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Ophiopogon japonicus--A phytochemical, ethnomedicinal and pharmacological review.
Chen MH, Chen XJ, Wang M, Lin LG, Wang YT. Chen MH, et al. J Ethnopharmacol. 2016 Apr 2;181:193-213. doi: 10.1016/j.jep.2016.01.037. Epub 2016 Jan 27. J Ethnopharmacol. 2016. PMID: 26826325 Review.
ETHNOPHARMACOLOGICAL RELEVANCE: Ophiopogonis Radix (Maidong in Chinese), the root of Ophiopogon japonicus, is widely used in local medicines of China, Japan and some south-eastern Asian countries. According to the traditional Chinese medicine (TCM) principle, Ophiopogonis …
ETHNOPHARMACOLOGICAL RELEVANCE: Ophiopogonis Radix (Maidong in Chinese), the root of Ophiopogon japonicus, is widely used in local me …
Anti-inflammatory activity of the Tongmai Yangxin pill in the treatment of coronary heart disease is associated with estrogen receptor and NF-κB signaling pathway.
Fan Y, Liu J, Miao J, Zhang X, Yan Y, Bai L, Chang J, Wang Y, Wang L, Bian Y, Zhou H. Fan Y, et al. J Ethnopharmacol. 2021 Aug 10;276:114106. doi: 10.1016/j.jep.2021.114106. Epub 2021 Apr 7. J Ethnopharmacol. 2021. PMID: 33838287 Clinical Trial.
ETHNOPHARMACOLOGICAL RELEVANCE: The Tongmai Yangxin Pill (TMYX) is a patented traditional Chinese medicine originating from two classic prescriptions, Zhigancao Decoction and Shenmai Yin, which composed of 11 Chinese medicinal herbs: Rehmannia glutinosa (Gaertn.) DC., Spatholobus …
ETHNOPHARMACOLOGICAL RELEVANCE: The Tongmai Yangxin Pill (TMYX) is a patented traditional Chinese medicine originating from two classic pres …
Ophiopogonin D alleviates diabetic myocardial injuries by regulating mitochondrial dynamics.
Li W, Ji L, Tian J, Tang W, Shan X, Zhao P, Chen H, Zhang C, Xu M, Lu R, Guo W. Li W, et al. J Ethnopharmacol. 2021 May 10;271:113853. doi: 10.1016/j.jep.2021.113853. Epub 2021 Jan 22. J Ethnopharmacol. 2021. PMID: 33485986
ETHNOPHARMACOLOGICAL RELEVANCE: Ophiopogonin D (OP-D) is a steroidal saponin extracted from Ophiopogon japonicus (Thunb.) Ker Gawl. (Liliaceae), that has been traditionally used to treat cough, sputum, and thirst in some Asian countries. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Ophiopogonin D (OP-D) is a steroidal saponin extracted from Ophiopogon japonicus (Thunb.) Ker Gawl. ( …
Cardioprotective effect of the polysaccharide from Ophiopogon japonicus on isoproterenol-induced myocardial ischemia in rats.
Fan S, Zhang J, Xiao Q, Liu P, Zhang Y, Yao E, Chen X. Fan S, et al. Int J Biol Macromol. 2020 Mar 15;147:233-240. doi: 10.1016/j.ijbiomac.2020.01.068. Epub 2020 Jan 8. Int J Biol Macromol. 2020. PMID: 31923517
The polysaccharide (OJP1), extracted from the root of Ophiopogon japonicus, is a well-known traditional Chinese medicine used to treat cardiovascular diseases. ...Results showed that pretreatment with OJP1 (100, 200 and 300 mg/kg) significantly reduced ISO-induced ST-segme …
The polysaccharide (OJP1), extracted from the root of Ophiopogon japonicus, is a well-known traditional Chinese medicine used to trea …
Cardiovascular protective effect of polysaccharide from Ophiopogon japonicus in diabetic rats.
Zhang J, Fan S, Mao Y, Ji Y, Jin L, Lu J, Chen X. Zhang J, et al. Int J Biol Macromol. 2016 Jan;82:505-13. doi: 10.1016/j.ijbiomac.2015.09.069. Epub 2015 Oct 3. Int J Biol Macromol. 2016. PMID: 26434529
Ophiopogon japonicus (Thunb.) Ker-Gawl is a well known traditional Chinese medicine used to treat cardiovascular and chronic inflammatory diseases for thousands of years. ...Meanwhile, the histopathological analysis showed that OJP1 alleviates the heart injury in di
Ophiopogon japonicus (Thunb.) Ker-Gawl is a well known traditional Chinese medicine used to treat cardiovascular and chronic inflamma
Composition of Ophiopogon Polysaccharide, Notoginseng Total Saponins and Rhizoma Coptidis Alkaloids Inhibits the Myocardial Apoptosis on Diabetic Atherosclerosis Rabbit.
