Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1949 2
1950 3
1951 1
1953 1
1954 5
1955 3
1956 1
1957 1
1958 2
1959 3
1960 1
1961 1
1963 1
1964 17
1965 71
1966 91
1967 131
1968 180
1969 215
1970 281
1971 362
1972 296
1973 370
1974 456
1975 453
1976 412
1977 368
1978 376
1979 499
1980 573
1981 509
1982 418
1983 353
1984 305
1985 278
1986 263
1987 264
1988 151
1989 43
1990 40
1991 41
1992 50
1993 32
1994 33
1995 41
1996 34
1997 33
1998 33
1999 50
2000 38
2001 32
2002 32
2003 42
2004 37
2005 39
2006 47
2007 42
2008 50
2009 36
2010 42
2011 60
2012 84
2013 151
2014 189
2015 277
2016 466
2017 761
2018 1033
2019 1360
2020 2141
2021 2847
2022 3058
2023 3306
2024 34

Text availability

Article attribute

Article type

Publication date

Search Results

22,890 results

Results by year

Filters applied: . Clear all
Page 1
Neural cell engraftment therapy for sporadic Creutzfeldt-Jakob disease restores neuroelectrophysiological parameters in a cerebral organoid model.
Williams K, Foliaki ST, Race B, Smith A, Thomas T, Groveman BR, Haigh CL. Williams K, et al. Stem Cell Res Ther. 2023 Dec 5;14(1):348. doi: 10.1186/s13287-023-03591-2. Stem Cell Res Ther. 2023. PMID: 38049877
METHODS: Here, we use a novel approach to study cell therapies in sCJD using a human cerebral organoid model. Cerebral organoids can be infected with sCJD prions allowing us to assess how neural precursor cell (NPC) therapy impacts the progression of sCJD. ...RESULT …
METHODS: Here, we use a novel approach to study cell therapies in sCJD using a human cerebral organoid model. Cerebral organoids …
CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoids.
Pan D, Zhang X, Jin K, Jin ZB. Pan D, et al. Stem Cell Res Ther. 2023 Dec 5;14(1):346. doi: 10.1186/s13287-023-03590-3. Stem Cell Res Ther. 2023. PMID: 38049871
METHODS: We created monoallelic CRX by replacing one allele with tdTomato in human embryonic stem cells (hESCs) and subsequently dissect pathogenesis in hESCs-derived retinal organoids. We used transcriptome and immunofluorescence analyses to dissect phenotypic differences …
METHODS: We created monoallelic CRX by replacing one allele with tdTomato in human embryonic stem cells (hESCs) and subsequently dissect pat …
JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer's disease.
Scopa C, Barnada SM, Cicardi ME, Singer M, Trotti D, Trizzino M. Scopa C, et al. Nat Commun. 2023 Dec 4;14(1):8021. doi: 10.1038/s41467-023-43728-8. Nat Commun. 2023. PMID: 38049398
Combining functional genomics with the differentiation of familial and sporadic AD patient derived-iPSCs into hippocampal progenitors, CA3 neurons, and cerebral organoids, we found that the upregulation of the AP-1 subunit, c-Jun, triggers decondensation of genomic regions …
Combining functional genomics with the differentiation of familial and sporadic AD patient derived-iPSCs into hippocampal progenitors, CA3 n …
In silico screening of herbal phytochemicals to develop a Rasayana for immunity against Nipah virus.
Debroy B, De A, Bhattacharya S, Pal K. Debroy B, et al. J Ayurveda Integr Med. 2023 Dec 3;14(6):100825. doi: 10.1016/j.jaim.2023.100825. Online ahead of print. J Ayurveda Integr Med. 2023. PMID: 38048723
However, it is essential to further evaluate the efficacy of this approach through cell-based experiments, organoid models, and eventually clinical trials....
However, it is essential to further evaluate the efficacy of this approach through cell-based experiments, organoid models, and event …
The circadian regulator PER1 promotes cell reprogramming by inhibiting inflammatory signaling from macrophages.
Katoku-Kikyo N, Lim S, Yuan C, Koroth J, Nakagawa Y, Bradley EW, Kikyo N. Katoku-Kikyo N, et al. PLoS Biol. 2023 Dec 4;21(12):e3002419. doi: 10.1371/journal.pbio.3002419. Online ahead of print. PLoS Biol. 2023. PMID: 38048364
This study uncovers mechanistic links between cell reprogramming, bystander inflammatory macrophages, and circadian rhythms, which are particularly relevant to in vivo reprogramming and organoid formation incorporating immune cells....
This study uncovers mechanistic links between cell reprogramming, bystander inflammatory macrophages, and circadian rhythms, which are parti …
Stage-specific dynamic reorganization of genome topology shapes transcriptional neighborhoods in developing human retinal organoids.
Qu Z, Batz Z, Singh N, Marchal C, Swaroop A. Qu Z, et al. Cell Rep. 2023 Dec 2;42(12):113543. doi: 10.1016/j.celrep.2023.113543. Online ahead of print. Cell Rep. 2023. PMID: 38048222
We have generated a high-resolution Hi-C map of developing human retinal organoids to elucidate spatiotemporal dynamics of genomic architecture and its relationship with gene expression patterns. ...These genes gain chromatin contacts at their transcription start site as …
We have generated a high-resolution Hi-C map of developing human retinal organoids to elucidate spatiotemporal dynamics of genomic ar …
Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer.
Plattner C, Lamberti G, Blattmann P, Kirchmair A, Rieder D, Loncova Z, Sturm G, Scheidl S, Ijsselsteijn M, Fotakis G, Noureen A, Lisandrelli R, Böck N, Nemati N, Krogsdam A, Daum S, Finotello F, Somarakis A, Schäfer A, Wilflingseder D, Gonzalez Acera M, Öfner D, Huber LA, Clevers H, Becker C, Farin HF, Greten FR, Aebersold R, de Miranda NFCC, Trajanoski Z. Plattner C, et al. iScience. 2023 Nov 4;26(12):108399. doi: 10.1016/j.isci.2023.108399. eCollection 2023 Dec 15. iScience. 2023. PMID: 38047086 Free PMC article.
We extend this paradigm to measuring proteome activity landscapes by acquiring quantitative phosphoproteomic data from patient-derived organoids (PDOs). We show that kinase inhibitors induce inhibitor- and patient-specific off-target effects and pathway crosstalk. ...
We extend this paradigm to measuring proteome activity landscapes by acquiring quantitative phosphoproteomic data from patient-derived or …
Cultivation of enteroids from fresh and cryopreserved bovine duodenal tissues.
Nishihara K, Wood KM, Guan LL, Steele MA. Nishihara K, et al. JDS Commun. 2023 Aug 19;4(6):518-523. doi: 10.3168/jdsc.2023-0379. eCollection 2023 Nov. JDS Commun. 2023. PMID: 38045896 Free PMC article.
Embedded crypts were seeded in a 24-well plate and cultured in IntestiCult Organoid Growth Medium (Mouse) with inhibitors cocktail and Primocin. ...
Embedded crypts were seeded in a 24-well plate and cultured in IntestiCult Organoid Growth Medium (Mouse) with inhibitors cocktail an …
Urine-derived cells from the aged donor for the 2D/3D modeling of neural cells via iPSCs.
Supakul S, Hatakeyama Y, Leventoux N, Itsuno M, Numata N, Hiramine H, Morimoto S, Iwata A, Maeda S, Okano H. Supakul S, et al. Aging Brain. 2023 Nov 19;4:100101. doi: 10.1016/j.nbas.2023.100101. eCollection 2023. Aging Brain. 2023. PMID: 38045491 Free PMC article.
In this study, we reported a case of using the UDCs from the urine sample of an 89-year-old AD patient, and the UDCs were successfully reprogrammed into iPSCs and differentiated into neural cells in four different ways: (i) the dual SMAD inhibition with small-molecules via the ne …
In this study, we reported a case of using the UDCs from the urine sample of an 89-year-old AD patient, and the UDCs were successfully repro …
A novel thin plate spline methodology to model tissue surfaces and quantify tumor cell invasion in organ-on-chip models.
Elton E, Strelez C, Ung N, Perez R, Ghaffarian K, Matasci N, Mumenthaler SM. Elton E, et al. bioRxiv. 2023 Nov 21:2023.11.20.567272. doi: 10.1101/2023.11.20.567272. Preprint. bioRxiv. 2023. PMID: 38045424 Free PMC article.
., utilizing a two-channel system with endothelial cells in the bottom channel and colorectal cancer (CRC) patient-derived organoids (PDOs) in the top channel. Initial application and visualization of this method revealed boundary variations due to microscope stage tilt an …
., utilizing a two-channel system with endothelial cells in the bottom channel and colorectal cancer (CRC) patient-derived organoids …
Nephron progenitors rhythmically alternate between renewal and differentiation in synchrony with kidney branching morphogenesis.
Davis SN, Grindel SH, Viola JM, Liu GY, Liu J, Qian G, Porter CM, Hughes AJ. Davis SN, et al. bioRxiv. 2023 Nov 21:2023.11.21.568157. doi: 10.1101/2023.11.21.568157. Preprint. bioRxiv. 2023. PMID: 38045273 Free PMC article.
