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Oral doxycycline versus intravenous ceftriaxone for European Lyme neuroborreliosis: a multicentre, non-inferiority, double-blind, randomised trial.
Ljøstad U, Skogvoll E, Eikeland R, Midgard R, Skarpaas T, Berg A, Mygland A. Ljøstad U, et al. Lancet Neurol. 2008 Aug;7(8):690-5. doi: 10.1016/S1474-4422(08)70119-4. Epub 2008 Jun 21. Lancet Neurol. 2008. PMID: 18567539 Clinical Trial.
BACKGROUND: Use of intravenous penicillin and ceftriaxone to treat Lyme neuroborreliosis is well documented, although oral doxycycline could be a cost-effective alternative. We aimed to compare the efficacy of oral doxycycline with intravenous c …
BACKGROUND: Use of intravenous penicillin and ceftriaxone to treat Lyme neuroborreliosis is well documented, although oral …
Oral doxycycline versus intravenous ceftriaxone for treatment of multiple erythema migrans: an open-label alternate-treatment observational trial.
Stupica D, Velušcek M, Blagus R, Bogovic P, Rojko T, Cerar T, Strle F. Stupica D, et al. J Antimicrob Chemother. 2018 May 1;73(5):1352-1358. doi: 10.1093/jac/dkx534. J Antimicrob Chemother. 2018. PMID: 29385444 Free article. Clinical Trial.
METHODS: Oral doxycycline (100 mg q12h) was compared on a non-inferiority premise with intravenous ceftriaxone (2 g q24h) for 14 days in 200 adult European patients with multiple EM in an open-label alternate-treatment observational trial performed in a single-centr …
METHODS: Oral doxycycline (100 mg q12h) was compared on a non-inferiority premise with intravenous ceftriaxone (2 g q24h) for …
Would Parents Consent to a Comparative Effectiveness Trial of Oral Doxycycline Versus Intravenous Ceftriaxone for the Treatment of Children with Lyme Meningitis?
Garro A, Koster M, LaRue M, Hipolito E, Congdon E, Burnett K, Cullen N, Nigrovic LE. Garro A, et al. Pediatr Infect Dis J. 2018 May;37(5):e140-e142. doi: 10.1097/INF.0000000000001793. Pediatr Infect Dis J. 2018. PMID: 28984721
Children with Lyme meningitis are often treated with intravenous ceftriaxone, although oral doxycycline may be effective. Parents were surveyed after observing a video describing a hypothetical Lyme meningitis treatment trial. Eighty-four of 102 (82%) …
Children with Lyme meningitis are often treated with intravenous ceftriaxone, although oral doxycycline may be effectiv …
Cost-effectiveness of longer-term versus shorter-term provision of antibiotics in patients with persistent symptoms attributed to Lyme disease.
Berende A, Nieuwenhuis L, Ter Hofstede HJM, Vos FJ, Vogelaar ML, Tromp M, van Middendorp H, Donders ART, Evers AWM, Kullberg BJ, Adang EMM. Berende A, et al. PLoS One. 2018 Apr 2;13(4):e0195260. doi: 10.1371/journal.pone.0195260. eCollection 2018. PLoS One. 2018. PMID: 29608590 Free PMC article. Clinical Trial.
BACKGROUND: The treatment of persistent symptoms attributed to Lyme disease remains controversial. Recently, the PLEASE study did not demonstrate any additional clinical benefit of longer-term versus shorter-term antibiotic treatment. However, the economic im …
BACKGROUND: The treatment of persistent symptoms attributed to Lyme disease remains controversial. Recently, the PLEASE study did not …
Isolated Intracranial Hypertension as a Presentation of Pediatric Lyme Borreliosis: A Case Report and Literature Review.
Mah JM, Lo C, O'Connor MD. Mah JM, et al. Pediatr Neurol. 2024 Mar;152:196-199. doi: 10.1016/j.pediatrneurol.2023.12.025. Epub 2024 Jan 2. Pediatr Neurol. 2024. PMID: 38301323 Review.
BACKGROUND: It is extremely rare for Lyme borreliosis to present solely with features of increased intracranial pressure. The treatment of pediatric Lyme neuroborreliosis with oral versus intravenous antibiotics remains controversial. ... …
BACKGROUND: It is extremely rare for Lyme borreliosis to present solely with features of increased intracranial pressure. The treatme …
Doxycycline versus ceftriaxone for the treatment of patients with chronic Lyme borreliosis.
Ogrinc K, Logar M, Lotric-Furlan S, Cerar D, Ruzić-Sabljić E, Strle F. Ogrinc K, et al. Wien Klin Wochenschr. 2006 Nov;118(21-22):696-701. doi: 10.1007/s00508-006-0698-7. Wien Klin Wochenschr. 2006. PMID: 17160610
BACKGROUND: Therapeutic guidelines for treatment of late manifestations of Lyme borreliosis have not yet become well established. Patients with symptoms suggesting central nervous system involvement are often treated with courses of intravenous ceftriaxone. ...PATIE …
BACKGROUND: Therapeutic guidelines for treatment of late manifestations of Lyme borreliosis have not yet become well established. Pat …
Antibiotics for the neurological complications of Lyme disease.
Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H. Cadavid D, et al. Cochrane Database Syst Rev. 2016 Dec 8;12(12):CD006978. doi: 10.1002/14651858.CD006978.pub2. Cochrane Database Syst Rev. 2016. PMID: 27931077 Free PMC article.
One study tested a three-month course of oral amoxicillin versus placebo following initial treatment with intravenous ceftriaxone. ...No evidence of additional efficacy was observed when, in one study, an initial antibiotic treatment with intravenou …
One study tested a three-month course of oral amoxicillin versus placebo following initial treatment with intravenous c …