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Page 1
Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion.
Sun X, Wu B, Chiang HC, Deng H, Zhang X, Xiong W, Liu J, Rozeboom AM, Harris BT, Blommaert E, Gomez A, Garcia RE, Zhou Y, Mitra P, Prevost M, Zhang D, Banik D, Isaacs C, Berry D, Lai C, Chaldekas K, Latham PS, Brantner CA, Popratiloff A, Jin VX, Zhang N, Hu Y, Pujana MA, Curiel TJ, An Z, Li R. Sun X, et al. Nature. 2021 Nov;599(7886):673-678. doi: 10.1038/s41586-021-04057-2. Epub 2021 Nov 3. Nature. 2021. PMID: 34732895 Free PMC article.
Belly Fat Weakens Immune Fitness.
Conejo-Garcia JR, Curiel TJ. Conejo-Garcia JR, et al. Cancer Discov. 2022 Aug 5;12(8):1841-1843. doi: 10.1158/2159-8290.CD-22-0611. Cancer Discov. 2022. PMID: 35929132
Botensilimab, an Fc-Enhanced Anti-CTLA-4 Antibody, Is Effective against Tumors Poorly Responsive to Conventional Immunotherapy.
Chand D, Savitsky DA, Krishnan S, Mednick G, Delepine C, Garcia-Broncano P, Soh KT, Wu W, Wilkens MK, Udartseva O, Vincent S, Joshi B, Keith JG, Manrique M, Marques M, Tanne A, Levey DL, Han H, Ng S, Ridpath J, Huber O, Morin B, Galand C, Bourdelais S, Gombos RB, Ward R, Qin Y, Waight JD, Costa MR, Sebastian-Yague A, Rudqvist NP, Pupecka-Swider M, Venkatraman V, Slee A, Patel JM, Grossman JE, Wilson NS, Von Hoff DD, Stebbing J, Curiel TJ, Buell JS, O'Day SJ, Stein RB. Chand D, et al. Cancer Discov. 2024 Dec 2;14(12):2407-2429. doi: 10.1158/2159-8290.CD-24-0190. Cancer Discov. 2024. PMID: 39083809 Free PMC article.
Programmed death ligand 1 signals in cancer cells.
Kornepati AVR, Vadlamudi RK, Curiel TJ. Kornepati AVR, et al. Nat Rev Cancer. 2022 Mar;22(3):174-189. doi: 10.1038/s41568-021-00431-4. Epub 2022 Jan 14. Nat Rev Cancer. 2022. PMID: 35031777 Free PMC article. Review.
Ligand-receptor interactions induce and mediate regulatory functions of BATF3+ B cells.
Yan H, Wang R, Viswanadhapalli S, Cervantes C, He F, Wu S, Khosh A, Luo W, Wang J, Fernandez MJ, Pratap UP, Khan M, Hinton K, Vankamamidi SE, Perez D, Rivera CE, Gupta HB, Zhang F, Ye Z, Chen Y, Li XD, Sareddy GR, Zan H, Li Y, Wang E, Bunnik EM, Zhong G, Hunter CA, Kedl RM, Yin Z, Min B, Ebrahimi D, Zheng S, Curiel TJ, Xiang Y, Vadlamudi RK, Casali P, Xu Z. Yan H, et al. Sci Adv. 2025 Oct 10;11(41):eadx9917. doi: 10.1126/sciadv.adx9917. Epub 2025 Oct 8. Sci Adv. 2025. PMID: 41061049 Free PMC article.
Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling.
Ontiveros CO, Garcia MG, Murray CE, Deng Y, Bai H, Tanner C, Leung B, Li X, Padron A, Reyes RM, Kancharla A, Soh KT, Krishnan S, Chand D, Balasubramanian A, Hegner C, Jakubzick CV, Gupta HB, Turk MJ, Sundrud M, Conejo-Garcia JR, Curiel TJ. Ontiveros CO, et al. Nat Commun. 2025 Nov 19;16(1):10176. doi: 10.1038/s41467-025-65025-2. Nat Commun. 2025. PMID: 41261166 Free PMC article.
The Allogeneic FAP-CAR-IL15 iNKT Therapy MiNK-215 Remodels the Tumor Stroma to Enhance Antitumor Immunity.
Chantzoura E, Altman-Sharoni E, Michelet X, Popis MC, Niedzielska M, Joshi B, Masakayan R, Rubi-Sans G, Addis S, Keith JG, Krishnan S, Choi JS, Sanders S, Sebastian-Yague A, Boi SK, Pinzan-Rossi M, Antonopoulos G, Ibbett P, Wright DE, Le Tonqueze O, Kushner N, Pathak C, Soh KT, Chalmers AL, Smith R, Venkatraman V, Farahi S, Pravin J, Iyer P, Briend E, Ignatovich O, Purbhoo MA, Curiel TJ, Exley MA, Stein RB, Kim E, Buell JS, van Dijk MA, Chand D. Chantzoura E, et al. Cancer Immunol Res. 2026 Feb 3;14(2):243-260. doi: 10.1158/2326-6066.CIR-25-0349. Cancer Immunol Res. 2026. PMID: 41236523
26 results