We then reveal stark differences in progenitor renewal vs. differentiation rates depending on whether Yap is activated in- or out-of-phase with Wnt/beta-catenin-induced differentiation of human stem-cell derived nephron progenitor organoids. Our data brings temporal resolu …
We then reveal stark differences in progenitor renewal vs. differentiation rates depending on whether Yap is activated in- or out-of-phase w …
Retinogenesis in a Dish: Bibliometric Analysis and Visualization of Retinal Organoids From 2011 to 2022.
Shen W, Shao A, Zhou W, Lou L, Grzybowski A, Jin K, Ye J. Shen W, et al. Cell Transplant. 2023 Jan-Dec;32:9636897231214321. doi: 10.1177/09636897231214321. Cell Transplant. 2023. PMID: 38044501
Retinal organoid (RO) is the three-dimensional (3D) retinal culture derived from pluripotent or embryonic stem cells which recapitulates organ functions, which was a revolutionary milestone in stem cell technology. ...
Retinal organoid (RO) is the three-dimensional (3D) retinal culture derived from pluripotent or embryonic stem cells which recapitula …
Development of Physiologically Relevant Skin Organoids from Human Induced Pluripotent Stem Cells.
Shafiee A, Sun J, Ahmed IA, Phua F, Rossi GR, Lin CY, Souza-Fonseca-Guimaraes F, Wolvetang EJ, Brown J, Khosrotehrani K. Shafiee A, et al. Small. 2023 Dec 3:e2304879. doi: 10.1002/smll.202304879. Online ahead of print. Small. 2023. PMID: 38044307
Human induced pluripotent stem cells (hiPSCs) are successfully used to derive skin cells, but the field is still far from meeting the goal of creating skin containing appendages, such as hair follicles and sweat glands. Here, the goal is to generate skin organoids (SKOs) f …
Human induced pluripotent stem cells (hiPSCs) are successfully used to derive skin cells, but the field is still far from meeting the goal o …
Patient stem cell-derived in vitro disease models for developing novel therapies of retinal ciliopathies.
Kruczek K, Swaroop A. Kruczek K, et al. Curr Top Dev Biol. 2023;155:127-163. doi: 10.1016/bs.ctdb.2023.09.003. Epub 2023 Nov 4. Curr Top Dev Biol. 2023. PMID: 38043950
In this article, we review current protocols to differentiate human pluripotent stem cells into retinal cell types, and discuss how these cellular and/or organoid models can be utilized to interrogate pathobiology of ciliopathies affecting the retina and for testing prospe …
In this article, we review current protocols to differentiate human pluripotent stem cells into retinal cell types, and discuss how these ce …
Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche.
Manieri E, Tie G, Malagola E, Seruggia D, Madha S, Maglieri A, Huang K, Fujiwara Y, Zhang K, Orkin SH, Wang TC, He R, McCarthy N, Shivdasani RA. Manieri E, et al. Nat Commun. 2023 Dec 2;14(1):7978. doi: 10.1038/s41467-023-43619-y. Nat Commun. 2023. PMID: 38042929 Free PMC article.
Our high-resolution imaging, transcriptional profiling, and organoid assays identify regional subpopulations and supportive capacities of purified mouse corpus and antral PDGFRA(+) cells. ...
Our high-resolution imaging, transcriptional profiling, and organoid assays identify regional subpopulations and supportive capacitie …
Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models.
Lepore Signorile M, Fasano C, Forte G, De Marco K, Sanese P, Disciglio V, Di Nicola E, Pantaleo A, Simone C, Grossi V. Lepore Signorile M, et al. Cell Biosci. 2023 Dec 1;13(1):223. doi: 10.1186/s13578-023-01175-4. Cell Biosci. 2023. PMID: 38041178 Free PMC article.
METHODS: The functional relationship between p38alpha and beta-catenin was characterized in CRC cells, patient-derived CRC stem cells, patient-derived tumor intestinal organoids, and in vivo models (C57BL/6-APC(Min/+) mice). The role of p38alpha in beta-catenin transcripti …
METHODS: The functional relationship between p38alpha and beta-catenin was characterized in CRC cells, patient-derived CRC stem cells, patie …
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease.
Geng L, Gao W, Saiyin H, Li Y, Zeng Y, Zhang Z, Li X, Liu Z, Gao Q, An P, Jiang N, Yu X, Chen X, Li S, Chen L, Lu B, Li A, Chen G, Shen Y, Zhang H, Tian M, Zhang Z, Li J. Geng L, et al. Mol Neurodegener. 2023 Dec 1;18(1):94. doi: 10.1186/s13024-023-00686-5. Mol Neurodegener. 2023. PMID: 38041169 Free PMC article.
Here, we investigated the neuroprotective role of MLKL inhibition or ablation against primary neuronal cells and human iPSC-derived midbrain organoids induced by toxic alpha-Synuclein preformed fibrils (PFFs). ...
Here, we investigated the neuroprotective role of MLKL inhibition or ablation against primary neuronal cells and human iPSC-derived midbrain …
Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions.
Wang S, Wu W, Lin X, Zhang KM, Wu Q, Luo M, Zhou J. Wang S, et al. Cell Biosci. 2023 Dec 1;13(1):224. doi: 10.1186/s13578-023-01171-8. Cell Biosci. 2023. PMID: 38041134 Free PMC article. Review.
Beyond that, we briefly explore the potential of new technologies such as single-cell sequencing and organoid models, which will improve our understanding of tumor heterogeneity and aid in the development of improved biomarkers. ...
Beyond that, we briefly explore the potential of new technologies such as single-cell sequencing and organoid models, which will impr …
Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool.
Obreque J, Vergara-Gómez L, Venegas N, Weber H, Owen GI, Pérez-Moreno P, Leal P, Roa JC, Bizama C. Obreque J, et al. Biol Res. 2023 Dec 2;56(1):63. doi: 10.1186/s40659-023-00476-9. Biol Res. 2023. PMID: 38041132 Free PMC article. Review.
In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo animal testing before clinical evaluation, a declaration that now demands the establishment and verification of ex vivo preclinical models that closely repres …
In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo animal testing bef …
Efficient generation of brain organoids using magnetized gold nanoparticles.
Kim H, Lee YJ, Kwon Y, Kim J. Kim H, et al. Sci Rep. 2023 Dec 1;13(1):21240. doi: 10.1038/s41598-023-48655-8. Sci Rep. 2023. PMID: 38040919 Free PMC article.
However, creating these organoids can be a complicated and difficult process due to various technological hurdles. ...By exposing mature cerebral organoids to magnetized AuNPs, we were able to cultivate them in less than 3 weeks. ...
However, creating these organoids can be a complicated and difficult process due to various technological hurdles. ...By exposing mat …
An AI-based segmentation and analysis pipeline for high-field MR monitoring of cerebral organoids.
Deininger L, Jung-Klawitter S, Mikut R, Richter P, Fischer M, Karimian-Jazi K, Breckwoldt MO, Bendszus M, Heiland S, Kleesiek J, Opladen T, Hübschmann OK, Hübschmann D, Schwarz D. Deininger L, et al. Sci Rep. 2023 Dec 1;13(1):21231. doi: 10.1038/s41598-023-48343-7. Sci Rep. 2023. PMID: 38040865 Free PMC article.
Three specific objectives are addressed, (I) organoid segmentation to investigate organoid development over time, (II) global cysticity classification and (III) local cyst segmentation for organoid quality assessment. We show that organoid growth can b …
Three specific objectives are addressed, (I) organoid segmentation to investigate organoid development over time, (II) global …
SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors.
Liu NQ, Paassen I, Custers L, Zeller P, Teunissen H, Ayyildiz D, He J, Buhl JL, Hoving EW, van Oudenaarden A, de Wit E, Drost J. Liu NQ, et al. Nat Commun. 2023 Dec 1;14(1):7762. doi: 10.1038/s41467-023-43498-3. Nat Commun. 2023. PMID: 38040699 Free PMC article.
Here, we study derailed regulatory landscapes as a consequence of SMARCB1 loss in the context of MRT. Our multi-omics approach on patient-derived MRT organoids reveals a dramatic reshaping of the regulatory landscape upon SMARCB1 reconstitution. ...
Here, we study derailed regulatory landscapes as a consequence of SMARCB1 loss in the context of MRT. Our multi-omics approach on patient-de …
Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance.
Beckers C, Vasilikos L, Sanchez-Fernandez A, Moor L, Pruschy M. Beckers C, et al. Radiother Oncol. 2023 Nov 29:110039. doi: 10.1016/j.radonc.2023.110039. Online ahead of print. Radiother Oncol. 2023. PMID: 38040123
The combined treatment modality of IR and DYRK1B inhibition was investigated in 2D and in spheroids derived from the colorectal cancer cell line SW620, and in primary patient-derived colorectal carcinoma (CRC) organoids. RESULTS: Expression of DYRK1B was upregulated under …
The combined treatment modality of IR and DYRK1B inhibition was investigated in 2D and in spheroids derived from the colorectal cancer cell …
ASCL1 induces neurogenesis in human Müller glia.