Jin ZH, Gao P, Liu ZT, Jin B, Song GY, Xiang TY. Jin ZH, et al. Chin J Integr Med. 2020 May;26(5):353-360. doi: 10.1007/s11655-018-3014-2. Epub 2018 Oct 17. Chin J Integr Med. 2020. PMID: 30328567
OBJECTIVE: To investigate the effects of Composition of Ophiopogon polysaccharide, Notoginseng total saponins and Rhizoma Coptidis alkaloids (CONR) on myocardial apoptosis of diabetic atherosclerosis (DA) rabbits METHODS: Sixty male New Zealand white rabbits were randomly …
OBJECTIVE: To investigate the effects of Composition of Ophiopogon polysaccharide, Notoginseng total saponins and Rhizoma Coptidis al …
Ophiopogon japonicus strains from different cultivation regions exhibit markedly different properties on cytotoxicity, pregnane X receptor activation and cytochrome P450 3A4 induction.
Ge LL, Kan LD, Zhuge ZB, Ma KE, Chen SQ. Ge LL, et al. Biomed Rep. 2015 May;3(3):430-434. doi: 10.3892/br.2015.443. Epub 2015 Mar 17. Biomed Rep. 2015. PMID: 26137250 Free PMC article.
Maidong, known as Ophiopogon japonicus, is one of the two basic ingredients of Shenmai injection, which is a widely used herbal preparation in traditional Chinese medicine (TCM) for the treatment of atherosclerotic coronary heart disease and viral myocarditis …
Maidong, known as Ophiopogon japonicus, is one of the two basic ingredients of Shenmai injection, which is a widely used herbal prepa …
Effects of steroidal saponins extract from Ophiopogon japonicus root ameliorates doxorubicin-induced chronic heart failure by inhibiting oxidative stress and inflammatory response.
Wu Z, Zhao X, Miyamoto A, Zhao S, Liu C, Zheng W, Wang H. Wu Z, et al. Pharm Biol. 2019 Dec;57(1):176-183. doi: 10.1080/13880209.2019.1577467. Pharm Biol. 2019. PMID: 30860934 Free PMC article.
CONTEXT: Ophiopogonis Radix, the root of Ophiopogon japonicus (Thunb.) Ker-Gawl (Liliaceae), is a Traditional Chinese Medicine, which has been investigated to possess effective treatment of cardiovascular diseases. OBJECTIVE: This study evaluates the cardioprotective effec …
CONTEXT: Ophiopogonis Radix, the root of Ophiopogon japonicus (Thunb.) Ker-Gawl (Liliaceae), is a Traditional Chinese Medicine, which …
Chemical constituents from the fibrous root of Ophiopogon japonicus, and their effect on tube formation in human myocardial microvascular endothelial cells.
Lan S, Yi F, Shuang L, Chenjie W, Zheng XW. Lan S, et al. Fitoterapia. 2013 Mar;85:57-63. doi: 10.1016/j.fitote.2012.12.025. Epub 2012 Dec 27. Fitoterapia. 2013. PMID: 23274777
In an effort to identify novel active constituents on the cardiovascular system, a systematic study on macroporous resin adsorption of extracts from the fibrous root of Ophiopogon japonicus was performed in a human myocardial microvascular endothelial cell line (HMMEC) bas …
In an effort to identify novel active constituents on the cardiovascular system, a systematic study on macroporous resin adsorption of extra …
8-Formylophiopogonanone B antagonizes doxorubicin-induced cardiotoxicity by suppressing heme oxygenase-1-dependent myocardial inflammation and fibrosis.
Qin D, Yue R, Deng P, Wang X, Zheng Z, Lv M, Zhang Y, Pu J, Xu J, Liang Y, Pi H, Yu Z, Hu H. Qin D, et al. Biomed Pharmacother. 2021 Aug;140:111779. doi: 10.1016/j.biopha.2021.111779. Epub 2021 May 29. Biomed Pharmacother. 2021. PMID: 34062415 Free article.
We previously reported that 8-formylophiopogonanone B (8-FOB), a natural isoflavone in Ophiopogon japonicas, antagonizes paraquat-induced hepatotoxicity. Here, we explored the mechanisms underlying DOX-induced cardiotoxicity as well as whether 8-FOB can alleviate DOX-induc …
We previously reported that 8-formylophiopogonanone B (8-FOB), a natural isoflavone in Ophiopogon japonicas, antagonizes paraquat-ind …
50 results