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72 results

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Page 1
Diabetic keratopathy and treatment by modulation of the opioid growth factor (OGF)-OGF receptor (OGFr) axis with naltrexone: a review.
McLaughlin PJ, Sassani JW, Klocek MS, Zagon IS. McLaughlin PJ, et al. Brain Res Bull. 2010 Feb 15;81(2-3):236-47. doi: 10.1016/j.brainresbull.2009.08.008. Epub 2009 Aug 14. Brain Res Bull. 2010. PMID: 19683562 Free PMC article. Review.
The opioid growth factor (OGF)-OGF receptors (OGFr) axis plays an important role in the homeostasis and re-epithelialization of the mammalian cornea. ...Blockade of OGF-OGFr interfacing by systemic or topical administration of opioid …
The opioid growth factor (OGF)-OGF receptors (OGFr) axis plays an important role in the homeostasis and r …
Opioid growth factor (OGF) inhibits anchorage-independent growth in human cancer cells.
Zagon IS, McLaughlin PJ. Zagon IS, et al. Int J Oncol. 2004 Jun;24(6):1443-8. Int J Oncol. 2004. PMID: 15138586
Opioid growth factor (OGF) is a native endogenous opioid peptide ([Met5]-enkephalin) that interacts with the OGF receptor (OGFr), and serves as a tonically active negative growth factor in neoplasia. ...These data suggest th …
Opioid growth factor (OGF) is a native endogenous opioid peptide ([Met5]-enkephalin) that interacts with …
The opioid growth factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancer.
Cheng F, Zagon IS, Verderame MF, McLaughlin PJ. Cheng F, et al. Cancer Res. 2007 Nov 1;67(21):10511-8. doi: 10.1158/0008-5472.CAN-07-1922. Cancer Res. 2007. PMID: 17974995
Head and neck squamous cell carcinoma (HNSCC) represents 5.5% of malignancies worldwide, with approximately 30,000 new cases and approximately 11,000 deaths reported in the United States annually. The opioid growth factor (OGF; [Met(5)]-enkephalin) and …
Head and neck squamous cell carcinoma (HNSCC) represents 5.5% of malignancies worldwide, with approximately 30,000 new cases and approximate …
The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice.
Donahue RN, McLaughlin PJ, Zagon IS. Donahue RN, et al. Gynecol Oncol. 2011 Aug;122(2):382-8. doi: 10.1016/j.ygyno.2011.04.009. Epub 2011 Apr 30. Gynecol Oncol. 2011. PMID: 21531450
OBJECTIVE: The opioid growth factor (OGF) and its receptor, OGFr, serve as a tonically active inhibitory axis regulating cell proliferation in normal cells and a variety of cancers, including human ovarian cancer. Blockade of OGF and OGFr with t …
OBJECTIVE: The opioid growth factor (OGF) and its receptor, OGFr, serve as a tonically active inhibitory axis re …
Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude mice.
McLaughlin PJ, Levin RJ, Zagon IS. McLaughlin PJ, et al. Cancer Lett. 2003 Sep 25;199(2):209-17. doi: 10.1016/s0304-3835(03)00341-0. Cancer Lett. 2003. PMID: 12969794
Opioid growth factor (OGF) interacts with the OGF receptor (OGFr) and serves as a native inhibitory growth factor. ...OGF activity was receptor-mediated. Opioid-receptor blockade by the potent opioid antagonist …
Opioid growth factor (OGF) interacts with the OGF receptor (OGFr) and serves as a native inhibitory gr …
Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis.
McLaughlin PJ, Zagon IS, Park SS, Conway A, Donahue RN, Goldenberg D. McLaughlin PJ, et al. BMC Cancer. 2009 Oct 18;9:369. doi: 10.1186/1471-2407-9-369. BMC Cancer. 2009. PMID: 19835629 Free PMC article.
Follicular carcinoma (FTC) is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers. Opioid Growth Factor (OGF; chemical term - [Met5]-enkephalin) and its receptor, …
Follicular carcinoma (FTC) is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one o …
Prevention and diminished expression of experimental autoimmune encephalomyelitis by low dose naltrexone (LDN) or opioid growth factor (OGF) for an extended period: Therapeutic implications for multiple sclerosis.
Rahn KA, McLaughlin PJ, Zagon IS. Rahn KA, et al. Brain Res. 2011 Mar 24;1381:243-53. doi: 10.1016/j.brainres.2011.01.036. Epub 2011 Jan 20. Brain Res. 2011. PMID: 21256121
This study examined the long term effects of the opioid growth factor (OGF, [Met(5)]-enkephalin) and a low dose of the opioid antagonist naltrexone (LDN) on expression of myelin oligodendrocyte glycoprotein (MOG)-induced EAE. C57BL/6 mice …
This study examined the long term effects of the opioid growth factor (OGF, [Met(5)]-enkephalin) and a low dose …
Elevated Opioid Growth Factor Alters the Limbus in Type 1 Diabetic Rats.
McLaughlin PJ, Sassani JW, Diaz D, Zagon IS. McLaughlin PJ, et al. J Diabetes Clin Res. 2023;5(1):1-10. doi: 10.33696/diabetes.4.054. J Diabetes Clin Res. 2023. PMID: 37304310 Free PMC article.
The vascular limbus, adjacent to the avascular cornea, is the source of circulating growth factors, elevated glucose, and cytokines for the cornea. The Opioid Growth Factor (OGF) - Opioid OGF Receptor (OGFr) axis is comprised of it …
The vascular limbus, adjacent to the avascular cornea, is the source of circulating growth factors, elevated glucose, and cytokines f …
Opioid growth factor and low-dose naltrexone impair central nervous system infiltration by CD4 + T lymphocytes in established experimental autoimmune encephalomyelitis, a model of multiple sclerosis.
Hammer LA, Waldner H, Zagon IS, McLaughlin PJ. Hammer LA, et al. Exp Biol Med (Maywood). 2016 Jan;241(1):71-8. doi: 10.1177/1535370215596384. Epub 2015 Jul 22. Exp Biol Med (Maywood). 2016. PMID: 26202376 Free PMC article.
Regulatory CD4(+) T cells suppress immune reactions and have been demonstrated to be dysfunctional in MS patients. Opioid growth factor (OGF), chemically termed [Met(5)]-enkephalin, is a negative growth factor that interacts with the O …
Regulatory CD4(+) T cells suppress immune reactions and have been demonstrated to be dysfunctional in MS patients. Opioid growth …
Opioid growth factor (OGF) for hepatoblastoma: a novel non-toxic treatment.
Rogosnitzky M, Finegold MJ, McLaughlin PJ, Zagon IS. Rogosnitzky M, et al. Invest New Drugs. 2013 Aug;31(4):1066-70. doi: 10.1007/s10637-012-9918-3. Epub 2012 Dec 30. Invest New Drugs. 2013. PMID: 23275062
In this report, the authors present two cases of hepatoblastoma treated with surgical resection and a novel biotherapeutic regimen that included opioid growth factor (OGF). Case #1 is an infant diagnosed with a large mass on prenatal ultrasound. ...Fol …
In this report, the authors present two cases of hepatoblastoma treated with surgical resection and a novel biotherapeutic regimen that incl …
72 results