Wohlschlegel J, Finkbeiner C, Hoffer D, Kierney F, Prieve A, Murry AD, Haugan AK, Ortuño-Lizarán I, Rieke F, Golden SA, Reh TA. Wohlschlegel J, et al. Stem Cell Reports. 2023 Nov 21:S2213-6711(23)00423-X. doi: 10.1016/j.stemcr.2023.10.021. Online ahead of print. Stem Cell Reports. 2023. PMID: 38039971
In this study, we applied the same strategy to reprogram human MG derived from fetal retina and retinal organoids into neurons. Combining single cell RNA sequencing, single cell ATAC sequencing, immunofluorescence, and electrophysiology we demonstrate that human MG can be …
In this study, we applied the same strategy to reprogram human MG derived from fetal retina and retinal organoids into neurons. Combi …
Single-cell transcriptomic analysis of corneal organoids during development.
Swarup A, Phansalkar R, Morri M, Agarwal A, Subramaniam V, Li B, Wu AY. Swarup A, et al. Stem Cell Reports. 2023 Nov 13:S2213-6711(23)00424-1. doi: 10.1016/j.stemcr.2023.10.022. Online ahead of print. Stem Cell Reports. 2023. PMID: 38039970
Corneal organoids are useful tools for disease modeling and tissue transplantation; however, they have not yet been well studied during maturation. ...We found pluripotent cell clusters committed to epithelial cell lineage at 1 month; early corneal epithelial, endothelial, …
Corneal organoids are useful tools for disease modeling and tissue transplantation; however, they have not yet been well studied duri …
Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD.
Mae SI, Hattanda F, Morita H, Nozaki A, Katagiri N, Ogawa H, Teranaka K, Nishimura Y, Kudoh A, Yamanaka S, Matsuse K, Ryosaka M, Watanabe A, Soga T, Nishio S, Osafune K. Mae SI, et al. Cell Rep. 2023 Nov 10:113431. doi: 10.1016/j.celrep.2023.113431. Online ahead of print. Cell Rep. 2023. PMID: 38039961 Free article.
Here, by establishing expansion cultures of hiPSC-derived ureteric bud tip cells, an embryonic precursor that gives rise to CDs, we succeed in advancing the developmental stage of CD organoids and show that all CD organoids derived from PKD1(-/-) hiPSCs spontaneousl …
Here, by establishing expansion cultures of hiPSC-derived ureteric bud tip cells, an embryonic precursor that gives rise to CDs, we succeed …
Protocol to characterize basement membranes during kidney development using mass spectrometry-based label-free quantitative proteomics.
Morais MRPT, Tian P, O'cualain R, Lawless C, Lennon R. Morais MRPT, et al. STAR Protoc. 2023 Nov 29;4(4):102741. doi: 10.1016/j.xpro.2023.102741. Online ahead of print. STAR Protoc. 2023. PMID: 38039136
Here, we present a mass spectrometry-based label-free quantitative proteomics protocol to investigate basement membranes and define their composition using samples from human kidney organoids and mouse fetal kidneys. This protocol facilitates the study of basement membrane …
Here, we present a mass spectrometry-based label-free quantitative proteomics protocol to investigate basement membranes and define their co …
NGLY1 mutations cause protein aggregation in human neurons.
Manole A, Wong T, Rhee A, Novak S, Chin SM, Tsimring K, Paucar A, Williams A, Newmeyer TF, Schafer ST, Rosh I, Kaushik S, Hoffman R, Chen S, Wang G, Snyder M, Cuervo AM, Andrade L, Manor U, Lee K, Jones JR, Stern S, Marchetto MC, Gage FH. Manole A, et al. Cell Rep. 2023 Nov 30;42(12):113466. doi: 10.1016/j.celrep.2023.113466. Online ahead of print. Cell Rep. 2023. PMID: 38039131 Free article.
Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity.
Awad D, Cao PHA, Pulliam TL, Spradlin M, Subramani E, Tellman TV, Ribeiro CF, Muzzioli R, Jewell BE, Pakula H, Ackroyd JJ, Murray MM, Han JJ, Leng M, Jain A, Piyarathna B, Liu J, Song X, Zhang J, Klekers AR, Drake JM, Ittmann MM, Coarfa C, Piwnica-Worms D, Farach-Carson MC, Loda M, S Eberlin L, Frigo DE. Awad D, et al. Cancer Res. 2023 Dec 1. doi: 10.1158/0008-5472.CAN-23-0555. Online ahead of print. Cancer Res. 2023. PMID: 38038968
Molecular, genetic, or pharmacological inhibition of ATGL impaired human and murine prostate cancer growth in vivo and in cell culture or organoids under conditions mimicking the tumor microenvironment. Mass spectrometry imaging demonstrated ATGL profoundly regulates lipid …
Molecular, genetic, or pharmacological inhibition of ATGL impaired human and murine prostate cancer growth in vivo and in cell culture or …
Analysis of Matrix Metalloproteinase Activity and Inhibition in Cancer Spheroids.
Knapinska AM, Onwuha-Ekpete L, Drotleff G, Twohill D, Chai C, Ernce A, Grande I, Rodríguez M, Tokmina-Roszyk D, Larson B, Fields GB. Knapinska AM, et al. Methods Mol Biol. 2024;2747:189-209. doi: 10.1007/978-1-0716-3589-6_16. Methods Mol Biol. 2024. PMID: 38038942
The utilization of tumor spheroids and organoids has greatly facilitated mechanistic understanding of tumor growth and invasion and lead to more effective high-throughput analysis of potential chemotherapeutic agents. In spheroid and organoid systems, tumor invasion …
The utilization of tumor spheroids and organoids has greatly facilitated mechanistic understanding of tumor growth and invasion and l …
Spatially Self-Organized Three-Dimensional Neural Concentroid as a Novel Reductionist Humanized Model to Study Neurovascular Development.
Chai YC, To SK, Simorgh S, Zaunz S, Zhu Y, Ahuja K, Lemaitre A, Ramezankhani R, van der Veer BK, Wierda K, Verhulst S, van Grunsven LA, Pasque V, Verfaillie C. Chai YC, et al. Adv Sci (Weinh). 2023 Nov 30:e2304421. doi: 10.1002/advs.202304421. Online ahead of print. Adv Sci (Weinh). 2023. PMID: 38037510
Although human pluripotent stem cell (PSC)-derived brain organoids have enabled researchers to gain insight into human brain development and disease, these organoids contain solely ectodermal cells and are not vascularized as occurs during brain development. ...Sing …
Although human pluripotent stem cell (PSC)-derived brain organoids have enabled researchers to gain insight into human brain developm …
Patient- and xenograft-derived organoids recapitulate pediatric brain tumor features and patient treatments.
Lago C, Federico A, Leva G, Mack NL, Schwalm B, Ballabio C, Gianesello M, Abballe L, Giovannoni I, Reddel S, Rossi S, Leone N, Carai A, Mastronuzzi A, Bisio A, Soldano A, Quintarelli C, Locatelli F, Kool M, Miele E, Tiberi L. Lago C, et al. EMBO Mol Med. 2023 Nov 30:e18199. doi: 10.15252/emmm.202318199. Online ahead of print. EMBO Mol Med. 2023. PMID: 38037472 Free article.
We present a protocol that enables efficient generation, expansion, and biobanking of pediatric brain cancer organoids. Utilizing our protocol, we have established patient-derived organoids (PDOs) from ependymomas, medulloblastomas, low-grade glial tumors, and patie …
We present a protocol that enables efficient generation, expansion, and biobanking of pediatric brain cancer organoids. Utilizing our …
Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy.
Wei D, Su Y, Leung PCK, Li Y, Chen ZJ. Wei D, et al. Hum Reprod Update. 2023 Nov 30:dmad031. doi: 10.1093/humupd/dmad031. Online ahead of print. Hum Reprod Update. 2023. PMID: 38037193
Along with emerging technologies such as tissue microarrays, 3D organoid cultures and advanced single-cell transcriptomics, and given the clinical availability of recombinant human proteins and ongoing pharmaceutical development, it is now clear that BMPs exert multiple ro …
Along with emerging technologies such as tissue microarrays, 3D organoid cultures and advanced single-cell transcriptomics, and given …
LC-MS Approaches for Oxysterols in Various Biosamples.
Kømurcu KS, Wilson SR, Røberg-Larsen H. Kømurcu KS, et al. Adv Exp Med Biol. 2024;1440:57-71. doi: 10.1007/978-3-031-43883-7_4. Adv Exp Med Biol. 2024. PMID: 38036875
We then round off with descriptions and applications of various sample preparations for different biological matrices, from blood to cells, and biosamples with emerging attention, for example, exosomes and organoids. Taken together, oxysterol analysis is highly compatible …
We then round off with descriptions and applications of various sample preparations for different biological matrices, from blood to cells, …
Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment.
Li N, Zhu Q, Tian Y, Ahn KJ, Wang X, Cramer Z, Jou J, Folkert IW, Yu P, Adams-Tzivelekidis S, Sehgal P, Mahmoud NN, Aarons CB, Roses RE, Thomas-Tikhonenko A, Furth EE, Stanger BZ, Rustgi A, Haldar M, Katona BW, Tan K, Lengner CJ. Li N, et al. Nat Commun. 2023 Nov 30;14(1):7915. doi: 10.1038/s41467-023-43746-6. Nat Commun. 2023. PMID: 38036590 Free PMC article.
