Radiosensitization mediated by a transfected anti-erbB-2 single-chain antibody in vitro and in vivo.
Stackhouse MA, Buchsbaum DJ, Grizzle WE, Bright SJ, Olsen CC, Kancharla S, Mayo MS, Curiel DT.
Stackhouse MA, et al. Among authors: olsen cc.
Int J Radiat Oncol Biol Phys. 1998 Nov 1;42(4):817-22. doi: 10.1016/s0360-3016(98)00330-7.
Int J Radiat Oncol Biol Phys. 1998.
PMID: 9845103
The anti-erbB-2 sFv also sensitizes erbB-2 overexpressing cells to the cytotoxic effects of cisplatin. On this basis, we hypothesized that human ovarian cancer cells expressing anti-erbB-2 sFv with downregulated erbB-2 product, p185erbB-2, also would be sensitized to ioniz …
The anti-erbB-2 sFv also sensitizes erbB-2 overexpressing cells to the cytotoxic effects of cisplatin. On this basis, we hypothesized that h …