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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1973 1
1975 2
1977 1
1978 1
1979 3
1980 2
1981 7
1982 6
1983 13
1984 8
1985 8
1986 9
1987 4
1988 12
1989 16
1990 14
1991 15
1992 14
1993 17
1994 23
1995 30
1996 21
1997 44
1998 43
1999 51
2000 58
2001 50
2002 54
2003 79
2004 88
2005 93
2006 101
2007 100
2008 124
2009 118
2010 119
2011 150
2012 172
2013 155
2014 159
2015 162
2016 163
2017 163
2018 149
2019 153
2020 185
2021 145
2022 147
2023 118
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2025 101
2026 62

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3,267 results

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Page 1
A comprehensive review of opioid-induced hyperalgesia.
Lee M, Silverman SM, Hansen H, Patel VB, Manchikanti L. Lee M, et al. Pain Physician. 2011 Mar-Apr;14(2):145-61. Pain Physician. 2011. PMID: 21412369 Free article. Review.
Opioid-induced hyperalgesia (OIH) is defined as a state of nociceptive sensitization caused by exposure to opioids. ...Most studies have been conducted using several distinct cohorts and methodologies utilizing former opioid addicts on methadone …
Opioid-induced hyperalgesia (OIH) is defined as a state of nociceptive sensitization caused by exposure to opioids …
Opioid-Induced Tolerance and Hyperalgesia.
Mercadante S, Arcuri E, Santoni A. Mercadante S, et al. CNS Drugs. 2019 Oct;33(10):943-955. doi: 10.1007/s40263-019-00660-0. CNS Drugs. 2019. PMID: 31578704 Review.
Other than adverse effects and dependence, the development of tolerance is a significant problem, as it requires increased opioid drug doses to achieve the same effect. Mechanisms of opioid tolerance include drug-induced adaptations or allostatic changes at t …
Other than adverse effects and dependence, the development of tolerance is a significant problem, as it requires increased opioid dru …
Perioperative opioid analgesia-when is enough too much? A review of opioid-induced tolerance and hyperalgesia.
Colvin LA, Bull F, Hales TG. Colvin LA, et al. Lancet. 2019 Apr 13;393(10180):1558-1568. doi: 10.1016/S0140-6736(19)30430-1. Lancet. 2019. PMID: 30983591 Review.
Opioid tolerance (increased dose needed for analgesia) and opioid-induced hyperalgesia (paradoxical increase in pain with opioid administration) can contribute to both poorly controlled pain and dose escalation. Hyperalgesia is particular …
Opioid tolerance (increased dose needed for analgesia) and opioid-induced hyperalgesia (paradoxical increase in …
Opioid Induced Hyperalgesia.
Yi P, Pryzbylkowski P. Yi P, et al. Pain Med. 2015 Oct;16 Suppl 1:S32-6. doi: 10.1111/pme.12914. Pain Med. 2015. PMID: 26461074 Review.
OBJECTIVE: To discuss the phenomenon of opioid induced hyperalgesia (OIH) and investigate the data and clinical recommendations available on this topic. ...RESULTS: Existing studies and reviews on the pathophysiology, diagnosis, and clinical management of OIH …
OBJECTIVE: To discuss the phenomenon of opioid induced hyperalgesia (OIH) and investigate the data and clinical recomme …
Opioid-induced hyperalgesia.
Lee MO Jr. Lee MO Jr. J Clin Rheumatol. 2012 Oct;18(7):325-6. doi: 10.1097/RHU.0b013e3182733011. J Clin Rheumatol. 2012. PMID: 23047531 No abstract available.
Opioid-induced hyperalgesia: where are we now?
Bannister K. Bannister K. Curr Opin Support Palliat Care. 2015 Jun;9(2):116-21. doi: 10.1097/SPC.0000000000000137. Curr Opin Support Palliat Care. 2015. PMID: 25872113 Review.
PURPOSE OF REVIEW: Patients receiving chronic opioid treatment who develop paradoxical pain sensations, as well as worsening existing pain, can be diagnosed as suffering from opioid-induced hyperalgesia (OIH). ...According to recent literature, for tho …
PURPOSE OF REVIEW: Patients receiving chronic opioid treatment who develop paradoxical pain sensations, as well as worsening existing …
Opioid tolerance and opioid-induced hyperalgesia: Is TrkB modulation a potential pharmacological solution?
Lim SY, Cengiz P. Lim SY, et al. Neuropharmacology. 2022 Dec 1;220:109260. doi: 10.1016/j.neuropharm.2022.109260. Epub 2022 Sep 19. Neuropharmacology. 2022. PMID: 36165856 Review.
However, long-term opioid use can cause opioid tolerance and opioid-induced hyperalgesia (OIH), contributing to the opioid misuse and addiction crisis. Strategies to mitigate opioid tolerance and OIH are needed to reduce opioid …
However, long-term opioid use can cause opioid tolerance and opioid-induced hyperalgesia (OIH), contribut …
Opioid-Induced Hyperalgesia in the Nonsurgical Setting: A Systematic Review.
Yang DZ, Sin B, Beckhusen J, Xia D, Khaimova R, Iliev I. Yang DZ, et al. Am J Ther. 2019 May/Jun;26(3):e397-e405. doi: 10.1097/MJT.0000000000000734. Am J Ther. 2019. PMID: 29726847
BACKGROUND: Opioid-induced hyperalgesia (OIH) is a phenomenon that causes an increased pain sensitization and perception of pain to noxious stimuli secondary to opioid exposure. ...The clinical outcomes of interest were identification of OIH, adverse e …
BACKGROUND: Opioid-induced hyperalgesia (OIH) is a phenomenon that causes an increased pain sensitization and perceptio …
Opioid-induced hyperalgesia.
Pasero C, McCaffery M. Pasero C, et al. J Perianesth Nurs. 2012 Feb;27(1):46-50. doi: 10.1016/j.jopan.2011.11.002. J Perianesth Nurs. 2012. PMID: 22264622 Review. No abstract available.
Opioid-induced hyperalgesia (OIH).
Leal Pda C, Clivatti J, Garcia JB, Sakata RK. Leal Pda C, et al. Rev Bras Anestesiol. 2010 Nov-Dec;60(6):639-47, 355-9. doi: 10.1016/S0034-7094(10)70080-5. Rev Bras Anestesiol. 2010. PMID: 21146061 Free article. Review. English, Portuguese, Spanish.
BACKGROUND AND OBJECTIVES: Opioids are commonly used for pain control; however, they can cause hyperalgesia. The reason why this can happen is not known. ...CONTENTS: The factors implicated in the development of opioid-induced hyperalgesia (OIH) …
BACKGROUND AND OBJECTIVES: Opioids are commonly used for pain control; however, they can cause hyperalgesia. The reason why th …
3,267 results