Here we predict cancer-TME interactions from single cell transcriptomic maps of both human colorectal cancers (CRCs) and mouse CRC models, ask how these interactions are altered in human tumor organoid (tumoroid) cultures, and functionally recapitulate human myeloid-carcin …
Here we predict cancer-TME interactions from single cell transcriptomic maps of both human colorectal cancers (CRCs) and mouse CRC models, a …
The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment.
Contenti J, Guo Y, Mazzu A, Irondelle M, Rouleau M, Lago C, Leva G, Tiberi L, Ben-Sahra I, Bost F, Mazure NM. Contenti J, et al. Cell Death Dis. 2023 Nov 30;14(11):784. doi: 10.1038/s41419-023-06275-0. Cell Death Dis. 2023. PMID: 38036520 Free PMC article.
Furthermore, inhibition of the cytosolic NAD+ recycling enzyme lactate dehydrogenase A (LDHA), enhanced the effects of the NADH shuttle inhibitors. In a 3D model using Group 3 human cerebellar organoids, tumor cells also underwent apoptosis upon treatment with NADH shuttle …
Furthermore, inhibition of the cytosolic NAD+ recycling enzyme lactate dehydrogenase A (LDHA), enhanced the effects of the NADH shuttle inhi …
Human Motor System-Based Biohybrid Robot-On-a-Chip for Drug Evaluation of Neurodegenerative Disease.
Shin M, Ha T, Lim J, An J, Beak G, Choi JH, Melvin AA, Yoon J, Choi JW. Shin M, et al. Adv Sci (Weinh). 2023 Nov 30:e2305371. doi: 10.1002/advs.202305371. Online ahead of print. Adv Sci (Weinh). 2023. PMID: 38036423
The electrophysiological signals from the cerebral organoid induced the muscle bundle movement through motor neuron spheroids. To evaluate the drug effect on Parkinson's disease (PD), a patient-derived midbrain organoid is generated and incorporated into a biohybrid …
The electrophysiological signals from the cerebral organoid induced the muscle bundle movement through motor neuron spheroids. To eva …
Progress and harmonization of gene editing to treat human diseases: Proceeding of COST Action CA21113 GenE-HumDi.
Cavazza A, Hendel A, Bak RO, Rio P, Güell M, Lainšček D, Arechavala-Gomeza V, Peng L, Hapil FZ, Harvey J, Ortega FG, Gonzalez-Martinez C, Lederer CW, Mikkelsen K, Gasiunas G, Kalter N, Gonçalves MAFV, Petersen J, Garanto A, Montoliu L, Maresca M, Seemann SE, Gorodkin J, Mazini L, Sanchez R, Rodriguez-Madoz JR, Maldonado-Pérez N, Laura T, Schmueck-Henneresse M, Maccalli C, Grünewald J, Carmona G, Kachamakova-Trojanowska N, Miccio A, Martin F, Turchiano G, Cathomen T, Luo Y, Tsai SQ, Benabdellah K; COST Action CA21113. Cavazza A, et al. Mol Ther Nucleic Acids. 2023 Oct 29;34:102066. doi: 10.1016/j.omtn.2023.102066. eCollection 2023 Dec 12. Mol Ther Nucleic Acids. 2023. PMID: 38034032 Free PMC article. Review.
Exploring maternal-fetal interface with in vitro placental and trophoblastic models.
Liu X, Wang G, Huang H, Lv X, Si Y, Bai L, Wang G, Li Q, Yang W. Liu X, et al. Front Cell Dev Biol. 2023 Nov 14;11:1279227. doi: 10.3389/fcell.2023.1279227. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 38033854 Free PMC article. Review.
In vitro models have been employed to study the physiological features and molecular regulatory mechanisms of placental development, aiming to gain a detailed understanding of the pathogenesis of pregnancy-related diseases. Among these models, trophoblast stem cell culture and …
In vitro models have been employed to study the physiological features and molecular regulatory mechanisms of placental development, aiming …
Effect of Mechanical Stimuli on the Phenotypic Plasticity of Induced Pluripotent Stem-Cell-Derived Vascular Smooth Muscle Cells in a 3D Hydrogel.
Meijer EM, Giles R, van Dijk CGM, Maringanti R, Wissing TB, Appels Y, Chrifi I, Crielaard H, Verhaar MC, Smits AIPM, Cheng C. Meijer EM, et al. ACS Appl Bio Mater. 2023 Nov 30. doi: 10.1021/acsabm.3c00840. Online ahead of print. ACS Appl Bio Mater. 2023. PMID: 38032545
Here, we aim to investigate the impact of intrinsic substrate properties, such as the hydrogel's elastic modulus and cross-linking density in a 3D static and dynamic environment, on the phenotypical adaptation of human mural cells derived from hiPSC-derived organoids (ODMC …
Here, we aim to investigate the impact of intrinsic substrate properties, such as the hydrogel's elastic modulus and cross-linking density i …
Use and application of organ-on-a-chip platforms in cancer research.
Yu Y, Zhou T, Cao L. Yu Y, et al. J Cell Commun Signal. 2023 Nov 30. doi: 10.1007/s12079-023-00790-7. Online ahead of print. J Cell Commun Signal. 2023. PMID: 38032444 Review.
The development of organ-on-a-chip models has enabled the integration of organoids, microfluidics, tissue engineering, biomaterials research, and microfabrication, offering conditions that mimic tumor physiology. ...
The development of organ-on-a-chip models has enabled the integration of organoids, microfluidics, tissue engineering, biomaterials r …
Intestinal organoid technology and applications in probiotics.
Tan H, Chen X, Wang C, Song J, Xu J, Zhang Y, Suo H. Tan H, et al. Crit Rev Food Sci Nutr. 2023 Nov 30:1-15. doi: 10.1080/10408398.2023.2288887. Online ahead of print. Crit Rev Food Sci Nutr. 2023. PMID: 38032232 Review.
It overcomes challenges posed by animal models and 2D cell models in accurately simulating the in vivo environment. This review summarizes the development of intestinal organoid technology and its potential applications in intestinal health research as well as highlights t …
It overcomes challenges posed by animal models and 2D cell models in accurately simulating the in vivo environment. This review summarizes t …
FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe.
O'Brien S, Ubhi T, Wolf L, Gandhi K, Lin S, Chaudary N, Dhani NC, Milosevic M, Brown GW, Angers S. O'Brien S, et al. Cancer Res Commun. 2023 Nov 30. doi: 10.1158/2767-9764.CRC-23-0306. Online ahead of print. Cancer Res Commun. 2023. PMID: 38032106
ATR-inhibition induces an accelerated S-phase, leading to mitotic catastrophe and cell death caused by the high replication stress present in FBXW7-/- cells. In addition, we provide evidence in cell and organoid studies, and mining of publicly available high throughput dru …
ATR-inhibition induces an accelerated S-phase, leading to mitotic catastrophe and cell death caused by the high replication stress present i …
Germline PTEN genotype-dependent phenotypic divergence during the early neural developmental process of forebrain organoids.
Kang SC, Sarn NB, Venegas J, Tan Z, Hitomi M, Eng C. Kang SC, et al. Mol Psychiatry. 2023 Nov 29. doi: 10.1038/s41380-023-02325-3. Online ahead of print. Mol Psychiatry. 2023. PMID: 38030818
Here, we show that the PTEN(G132D) allele disrupts early neuroectoderm formation during the first several days of organoid generation, and results in deficient electrophysiology. While organoids generated from PTEN(M134R) hiPSCs remained morphologically similar to w …
Here, we show that the PTEN(G132D) allele disrupts early neuroectoderm formation during the first several days of organoid generation …
Darolutamide added to docetaxel augments antitumor effect in models of prostate cancer through cell cycle arrest at the G1-S transition.
Buck SAJ, Van Hemelryk A, de Ridder C, Stuurman D, Erkens-Schulze S, Van 't Geloof S, Teubel WJ, Koolen SLW, Martens-Uzunova ES, van Royen ME, de Wit R, Mathijssen RHJ, van Weerden WM. Buck SAJ, et al. Mol Cancer Ther. 2023 Nov 30. doi: 10.1158/1535-7163.MCT-23-0420. Online ahead of print. Mol Cancer Ther. 2023. PMID: 38030379
We hypothesized that AR signaling inhibitor (ARSi) darolutamide in combination with docetaxel could augment antitumor effect by impeding the proliferation of taxane-resistant cancer cells. We monitored cell viability in organoids, tumor volume and PSA secretion in patient- …
We hypothesized that AR signaling inhibitor (ARSi) darolutamide in combination with docetaxel could augment antitumor effect by impeding the …
Common analysis of direct RNA sequencinG CUrrently leads to misidentification of m5C at GCU motifs.
Watson KJ, Bromley RE, Sparklin BC, Gasser MT, Bhattacharya T, Lebov JF, Tyson T, Dai N, Teigen LE, Graf KT, Foster JM, Michalski M, Bruno VM, Lindsey AR, Corrêa IR Jr, Hardy RW, Newton IL, Dunning Hotopp JC. Watson KJ, et al. Life Sci Alliance. 2023 Nov 29;7(2):e202302201. doi: 10.26508/lsa.202302201. Print 2024 Feb. Life Sci Alliance. 2023. PMID: 38030223 Free PMC article.
