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2004 3
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151 results

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Page 1
A Roadmap for the Success of Oncolytic Parvovirus-Based Anticancer Therapies.
Hartley A, Kavishwar G, Salvato I, Marchini A. Hartley A, et al. Annu Rev Virol. 2020 Sep 29;7(1):537-557. doi: 10.1146/annurev-virology-012220-023606. Epub 2020 Jun 29. Annu Rev Virol. 2020. PMID: 32600158 Review.
Various strategies have been employed to improve the anticancer activities of oncolytic PVs, including development of second-generation parvoviruses with enhanced oncolytic and immunostimulatory activities and rational combination of PVs with other therapies. …
Various strategies have been employed to improve the anticancer activities of oncolytic PVs, including development of second-generati …
Canine Parvovirus and Its Non-Structural Gene 1 as Oncolytic Agents: Mechanism of Action and Induction of Anti-Tumor Immune Response.
Arora R, Malla WA, Tyagi A, Mahajan S, Sajjanar B, Tiwari AK. Arora R, et al. Front Oncol. 2021 May 3;11:648873. doi: 10.3389/fonc.2021.648873. eCollection 2021. Front Oncol. 2021. PMID: 34012915 Free PMC article. Review.
Canine parvovirus (CPV) is an oncolytic virus that specifically targets and kills cancer cells by causing DNA damage, caspase activation, and mitochondrial damage. Non-structural gene 1 (NS1) of CPV, involved in viral DNA replication is a key mediator of cytotoxicit …
Canine parvovirus (CPV) is an oncolytic virus that specifically targets and kills cancer cells by causing DNA damage, caspase …
Oncolytic virotherapy as emerging immunotherapeutic modality: potential of parvovirus h-1.
Moehler M, Goepfert K, Heinrich B, Breitbach CJ, Delic M, Galle PR, Rommelaere J. Moehler M, et al. Front Oncol. 2014 May 1;4:92. doi: 10.3389/fonc.2014.00092. eCollection 2014. Front Oncol. 2014. PMID: 24822170 Free PMC article. Review.
By generating tumor cell lysates in situ, oncolytic viruses overcome cellular tumor resistance mechanisms and induce immunogenic tumor cell death resulting in the recognition of newly released tumor antigens. This is in particular the case of the oncolytic parvov …
By generating tumor cell lysates in situ, oncolytic viruses overcome cellular tumor resistance mechanisms and induce immunogenic tumo …
Oncolytic H-1 Parvovirus Hijacks Galectin-1 to Enter Cancer Cells.
Ferreira T, Kulkarni A, Bretscher C, Nazarov PV, Hossain JA, Ystaas LAR, Miletic H, Röth R, Niesler B, Marchini A. Ferreira T, et al. Viruses. 2022 May 11;14(5):1018. doi: 10.3390/v14051018. Viruses. 2022. PMID: 35632759 Free PMC article.
We also find a direct correlation between LGALS1 transcript levels and H-1PV oncolytic activity in 53 cancer cell lines from different tumour origins. ...
We also find a direct correlation between LGALS1 transcript levels and H-1PV oncolytic activity in 53 cancer cell lines from differen …
New Insights into Parvovirus Research.
Gallinella G. Gallinella G. Viruses. 2019 Nov 13;11(11):1053. doi: 10.3390/v11111053. Viruses. 2019. PMID: 31766142 Free PMC article.
The Special Issue of 'Viruses' dedicated to the 'New Insights into Parvovirus Research' aimed at presenting a 'state of the art' in many aspects of research in the field, at collecting the newest contributions on unresolved issues, and at presenting new approaches exploiti …
The Special Issue of 'Viruses' dedicated to the 'New Insights into Parvovirus Research' aimed at presenting a 'state of the art' in m …
Oncolytic H-1 Parvovirus Enters Cancer Cells through Clathrin-Mediated Endocytosis.
Ferreira T, Kulkarni A, Bretscher C, Richter K, Ehrlich M, Marchini A. Ferreira T, et al. Viruses. 2020 Oct 21;12(10):1199. doi: 10.3390/v12101199. Viruses. 2020. PMID: 33096814 Free PMC article.
H-1 protoparvovirus (H-1PV) is a self-propagating virus that is non-pathogenic in humans and has oncolytic and oncosuppressive activities. H-1PV is the first member of the Parvoviridae family to undergo clinical testing as an anticancer agent. ...This is the first study th …
H-1 protoparvovirus (H-1PV) is a self-propagating virus that is non-pathogenic in humans and has oncolytic and oncosuppressive activi …
Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response.
Wu YY, Sun TK, Chen MS, Munir M, Liu HJ. Wu YY, et al. Front Cell Infect Microbiol. 2023 Mar 15;13:1142172. doi: 10.3389/fcimb.2023.1142172. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37009515 Free PMC article. Review.
Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis virus (VSV), parvovirus, mammalian reovirus (MRV), human adenovirus, Newcast …
Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer therapy. The infection of OVs such as …
Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry.
Kulkarni A, Ferreira T, Bretscher C, Grewenig A, El-Andaloussi N, Bonifati S, Marttila T, Palissot V, Hossain JA, Azuaje F, Miletic H, Ystaas LAR, Golebiewska A, Niclou SP, Roeth R, Niesler B, Weiss A, Brino L, Marchini A. Kulkarni A, et al. Nat Commun. 2021 Jun 22;12(1):3834. doi: 10.1038/s41467-021-24034-7. Nat Commun. 2021. PMID: 34158478 Free PMC article.
H-1 parvovirus (H-1PV) is a promising anticancer therapy. However, in-depth understanding of its life cycle, including the host cell factors needed for infectivity and oncolysis, is lacking. ...We also provide evidence of a direct correlation between LAMC1 expression level …
H-1 parvovirus (H-1PV) is a promising anticancer therapy. However, in-depth understanding of its life cycle, including the host cell …
Oncolytic viruses as treatment for adult and pediatric high-grade gliomas: On the way to clinical success.
Hervás-Corpión I, Alonso MM. Hervás-Corpión I, et al. Int Rev Cell Mol Biol. 2023;379:169-188. doi: 10.1016/bs.ircmb.2023.04.001. Epub 2023 Apr 26. Int Rev Cell Mol Biol. 2023. PMID: 37541723 Review.
Despite the multimodal treatment modality currently available for HGG, the prognosis is dismal, with a low overall survival rate at two years after diagnosis. In the last decade, oncolytic virotherapy has emerged as a promising and feasible therapeutic tool in management o …
Despite the multimodal treatment modality currently available for HGG, the prognosis is dismal, with a low overall survival rate at two year …
Oncolytic viral therapy for pancreatic cancer.
Rahal A, Musher B. Rahal A, et al. J Surg Oncol. 2017 Jul;116(1):94-103. doi: 10.1002/jso.24626. Epub 2017 Apr 13. J Surg Oncol. 2017. PMID: 28407327 Review.
Nevertheless, growing insight into antitumor immunity and the tumor microenvironment has inspired the discovery of novel agents targeting PDA. Oncolytic viruses represent an emerging class of immunotherapeutic agents that have undergone extensive preclinical investigation …
Nevertheless, growing insight into antitumor immunity and the tumor microenvironment has inspired the discovery of novel agents targeting PD …
151 results