplantation....
The mechanical properties of the dual-cross-linked, multi-stimuli-responsive hydrogels were tuned as high as 30 kPa at body temperature and …