In the absence of further validation, several published predictions of m(5)C in a GCU context should be reconsidered, including those from human coronavirus and human cerebral organoid samples....
In the absence of further validation, several published predictions of m(5)C in a GCU context should be reconsidered, including those from h …
Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells.
Kopsida M, Clavero AL, Khaled J, Balgoma D, Luna-Marco C, Chowdhury A, Nyman SS, Rorsman F, Barbier CE, Bergsten P, Lennernäs H, Hedeland M, Heindryckx F. Kopsida M, et al. Mol Metab. 2023 Nov 27:101846. doi: 10.1016/j.molmet.2023.101846. Online ahead of print. Mol Metab. 2023. PMID: 38030123
In vitro models, including HCC cells, spheroids, and patient-derived liver organoids were subjected to 4mu8C and/or DOX, enabling us to assess their synergistic effects on cellular viability, lipid metabolism, and oxygen consumption rate. ...
In vitro models, including HCC cells, spheroids, and patient-derived liver organoids were subjected to 4mu8C and/or DOX, enabling us …
Multi-chamber cardioids unravel human heart development and cardiac defects.
Schmidt C, Deyett A, Ilmer T, Haendeler S, Torres Caballero A, Novatchkova M, Netzer MA, Ceci Ginistrelli L, Mancheno Juncosa E, Bhattacharya T, Mujadzic A, Pimpale L, Jahnel SM, Cirigliano M, Reumann D, Tavernini K, Papai N, Hering S, Hofbauer P, Mendjan S. Schmidt C, et al. Cell. 2023 Nov 16:S0092-8674(23)01181-9. doi: 10.1016/j.cell.2023.10.030. Online ahead of print. Cell. 2023. PMID: 38029745
Advanced lung organoids and lung-on-a-chip for cancer research and drug evaluation: a review.
Zhu L, Zhang J, Guo Q, Kuang J, Li D, Wu M, Mo Y, Zhang T, Gao X, Tan J. Zhu L, et al. Front Bioeng Biotechnol. 2023 Nov 7;11:1299033. doi: 10.3389/fbioe.2023.1299033. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 38026900 Free PMC article. Review.
The advent of innovative three-dimensional (3D) culture systems such as organoid and organ-on-a-chip models provides opportunities to address these challenges and revolutionise lung cancer research and drug evaluation. In this review, we introduce the advancements in lung- …
The advent of innovative three-dimensional (3D) culture systems such as organoid and organ-on-a-chip models provides opportunities to …
Advances in current in vitro models on neurodegenerative diseases.
Pereira I, Lopez-Martinez MJ, Samitier J. Pereira I, et al. Front Bioeng Biotechnol. 2023 Nov 6;11:1260397. doi: 10.3389/fbioe.2023.1260397. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 38026882 Free PMC article. Review.
Although necessary in the drug discovery process, in vivo animal models need to be reduced and show relevant differences with the human tissues that guide scientists to inquire about other possible options which lead to in vitro models being explored. From organoids to org …
Although necessary in the drug discovery process, in vivo animal models need to be reduced and show relevant differences with the human tiss …
Cartilage organoids and osteoarthritis research: a narrative review.
Zeng D, Chen Y, Liao Z, Wei G, Huang X, Liang R, Lu WW, Yi D, Chen Y. Zeng D, et al. Front Bioeng Biotechnol. 2023 Nov 9;11:1278692. doi: 10.3389/fbioe.2023.1278692. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 38026876 Free PMC article. Review.
This review will briefly analyze the research progress of OA, focusing on the construction and current development of cartilage organoids, and then describe the application of cartilage organoids in OA modeling, drug screening, and regeneration and repair of cartila …
This review will briefly analyze the research progress of OA, focusing on the construction and current development of cartilage organoids …
Spatiotemporal analysis of 3D human iPSC-derived neural networks using a 3D multi-electrode array.
Lam D, Enright HA, Cadena J, George VK, Soscia DA, Tooker AC, Triplett M, Peters SKG, Karande P, Ladd A, Bogguri C, Wheeler EK, Fischer NO. Lam D, et al. Front Cell Neurosci. 2023 Nov 13;17:1287089. doi: 10.3389/fncel.2023.1287089. eCollection 2023. Front Cell Neurosci. 2023. PMID: 38026689 Free PMC article.
While there is a growing appreciation of three-dimensional (3D) neural tissues (i.e., hydrogel-based, organoids, and spheroids), shown to improve cellular health and network activity to mirror brain-like activity in vivo, functional assessment using current electrophysiolo …
While there is a growing appreciation of three-dimensional (3D) neural tissues (i.e., hydrogel-based, organoids, and spheroids), show …
Patient-derived organoids as personalized avatars and a potential immunotherapy model in cervical cancer.
Huang H, Pan Y, Huang J, Zhang C, Liao Y, Du Q, Qin S, Chen Y, Tan H, Chen M, Xu M, Xia M, Liu Y, Li J, Liu T, Zou Q, Zhou Y, Yuan L, Wang W, Liang Y, Pan CY, Liu J, Yao S. Huang H, et al. iScience. 2023 Oct 12;26(11):108198. doi: 10.1016/j.isci.2023.108198. eCollection 2023 Nov 17. iScience. 2023. PMID: 38026204 Free PMC article.
However, finding a preclinical model that accurately reproduces tumor characteristics is challenging. Therefore, we established a patient-derived organoids (PDOs) biobank containing 67 cases of heterogeneous cervical cancer that mimic the histopathological and genomic char …
However, finding a preclinical model that accurately reproduces tumor characteristics is challenging. Therefore, we established a patient-de …
Modeling gut neuro-epithelial connections in a novel microfluidic device.
de Hoyos-Vega JM, Yu X, Gonzalez-Suarez AM, Chen S, Mercado-Perez A, Krueger E, Hernandez J, Fedyshyn Y, Druliner BR, Linden DR, Beyder A, Revzin A. de Hoyos-Vega JM, et al. Microsyst Nanoeng. 2023 Nov 14;9:144. doi: 10.1038/s41378-023-00615-y. eCollection 2023. Microsyst Nanoeng. 2023. PMID: 38025883 Free PMC article.
The epithelial compartment was designed for cell seeding via injection and confinement of intestinal epithelial cells derived from human intestinal organoids. We demonstrated that organoids planarized effectively and retained epithelial phenotype for over a week. .. …
The epithelial compartment was designed for cell seeding via injection and confinement of intestinal epithelial cells derived from human int …
Potential application of PBM use in hair follicle organoid culture for the treatment of androgenic alopecia.
Roets B. Roets B. Mater Today Bio. 2023 Nov 3;23:100851. doi: 10.1016/j.mtbio.2023.100851. eCollection 2023 Dec. Mater Today Bio. 2023. PMID: 38024838 Free PMC article. Review.
Therefore, to address the limitations of current treatment options a novel regenerative treatment option is required. One promising approach is organoids, organoids are 3D cell aggregates with similar structures and functions to a target organ. Hair follicle orga …
Therefore, to address the limitations of current treatment options a novel regenerative treatment option is required. One promising approach …
Generation of Mouse Primitive Endoderm Stem Cells.
Ohinata Y, Saraya A, Koseki H. Ohinata Y, et al. Bio Protoc. 2023 Nov 20;13(22):e4878. doi: 10.21769/BioProtoc.4878. eCollection 2023 Nov 20. Bio Protoc. 2023. PMID: 38023790 Free PMC article.
Key features Establishment and maintenance of primitive endoderm stem cell (PrESCs) capable of recapitulating the developmental prowess inherent to PrE. Offering a source of PrE lineage for embryo-like organoid reconstitution studies....
Key features Establishment and maintenance of primitive endoderm stem cell (PrESCs) capable of recapitulating the developmental prowess inhe …
m6A epitranscriptome analysis reveals differentially methylated transcripts that drive early chemoresistance in bladder cancer.
Hodara E, Mades A, Swartz L, Iqbal M, Xu T, Bsteh D, Farnham PJ, Rhie SK, Goldkorn A. Hodara E, et al. NAR Cancer. 2023 Nov 16;5(4):zcad054. doi: 10.1093/narcan/zcad054. eCollection 2023 Dec. NAR Cancer. 2023. PMID: 38023731 Free PMC article.
Consistent with this, cisplatin-sensitive BC cell lines and patient-derived organoids exposed to cisplatin for as little as 48 h exhibited similar mechanisms of SLC7A11 upregulation and chemoresistance, trends that were also reflected in public cancer survival databases. . …
Consistent with this, cisplatin-sensitive BC cell lines and patient-derived organoids exposed to cisplatin for as little as 48 h exhi …
Use of patient-derived tumor organoid platform to predict the benefit of postoperative adjuvant chemotherapy for poor responders to neoadjuvant chemoradiotherapy in locally advanced rectal cancer.
Xue W, Wang T, Yao J, Wu W, Chen D, Yan B, Dong X, Tang Y, Zeng Y, He Y, Cao P, Shao F, Huang W, Deng C, Yan J. Xue W, et al. Bioeng Transl Med. 2023 Aug 16;8(6):e10586. doi: 10.1002/btm2.10586. eCollection 2023 Nov. Bioeng Transl Med. 2023. PMID: 38023722 Free PMC article.
Postoperative adjuvant chemotherapy (AC) for poor responders to neoadjuvant chemoradiotherapy (nCRT) remains debatable among patients with locally advanced rectal cancer (LARC), necessitating biomarkers to accurately predict the benefits of AC. This study aimed to develop a patie …
Postoperative adjuvant chemotherapy (AC) for poor responders to neoadjuvant chemoradiotherapy (nCRT) remains debatable among patients with l …
Tissue-specific micropattern array chips fabricated via decellularized ECM for 3D cell culture.
Zhu X, Li Y, Long H, Liang Z, He Y, Zhou Y, Li S, Bao J. Zhu X, et al. MethodsX. 2023 Oct 31;11:102463. doi: 10.1016/j.mex.2023.102463. eCollection 2023 Dec. MethodsX. 2023. PMID: 38023305 Free PMC article.
Multicellular three-dimensional (3D) in vitro models, such as cell spheroids and organoids, can significantly improve the viability, histomorphology, genotype stability, function and drug metabolism of cells [1], [2], [3]. In general, several culture methods of 3D models, …
Multicellular three-dimensional (3D) in vitro models, such as cell spheroids and organoids, can significantly improve the viability, …
Unveiling the novel immune and molecular signatures of ovarian cancer: insights and innovations from single-cell sequencing.
Li Z, Gu H, Xu X, Tian Y, Huang X, Du Y. Li Z, et al. Front Immunol. 2023 Nov 1;14:1288027. doi: 10.3389/fimmu.2023.1288027. eCollection 2023. Front Immunol. 2023. PMID: 38022625 Free PMC article. Review.
It encompasses the identification and characterization of novel cell subpopulations, the elucidation of tumor heterogeneity, the investigation of the tumor microenvironment, the analysis of mechanisms underlying metastasis, and the integration of innovative approaches such as …
It encompasses the identification and characterization of novel cell subpopulations, the elucidation of tumor heterogeneity, the investigati …
Epithelial cells/progenitor cells in developing human lower respiratory tract: Characterization and transplantation to rat model of pulmonary injury.
Ganji F, Ebrahimi M, Shirani A, Golmohammadi M, Gholipourmalekabadi M, Kashanian M, Koolaeinezhad K, Davari HR, Mousavi SAJ, Aghayan HR, Arjmand B, Heshmat R, Karkuki Osguei N, Samadikuchaksaraei A. Ganji F, et al. Bioimpacts. 2023;13(6):505-520. doi: 10.34172/bi.2023.26456. Epub 2023 Jul 22. Bioimpacts. 2023. PMID: 38022383 Free PMC article.
METHODS: Human fetal lower respiratory tissues from pseudoglandular and canalicular stages and their isolated epithelial cells were evaluated by immunostaining, electron microscopy, flow cytometry, organoid assay, and gene expression studies. The regenerative potential of …
METHODS: Human fetal lower respiratory tissues from pseudoglandular and canalicular stages and their isolated epithelial cells were evaluate …
Ethical, legal and social aspects of human cerebral organoids and their governance in Germany, the United Kingdom and the United States.
Pichl A, Ranisch R, Altinok OA, Antonakaki M, Barnhart AJ, Bassil K, Boyd JL, Chinaia AA, Diner S, Gaillard M, Greely HT, Jowitt J, Kreitmair K, Lawrence D, Lee TN, McKeown A, Sachdev V, Schicktanz S, Sugarman J, Trettenbach K, Wiese L, Wolff H, Árnason G. Pichl A, et al. Front Cell Dev Biol. 2023 Nov 13;11:1194706. doi: 10.3389/fcell.2023.1194706. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 38020890 Free PMC article.
Human cerebral organoids (HCOs) are model systems that enable researchers to investigate the human brain in ways that had previously been impossible. ...This perspective article resulted from an international and interdisciplinary research retreat "Ethical, Legal and Socia …
Human cerebral organoids (HCOs) are model systems that enable researchers to investigate the human brain in ways that had previously …
Dual function of angiogenin-4 inducing intestinal stem cells and apoptosis.
Abo H, Sultana MF, Kawashima H. Abo H, et al. Front Cell Dev Biol. 2023 Nov 2;11:1181145. doi: 10.3389/fcell.2023.1181145. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 38020881 Free PMC article.
We revealed that Ang4 is highly expressed by Paneth cells in the small intestine, as well as regenerating islet-derived family member-4 (Reg4) expressing goblet cells in the colon, and both cell subsets highly contribute to ISC maintenance. Functional analysis using intestinal …
We revealed that Ang4 is highly expressed by Paneth cells in the small intestine, as well as regenerating islet-derived family member-4 (Reg …
A T cell receptor β chain-directed antibody fusion molecule activates and expands subsets of T cells to promote antitumor activity.
Hsu J, Donahue RN, Katragadda M, Lowry J, Huang W, Srinivasan K, Guntas G, Tang J, Servattalab R, Moisan J, Tsai YT, Stoop A, Palakurthi S, Chopra R, Liu K, Wherry EJ, Su Z, Gulley JL, Bayliffe A, Schlom J. Hsu J, et al. Sci Transl Med. 2023 Nov 29;15(724):eadi0258. doi: 10.1126/scitranslmed.adi0258. Epub 2023 Nov 29. Sci Transl Med. 2023. PMID: 38019931
These immunological and antitumor effects in mice were recapitulated in studies of STAR0602 in nonhuman primates and human ex vivo models, wherein STAR0602 boosted human antigen-specific T cell responses and killing of tumor organoids. Thus, STAR0602 represents a distinct …
These immunological and antitumor effects in mice were recapitulated in studies of STAR0602 in nonhuman primates and human ex vivo models, w …
GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders.
López-Tobón A, Shyti R, Villa CE, Cheroni C, Fuentes-Bravo P, Trattaro S, Caporale N, Troglio F, Tenderini E, Mihailovich M, Skaros A, Gibson WT, Cuomo A, Bonaldi T, Mercurio C, Varasi M, Osborne L, Testa G. López-Tobón A, et al. Sci Adv. 2023 Dec;9(48):eadh2726. doi: 10.1126/sciadv.adh2726. Epub 2023 Nov 29. Sci Adv. 2023. PMID: 38019906 Free PMC article.
We integrated proteomic and transcriptomic profiling of patient-derived cortical organoids, including longitudinally at single-cell resolution, to dissect 7q11.23 dosage-dependent and GTF2I-specific disease mechanisms. ...
We integrated proteomic and transcriptomic profiling of patient-derived cortical organoids, including longitudinally at single-cell r …
Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells.
Li C, Liu Z, Anderson J, Liu Z, Tang L, Li Y, Peng N, Chen J, Liu X, Fu L, Townes TM, Rowe SM, Bedwell DM, Guimbellot J, Zhao R. Li C, et al. PLoS One. 2023 Nov 29;18(11):e0295009. doi: 10.1371/journal.pone.0295009. eCollection 2023. PLoS One. 2023. PMID: 38019847 Free PMC article.
We demonstrated that prime editing corrected one mutant allele in iPSCs, which effectively restored CFTR function in iPSC-derived airway epithelial cells and organoids. We further demonstrated that prime editing may directly repair mutations in iPSC-derived airway epitheli …
We demonstrated that prime editing corrected one mutant allele in iPSCs, which effectively restored CFTR function in iPSC-derived airway epi …
Three-Dimensional In Vitro Human Placental Organoids from Mononuclear Villous Trophoblasts or Trophoblast Stem Cells to Understand Trophoblast Dysfunction in Fetal Growth Restriction.
Sun C, James JL, Murthi P. Sun C, et al. Methods Mol Biol. 2024;2728:235-245. doi: 10.1007/978-1-0716-3495-0_19. Methods Mol Biol. 2024. PMID: 38019405
Here, we describe detailed methods to isolate mononuclear villous trophoblasts (containing cytotrophoblasts and trophoblast stem cells) from first trimester placentae, and use both these and trophoblast stem cell populations that can be grown long term in a three-dimensional (3D) …
Here, we describe detailed methods to isolate mononuclear villous trophoblasts (containing cytotrophoblasts and trophoblast stem cells) from …
Trophoblast Organoids as a Novel Tool to Study Human Placental Development and Function.
Haider S, Knöfler M, Latos PA. Haider S, et al. Methods Mol Biol. 2024;2728:195-222. doi: 10.1007/978-1-0716-3495-0_17. Methods Mol Biol. 2024. PMID: 38019403
Recent establishment of 2D human trophoblast stem cells and 3D trophoblast organoids has been a major advancement that opened new avenues for trophoblast research. Here we provide a protocol detailing isolation of cytotrophoblast from the first trimester human placenta, es …
Recent establishment of 2D human trophoblast stem cells and 3D trophoblast organoids has been a major advancement that opened new ave …
[For a good understanding and use of the term "organoids"].
Chneiweiss H, Dubart-Kupperschmitt A, Duclos-Vallée JC, Clément B, Flacher V, Galzi JL, Gidrol X, Goureau O, Guasch G, Haiech J, Lemaitre C, Mahé MM, Martin S, Poulain L, Sebastiani C, Vergnolle N, Yates F. Chneiweiss H, et al. Med Sci (Paris). 2023 Nov;39(11):876-878. doi: 10.1051/medsci/2023155. Epub 2023 Nov 29. Med Sci (Paris). 2023. PMID: 38018932 French.
Microfluidic Organoid Cultures Derived from Pancreatic Cancer Biopsies for Personalized Testing of Chemotherapy and Immunotherapy.
Choi D, Gonzalez-Suarez AM, Dumbrava MG, Medlyn M, de Hoyos-Vega JM, Cichocki F, Miller JS, Ding L, Zhu M, Stybayeva G, Gaspar-Maia A, Billadeau DD, Ma WW, Revzin A. Choi D, et al. Adv Sci (Weinh). 2023 Nov 29:e2303088. doi: 10.1002/advs.202303088. Online ahead of print. Adv Sci (Weinh). 2023. PMID: 38018486
Patient-derived cancer organoids (PDOs) hold considerable promise for personalizing therapy selection and improving patient outcomes. ...It is demonstrated that microfluidic PDOs are phenotypically and genotypically similar to the gold-standard Matrigel organoids wi …
Patient-derived cancer organoids (PDOs) hold considerable promise for personalizing therapy selection and improving patient outcomes. …
Temporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identity.
Pagliaro A, Finger R, Zoutendijk I, Bunschuh S, Clevers H, Hendriks D, Artegiani B. Pagliaro A, et al. Nat Commun. 2023 Nov 28;14(1):7361. doi: 10.1038/s41467-023-43141-1. Nat Commun. 2023. PMID: 38016960 Free PMC article.
Here, we show that initiating neural induction in a temporal stepwise gradient guides the generation of brain organoids composed of a single, self-organized apical-out neuroepithelium, termed ENOs (expanded neuroepithelium organoids). This is at odds with standard b …
Here, we show that initiating neural induction in a temporal stepwise gradient guides the generation of brain organoids composed of a …
Internet-connected cortical organoids for project-based stem cell and neuroscience education.
Elliott MAT, Schweiger HE, Robbins A, Vera-Choqqueccota S, Ehrlich D, Hernandez S, Voitiuk K, Geng J, Sevetson JL, Core C, Rosen YM, Teodorescu M, Wagner NO, Haussler D, Mostajo-Radji MA. Elliott MAT, et al. eNeuro. 2023 Nov 24:ENEURO.0308-23.2023. doi: 10.1523/ENEURO.0308-23.2023. Online ahead of print. eNeuro. 2023. PMID: 38016807 Free article.
By connecting laboratory equipment to the cloud, we introduce students to experimentation in pluripotent stem cell-derived cortical organoids in two different settings: Using microscopy to monitor organoid growth in an introductory tissue culture course and using hi …
By connecting laboratory equipment to the cloud, we introduce students to experimentation in pluripotent stem cell-derived cortical organ …
Multimodal spatiotemporal monitoring of basal stem cell-derived organoids reveals progression of olfactory dysfunction in Alzheimer's disease.
Liu M, Jiang N, Qin C, Xue Y, Wu J, Qiu Y, Yuan Q, Chen C, Huang L, Zhuang L, Wang P. Liu M, et al. Biosens Bioelectron. 2023 Nov 14;246:115832. doi: 10.1016/j.bios.2023.115832. Online ahead of print. Biosens Bioelectron. 2023. PMID: 38016198
However, the roles of peripheral olfactory system in disease progression and the mechanisms behind neurodegeneration remain to be studied. Olfactory epithelium (OE) organoid is an ideal model to study pathophysiology in vitro, yet the reliance on 3D culture condition limit …
However, the roles of peripheral olfactory system in disease progression and the mechanisms behind neurodegeneration remain to be studied. O …
One mutation to rule them all: Mutant KRAS controls tumor intrinsic and microenvironment signaling.
Müller S, Krishnamurty AT. Müller S, et al. Cancer Res. 2023 Nov 28. doi: 10.1158/0008-5472.CAN-23-3682. Online ahead of print. Cancer Res. 2023. PMID: 38016110
In a recent study published in Cancer Discovery, Hsu and colleagues employ an elegant combination of single-cell and bulk RNA-seq experiments from mouse and human colorectal cancer (CRC) samples, patient-derived organoids, 2D in vitro systems, and in vivo validation in gen …
In a recent study published in Cancer Discovery, Hsu and colleagues employ an elegant combination of single-cell and bulk RNA-seq experiment …
Advances in the Construction and Application of Thyroid Organoids.
Zhang Y, Fu M, Wang H, Sun H. Zhang Y, et al. Physiol Res. 2023 Nov 28;72(5):557-564. Physiol Res. 2023. PMID: 38015755 Free article. Review.
This review describes the construction of thyroid organoids and the research progress that has occurred in models of thyroid-related disease. As a novel tool for modeling in a 3D multicellular environment, organoids help provide some useful references for the study …
This review describes the construction of thyroid organoids and the research progress that has occurred in models of thyroid-related …
Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides.
Achimba F, Faezov B, Cohen B, Dunbrack R, Holford M. Achimba F, et al. Mol Cancer Ther. 2023 Nov 28. doi: 10.1158/1535-7163.MCT-23-0256. Online ahead of print. Mol Cancer Ther. 2023. PMID: 38015557
Finally, we summarize the role of cell culture, animal, and organoid models in developing effective therapies against HCC and highlight the need for creating models that represent the most disproportionately affected ethnicities in HCC....
Finally, we summarize the role of cell culture, animal, and organoid models in developing effective therapies against HCC and highlig …
Spatially segregated defects and IGF1-responsiveness of hilar and peripheral biliary organoids from a model of Alagille syndrome.
Iqbal A, Van Hul N, Belicova L, Corbat AA, Hankeova S, Andersson ER. Iqbal A, et al. Liver Int. 2023 Nov 28. doi: 10.1111/liv.15789. Online ahead of print. Liver Int. 2023. PMID: 38014627
Here, we investigated region-specific IHBD characteristics and addressed whether IGF1, a cholangiocyte mitogen that is downregulated in ALGS and in Jag1(Ndr/Ndr) mice, can improve biliary outcomes. METHODS: Intrahepatic cholangiocyte organoids (ICOs) were derived from hila …
Here, we investigated region-specific IHBD characteristics and addressed whether IGF1, a cholangiocyte mitogen that is downregulated in ALGS …
Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active CpG sites in neo-cartilage organoids.
Bloks NG, Dicks A, Harissa Z, Nelissen RG, Hajmousa G, Ramos YF, Almeida RC, Guilak F, Meulenbelt I. Bloks NG, et al. Res Sq. 2023 Nov 15:rs.3.rs-3568544. doi: 10.21203/rs.3.rs-3568544/v1. Preprint. Res Sq. 2023. PMID: 38014245 Free PMC article.
The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.
Jones-Tabah J, He K, Senkevich K, Karpilovsky N, Deyab G, Cousineau Y, Nikanorova D, Goldsmith T, Pellitero EDC, Chen CX, Luo W, You Z, Abdian N, Pietrantonio I, Goiran T, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Waters C, Monchi O, Dauvilliers Y, Dupré N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, Hassin-Baer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z, Fon EA. Jones-Tabah J, et al. bioRxiv. 2023 Nov 15:2023.11.11.566693. doi: 10.1101/2023.11.11.566693. Preprint. bioRxiv. 2023. PMID: 38014143 Free PMC article.
In cell lines, reduction of CTSB gene expression impairs the degradation of pre-formed alpha-synuclein fibrils, whereas CTSB gene activation enhances fibril clearance. In midbrain organoids and dopaminergic neurons treated with alpha-synuclein fibrils, catB inhibition pote …
In cell lines, reduction of CTSB gene expression impairs the degradation of pre-formed alpha-synuclein fibrils, whereas CTSB gene activation …
Multiplexed live-cell imaging for drug responses in patient-derived organoid models of cancer.
Colling KE, Symons EL, Buroni L, Sumanisiri HK, Andrew-Udoh J, Witt E, Losh HA, Morrison AM, Leslie KK, Dunnill CJ, De Bono JS, Thiel KW. Colling KE, et al. bioRxiv. 2023 Nov 17:2023.11.15.567243. doi: 10.1101/2023.11.15.567243. Preprint. bioRxiv. 2023. PMID: 38014133 Free PMC article.
Patient-derived organoid (PDO) models of cancer are a multifunctional research system that better recapitulates human disease as compared to cancer cell lines. ...
Patient-derived organoid (PDO) models of cancer are a multifunctional research system that better recapitulates human disease as comp …
Dynamic neuroinflammatory profiles predict Alzheimer's disease pathology in microglia-containing cerebral organoids.
Kuhn MK, Tagay Y, Tabdanov ED, Elcheva IA, Proctor EA. Kuhn MK, et al. bioRxiv. 2023 Nov 16:2023.11.16.567220. doi: 10.1101/2023.11.16.567220. Preprint. bioRxiv. 2023. PMID: 38014053 Free PMC article.
AD organoids exhibited an overall reduction in cytokine secretion after an initial amplified immune response. We demonstrate that reduced synapse density observed in the AD organoids is prevented with microglial depletion. Crucially, these differential effects of dy …
AD organoids exhibited an overall reduction in cytokine secretion after an initial amplified immune response. We demonstrate that red …
Multiplexed 3D Analysis of Cell Plasticity and Immune Niches in Melanoma.
Yapp C, Nirmal AJ, Zhou F, Maliga Z, Llopis PM, Murphy GF, Lian CG, Danuser G, Santagata S, Sorger PK; Human Tumor Atlas Network. Yapp C, et al. bioRxiv. 2023 Nov 15:2023.11.10.566670. doi: 10.1101/2023.11.10.566670. Preprint. bioRxiv. 2023. PMID: 38014052 Free PMC article.
These data provide new insight into the transitions occurring during early tumour formation and demonstrate the potential for phenotyping tissues at a level of detail previously restricted to cultured cells and organoids....
These data provide new insight into the transitions occurring during early tumour formation and demonstrate the potential for phenotyping ti …
PCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1F.
Ivanchenko MV, Hathaway DM, Mulhall EM, Booth KT, Wang M, Peters CW, Klein AJ, Chen X, Li Y, György B, Corey DP. Ivanchenko MV, et al. bioRxiv. 2023 Nov 13:2023.11.09.566447. doi: 10.1101/2023.11.09.566447. Preprint. bioRxiv. 2023. PMID: 38014037 Free PMC article.
Importantly, our approach also proves successful in expressing PCDH15 in clinically relevant retinal models, including human retinal organoids and non-human primate retina, showing efficient targeting of photoreceptors and proper protein expression in the calyceal processe …
Importantly, our approach also proves successful in expressing PCDH15 in clinically relevant retinal models, including human retinal orga …
Brain organoids: A revolutionary tool for modeling neurological disorders and development of therapeutics.
Acharya P, Choi NY, Shrestha S, Jeong S, Lee MY. Acharya P, et al. Biotechnol Bioeng. 2023 Nov 28. doi: 10.1002/bit.28606. Online ahead of print. Biotechnol Bioeng. 2023. PMID: 38013504 Review.
Brain organoids are self-organized, three-dimensional (3D) aggregates derived from pluripotent stem cells that have cell types and cellular architectures resembling those of the developing human brain. ...In this review article, we first summarize an overview of the existi …
Brain organoids are self-organized, three-dimensional (3D) aggregates derived from pluripotent stem cells that have cell types and ce …
Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases.
Liang Y, Sun X, Duan C, Tang S, Chen J. Liang Y, et al. Stem Cell Res Ther. 2023 Nov 27;14(1):340. doi: 10.1186/s13287-023-03564-5. Stem Cell Res Ther. 2023. PMID: 38012786 Free PMC article. Review.
Finally, the importance of human iPSCs and organoids in combination with emerging technologies such as multi-omics integration analysis, 3D bioprinting, or microfluidic chip platform are highlighted. Patient-derived retinal organoids may be a preferred choice for mo …
Finally, the importance of human iPSCs and organoids in combination with emerging technologies such as multi-omics integration analys …
Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer.
Zheng S, Tian Q, Yuan Y, Sun S, Li T, Xia R, He R, Luo Y, Lin Q, Fu Z, Zhou Y, Chen R, Hu C. Zheng S, et al. J Exp Clin Cancer Res. 2023 Nov 28;42(1):324. doi: 10.1186/s13046-023-02854-3. J Exp Clin Cancer Res. 2023. PMID: 38012734 Free PMC article.
Then, the effects of EV-packaged circBIRC6 on CAF-induced oxaliplatin resistance were investigated by flow cytometry, colony formation, viability of pancreatic cancer organoids in vitro and by xenograft models in vivo. RNA pulldown, RNA immunoprecipitation, and sites mutat …
Then, the effects of EV-packaged circBIRC6 on CAF-induced oxaliplatin resistance were investigated by flow cytometry, colony formation, viab …
Author Correction: Changing the public perception of human embryology.
Rivron NC, Martinez-Arias A, Sermon K, Mummery C, Schöler HR, Wells J, Nichols J, Hadjantonakis AK, Lancaster MA, Moris N, Fu J, Sturmey RG, Niakan K, Rossant J, Kato K. Rivron NC, et al. Nat Cell Biol. 2023 Nov 27. doi: 10.1038/s41556-023-01319-1. Online ahead of print. Nat Cell Biol. 2023. PMID: 38012405 No abstract available.
NAxtra magnetic nanoparticles for low-cost, efficient isolation of mammalian DNA and RNA.
Starheim EJ, Ravlo E, Schjølberg JO, Solvang V, Wang W, Scrimgeour NR, Manaf A, Erlandsen SE, Aas PA, Hagen L, de Sousa MML, Bjørås M. Starheim EJ, et al. Sci Rep. 2023 Nov 27;13(1):20836. doi: 10.1038/s41598-023-46868-5. Sci Rep. 2023. PMID: 38012172 Free PMC article.
Thus, based on this low-cost nucleic acid extraction technology, we developed a simple, low- and high-throughput, efficient method for isolation of high-integrity total NA, DNA and RNA from mammalian cell lines (monolayer) and organoids (3D-cultures). The extracted NA are …
Thus, based on this low-cost nucleic acid extraction technology, we developed a simple, low- and high-throughput, efficient method for isola …
Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice.
Huang HZ, Ai WQ, Wei N, Zhu LS, Liu ZQ, Zhou CW, Deng MF, Zhang WT, Zhang JC, Yang CQ, Hu YZ, Han ZT, Zhang HH, Jia JJ, Wang J, Liu FF, Li K, Xu Q, Yuan M, Man H, Guo Z, Lu Y, Shu K, Zhu LQ, Liu D. Huang HZ, et al. Protein Cell. 2023 Nov 27:pwad056. doi: 10.1093/procel/pwad056. Online ahead of print. Protein Cell. 2023. PMID: 38011644 Free article.
Live Imaging of 3D Hanging Drop Arrays through Manipulation of Light-Responsive Pyroelectric Slippery Surface and Chip Adhesion.
Zhou S, Yang J, Li R, Chen Y, Li C, Chen C, Tao Y, Fan S, Wu D, Wen L, Qiu B, Ding W. Zhou S, et al. Nano Lett. 2023 Nov 27. doi: 10.1021/acs.nanolett.3c02570. Online ahead of print. Nano Lett. 2023. PMID: 38010943
Three-dimensional (3D) hanging drop cell culture is widely used in organoid culture because of its lack of selection pressure and rapid cell aggregation. ...
Three-dimensional (3D) hanging drop cell culture is widely used in organoid culture because of its lack of selection pressure and rap …
Patient-Derived Microphysiological Systems for Precision Medicine.
Ko J, Song J, Choi N, Kim HN. Ko J, et al. Adv Healthc Mater. 2023 Nov 27:e2303161. doi: 10.1002/adhm.202303161. Online ahead of print. Adv Healthc Mater. 2023. PMID: 38010253 Review.
This review discusses the development of P-MPS as an integration of patient-derived samples, including patient-derived cells, organoids, and induced pluripotent stem cells, into well-defined microphysiological systems. ...
This review discusses the development of P-MPS as an integration of patient-derived samples, including patient-derived cells, organoids …
Ailanthone synergizes with PARP1 inhibitor in tumour growth inhibition through crosstalk of DNA repair pathways in gastric cancer.
Wang C, Yi T, Li X, Cui J, Li B, Qin Y, Tang S, Zhang J. Wang C, et al. J Cell Mol Med. 2023 Nov 27. doi: 10.1111/jcmm.18033. Online ahead of print. J Cell Mol Med. 2023. PMID: 38009603 Free article.
In our previous research, we proved that ailanthone (AIL) inhibits the growth of gastric cancer (GC) cells and causes apoptosis by inhibiting P23. However, we still find some GC organoids are insensitive to AIL. We have done some sequencing analysis and found that the inse …
In our previous research, we proved that ailanthone (AIL) inhibits the growth of gastric cancer (GC) cells and causes apoptosis by inhibitin …
Listen to Your Gut: Key Concepts for Bioengineering Advanced Models of the Intestine.
Cameron O, Neves JF, Gentleman E. Cameron O, et al. Adv Sci (Weinh). 2023 Nov 27:e2302165. doi: 10.1002/advs.202302165. Online ahead of print. Adv Sci (Weinh). 2023. PMID: 38009508 Review.
The discovery that the intestinal epithelium can be reproduced in vitro as intestinal organoids introduced a new way to understand intestinal development, homeostasis, and disease. However, organoids reflect the intestinal epithelium in isolation whereas the underly …
The discovery that the intestinal epithelium can be reproduced in vitro as intestinal organoids introduced a new way to understand in …
Assessment of hepatitis B virus infection and interhost cellular responses using intrahepatic cholangiocyte organoids.
Lim CK, Romeo O, Tran BM, Flanagan DJ, Kirby EN, McCartney EM, Tse E, Vincan E, Beard MR. Lim CK, et al. J Med Virol. 2023 Nov;95(11):e29232. doi: 10.1002/jmv.29232. J Med Virol. 2023. PMID: 38009279
The intrahepatic cholangiocyte organoids (ICOs) model was evaluated for host differences in hepatitis B virus (HBV) infection, cellular responses, antiviral and immunomodulator responses. ...
The intrahepatic cholangiocyte organoids (ICOs) model was evaluated for host differences in hepatitis B virus (HBV) infection, cellul …
22,890 results
You have reached the last available page of results. Please see the User Guide for more information.

Searches related to "organoid"